ATE451362T1 - Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten - Google Patents
Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheitenInfo
- Publication number
- ATE451362T1 ATE451362T1 AT04077618T AT04077618T ATE451362T1 AT E451362 T1 ATE451362 T1 AT E451362T1 AT 04077618 T AT04077618 T AT 04077618T AT 04077618 T AT04077618 T AT 04077618T AT E451362 T1 ATE451362 T1 AT E451362T1
- Authority
- AT
- Austria
- Prior art keywords
- diseases
- salts
- treatment
- acid derivatives
- liponic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10562898P | 1998-10-26 | 1998-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE451362T1 true ATE451362T1 (de) | 2009-12-15 |
Family
ID=22306916
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04077618T ATE451362T1 (de) | 1998-10-26 | 1999-10-26 | Salze von liponsaürederivaten und deren verwendung bei der behandlung von krankheiten |
AT99956698T ATE277034T1 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99956698T ATE277034T1 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Country Status (12)
Country | Link |
---|---|
US (2) | US6331559B1 (de) |
EP (3) | EP1486495B1 (de) |
JP (2) | JP4728481B2 (de) |
AT (2) | ATE451362T1 (de) |
AU (1) | AU774362B2 (de) |
BR (1) | BR9914789A (de) |
CA (1) | CA2348998C (de) |
DE (2) | DE69941800D1 (de) |
ES (2) | ES2340488T3 (de) |
IL (2) | IL142824A0 (de) |
MX (1) | MXPA01004152A (de) |
WO (1) | WO2000024734A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
EP1133487B1 (de) * | 1998-11-25 | 2004-09-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Antioxidationsmittel |
AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
ES2162586B1 (es) * | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
US7109362B2 (en) | 2000-11-30 | 2006-09-19 | Basf Aktiengesellschaft | Process for the preparation of lipoic acid and dihydrolipoic acid |
EP1371640B1 (de) * | 2001-03-19 | 2009-10-28 | Senju Pharmaceutical Co., Ltd. | Neues a-liponsäurederivat und dessen verwendung |
US6936641B2 (en) * | 2002-06-25 | 2005-08-30 | Johnson & Johnson Vision Care, Inc. | Macromer forming catalysts |
WO2004006859A2 (en) * | 2002-07-16 | 2004-01-22 | Sonus Pharmaceuticals, Inc. | Platinum compound |
KR100973450B1 (ko) * | 2002-09-13 | 2010-08-02 | 유겐가이샤 오가 리서치 | 멜라닌 소거제 |
WO2004071458A2 (en) | 2003-02-13 | 2004-08-26 | Albert Einstein College Of Medicine Of Yeshiva University | REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS |
US20040248982A1 (en) * | 2003-06-09 | 2004-12-09 | Dyer Gordon Wayne | Use of compounds for the inhibition of proteins and UV protection |
EP1651207A4 (de) * | 2003-06-12 | 2008-10-01 | Univ Colorado | Systeme und verfahren zur behandlung von entzündlichen und proliferativen erkrankungen und wunden des menschen mit fettsäure-stoffwechsel-hemmern und/oder glykolytischen hemmern |
US7510710B2 (en) * | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
CA2560059A1 (en) * | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
WO2006116217A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of Colorado | Therapeutic bifunctional compounds |
AU2006242667A1 (en) * | 2005-05-02 | 2006-11-09 | The Regents Of The University Of Colorado | Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound,that provides fatty acid metabolism and glycolysis inhibition |
US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
AU2008242827B2 (en) * | 2007-04-18 | 2014-06-05 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
KR101644192B1 (ko) * | 2007-04-18 | 2016-07-29 | 코너스톤 파마슈티칼스, 인크. | 리포산 유도체 |
WO2009105230A2 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
MX2010009673A (es) * | 2008-03-04 | 2011-03-15 | Robert Shorr | Modulacion de la estructura, actividad y/o nivel de expresion enzimaticos. |
SG10201608068SA (en) | 2008-04-01 | 2016-11-29 | Antipodean Pharmaceuticals Inc | Compositions And Methods For Skin Care |
WO2009123597A1 (en) * | 2008-04-04 | 2009-10-08 | Robert Shorr | Pharmaceutical composition |
CA2730773A1 (en) | 2008-07-14 | 2010-01-21 | Martha Karen Newell | Methods and products for treating proliferative diseases |
WO2010019225A1 (en) * | 2008-08-15 | 2010-02-18 | Robert Shorr | Pharmaceutical composition |
EP2350274B1 (de) | 2008-10-21 | 2019-01-23 | The General Hospital Corporation | Zelltransplantation |
FR2937867B1 (fr) | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
WO2010062381A1 (en) * | 2008-11-28 | 2010-06-03 | Robert Shorr | Organelle-specific drug delivery |
RU2011124739A (ru) * | 2008-12-01 | 2013-01-10 | Инваск Терапьютикс, Инк. | Композиции, содержащие ингибиторы системы ренин-ангиотензин альдостерона и соединения липоевой кислоты, и их применение для лечения заболеваний, связанных с системой ренин-ангиотензин альдостерона |
CN101787013B (zh) * | 2009-01-22 | 2013-04-24 | 杭州民生药业有限公司 | 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途 |
WO2010110887A1 (en) * | 2009-03-24 | 2010-09-30 | Robert Shorr | Fatty acids |
WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
WO2011046583A1 (en) * | 2009-09-11 | 2011-04-21 | Robert Shorr | Pharmaceutical exploitation of oxidative stress in transformed cells |
FR2959668B1 (fr) * | 2010-05-05 | 2012-07-13 | Biorebus | Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
WO2011138565A1 (fr) | 2010-05-05 | 2011-11-10 | Biorebus | Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
WO2011143593A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
WO2011143590A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
BR112013002859B1 (pt) | 2010-08-06 | 2020-10-06 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Método e aparelho para tratamento de células |
EP2934542A4 (de) * | 2012-12-19 | 2016-08-10 | Robert Shorr | Pharmazeutische verbindungen |
US9605012B2 (en) * | 2013-01-17 | 2017-03-28 | Garnett Mckeen Laboratory, Inc. | Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases |
AU2014398233B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
ES2819175T3 (es) | 2014-06-19 | 2021-04-15 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
US10052305B2 (en) | 2015-10-07 | 2018-08-21 | Buck Institute For Research On Aging | Lipoic acid and derivatives thereof for the treatment of cystinuria |
Family Cites Families (29)
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---|---|---|---|---|
DE362916C (de) | 1921-08-13 | 1922-11-02 | Eduard Duerr | Abnehmbares Mikrometer fuer Schublehren |
GB758897A (en) * | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
US2853497A (en) | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
US2872458A (en) * | 1954-12-30 | 1959-02-03 | Merck & Co Inc | Addition product of a metal hydrocarbon mercaptide with an alpha-halogamma-butyrolactone |
JPS57123107A (en) | 1981-01-26 | 1982-07-31 | Pola Chem Ind Inc | Cosmetic |
DE3512911A1 (de) * | 1985-04-11 | 1986-10-16 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
DE3626116A1 (de) | 1986-08-01 | 1988-02-11 | Karl Thiel | Thermostatische regeleinrichtung fuer heizungen bzw. heizaggregate |
DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
DE3900649A1 (de) | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Verfahren zur abloesung eines analyten von seinem bindeprotein |
JPH03193758A (ja) * | 1989-12-25 | 1991-08-23 | Nisshin Oil Mills Ltd:The | 新規γ―アミノ酪酸誘導体 |
DK0530446T3 (da) * | 1991-07-05 | 1998-09-23 | Asta Medica Ag | Anvendelse af svovlholdige carboxylsyrer til bekæmpelse af pathophysiologisk betingede exitationsforstyrrelser |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
WO1994006794A1 (en) | 1992-09-24 | 1994-03-31 | National Institutes Of Health | Aralkyl diazabicycloalkane derivatives for cns disorders |
DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
DE19601787C1 (de) * | 1996-01-19 | 1997-07-24 | Asta Medica Ag | Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure |
WO1998001440A2 (en) * | 1996-07-05 | 1998-01-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
EP0855396A1 (de) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Metabolite von Thioctsäure und deren Verwendung |
EP0979073A4 (de) * | 1997-03-31 | 2004-04-07 | Childrens Medical Center | Nitrosylierung zur inaktivierung apoptotischer enzyme |
AU728488B2 (en) * | 1997-04-02 | 2001-01-11 | Sankyo Company Limited | Dithiolan derivatives, their preparation and their therapeutic effect |
JPH11124379A (ja) * | 1997-10-17 | 1999-05-11 | Ss Pharmaceut Co Ltd | ジチオリリデンアセトアミド誘導体 |
FR2777001B1 (fr) | 1998-04-01 | 2000-06-09 | Cird Galderma | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
US6387945B2 (en) * | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
US10562898B2 (en) | 2016-02-05 | 2020-02-18 | Ea Pharma Co., Ltd. | Substituted benzenesulfonamides as inhibitors of alpha-4 beta-7 integrin activity |
-
1999
- 1999-10-26 MX MXPA01004152A patent/MXPA01004152A/es active IP Right Grant
- 1999-10-26 IL IL14282499A patent/IL142824A0/xx unknown
- 1999-10-26 JP JP2000578304A patent/JP4728481B2/ja not_active Expired - Lifetime
- 1999-10-26 DE DE69941800T patent/DE69941800D1/de not_active Expired - Lifetime
- 1999-10-26 AT AT04077618T patent/ATE451362T1/de not_active IP Right Cessation
- 1999-10-26 BR BR9914789-0A patent/BR9914789A/pt not_active Application Discontinuation
- 1999-10-26 ES ES04077618T patent/ES2340488T3/es not_active Expired - Lifetime
- 1999-10-26 DE DE69920497T patent/DE69920497T2/de not_active Expired - Lifetime
- 1999-10-26 ES ES99956698T patent/ES2229790T3/es not_active Expired - Lifetime
- 1999-10-26 CA CA2348998A patent/CA2348998C/en not_active Expired - Lifetime
- 1999-10-26 US US09/427,477 patent/US6331559B1/en not_active Expired - Lifetime
- 1999-10-26 EP EP04077618A patent/EP1486495B1/de not_active Expired - Lifetime
- 1999-10-26 WO PCT/US1999/025140 patent/WO2000024734A1/en active IP Right Grant
- 1999-10-26 AU AU13246/00A patent/AU774362B2/en not_active Expired
- 1999-10-26 EP EP99956698A patent/EP1124820B1/de not_active Expired - Lifetime
- 1999-10-26 AT AT99956698T patent/ATE277034T1/de not_active IP Right Cessation
- 1999-10-26 EP EP09012728A patent/EP2145883A1/de not_active Withdrawn
-
2001
- 2001-04-26 IL IL142824A patent/IL142824A/en not_active IP Right Cessation
- 2001-09-24 US US09/962,372 patent/US6951887B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126848A patent/JP5727721B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE277034T1 (de) | 2004-10-15 |
US6951887B2 (en) | 2005-10-04 |
US20020107234A1 (en) | 2002-08-08 |
EP1486495A1 (de) | 2004-12-15 |
CA2348998C (en) | 2012-03-06 |
AU774362B2 (en) | 2004-06-24 |
IL142824A0 (en) | 2002-03-10 |
IL142824A (en) | 2010-11-30 |
EP1124820A1 (de) | 2001-08-22 |
JP5727721B2 (ja) | 2015-06-03 |
MXPA01004152A (es) | 2002-06-04 |
JP4728481B2 (ja) | 2011-07-20 |
AU1324600A (en) | 2000-05-15 |
WO2000024734A1 (en) | 2000-05-04 |
DE69920497T2 (de) | 2006-02-09 |
ES2340488T3 (es) | 2010-06-04 |
JP2002528446A (ja) | 2002-09-03 |
JP2010248203A (ja) | 2010-11-04 |
EP1486495B1 (de) | 2009-12-09 |
DE69941800D1 (de) | 2010-01-21 |
EP2145883A1 (de) | 2010-01-20 |
DE69920497D1 (de) | 2004-10-28 |
BR9914789A (pt) | 2001-10-02 |
US6331559B1 (en) | 2001-12-18 |
ES2229790T3 (es) | 2005-04-16 |
CA2348998A1 (en) | 2000-05-04 |
EP1124820B1 (de) | 2004-09-22 |
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