CA2249654A1 - Benzoxazines for enhancing synaptic response - Google Patents
Benzoxazines for enhancing synaptic responseInfo
- Publication number
- CA2249654A1 CA2249654A1 CA002249654A CA2249654A CA2249654A1 CA 2249654 A1 CA2249654 A1 CA 2249654A1 CA 002249654 A CA002249654 A CA 002249654A CA 2249654 A CA2249654 A CA 2249654A CA 2249654 A1 CA2249654 A1 CA 2249654A1
- Authority
- CA
- Canada
- Prior art keywords
- compounds
- group
- subjects
- ampa receptors
- enhancing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compounds of formula (I) in which R1 and R2 are independently selected from the group consisting of H and R4O such that at least one of R1 and R2 is R4O; in which R4 is a member selected from the group consisting of H, alkyl and halo-substituted alkyl; or R1 and R2 together form a single divalent moiety selected from the group consisting of (II), (III), (IV), (V), (VI) and (VII) are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating schizophrenia, and for improving memory encoding.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/624,335 | 1996-04-03 | ||
| US08/624,335 US5736543A (en) | 1996-04-03 | 1996-04-03 | Benzoxazines for enhancing synaptic response |
| PCT/US1997/005184 WO1997036907A1 (en) | 1996-04-03 | 1997-03-28 | Benzoxazines for enhancing synaptic response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2249654A1 true CA2249654A1 (en) | 1997-10-09 |
| CA2249654C CA2249654C (en) | 2006-10-03 |
Family
ID=37101804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002249654A Expired - Fee Related CA2249654C (en) | 1996-04-03 | 1997-03-28 | Benzoxazines for enhancing synaptic response |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2249654C (en) |
-
1997
- 1997-03-28 CA CA002249654A patent/CA2249654C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2249654C (en) | 2006-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130328 |