BR9914789A - Derivados de ácido lipóico e seus usos no tratamento de doença - Google Patents

Derivados de ácido lipóico e seus usos no tratamento de doença

Info

Publication number
BR9914789A
BR9914789A BR9914789-0A BR9914789A BR9914789A BR 9914789 A BR9914789 A BR 9914789A BR 9914789 A BR9914789 A BR 9914789A BR 9914789 A BR9914789 A BR 9914789A
Authority
BR
Brazil
Prior art keywords
disease
treatment
acid derivatives
lipoic acid
diseased cells
Prior art date
Application number
BR9914789-0A
Other languages
English (en)
Inventor
Paul M Bingham
Zuzana Zachar
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Publication of BR9914789A publication Critical patent/BR9914789A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00

Abstract

"DERIVADOS DE áCIDO LIPóICO E SEUS USOS NO TRATAMENTO DE DOENçAS" Esta invenção refere-se à identificação de uma nova classe de agentes terapêuticos que alvejam seletivamente e matam células de tumor e certos outros tipos de células adoentadas, e a composições compreendendo derivados de ácido lipóico que envenenam o complexo piruvato desidrogenase especificamente em tais células. Esta invenção também provê métodos de uso de quantidades terapeuticamente efetivas dos derivados de ácido lipóico para o tratamento de câncer e outras doenças. Os derivados de ácido lipóico aqui descritos têm uma ampla faixa de aplicações preventivas e terapêuticas.
BR9914789-0A 1998-10-26 1999-10-26 Derivados de ácido lipóico e seus usos no tratamento de doença BR9914789A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10562898P 1998-10-26 1998-10-26
PCT/US1999/025140 WO2000024734A1 (en) 1998-10-26 1999-10-26 Lipoic acid derivatives and their use in treatment of disease

Publications (1)

Publication Number Publication Date
BR9914789A true BR9914789A (pt) 2001-10-02

Family

ID=22306916

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914789-0A BR9914789A (pt) 1998-10-26 1999-10-26 Derivados de ácido lipóico e seus usos no tratamento de doença

Country Status (12)

Country Link
US (2) US6331559B1 (pt)
EP (3) EP1124820B1 (pt)
JP (2) JP4728481B2 (pt)
AT (2) ATE451362T1 (pt)
AU (1) AU774362B2 (pt)
BR (1) BR9914789A (pt)
CA (1) CA2348998C (pt)
DE (2) DE69920497T2 (pt)
ES (2) ES2340488T3 (pt)
IL (2) IL142824A0 (pt)
MX (1) MXPA01004152A (pt)
WO (1) WO2000024734A1 (pt)

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WO2010019225A1 (en) * 2008-08-15 2010-02-18 Robert Shorr Pharmaceutical composition
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Also Published As

Publication number Publication date
AU774362B2 (en) 2004-06-24
ATE451362T1 (de) 2009-12-15
ATE277034T1 (de) 2004-10-15
ES2229790T3 (es) 2005-04-16
DE69920497T2 (de) 2006-02-09
EP2145883A1 (en) 2010-01-20
MXPA01004152A (es) 2002-06-04
IL142824A (en) 2010-11-30
CA2348998C (en) 2012-03-06
DE69920497D1 (de) 2004-10-28
JP2002528446A (ja) 2002-09-03
JP4728481B2 (ja) 2011-07-20
WO2000024734A1 (en) 2000-05-04
US6951887B2 (en) 2005-10-04
DE69941800D1 (de) 2010-01-21
IL142824A0 (en) 2002-03-10
JP5727721B2 (ja) 2015-06-03
US6331559B1 (en) 2001-12-18
US20020107234A1 (en) 2002-08-08
EP1486495B1 (en) 2009-12-09
EP1486495A1 (en) 2004-12-15
AU1324600A (en) 2000-05-15
EP1124820B1 (en) 2004-09-22
JP2010248203A (ja) 2010-11-04
ES2340488T3 (es) 2010-06-04
EP1124820A1 (en) 2001-08-22
CA2348998A1 (en) 2000-05-04

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B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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