DK0857211T3 - Stærk homolog promoter fra hamster - Google Patents

Stærk homolog promoter fra hamster

Info

Publication number
DK0857211T3
DK0857211T3 DK96937224T DK96937224T DK0857211T3 DK 0857211 T3 DK0857211 T3 DK 0857211T3 DK 96937224 T DK96937224 T DK 96937224T DK 96937224 T DK96937224 T DK 96937224T DK 0857211 T3 DK0857211 T3 DK 0857211T3
Authority
DK
Denmark
Prior art keywords
hamster
promoter
homologous promoter
strong homologous
gene
Prior art date
Application number
DK96937224T
Other languages
Danish (da)
English (en)
Inventor
Klaus Bergemann
Barbara Enenkel
Frank Gannon
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0857211T3 publication Critical patent/DK0857211T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK96937224T 1995-10-24 1996-10-24 Stærk homolog promoter fra hamster DK0857211T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19539493A DE19539493A1 (de) 1995-10-24 1995-10-24 Starker homologer Promotor aus Hamster
PCT/EP1996/004631 WO1997015664A1 (de) 1995-10-24 1996-10-24 Starker homologer promotor aus hamster

Publications (1)

Publication Number Publication Date
DK0857211T3 true DK0857211T3 (da) 2007-03-26

Family

ID=7775593

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96937224T DK0857211T3 (da) 1995-10-24 1996-10-24 Stærk homolog promoter fra hamster

Country Status (11)

Country Link
US (1) US6063598A (enExample)
EP (2) EP0857211B1 (enExample)
JP (2) JP3966903B2 (enExample)
AT (1) ATE355370T1 (enExample)
CA (1) CA2234071C (enExample)
DE (2) DE19539493A1 (enExample)
DK (1) DK0857211T3 (enExample)
ES (1) ES2281905T3 (enExample)
MX (1) MX9802764A (enExample)
PT (1) PT857211E (enExample)
WO (1) WO1997015664A1 (enExample)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0961830A1 (en) * 1997-01-29 1999-12-08 Neurosearch A/S EXPRESSION VECTORS AND METHODS FOR $i(IN VIVO) EXPRESSION OF THERAPEUTIC POLYPEPTIDES
CA2423082A1 (en) * 2000-09-18 2002-03-28 Genzyme Corporation Expression vectors containing hybrid ubiquitin promoters
EP1624067A3 (en) * 2000-09-18 2006-03-15 Genzyme Corporation Expression vectors containing hybrid ubiquitin promoters
ATE466941T1 (de) * 2001-07-04 2010-05-15 Chromagenics Bv Dns-sequenzen mit anti-repressor-aktivität
US7344886B2 (en) * 2002-11-29 2008-03-18 Boehringer Ingelheim Pharma Gmbh & Co., Kg Neomycin-phosphotransferase-genes and methods for the selection of recombinant cells producing high levels of a desired gene product
DE10256083A1 (de) * 2002-11-29 2004-08-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Expressionsvektor, Verfahren zur Herstellung von heterologen Genprodukten und Selektionsverfahren für hochproduzierende rekombinante Zellen
US7384744B2 (en) 2002-11-29 2008-06-10 Boehringer Ingelheim Pharma Gmbh & Co., Kg Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
US8669109B2 (en) 2003-08-19 2014-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methods of producing proteins in Chinese hamster ovary (CHO) cells
DE10338531A1 (de) 2003-08-19 2005-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Reklonierung von Produktionszellen
US20050101017A1 (en) * 2003-11-10 2005-05-12 Wojtek Auerbach Method of improving gene targeting using a ubiquitin promoter
GB0509965D0 (en) * 2005-05-17 2005-06-22 Ml Lab Plc Improved expression elements
CA2611946C (en) * 2005-06-20 2013-04-16 Cadila Healthcare Limited Expression vector and methods of producing high levels of proteins
EP1806365A1 (en) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
US20080124760A1 (en) * 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
CN107880123A (zh) 2011-10-28 2018-04-06 普罗典娜生物科学有限公司 识别α‑突触核蛋白的人源化抗体
AU2013211874B2 (en) 2012-01-27 2017-11-02 Prothena Biosciences Limited Humanized antibodies that recognize alpha-synuclein
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
WO2014102101A1 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
WO2014102103A2 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within a signal peptide
CA2902026C (en) 2013-03-13 2023-08-29 Prothena Biosciences Limited Tau immunotherapy
WO2014182972A2 (en) 2013-05-10 2014-11-13 The Regents Of The University Of California Diagnostic and monitoring system for huntington's disease
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
US9850302B2 (en) 2013-07-12 2017-12-26 Prothena Biosciences Limited Antibodies that recognize IAPP
WO2015004633A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize islet-amyloid polypeptide (iapp)
WO2015075635A2 (en) 2013-11-19 2015-05-28 Prothena Biosciences Limited Monitoring immunotherapy of lewy body disease from constipation symptoms
WO2015102487A1 (en) * 2013-12-31 2015-07-09 R1 B3 Holding B.V. Construct and sequence for enhanced gene expression
CA2938933A1 (en) 2014-03-12 2015-09-17 Prothena Biosciences Limited Anti-laminin4 antibodies specific for lg4-5
TW201623331A (zh) 2014-03-12 2016-07-01 普羅帝納生物科學公司 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法
JP2017512772A (ja) 2014-03-12 2017-05-25 プロセナ バイオサイエンシーズ リミテッド Lg1〜3に特異的な抗ラミニン4抗体
DK3116911T3 (da) 2014-03-12 2019-09-30 Prothena Biosciences Ltd Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse
CA2944402A1 (en) 2014-04-08 2015-10-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
TWI746427B (zh) 2014-12-10 2021-11-21 以色列商歐科生物製品有限公司 製造長效ctp修飾的多肽之方法
TWI718121B (zh) 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
TWI786505B (zh) 2015-01-28 2022-12-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
TWI711631B (zh) 2015-01-28 2020-12-01 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
EP3297442A4 (en) 2015-05-18 2018-11-07 Zymtronix, LLC Magnetically immobilized microbiocidal enzymes
US10792649B2 (en) 2015-07-15 2020-10-06 Zymtronix, Llc Automated bionanocatalyst production
WO2017046774A2 (en) 2015-09-16 2017-03-23 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis
JP2018530540A (ja) 2015-09-16 2018-10-18 プロセナ バイオサイエンシーズ リミテッド 巨細胞動脈炎、リウマチ性多発筋痛症又は高安動脈炎の処置又は予防のための抗mcam抗体の使用
WO2017149513A1 (en) 2016-03-03 2017-09-08 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
WO2017153955A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
WO2017153953A1 (en) 2016-03-09 2017-09-14 Prothena Biosciences Limited Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases
US10752679B2 (en) 2016-05-02 2020-08-25 Prothena Biosciences Limited Tau immunotherapy
EP3452508A1 (en) 2016-05-02 2019-03-13 Prothena Biosciences Limited Antibodies recognizing tau
PE20190208A1 (es) 2016-05-02 2019-02-07 Prothena Biosciences Ltd Anticuerpos que reconocen tau
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
WO2018007924A2 (en) 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7016470B2 (ja) 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
EP3478714A2 (en) 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
ES2963725T3 (es) 2016-07-11 2024-04-01 Opko Biologics Ltd Factor VII de coagulación de acción prolongada y métodos para producir el mismo
CN109788762B (zh) 2016-08-13 2023-07-11 齐姆特罗尼克斯催化系统股份有限公司 磁性固定化的杀生物酶和杀生物化学品
KR20190103373A (ko) 2017-01-13 2019-09-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 면역조작된 만능 세포
MX2019013045A (es) 2017-05-02 2020-02-12 Prothena Biosciences Ltd Anticuerpos que reconocen tau.
AU2017434556B2 (en) 2017-09-28 2024-11-14 F. Hoffmann-La Roche Ag Dosing regimes for treatment of synucleinopathies
MX2020003043A (es) 2017-10-06 2020-10-05 Prothena Biosciences Ltd Métodos para detectar transtiretina.
CN111433223B (zh) 2017-11-29 2024-08-27 诺和诺德A/S(股份有限公司) 抗甲状腺素运载蛋白单克隆抗体的冻干制剂
US20210263001A1 (en) 2018-09-05 2021-08-26 Zymtronix Catalytic Systems, Inc. Immobilized enzymes and microsomes on magnetic scaffolds
UA129124C2 (uk) 2018-11-08 2025-01-22 Протена Біосайєнсіс Лімітед Антитіла, що розпізнають тау
EP3817773B1 (en) 2018-11-26 2024-07-24 Forty Seven, Inc. Humanized antibodies against c-kit
AU2020231366A1 (en) 2019-03-03 2021-08-12 Prothena Biosciences Limited Antibodies recognizing tau
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
CN113811362A (zh) 2019-05-10 2021-12-17 加利福尼亚大学董事会 修饰的多能细胞
EP3990627A4 (en) 2019-06-26 2023-07-19 The Regents of The University of California SIRP-ALPHA SILENCED NATURAL KILLER CELLS (NK)
WO2021022223A1 (en) 2019-08-01 2021-02-04 Sana Biotechnology, Inc. Dux4 expressing cells and uses thereof
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー,インコーポレイテッド Cd24発現細胞およびそれらの用途
JP2023510872A (ja) 2020-01-13 2023-03-15 サナ バイオテクノロジー,インコーポレイテッド 血液型抗原の修飾
EP4090349A4 (en) 2020-01-15 2024-06-05 The Regents of The University of California TRANSPLANTED CELL PROTECTION BY INHIBITING POLYMORPHENUCULAR CELLS
WO2021146627A1 (en) 2020-01-17 2021-07-22 Sana Biotechnology, Inc. Safety switches for regulation of gene expression
BR112022019060A2 (pt) 2020-03-25 2022-11-29 Sana Biotechnology Inc Células neurais hipoimunogênicas para o tratamento de distúrbios e condições neurológicas
KR20230026489A (ko) 2020-06-24 2023-02-24 프로테나 바이오사이언시즈 리미티드 소르틸린을 인지하는 항체
US20220049226A1 (en) 2020-08-13 2022-02-17 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
IL303473A (en) 2020-12-31 2023-08-01 Sana Biotechnology Inc Methods and compositions for modulating car-t activity
AU2022277931A1 (en) 2021-05-19 2023-11-30 Sana Biotechnology, Inc. Hypoimmunogenic rhd negative primary t cells
CA3216346A1 (en) 2021-05-27 2022-12-01 Edward Rebar Hypoimmunogenic cells comprising engineered hla-e or hla-g
CA3225283A1 (en) 2021-07-14 2023-01-19 Sonja SCHREPFER Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
EP4384193A2 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
AU2022325232A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified primary cells for allogeneic cell therapy
JP2024534772A (ja) 2021-08-11 2024-09-26 サナ バイオテクノロジー,インコーポレイテッド 同種異系細胞療法用の遺伝子改変細胞
US20240425820A1 (en) 2021-08-11 2024-12-26 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
IL315000A (en) 2022-02-17 2024-10-01 Sana Biotechnology Inc Engineered cd47 proteins and uses thereof
US20250101382A1 (en) 2022-03-11 2025-03-27 Sana Biotechnology, Inc. Genetically modified cells and compositions and uses thereof
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
EP4634388A1 (en) 2022-12-14 2025-10-22 Providence Therapeutics Holdings Inc. Compositions and methods for infectious diseases
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024229302A1 (en) 2023-05-03 2024-11-07 Sana Biotechnology, Inc. Methods of dosing and administration of engineered islet cells
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025043172A1 (en) 2023-08-23 2025-02-27 Sana Biotechnology, Inc. Modified cd47 proteins and their uses
TW202528337A (zh) 2023-09-15 2025-07-16 愛爾蘭商普羅希那平台科技有限公司 包括細胞穿透藥劑之方法、組合物、及套組
WO2025059487A2 (en) 2023-09-15 2025-03-20 Othair Prothena Limited Cell penetrating agents and uses thereof
AR133834A1 (es) 2023-09-15 2025-11-05 Prothena Biosciences Ltd Agentes de penetración célular y sus usos
AR133828A1 (es) 2023-09-15 2025-11-05 Prothena Biosciences Ltd Anticuerpos anti-tdp-43 y sus usos
WO2025166633A2 (en) 2024-02-07 2025-08-14 Westlake Genetech. Ltd. Split gene editing systems and uses thereof

Also Published As

Publication number Publication date
CA2234071C (en) 2003-01-21
JPH11513572A (ja) 1999-11-24
MX9802764A (es) 1998-11-30
JP3966903B2 (ja) 2007-08-29
EP0857211A1 (de) 1998-08-12
WO1997015664A1 (de) 1997-05-01
ATE355370T1 (de) 2006-03-15
CA2234071A1 (en) 1997-05-01
PT857211E (pt) 2007-03-30
ES2281905T3 (es) 2007-10-01
EP0857211B1 (de) 2007-02-28
DE19539493A1 (de) 1997-04-30
EP1803815A2 (de) 2007-07-04
DE59611420D1 (de) 2007-04-12
JP2006320330A (ja) 2006-11-30
US6063598A (en) 2000-05-16
EP1803815A3 (de) 2007-08-29

Similar Documents

Publication Publication Date Title
DK0857211T3 (da) Stærk homolog promoter fra hamster
DK0920498T3 (da) Hamster EF-1alfa transskriptionelt, regulatorisk DNA
ATE420192T1 (de) Verfahren zur verringerung der antigenität des adeno-assoziierten virus strukturproteins
DK0830376T3 (da) Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner
BR9712656A (pt) Promotor, uso do mesmo, cassete de expressão, vetor recombinante, uso do mesmo, microorganismo, uso do mesmo, planta transgênica, processo de produção da mesma, processo de isolamento de um promotor especìfico para folha, e, sequência de ácido nucléico.
ATE295426T1 (de) Qualitatives differentielles screening
PT763101E (pt) Sequencias de acido nucleico e sistemas de expressao para heparinase iii derivadas de flavobacterium heparinum
PL1824977T3 (pl) Promotorowy kwas nukleinowy pochodzący z rodzaju Corynebacterium, kaseta ekspresyjna zawierająca promotor i wektor, komórka gospodarza zawierająca wektor i sposób ekspresji genu z użyciem komórki
ATE179754T1 (de) Verfahren zur herstellung von thrombin
ATE264913T1 (de) Protease-resistente analoge des thrombomodulin
DE69732847D1 (de) Endothel-spezifischer expression unter einfluss von epcr kontrollelementen
CA2309600A1 (en) Low-temperature inducible expression vector
ATE416257T1 (de) Promotoren für wachstums-differenzierungsfaktoren und deren verwendung
FR2693463B1 (fr) Promoteur de levure et son utilisation.
ATE342998T1 (de) Replikation -defektive baculoviren expressionssystem
EP0811696A3 (en) Method to obtain nucleotide sequence using randomly primed amplification
ATE317020T1 (de) Neues regulationssystem zur kontrolle der expression eines transgens
ATE308612T1 (de) Als impfstoff verwendbares attenuiertes influenzavirus
DE69104357D1 (de) Klonierungs- und/oder expressionsvektoren, verfahren zur ihrer herstellung und verwendung.
PT1123396E (pt) Promotores minimos e seus usos
HUP9902298A2 (hu) Tirozin-hidroxiláz génből származó expressziós rendszer
DE69536047D1 (de) MN-Gen und -Protein
CA2259145A1 (en) Hamster ef-1.alpha. transcriptional regulatory dna
ES2148786T3 (es) Derivados de alfa-hidrazinoacidos y procedimiento para su preparacion.
AU7416100A (en) Dihydroorotase extracted from plants