EP2268278A4 - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number
EP2268278A4
EP2268278A4 EP08742562A EP08742562A EP2268278A4 EP 2268278 A4 EP2268278 A4 EP 2268278A4 EP 08742562 A EP08742562 A EP 08742562A EP 08742562 A EP08742562 A EP 08742562A EP 2268278 A4 EP2268278 A4 EP 2268278A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical composition
pharmaceutical
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08742562A
Other languages
German (de)
French (fr)
Other versions
EP2268278A1 (en
Inventor
Paul Bingham
Lakmal W Boteju
Zuzana Zachar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2268278A1 publication Critical patent/EP2268278A1/en
Publication of EP2268278A4 publication Critical patent/EP2268278A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP08742562A 2008-04-04 2008-04-04 Pharmaceutical composition Withdrawn EP2268278A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/004410 WO2009123597A1 (en) 2008-04-04 2008-04-04 Pharmaceutical composition

Publications (2)

Publication Number Publication Date
EP2268278A1 EP2268278A1 (en) 2011-01-05
EP2268278A4 true EP2268278A4 (en) 2011-11-09

Family

ID=41135840

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08742562A Withdrawn EP2268278A4 (en) 2008-04-04 2008-04-04 Pharmaceutical composition

Country Status (10)

Country Link
EP (1) EP2268278A4 (en)
JP (1) JP2011516473A (en)
KR (1) KR20110025168A (en)
CN (1) CN102056605A (en)
AU (1) AU2008354009A1 (en)
BR (1) BRPI0821894A2 (en)
CA (1) CA2720396A1 (en)
IL (1) IL208387A0 (en)
MX (1) MX2010010867A (en)
WO (1) WO2009123597A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2590635T3 (en) 2010-07-08 2017-09-29 Wm. Wrigley Jr. Company Chewing gum containing a cross-linked gelatin matrix gum base
US9421234B2 (en) * 2011-05-20 2016-08-23 Nutramax Laboratories, Inc. Orally administrable compositions comprising avocado/soybean unsaponifiables and lipoic acid and methods of administration
EP2822571A4 (en) * 2012-02-16 2016-03-09 Penn State Res Found Modulators of acyl-coa lysocardiolipin acyltransferase 1 ( alcat1) and uses thereof
CA2895029A1 (en) * 2012-12-19 2014-06-26 Robert Shorr Metal complexes of lipoic acid derivatives
WO2015195070A1 (en) 2014-06-19 2015-12-23 Robert Shorr Pharmaceutical compounds
AU2014398233B2 (en) 2014-06-19 2019-11-28 Rafael Pharmaceuticals, Inc. Pharmaceutical compounds
CN110590624B (en) * 2019-09-26 2021-02-26 苏州富士莱医药股份有限公司 Preparation method of lipoic acid derivative 8- (ethyl disulfide) -6- (phenyl disulfide) caprylic acid
EP4380567A1 (en) * 2021-08-04 2024-06-12 Cytacoat AB Disulfide compounds as medicaments
CN118236491A (en) * 2022-12-23 2024-06-25 中国科学院上海营养与健康研究所 PDK4 as cell senescence intervention target and application thereof in chemotherapy and anticancer

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
JPS61198148A (en) * 1985-01-29 1986-09-02 Fuji Photo Film Co Ltd Silver halide photographic sensitive material
EP0947503A1 (en) * 1998-04-01 1999-10-06 Galderma Research & Development, S.N.C. 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours
WO2000059899A1 (en) * 1999-04-02 2000-10-12 Societe De Conseil De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
WO2000061143A1 (en) * 1999-04-09 2000-10-19 Antibioticos S.P.A. The use of alpha lipoic acid in the antimetastatic treatment
WO2008131117A1 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
WO2008131114A2 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
WO2009110859A1 (en) * 2008-03-04 2009-09-11 Robert Shorr Modulation of enzymatic structure, activity, and/or expression level

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618934D0 (en) * 1996-09-11 1996-10-23 Univ London Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity
ATE526405T1 (en) * 1998-03-20 2011-10-15 Commw Scient Ind Res Org SYNTHETIC GENES AND GENETIC COMPOSITIONS CONTAINING THEM
ATE451362T1 (en) * 1998-10-26 2009-12-15 Univ New York State Res Found SALTS OF LIPONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES
DE19904794A1 (en) * 1999-02-05 2000-08-10 Biotechnolog Forschung Gmbh Methods for improving the primary metabolism of mammalian cell lines
US6284786B1 (en) * 1999-02-16 2001-09-04 The Center For The Improvement Of Human Functioning, Int'l., Inc. Treatment of cancer using lipoic acid in combination with ascorbic acid
AU2001260309A1 (en) * 2000-05-19 2001-12-03 F.Hoffmann-La Roche Ag A process for determining the tumoricidal potential of a sample by the use of a nucleic acid which is downregulated in human tumor cells
WO2006119355A2 (en) * 2005-05-03 2006-11-09 Albert Einstein College Of Medicine Of Yeshiva University Mammalian hypothalamic nutrient modulation of glucose metabolism
WO2007072219A2 (en) * 2005-09-21 2007-06-28 Aurelium Biopharma Inc. Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance
US20070212360A1 (en) * 2006-01-17 2007-09-13 Denko Nicholas C Modulation of mitochondrial oxygen consumption for therapeutic purposes

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2853497A (en) * 1953-12-04 1958-09-23 Merck & Co Inc 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof
US2789991A (en) * 1954-05-20 1957-04-23 American Cyanamid Co Substituted disulfones
JPS61198148A (en) * 1985-01-29 1986-09-02 Fuji Photo Film Co Ltd Silver halide photographic sensitive material
EP0947503A1 (en) * 1998-04-01 1999-10-06 Galderma Research & Development, S.N.C. 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours
WO2000059899A1 (en) * 1999-04-02 2000-10-12 Societe De Conseil De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Novel lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
WO2000061143A1 (en) * 1999-04-09 2000-10-19 Antibioticos S.P.A. The use of alpha lipoic acid in the antimetastatic treatment
WO2008131117A1 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Lipoic acid derivatives
WO2008131114A2 (en) * 2007-04-18 2008-10-30 Cornerstone Pharmaceuticals, Inc. Pharmaceutical formulations containing lipoic acid derivatives
WO2009110859A1 (en) * 2008-03-04 2009-09-11 Robert Shorr Modulation of enzymatic structure, activity, and/or expression level

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
COURVOISIER C ET AL: "Synthesis and effects of 3-methylthiopropanoyl thiolesters of lipoic acid, methional metabolite mimics", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 34, no. 1, 1 February 2006 (2006-02-01), pages 49 - 58, XP024896857, ISSN: 0045-2068, [retrieved on 20060201], DOI: 10.1016/J.BIOORG.2005.11.001 *
FELLER DENNIS R ET AL: "Selective PPARgamma versus PPARalpha agonist activity of a novel set of alpha-lipoic acid analogs of thiazolidinediones", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 17, no. 4-5, 1 March 2003 (2003-03-01), pages A1061, XP009133351, ISSN: 0892-6638 *
HYK W ET AL: "The extreme migrational enhancement of faradaic current at microelectrodes: experimental studies on sodium (6,8-diferrocenylmethylthio)octanoate electrooxidation", JOURNAL OF ELECTROANALYTICAL CHEMISTRY AND INTERFACIALELECTRO CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 575, no. 2, 1 February 2005 (2005-02-01), pages 321 - 328, XP025373180, ISSN: 0022-0728, [retrieved on 20050201] *
MARK VAN DE K ET AL: "ALPHA-LIPOIC ACID INDUCES P27KIP-DEPENDENT CELL CYCLE ARREST IN NON-TRANSFORMED CELL LINES AND APOPTOSIS IN TUMOR CELL LINES", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY LISS, NEW YORK, NY, US, vol. 194, no. 3, 1 March 2003 (2003-03-01), pages 325 - 340, XP008037152, ISSN: 0021-9541, DOI: 10.1002/JCP.10205 *
SATOH ET AL: "Simultaneous determination of alpha-lipoic acid and its reduced form by high-performance liquid chromatography with fluorescence detection", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 854, no. 1-2, 25 June 2007 (2007-06-25), pages 109 - 115, XP022127447, ISSN: 1570-0232, DOI: 10.1016/J.JCHROMB.2007.04.003 *
See also references of WO2009123597A1 *

Also Published As

Publication number Publication date
CA2720396A1 (en) 2009-10-08
BRPI0821894A2 (en) 2015-07-21
EP2268278A1 (en) 2011-01-05
CN102056605A (en) 2011-05-11
WO2009123597A1 (en) 2009-10-08
MX2010010867A (en) 2011-05-25
KR20110025168A (en) 2011-03-09
IL208387A0 (en) 2010-12-30
JP2011516473A (en) 2011-05-26
AU2008354009A1 (en) 2009-10-08

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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AX Request for extension of the european patent

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111012

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/19 20060101ALI20111006BHEP

Ipc: A61K 31/385 20060101AFI20111006BHEP

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Effective date: 20131101