DK0959072T3 - Sulfonamidderivat og fremgangsmåde til fremstilling deraf - Google Patents
Sulfonamidderivat og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0959072T3 DK0959072T3 DK99110998T DK99110998T DK0959072T3 DK 0959072 T3 DK0959072 T3 DK 0959072T3 DK 99110998 T DK99110998 T DK 99110998T DK 99110998 T DK99110998 T DK 99110998T DK 0959072 T3 DK0959072 T3 DK 0959072T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- unsubstituted
- sub
- hypertension
- sup
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7116213A JP3013752B2 (ja) | 1995-05-16 | 1995-05-16 | スルホンアミド誘導体 |
| JP14987295 | 1995-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0959072T3 true DK0959072T3 (da) | 2003-01-20 |
Family
ID=26454593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99110998T DK0959072T3 (da) | 1995-05-16 | 1996-05-14 | Sulfonamidderivat og fremgangsmåde til fremstilling deraf |
| DK96107694T DK0743307T3 (da) | 1995-05-16 | 1996-05-14 | Sulfonamidderivat og fremgangsmåde til fremstilling deraf |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96107694T DK0743307T3 (da) | 1995-05-16 | 1996-05-14 | Sulfonamidderivat og fremgangsmåde til fremstilling deraf |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5739333A (de) |
| EP (3) | EP0959072B1 (de) |
| KR (1) | KR100411358B1 (de) |
| CN (1) | CN1100043C (de) |
| AT (2) | ATE205482T1 (de) |
| CA (1) | CA2176776A1 (de) |
| DE (2) | DE69615085T2 (de) |
| DK (2) | DK0959072T3 (de) |
| ES (2) | ES2163548T3 (de) |
| GR (1) | GR3036611T3 (de) |
| MX (2) | MX9601837A (de) |
| PT (2) | PT743307E (de) |
| TW (1) | TW350839B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| WO1999065897A1 (en) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| EP1137642B1 (de) * | 1999-09-03 | 2007-12-05 | Actelion Pharmaceuticals Ltd. | Bis-sulfonamiden |
| US6720322B2 (en) | 1999-12-22 | 2004-04-13 | Actelion Pharamceuticals Ltd. | Butyne diol derivatives |
| JP2003518102A (ja) * | 1999-12-22 | 2003-06-03 | アクテリオン ファマシューティカルズ リミテッド | ブチンジオール誘導体 |
| MXPA02007192A (es) * | 2000-01-25 | 2002-12-09 | Hoffmann La Roche | Preparacion de sulfonamidas. |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| JP2004503542A (ja) * | 2000-06-13 | 2004-02-05 | ビーエーエスエフ アクチェンゲゼルシャフト | 殺真菌性５−フェニル置換２−（シアノアミノ）ピリミジン誘導体 |
| MY140724A (en) | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| US7091201B2 (en) * | 2000-09-25 | 2006-08-15 | Actelion Pharmaceuticals Ltd. | Arylalkane-sulfonamides having endothelin-antagonist activity |
| AU2002227984B8 (en) * | 2000-12-18 | 2007-01-04 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
| EA007719B1 (ru) * | 2001-03-15 | 2006-12-29 | Басф Акциенгезельшафт | 5-фенилпиримидины, способ и промежуточные продукты для их получения и их применение для борьбы с фитопатогенными грибами |
| CA2471220C (en) | 2002-01-02 | 2010-11-16 | Actelion Pharmaceuticals Ltd | Novel alkansulfonamides as endothelin antagonists |
| NZ566263A (en) * | 2002-05-24 | 2009-09-25 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
| CA2507334C (en) | 2002-12-02 | 2013-05-07 | Actelion Pharmaceuticals Ltd. | Pyrimidine-sulfamides and their use as endothelian receptor antagonist |
| CA2557372C (en) | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| DE102004044829A1 (de) * | 2004-09-16 | 2006-04-06 | Bayer Cropscience Ag | 5-Heterocyclylpyrimidine |
| TW200628467A (en) | 2004-11-11 | 2006-08-16 | Actelion Pharmaceuticals Ltd | Novel sulfamides |
| MX2008002731A (es) | 2005-09-01 | 2008-03-26 | Hoffmann La Roche | Diaminopirimidinas como moduladores de p2x3 y p3x2/3. |
| ES2562056T3 (es) | 2005-09-01 | 2016-03-02 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores P2X3 y P2X2/3 |
| EP1924564B1 (de) | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidine als p2x3- und p2x2/3-modulatoren |
| SG174050A1 (en) * | 2006-04-13 | 2011-09-29 | Actelion Pharmaceuticals Ltd | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
| US8664390B2 (en) * | 2007-06-29 | 2014-03-04 | Generics (Uk) Limited | Process for the introduction of hydroxyethoxy side chain in bosentan |
| MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| NZ585438A (en) * | 2007-10-24 | 2012-09-28 | Generics Uk Ltd | Novel crystalline forms of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yI]-benzenesulfonamide |
| ATE530531T1 (de) * | 2007-12-18 | 2011-11-15 | Dipharma Francis Srl | Verfahren zur herstellung von bosentan |
| CA2712860C (en) * | 2008-02-08 | 2014-11-18 | Abhay Gaitonde | Process for preparing bosentan |
| EP2268634A2 (de) * | 2008-03-13 | 2011-01-05 | Actavis Group PTC EHF | Verfahren zur herstellung von bosentan und verwandte verbindungen unter verwendung neuer zwischenprodukte |
| CA2741928A1 (en) | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | Hplc method for the analysis of bosentan and related substances and use of these substances as reference standards and markers |
| WO2012056468A1 (en) * | 2010-10-13 | 2012-05-03 | Matrix Laboratories Ltd | A process for the preparation of bosentan |
| CN104892528A (zh) * | 2014-12-10 | 2015-09-09 | 上海工程技术大学 | 一种2-硫代巴比妥酸衍生物的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1545944A1 (de) * | 1964-06-19 | 1969-12-11 | Hoffmann La Roche | Verfahren zur Herstellung von neuen Sulfonamiden der Pyrimidinreihe |
| DE3363743D1 (en) * | 1982-07-22 | 1986-07-03 | Pfizer Ltd | Dihydropyridine anti-ischaemic and antihypertensive agents |
| KR920009574B1 (ko) * | 1990-02-02 | 1992-10-19 | 재단법인 한국화학연구소 | 페닐아세트아미드 유도체 및 그의 제조방법 |
| TW270116B (de) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| TW287160B (de) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| EP0958135A1 (de) * | 1996-06-28 | 1999-11-24 | Ranpak Corp. | Polsterumwandlungsmaschine |
-
1996
- 1996-05-09 US US08/644,847 patent/US5739333A/en not_active Expired - Fee Related
- 1996-05-14 ES ES96107694T patent/ES2163548T3/es not_active Expired - Lifetime
- 1996-05-14 EP EP99110998A patent/EP0959072B1/de not_active Expired - Lifetime
- 1996-05-14 PT PT96107694T patent/PT743307E/pt unknown
- 1996-05-14 DK DK99110998T patent/DK0959072T3/da active
- 1996-05-14 ES ES99110998T patent/ES2184367T3/es not_active Expired - Lifetime
- 1996-05-14 DE DE69615085T patent/DE69615085T2/de not_active Expired - Fee Related
- 1996-05-14 EP EP96107694A patent/EP0743307B1/de not_active Expired - Lifetime
- 1996-05-14 AT AT96107694T patent/ATE205482T1/de not_active IP Right Cessation
- 1996-05-14 AT AT99110998T patent/ATE224879T1/de not_active IP Right Cessation
- 1996-05-14 DE DE69624010T patent/DE69624010T2/de not_active Expired - Fee Related
- 1996-05-14 DK DK96107694T patent/DK0743307T3/da active
- 1996-05-14 PT PT99110998T patent/PT959072E/pt unknown
- 1996-05-14 EP EP99110999A patent/EP0959073A1/de not_active Withdrawn
- 1996-05-15 MX MX9601837A patent/MX9601837A/es not_active IP Right Cessation
- 1996-05-16 KR KR1019960016486A patent/KR100411358B1/ko not_active Expired - Fee Related
- 1996-05-16 CN CN96106284A patent/CN1100043C/zh not_active Expired - Fee Related
- 1996-05-16 CA CA002176776A patent/CA2176776A1/en not_active Abandoned
- 1996-05-22 TW TW085106047A patent/TW350839B/zh active
-
2000
- 2000-11-10 MX MXPA00011111A patent/MXPA00011111A/es unknown
-
2001
- 2001-09-13 GR GR20010400308T patent/GR3036611T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2163548T3 (es) | 2002-02-01 |
| GR3036611T3 (en) | 2001-12-31 |
| DE69624010T2 (de) | 2003-05-22 |
| ATE205482T1 (de) | 2001-09-15 |
| MXPA00011111A (es) | 2003-04-25 |
| EP0959072A1 (de) | 1999-11-24 |
| ATE224879T1 (de) | 2002-10-15 |
| PT959072E (pt) | 2002-12-31 |
| EP0959072B1 (de) | 2002-09-25 |
| DE69624010D1 (de) | 2002-10-31 |
| CN1100043C (zh) | 2003-01-29 |
| US5739333A (en) | 1998-04-14 |
| KR100411358B1 (ko) | 2004-07-05 |
| DE69615085T2 (de) | 2002-06-06 |
| KR960041179A (ko) | 1996-12-19 |
| EP0959073A1 (de) | 1999-11-24 |
| EP0743307B1 (de) | 2001-09-12 |
| CA2176776A1 (en) | 1996-11-17 |
| TW350839B (en) | 1999-01-21 |
| MX9601837A (es) | 1997-07-31 |
| EP0743307A1 (de) | 1996-11-20 |
| CN1146990A (zh) | 1997-04-09 |
| ES2184367T3 (es) | 2003-04-01 |
| DK0743307T3 (da) | 2001-11-26 |
| PT743307E (pt) | 2001-12-28 |
| DE69615085D1 (de) | 2001-10-18 |
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