DE69941800D1 - Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten - Google Patents
Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von KrankheitenInfo
- Publication number
- DE69941800D1 DE69941800D1 DE69941800T DE69941800T DE69941800D1 DE 69941800 D1 DE69941800 D1 DE 69941800D1 DE 69941800 T DE69941800 T DE 69941800T DE 69941800 T DE69941800 T DE 69941800T DE 69941800 D1 DE69941800 D1 DE 69941800D1
- Authority
- DE
- Germany
- Prior art keywords
- diseases
- salts
- treatment
- acid derivatives
- lipoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10562898P | 1998-10-26 | 1998-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69941800D1 true DE69941800D1 (de) | 2010-01-21 |
Family
ID=22306916
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69920497T Expired - Lifetime DE69920497T2 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
DE69941800T Expired - Lifetime DE69941800D1 (de) | 1998-10-26 | 1999-10-26 | Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69920497T Expired - Lifetime DE69920497T2 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Country Status (12)
Country | Link |
---|---|
US (2) | US6331559B1 (de) |
EP (3) | EP1486495B1 (de) |
JP (2) | JP4728481B2 (de) |
AT (2) | ATE277034T1 (de) |
AU (1) | AU774362B2 (de) |
BR (1) | BR9914789A (de) |
CA (1) | CA2348998C (de) |
DE (2) | DE69920497T2 (de) |
ES (2) | ES2340488T3 (de) |
IL (2) | IL142824A0 (de) |
MX (1) | MXPA01004152A (de) |
WO (1) | WO2000024734A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
JP2002530396A (ja) * | 1998-11-25 | 2002-09-17 | イッサム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム | スカベンジャー化合物 |
AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
ES2162586B1 (es) * | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
DK1339705T3 (da) | 2000-11-30 | 2006-10-09 | Basf Ag | Fremgangsmåde til fremstilling af liponsyre og dihydroliponsyre |
ATE446949T1 (de) * | 2001-03-19 | 2009-11-15 | Senju Pharma Co | Neues a-liponsäurederivat und dessen verwendung |
US6936641B2 (en) * | 2002-06-25 | 2005-08-30 | Johnson & Johnson Vision Care, Inc. | Macromer forming catalysts |
US7038071B2 (en) * | 2002-07-16 | 2006-05-02 | Sonus Pharmaceuticals, Inc. | Platinum compounds |
CN100367949C (zh) * | 2002-09-13 | 2008-02-13 | 有限会社绪方研究 | 黑色素消除制剂 |
CN1964630A (zh) | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基-辅酶A(LC-CoA)的水平来调控食物摄取和葡萄糖产生 |
US20040248982A1 (en) * | 2003-06-09 | 2004-12-09 | Dyer Gordon Wayne | Use of compounds for the inhibition of proteins and UV protection |
CA2534816A1 (en) * | 2003-06-12 | 2004-12-23 | Evan Newell | Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors |
US7510710B2 (en) | 2004-01-08 | 2009-03-31 | The Regents Of The University Of Colorado | Compositions of UCP inhibitors, Fas antibody, a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor |
US7129368B2 (en) * | 2004-03-15 | 2006-10-31 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
EP1877060A2 (de) * | 2005-04-28 | 2008-01-16 | The Regents of the University of Colorado | Systeme und verfahren zur behandlung menschlicher entzündungskrankheiten und proliferativer erkrankungen mit einer für die hemmung des fettsäurestoffwechsels und der glykolyse sorgenden verbindung |
US8329753B2 (en) * | 2005-05-02 | 2012-12-11 | The Regents Of The University Of Colorado | Combination of compounds, or a bifunctional compound, that provides fatty acid metabolism and glycolysis inhibition |
US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
JP5480804B2 (ja) * | 2007-04-18 | 2014-04-23 | コーナーストーン ファーマシューティカルズ,インコーポレーテッド | リポ酸誘導体を含有する医薬製剤 |
EP2695614B1 (de) * | 2007-04-18 | 2017-07-05 | Cornerstone Pharmaceuticals, Inc. | Liponsäurederivate |
US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
US8394377B2 (en) * | 2008-02-21 | 2013-03-12 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
BRPI0821176A2 (pt) * | 2008-03-04 | 2015-10-06 | Robert Rodriguez | modulador do estado de fosforilação de pelo menos um complexo de enzimas, método para modular o complexo de pdh em um paciente que apresenta uma doença, condição, ou síndrome e método pra diagnosticar e predizer benefício em um paciente que apresenta sintomas de uma doença, condição, ou síndrome causada por uma alteração da estrutura e/ou da atividade do complexo de pdh |
US20090258841A1 (en) | 2008-04-01 | 2009-10-15 | Michael Patrick Murphy | Compositions and methods for skin care |
BRPI0821894A2 (pt) * | 2008-04-04 | 2015-07-21 | Robert Shorr | Modulador do estado de fosforilação farmaceuticamente aceitável de pelo menos uma enzima e/ou complexo enzimático, ou subunidades das mesma, nas mitocôndrias de células doentes de animais de sangue quente, incluindo seres humanos, método de modulação de pelo menos uma enzima ou um complexo enzimático, ou uma subunidade dos mesmos, em um paciente que apresenta uma doença, uma condição, ou uma síndrome que inclui uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou um complexo enzimático, ou uma subunidade das mesmas, e método para diagnosticar e prever o benefício em um paciente que apresenta sintomas de uma doença, uma condição, ou uma síndrome que incluem uma alteração do estado de fosforilação, de pelo menos uma enzima e/ou complexo enzimático, ou uma subunidade dos mesmos |
EP2313095A4 (de) | 2008-07-14 | 2013-04-17 | Univ Colorado | Verfahren und produkte zur behandlung proliferativer erkrankungen |
WO2010019225A1 (en) * | 2008-08-15 | 2010-02-18 | Robert Shorr | Pharmaceutical composition |
WO2010047793A2 (en) * | 2008-10-21 | 2010-04-29 | The General Hospital Corporation | Cell transplantation |
FR2937867B1 (fr) * | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
WO2010062381A1 (en) * | 2008-11-28 | 2010-06-03 | Robert Shorr | Organelle-specific drug delivery |
RU2011124739A (ru) * | 2008-12-01 | 2013-01-10 | Инваск Терапьютикс, Инк. | Композиции, содержащие ингибиторы системы ренин-ангиотензин альдостерона и соединения липоевой кислоты, и их применение для лечения заболеваний, связанных с системой ренин-ангиотензин альдостерона |
CN101787013B (zh) * | 2009-01-22 | 2013-04-24 | 杭州民生药业有限公司 | 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途 |
WO2010110887A1 (en) * | 2009-03-24 | 2010-09-30 | Robert Shorr | Fatty acids |
WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
WO2011046583A1 (en) * | 2009-09-11 | 2011-04-21 | Robert Shorr | Pharmaceutical exploitation of oxidative stress in transformed cells |
WO2011138565A1 (fr) | 2010-05-05 | 2011-11-10 | Biorebus | Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
FR2959668B1 (fr) * | 2010-05-05 | 2012-07-13 | Biorebus | Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
WO2011143590A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
WO2011143593A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
KR101809301B1 (ko) | 2010-08-06 | 2018-01-18 | 더 제너럴 하스피털 코포레이션 두잉 비즈니스 애즈 매사츄세츠 제너럴 하스피털 | 세포 처리 시스템 및 장치 |
AU2013364387B2 (en) * | 2012-12-19 | 2018-07-19 | Paul Bingham | Pharmaceutical compounds |
US9605012B2 (en) | 2013-01-17 | 2017-03-28 | Garnett Mckeen Laboratory, Inc. | Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases |
WO2015195071A1 (en) | 2014-06-19 | 2015-12-23 | Robert Shorr | Pharmaceutical compounds |
AU2014398232B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
US10052305B2 (en) | 2015-10-07 | 2018-08-21 | Buck Institute For Research On Aging | Lipoic acid and derivatives thereof for the treatment of cystinuria |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE362916C (de) | 1921-08-13 | 1922-11-02 | Eduard Duerr | Abnehmbares Mikrometer fuer Schublehren |
GB758897A (en) * | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
US2853497A (en) * | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
US2872458A (en) * | 1954-12-30 | 1959-02-03 | Merck & Co Inc | Addition product of a metal hydrocarbon mercaptide with an alpha-halogamma-butyrolactone |
JPS57123107A (en) * | 1981-01-26 | 1982-07-31 | Pola Chem Ind Inc | Cosmetic |
DE3512911A1 (de) * | 1985-04-11 | 1986-10-16 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
DE3626116A1 (de) | 1986-08-01 | 1988-02-11 | Karl Thiel | Thermostatische regeleinrichtung fuer heizungen bzw. heizaggregate |
DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
DE3900649A1 (de) * | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Verfahren zur abloesung eines analyten von seinem bindeprotein |
JPH03193758A (ja) * | 1989-12-25 | 1991-08-23 | Nisshin Oil Mills Ltd:The | 新規γ―アミノ酪酸誘導体 |
DE59209162D1 (de) * | 1991-07-05 | 1998-03-05 | Asta Medica Ag | Verwendung von Schwefel enthaltenden Carbonsäuren zur Bekämpfung von pathophysiologisch bedingten Erregungsstörungen |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
WO1994006794A1 (en) | 1992-09-24 | 1994-03-31 | National Institutes Of Health | Aralkyl diazabicycloalkane derivatives for cns disorders |
DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
DE19601787C1 (de) * | 1996-01-19 | 1997-07-24 | Asta Medica Ag | Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure |
ATE310738T1 (de) * | 1996-07-05 | 2005-12-15 | Us Gov Health & Human Serv | Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen |
EP0855396A1 (de) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Metabolite von Thioctsäure und deren Verwendung |
WO1998043621A1 (en) * | 1997-03-31 | 1998-10-08 | The Children's Medical Center Corporation | Nitrosylation to inactivate apoptotic enzymes |
IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
JPH11124379A (ja) * | 1997-10-17 | 1999-05-11 | Ss Pharmaceut Co Ltd | ジチオリリデンアセトアミド誘導体 |
FR2777001B1 (fr) * | 1998-04-01 | 2000-06-09 | Cird Galderma | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
US6387945B2 (en) * | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
HUE053354T2 (hu) | 2016-02-05 | 2021-06-28 | Ea Pharma Co Ltd | Szulfonamid-származékok és ezeket tartalmazó gyógyászati készítmények |
-
1999
- 1999-10-26 ES ES04077618T patent/ES2340488T3/es not_active Expired - Lifetime
- 1999-10-26 AT AT99956698T patent/ATE277034T1/de not_active IP Right Cessation
- 1999-10-26 BR BR9914789-0A patent/BR9914789A/pt not_active Application Discontinuation
- 1999-10-26 IL IL14282499A patent/IL142824A0/xx unknown
- 1999-10-26 AT AT04077618T patent/ATE451362T1/de not_active IP Right Cessation
- 1999-10-26 ES ES99956698T patent/ES2229790T3/es not_active Expired - Lifetime
- 1999-10-26 EP EP04077618A patent/EP1486495B1/de not_active Expired - Lifetime
- 1999-10-26 DE DE69920497T patent/DE69920497T2/de not_active Expired - Lifetime
- 1999-10-26 JP JP2000578304A patent/JP4728481B2/ja not_active Expired - Lifetime
- 1999-10-26 CA CA2348998A patent/CA2348998C/en not_active Expired - Lifetime
- 1999-10-26 EP EP09012728A patent/EP2145883A1/de not_active Withdrawn
- 1999-10-26 US US09/427,477 patent/US6331559B1/en not_active Expired - Lifetime
- 1999-10-26 DE DE69941800T patent/DE69941800D1/de not_active Expired - Lifetime
- 1999-10-26 MX MXPA01004152A patent/MXPA01004152A/es active IP Right Grant
- 1999-10-26 AU AU13246/00A patent/AU774362B2/en not_active Expired
- 1999-10-26 WO PCT/US1999/025140 patent/WO2000024734A1/en active IP Right Grant
- 1999-10-26 EP EP99956698A patent/EP1124820B1/de not_active Expired - Lifetime
-
2001
- 2001-04-26 IL IL142824A patent/IL142824A/en not_active IP Right Cessation
- 2001-09-24 US US09/962,372 patent/US6951887B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126848A patent/JP5727721B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE451362T1 (de) | 2009-12-15 |
WO2000024734A1 (en) | 2000-05-04 |
EP2145883A1 (de) | 2010-01-20 |
EP1124820B1 (de) | 2004-09-22 |
EP1124820A1 (de) | 2001-08-22 |
ATE277034T1 (de) | 2004-10-15 |
IL142824A (en) | 2010-11-30 |
AU1324600A (en) | 2000-05-15 |
ES2229790T3 (es) | 2005-04-16 |
BR9914789A (pt) | 2001-10-02 |
EP1486495A1 (de) | 2004-12-15 |
CA2348998C (en) | 2012-03-06 |
US6951887B2 (en) | 2005-10-04 |
AU774362B2 (en) | 2004-06-24 |
US20020107234A1 (en) | 2002-08-08 |
JP2010248203A (ja) | 2010-11-04 |
IL142824A0 (en) | 2002-03-10 |
JP4728481B2 (ja) | 2011-07-20 |
DE69920497T2 (de) | 2006-02-09 |
JP5727721B2 (ja) | 2015-06-03 |
EP1486495B1 (de) | 2009-12-09 |
CA2348998A1 (en) | 2000-05-04 |
ES2340488T3 (es) | 2010-06-04 |
MXPA01004152A (es) | 2002-06-04 |
JP2002528446A (ja) | 2002-09-03 |
DE69920497D1 (de) | 2004-10-28 |
US6331559B1 (en) | 2001-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69941800D1 (de) | Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten | |
DE3683318D1 (de) | Verwendung von alfuzosin zur behandlung von erkrankungen der harnwege. | |
CY1112845T1 (el) | Παραγωγα της 1-δεοξυ-γαλακτονογιριμυκινης και η χρηση τους στη θεραπεια αθροιστικων λυσοσωμικων ασθενειων μεσω ενισχυσης της λυσοσωμικης α-γαλακτοσιδασης α | |
DE69815090D1 (de) | Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen | |
DE69004081D1 (de) | Verwendung der Stearidonsäure zur Behandlung von Entzündungserkrankungen. | |
DE602005019890D1 (de) | Chinazolinderivate und ihre verwendung bei der behandlung von thrombocythämie | |
DE60013859D1 (de) | Indolderivate und deren verwendung zur behandlung von u.a. osteoporosis | |
ATE336485T1 (de) | Substituierte heterocyclen und deren verwendung in arzneimitteln | |
DE60036826D1 (de) | Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs | |
DE69528710D1 (de) | 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1-dioxiden, zusammensetzung und deren verwendung | |
ATE292975T1 (de) | Verwendung von tetrahydolipstatin in der behandlung von diabetes typ ii | |
DE3789347D1 (de) | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. | |
DE69734296D1 (de) | Neue dikaffeoylchinasäurederivate und deren verwendung zur behandlung von hepatitis b | |
DE69624707D1 (de) | Therapeutische verwendung von 1-amino-3-(n,n-dimethylamino)-propyliden-1,1-bisphosphonsäure und ihre salze | |
DE60027429D1 (de) | Dihydrobenzodiazepinen und deren verwendung zur behandlung von dyslipidämien | |
ATE254128T1 (de) | Substituierte tricyclische verbindungen und deren verwendung zur behandlung von spla2-bedingten erkrankungen | |
DE60008807D1 (de) | Binaphtol-monophosphorsäurederivate und deren Verwendung | |
DE69931487D1 (de) | Verwendung von apomorphin zur behandlung der vorzeitigen ejakulation | |
DE3876846D1 (de) | Morpholinderivate und deren verwendung. | |
DK205288A (da) | Nitrifikationshaemmende middel | |
MX9304626A (es) | Derivados heterociclicos utiles en el tratamiento de enfermedades cardiovasculares. | |
ATE206052T1 (de) | Verwendung von sphingosin-1-phosphat, sphingosin- 1-phosphat-derivaten und/oder deren gemische zur behandlung von entzündlichen hautkrankheiten | |
DE69940971D1 (de) | Verwendung von erythropoietin zur behandlung von primärer hämochromatosen | |
ATE25969T1 (de) | 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten. | |
NO20003629D0 (no) | Forbindelser med veksthormonfrigjørende egenskaper |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |