DK0914315T3 - Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse - Google Patents

Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse

Info

Publication number
DK0914315T3
DK0914315T3 DK97924007T DK97924007T DK0914315T3 DK 0914315 T3 DK0914315 T3 DK 0914315T3 DK 97924007 T DK97924007 T DK 97924007T DK 97924007 T DK97924007 T DK 97924007T DK 0914315 T3 DK0914315 T3 DK 0914315T3
Authority
DK
Denmark
Prior art keywords
salts
carnitine
carnitines
alkanoyl
compositions containing
Prior art date
Application number
DK97924007T
Other languages
Danish (da)
English (en)
Inventor
Aldo Fassi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI961116 external-priority patent/IT1283086B1/it
Priority claimed from IT97MI000409A external-priority patent/IT1289974B1/it
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK0914315T3 publication Critical patent/DK0914315T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97924007T 1996-05-31 1997-05-26 Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse DK0914315T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI961116 IT1283086B1 (it) 1996-05-31 1996-05-31 Sali stabili e non igroscopici di l-carnitina e di alcanoil l-carnitine
IT97MI000409A IT1289974B1 (it) 1997-02-25 1997-02-25 Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
PCT/EP1997/002693 WO1997046512A1 (en) 1996-05-31 1997-05-26 Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts

Publications (1)

Publication Number Publication Date
DK0914315T3 true DK0914315T3 (da) 2001-06-05

Family

ID=26331398

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97924007T DK0914315T3 (da) 1996-05-31 1997-05-26 Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse

Country Status (24)

Country Link
US (1) US5952379A (xx)
EP (1) EP0914315B1 (xx)
JP (1) JP4160634B2 (xx)
CN (1) CN1177807C (xx)
AT (1) ATE200479T1 (xx)
AU (1) AU718308B2 (xx)
BR (1) BR9709627A (xx)
CZ (1) CZ290902B6 (xx)
DE (1) DE69704561T2 (xx)
DK (1) DK0914315T3 (xx)
EE (1) EE03604B1 (xx)
ES (1) ES2156381T3 (xx)
GR (1) GR3035969T3 (xx)
HK (1) HK1024463A1 (xx)
HU (1) HU228008B1 (xx)
IL (1) IL127266A (xx)
IS (1) IS2085B (xx)
NO (1) NO323593B1 (xx)
NZ (1) NZ333061A (xx)
PL (1) PL188558B1 (xx)
PT (1) PT914315E (xx)
SK (1) SK283105B6 (xx)
TR (1) TR199802492T2 (xx)
WO (1) WO1997046512A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
JP2003508488A (ja) * 1999-09-03 2003-03-04 シグマ−タウ・ヘルスサイエンス・ソシエタ・ペル・アチオニ 超微細ｌ−カルニチン、その調製方法、それを含む組成物、及びその使用方法
IT1316988B1 (it) 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
US8252309B2 (en) * 2000-04-04 2012-08-28 Sigma-Tau Industrie Farmaceutiche Riunite Spa Dietary supplement energy-providing to skeletal muscles
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
ITRM20010044A1 (it) * 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa Integratore alimentare ad effetto dimagrante.
DE10133200A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
JP2006111550A (ja) * 2004-10-13 2006-04-27 Nisshin Pharma Inc カルニチン含有製品
US9084431B2 (en) * 2005-07-05 2015-07-21 Lonza Ltd. Spray-Drying process for producing a dry caritine powder or granulate
CN101209975B (zh) 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN102911067A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱丙酮酸盐及其制备方法与用途
CN102911068A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱l-苹果酸盐及其制备方法与用途
CA2910085C (en) * 2013-04-26 2021-05-25 Sanofi Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(s)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl-piperazin-1-yl)-3-oxo-propryl]amide
CN103664667A (zh) * 2013-12-16 2014-03-26 天津天成制药有限公司 乙酰左旋肉碱硝酸盐的制备方法
CN106045919B (zh) * 2016-07-07 2022-08-09 湖北楚维药业有限公司 一种左旋肉碱乳清酸盐的制备方法
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
CN112250588B (zh) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） 一种左旋肉碱离子液体及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5656M (xx) * 1965-10-12 1967-12-26
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1261808B (it) * 1993-07-06 1996-06-03 Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi

Also Published As

Publication number Publication date
IS4914A (is) 1998-11-30
HU228008B1 (en) 2012-08-28
IL127266A (en) 2002-09-12
US5952379A (en) 1999-09-14
AU2961297A (en) 1998-01-05
NO985562D0 (no) 1998-11-27
EE03604B1 (et) 2002-02-15
NZ333061A (en) 1999-05-28
ATE200479T1 (de) 2001-04-15
CZ391598A3 (cs) 1999-04-14
EP0914315B1 (en) 2001-04-11
HUP9903455A2 (hu) 2000-03-28
TR199802492T2 (xx) 1999-02-22
CN1177807C (zh) 2004-12-01
IL127266A0 (en) 1999-09-22
DE69704561D1 (de) 2001-05-17
NO985562L (no) 1999-01-05
JP4160634B2 (ja) 2008-10-01
NO323593B1 (no) 2007-06-11
JP2000514413A (ja) 2000-10-31
EE9800422A (et) 1999-06-15
ES2156381T3 (es) 2001-06-16
HK1024463A1 (en) 2000-10-13
DE69704561T2 (de) 2001-08-09
EP0914315A1 (en) 1999-05-12
BR9709627A (pt) 1999-08-10
GR3035969T3 (en) 2001-08-31
PL330189A1 (en) 1999-04-26
PT914315E (pt) 2001-07-31
IS2085B (is) 2006-02-15
CZ290902B6 (cs) 2002-11-13
CN1244191A (zh) 2000-02-09
SK164998A3 (en) 1999-05-07
PL188558B1 (pl) 2005-02-28
WO1997046512A1 (en) 1997-12-11
AU718308B2 (en) 2000-04-13
HUP9903455A3 (en) 2001-01-29
SK283105B6 (sk) 2003-02-04

Similar Documents

Publication Publication Date Title
DK0914315T3 (da) Stabile, ikke-hygroskopiske salte af L(-)-carnitin og alkanoyl-L(-)-carnitiner, fremgangsmåde til fremstilling af sådanne salte og faste sammensætninger indeholdende sådanne salte til oral indgivelse
CA2269807A1 (en) Substituted aminoalkanephosphonic acids
RS49688B (sr) Novi derivat 3-aril-2- hidroksipropionske kiseline (i)
CA2053253A1 (en) New aryl-and heteroarylethenylene derivatives and process for their preparation
FI964815A0 (fi) Piperatsiinijohdoksia 5-HT1A antagonisteina
ES8801920A1 (es) Procedimiento para la obtencio de enaminas
DK0464465T3 (da) Substituerede aminoalkylbiphenylderivater, antimykotiske præparater indeholdende disse derivater og mellemprodukter til fremstilling deraf
HUT60464A (en) Process for producing n-phenylbenzamide derivatives and pharmaceutical compositions comprising such compounds as active ingredient
BG44204A3 (en) Method for preparing of 2- oxyindol derivatives
CA2281630A1 (en) Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine
ES8607218A1 (es) Un procedimiento para preparar compuestos de amidina
ES8800122A1 (es) Un procedimiento para la preparacion de derivados de indeno y naftaleno.
NO840526L (no) Derivater av n-iminopyridiniumbetainer, fremgangsmaate til deres fremstilling og deres anvendelse i medikamenter
IL127687A0 (en) The preparation of 3-pyrroline-2-carboxylic acid derivatives
ES2001389A6 (es) Procedimiento para preparar derivados de o-toluidina
AU6701096A (en) Process for the manufacturing of iodinated contrast agents
IT1210926B (it) Derivati della 1-metil-5-nitro-imidazolina e composizioni terapeutiche che li comprendono come principio attivo.
YU43499A (sh) Kristalna hidratovana natrijumova so (e)-4,6-dihloro-3- (2-okso-1-fenilpirolidin-3-iliden metil)-1h-indol-2- karboksilne kiseline
AU2508584A (en) N-arylpiperazine derivatives
ES8308858A1 (es) "procedimiento de preparar derivados del acido sulfamico y similares".
MY101628A (en) Sulfonamide compounds and salts thereof, herbicidal compositions containing them, and process for producing them.
ZA966372B (en) The preparation of α-(N,N-dialkylamino) carboxamides.
AU1466592A (en) Gem-diphosphonic acid nitrosocarbamoyl derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
NO954410D0 (no) Fremgangsmåte og fremstilling av NG-monoalkyl-L-arginin og beslektede forbindelser
ES2003195A6 (es) Procedimiento de obtencion de nuevos derivados hidrosolubles del acido 4,5-difenil-2-oxazol-propionico.