DE69716414D1 - Benzoxazine zur erhöhung der synaptischen reaktionen - Google Patents
Benzoxazine zur erhöhung der synaptischen reaktionenInfo
- Publication number
- DE69716414D1 DE69716414D1 DE69716414T DE69716414T DE69716414D1 DE 69716414 D1 DE69716414 D1 DE 69716414D1 DE 69716414 T DE69716414 T DE 69716414T DE 69716414 T DE69716414 T DE 69716414T DE 69716414 D1 DE69716414 D1 DE 69716414D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- subjects
- ampa receptors
- benzoxazine
- reactions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/624,335 US5736543A (en) | 1996-04-03 | 1996-04-03 | Benzoxazines for enhancing synaptic response |
PCT/US1997/005184 WO1997036907A1 (en) | 1996-04-03 | 1997-03-28 | Benzoxazines for enhancing synaptic response |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69716414D1 true DE69716414D1 (de) | 2002-11-21 |
DE69716414T2 DE69716414T2 (de) | 2003-06-12 |
Family
ID=24501596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69716414T Expired - Lifetime DE69716414T2 (de) | 1996-04-03 | 1997-03-28 | Benzoxazine zur erhöhung der synaptischen reaktionen |
Country Status (10)
Country | Link |
---|---|
US (2) | US5736543A (de) |
EP (1) | EP0891365B1 (de) |
JP (1) | JP3170294B2 (de) |
AT (1) | ATE226206T1 (de) |
AU (1) | AU708212B2 (de) |
DE (1) | DE69716414T2 (de) |
DK (1) | DK0891365T3 (de) |
ES (1) | ES2185932T3 (de) |
NZ (1) | NZ331992A (de) |
WO (1) | WO1997036907A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU721936B2 (en) * | 1996-04-03 | 2000-07-20 | Regents Of The University Of California, The | Benzoxazines for enhancing synaptic response |
US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
ES2258825T3 (es) * | 1997-10-27 | 2006-09-01 | Cortex Pharmaceuticals, Inc. | Tratamiento de la esquizofrenia con ampakinas y neurolepticos. |
US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
US6943159B1 (en) | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
US6124278A (en) * | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
US6011991A (en) * | 1998-12-07 | 2000-01-04 | Technology Patents, Llc | Communication system and method including brain wave analysis and/or use of brain activity |
US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
TWI232863B (en) * | 2001-06-11 | 2005-05-21 | Akzo Nobel Nv | Benzoxazepine derivatives |
US7345036B2 (en) * | 2001-06-14 | 2008-03-18 | N.V. Organon | (Pyrido/thieno)—[f]—oxazepine-5-one derivatives |
GEP20063859B (en) * | 2001-11-26 | 2006-06-26 | Cortex Pharma Inc | Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses |
EP1546235B1 (de) | 2002-09-09 | 2021-10-20 | Nektar Therapeutics | Wasserlösliche polymer alkanale |
NZ540468A (en) | 2003-01-13 | 2008-03-28 | Univ California | Method of treating cognitive decline due to sleep deprivation and stress using an AMPA receptor potentiator |
WO2006034196A1 (en) * | 2004-09-17 | 2006-03-30 | Lifelike Biomatic Inc. | Compositions for enhancing memory and methods therefor |
TW200800959A (en) | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
US20100234349A1 (en) | 2006-09-04 | 2010-09-16 | Olsen Gunnar M | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
EA200900937A1 (ru) * | 2007-01-03 | 2009-12-30 | Кортекс Фармасеутикалс, Инк. | Соединения 3-замещенного-[1,2,3]бензотриазинона для усиления глутаматергических синаптических ответов |
RS52108B (en) * | 2007-01-03 | 2012-08-31 | Les Laboratoires Servier | 3-SUBSTITUTED [1,2,3] -BENZOTRIAZINONE UNIT TO INCREASE GLUTAMATERGIC SYNAPTIC ANSWERS |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
US20100069377A1 (en) * | 2007-03-23 | 2010-03-18 | The Regents Of The University Of California | Treatment of female sexual dysfunction by compounds that positively modulate ampa-type glutamate receptors |
EP2154970B1 (de) | 2007-05-17 | 2017-10-25 | RespireRx Pharmaceuticals Inc. | Disubstituierte amide zur verbesserung der glutamatergischen synaptischen reaktion |
US8263591B2 (en) * | 2007-08-10 | 2012-09-11 | Cortex Pharmaceuticals, Inc. | Bicyclic amides for enhancing glutamatergic synaptic responses |
US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
US8071914B2 (en) | 2007-12-26 | 2011-12-06 | Noboru Oshima | Heating apparatus |
US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
WO2011109398A2 (en) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
EP2801377B1 (de) | 2011-03-04 | 2019-08-07 | The Regents of The University of California | Hydrogel enthaltend Zellen zur lokalen Freisetzung von Wachstumsfaktoren zur Rückgewinnung der Bewegungsfähigkeit nach einem Schlaganfall |
EP2948135B1 (de) | 2013-01-25 | 2019-01-02 | Case Western Reserve University | Zusammensetzungen und verfahren zur behandlung von erkrankungen mit pervasiver entwicklung |
AU2014277952A1 (en) | 2013-06-13 | 2016-01-28 | Veroscience Llc | Compositions and methods for treating metabolic disorders |
CN107286114B (zh) | 2016-04-13 | 2020-08-18 | 中国人民解放军军事医学科学院毒物药物研究所 | Ampa受体增效剂的脑靶向前药及其医药用途 |
EP3684463A4 (de) | 2017-09-19 | 2021-06-23 | Neuroenhancement Lab, LLC | Verfahren und vorrichtung für neuro-enhancement |
US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
EP3731749A4 (de) | 2017-12-31 | 2022-07-27 | Neuroenhancement Lab, LLC | System und verfahren zur neuroverstärkung zur verbesserung der emotionalen reaktion |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
CA3112564A1 (en) | 2018-09-14 | 2020-03-19 | Neuroenhancement Lab, LLC | System and method of improving sleep |
US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3257396A (en) * | 1962-06-11 | 1966-06-21 | Geigy Chem Corp | Certain 1, 3-benzoxazinone derivatives |
DK0651746T3 (da) * | 1992-07-24 | 2002-07-29 | Univ California | Lægemidler, der forbedrer synaptiske responser medieret af AMPA-receptorer |
US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
-
1996
- 1996-04-03 US US08/624,335 patent/US5736543A/en not_active Expired - Lifetime
-
1997
- 1997-03-28 AT AT97919965T patent/ATE226206T1/de not_active IP Right Cessation
- 1997-03-28 EP EP97919965A patent/EP0891365B1/de not_active Expired - Lifetime
- 1997-03-28 DE DE69716414T patent/DE69716414T2/de not_active Expired - Lifetime
- 1997-03-28 ES ES97919965T patent/ES2185932T3/es not_active Expired - Lifetime
- 1997-03-28 JP JP53548897A patent/JP3170294B2/ja not_active Expired - Fee Related
- 1997-03-28 AU AU24274/97A patent/AU708212B2/en not_active Ceased
- 1997-03-28 NZ NZ331992A patent/NZ331992A/xx unknown
- 1997-03-28 WO PCT/US1997/005184 patent/WO1997036907A1/en active IP Right Grant
- 1997-03-28 DK DK97919965T patent/DK0891365T3/da active
-
1998
- 1998-02-06 US US09/019,883 patent/US5962447A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1997036907A1 (en) | 1997-10-09 |
DK0891365T3 (da) | 2003-02-10 |
ATE226206T1 (de) | 2002-11-15 |
US5736543A (en) | 1998-04-07 |
AU2427497A (en) | 1997-10-22 |
AU708212B2 (en) | 1999-07-29 |
NZ331992A (en) | 1999-02-25 |
DE69716414T2 (de) | 2003-06-12 |
ES2185932T3 (es) | 2003-05-01 |
EP0891365A1 (de) | 1999-01-20 |
JP2000503664A (ja) | 2000-03-28 |
JP3170294B2 (ja) | 2001-05-28 |
US5962447A (en) | 1999-10-05 |
EP0891365B1 (de) | 2002-10-16 |
Similar Documents
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DE69716414T2 (de) | Benzoxazine zur erhöhung der synaptischen reaktionen | |
PT839134E (pt) | Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica | |
CA2138533A1 (en) | Drugs that enhance synaptic responses mediated by ampa receptors | |
IL136783A0 (en) | Benzoxazine compounds for enhancing synaptic response | |
DK1355669T3 (da) | Forbedret kognitiv træning | |
DE69834590D1 (de) | Benzofurazanderivate und deren verwendung zur verbesserung glutaminerger synaptischer antworten | |
DE69910552D1 (de) | Acylbenzoxazine zur erhöhung der synaptischen reaktion(en) | |
EA200400584A1 (ru) | Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee | ||
8370 | Indication related to discontinuation of the patent is to be deleted |