DE69941800D1 - Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten - Google Patents

Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten

Info

Publication number
DE69941800D1
DE69941800D1 DE69941800T DE69941800T DE69941800D1 DE 69941800 D1 DE69941800 D1 DE 69941800D1 DE 69941800 T DE69941800 T DE 69941800T DE 69941800 T DE69941800 T DE 69941800T DE 69941800 D1 DE69941800 D1 DE 69941800D1
Authority
DE
Germany
Prior art keywords
diseases
salts
treatment
acid derivatives
lipoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941800T
Other languages
English (en)
Inventor
Zuzana Zachar
Paul M Bingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
Original Assignee
Research Foundation of State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York
Application granted granted Critical
Publication of DE69941800D1 publication Critical patent/DE69941800D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE69941800T 1998-10-26 1999-10-26 Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten Expired - Lifetime DE69941800D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10562898P 1998-10-26 1998-10-26

Publications (1)

Publication Number Publication Date
DE69941800D1 true DE69941800D1 (de) 2010-01-21

Family

ID=22306916

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69920497T Expired - Lifetime DE69920497T2 (de) 1998-10-26 1999-10-26 Liponsaürederivate und deren verwendung bei der behandlung von krankheiten
DE69941800T Expired - Lifetime DE69941800D1 (de) 1998-10-26 1999-10-26 Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69920497T Expired - Lifetime DE69920497T2 (de) 1998-10-26 1999-10-26 Liponsaürederivate und deren verwendung bei der behandlung von krankheiten

Country Status (12)

Country Link
US (2) US6331559B1 (de)
EP (3) EP1486495B1 (de)
JP (2) JP4728481B2 (de)
AT (2) ATE277034T1 (de)
AU (1) AU774362B2 (de)
BR (1) BR9914789A (de)
CA (1) CA2348998C (de)
DE (2) DE69920497T2 (de)
ES (2) ES2340488T3 (de)
IL (2) IL142824A0 (de)
MX (1) MXPA01004152A (de)
WO (1) WO2000024734A1 (de)

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US7510710B2 (en) 2004-01-08 2009-03-31 The Regents Of The University Of Colorado Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor
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US8329753B2 (en) * 2005-05-02 2012-12-11 The Regents Of The University Of Colorado Combination of compounds, or a bifunctional compound, that provides fatty acid metabolism and glycolysis inhibition
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JP5480804B2 (ja) * 2007-04-18 2014-04-23 コーナーストーン ファーマシューティカルズ，インコーポレーテッド リポ酸誘導体を含有する医薬製剤
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US8263653B2 (en) 2007-04-18 2012-09-11 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
US8394377B2 (en) * 2008-02-21 2013-03-12 The Regents Of The University Of Colorado Methods for treating cancer using combination therapy
BRPI0821176A2 (pt) * 2008-03-04 2015-10-06 Robert Rodriguez modulador do estado de fosforilação de pelo menos um complexo de enzimas, método para modular o complexo de pdh em um paciente que apresenta uma doença, condição, ou síndrome e método pra diagnosticar e predizer benefício em um paciente que apresenta sintomas de uma doença, condição, ou síndrome causada por uma alteração da estrutura e/ou da atividade do complexo de pdh
US20090258841A1 (en) 2008-04-01 2009-10-15 Michael Patrick Murphy Compositions and methods for skin care
BRPI0821894A2 (pt) * 2008-04-04 2015-07-21 Robert Shorr Modulador do estado de fosforilação farmaceuticamente aceitável de pelo menos uma enzima e/ou complexo enzimático, ou subunidades das mesma, nas mitocôndrias de células doentes de animais de sangue quente, incluindo seres humanos, método de modulação de pelo menos uma enzima ou um complexo enzimático, ou uma subunidade dos mesmos, em um paciente que apresenta uma doença, uma condição, ou uma síndrome que inclui uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou um complexo enzimático, ou uma subunidade das mesmas, e método para diagnosticar e prever o benefício em um paciente que apresenta sintomas de uma doença, uma condição, ou uma síndrome que incluem uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou complexo enzimático, ou uma subunidade dos mesmos
EP2313095A4 (de) 2008-07-14 2013-04-17 Univ Colorado Verfahren und produkte zur behandlung proliferativer erkrankungen
WO2010019225A1 (en) * 2008-08-15 2010-02-18 Robert Shorr Pharmaceutical composition
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FR2937867B1 (fr) * 2008-11-03 2011-03-04 Biorebus Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs.
WO2010062381A1 (en) * 2008-11-28 2010-06-03 Robert Shorr Organelle-specific drug delivery
RU2011124739A (ru) * 2008-12-01 2013-01-10 Инваск Терапьютикс, Инк. Композиции, содержащие ингибиторы системы ренин-ангиотензин альдостерона и соединения липоевой кислоты, и их применение для лечения заболеваний, связанных с системой ренин-ангиотензин альдостерона
CN101787013B (zh) * 2009-01-22 2013-04-24 杭州民生药业有限公司 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途
WO2010110887A1 (en) * 2009-03-24 2010-09-30 Robert Shorr Fatty acids
WO2010110771A2 (en) * 2009-03-25 2010-09-30 Frank Gibson Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof
WO2011046583A1 (en) * 2009-09-11 2011-04-21 Robert Shorr Pharmaceutical exploitation of oxidative stress in transformed cells
WO2011138565A1 (fr) 2010-05-05 2011-11-10 Biorebus Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs
FR2959668B1 (fr) * 2010-05-05 2012-07-13 Biorebus Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs
WO2011143590A1 (en) 2010-05-14 2011-11-17 Cornerstone Pharmaceuticals, Inc. Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent
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Also Published As

Publication number Publication date
ATE451362T1 (de) 2009-12-15
WO2000024734A1 (en) 2000-05-04
EP2145883A1 (de) 2010-01-20
EP1124820B1 (de) 2004-09-22
EP1124820A1 (de) 2001-08-22
ATE277034T1 (de) 2004-10-15
IL142824A (en) 2010-11-30
AU1324600A (en) 2000-05-15
ES2229790T3 (es) 2005-04-16
BR9914789A (pt) 2001-10-02
EP1486495A1 (de) 2004-12-15
CA2348998C (en) 2012-03-06
US6951887B2 (en) 2005-10-04
AU774362B2 (en) 2004-06-24
US20020107234A1 (en) 2002-08-08
JP2010248203A (ja) 2010-11-04
IL142824A0 (en) 2002-03-10
JP4728481B2 (ja) 2011-07-20
DE69920497T2 (de) 2006-02-09
JP5727721B2 (ja) 2015-06-03
EP1486495B1 (de) 2009-12-09
CA2348998A1 (en) 2000-05-04
ES2340488T3 (es) 2010-06-04
MXPA01004152A (es) 2002-06-04
JP2002528446A (ja) 2002-09-03
DE69920497D1 (de) 2004-10-28
US6331559B1 (en) 2001-12-18

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