ATE179754T1 - Verfahren zur herstellung von thrombin - Google Patents

Verfahren zur herstellung von thrombin

Info

Publication number
ATE179754T1
ATE179754T1 AT93902869T AT93902869T ATE179754T1 AT E179754 T1 ATE179754 T1 AT E179754T1 AT 93902869 T AT93902869 T AT 93902869T AT 93902869 T AT93902869 T AT 93902869T AT E179754 T1 ATE179754 T1 AT E179754T1
Authority
AT
Austria
Prior art keywords
thrombin
host cells
produced
transfected
transformed
Prior art date
Application number
AT93902869T
Other languages
English (en)
Inventor
Richard D Holly
Donald C Foster
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE179754T1 publication Critical patent/ATE179754T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
AT93902869T 1991-12-31 1992-12-30 Verfahren zur herstellung von thrombin ATE179754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81628191A 1991-12-31 1991-12-31
US86070192A 1992-03-31 1992-03-31

Publications (1)

Publication Number Publication Date
ATE179754T1 true ATE179754T1 (de) 1999-05-15

Family

ID=27124054

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902869T ATE179754T1 (de) 1991-12-31 1992-12-30 Verfahren zur herstellung von thrombin

Country Status (13)

Country Link
US (2) US5476777A (de)
EP (1) EP0624199B1 (de)
JP (1) JP3404038B2 (de)
AT (1) ATE179754T1 (de)
AU (1) AU683834B2 (de)
CA (1) CA2125783C (de)
DE (1) DE69229126T2 (de)
DK (1) DK0624199T3 (de)
ES (1) ES2134836T3 (de)
FI (1) FI117831B (de)
GR (1) GR3030820T3 (de)
NO (1) NO317018B1 (de)
WO (1) WO1993013208A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5457294A (en) * 1992-10-29 1994-05-24 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
US6096309A (en) * 1997-06-18 2000-08-01 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
CA2322741A1 (en) * 1998-03-10 1999-09-16 David H. Sierra Thrombin preparation and products and fibrin sealant methods employing same
JP2002514433A (ja) * 1998-05-14 2002-05-21 バッテル メモリアル インスティテュート トランスジェニック植物由来ヒト凝血因子
US20030096771A1 (en) * 2001-07-26 2003-05-22 Butler Madeline M. Antisense modulation of hormone-sensitive lipase expression
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
WO2001011952A1 (en) * 1999-08-19 2001-02-22 Us Transgenics, Inc. Transgenic prothrombin and related thrombin precursors and transgenics, methods, compositions, uses and the like relating thereto
CA2447050A1 (en) * 2001-05-14 2002-11-21 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
AU2003211128A1 (en) * 2002-02-20 2003-09-09 American Integrated Biologics, Inc. Transgenic production in saliva
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
WO2003079985A2 (en) * 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
WO2006132925A2 (en) * 2005-06-01 2006-12-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
EP1934288A2 (de) 2005-07-28 2008-06-25 Carnegie Mellon University Biokompatible polymere und verwendungsverfahren
US20090137001A1 (en) 2005-09-30 2009-05-28 Tatsufumi Onchi Process for preparing recombinant human thrombin with culture cell
CN101501216B (zh) * 2006-03-06 2013-10-02 胡玛基因公司 制备重组人凝血酶的方法
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
EP2114440A1 (de) * 2007-01-31 2009-11-11 Anders Jeppsson Verwendung von fibrinogen als prophylaktische behandlung zur verhinderung von blutungen während und nach einer operation und als biomarker zur identifizierung von patienten mit erhöhten risiko für übermässige blutungen und bluttransfusion
AU2008296206A1 (en) * 2007-09-05 2009-03-12 Zymogenetics, Inc. Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition
EP2271267A4 (de) * 2008-04-25 2015-04-01 Zymogenetics Inc Medizinische vorrichtung zur perioperativen abgabe von flüssigkeiten und anwendungsverfahren dafür
RU2015135227A (ru) 2013-01-22 2018-12-25 Кенкор Биотех Лтд. Способ получения рекомбинантного человеческого протромбина и фибриногена
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910005081B1 (ko) * 1988-09-23 1991-07-22 삼성전관 주식회사 칼라브라운관의 형광면 제작방법
JP2549224B2 (ja) * 1990-01-26 1996-10-30 イムノ・アクチェンゲゼルシャフト 組換えにより産生される血液因子及びその血液因子の発現方法並びにその方法に使用されるワクシニアウイルス組換え体
ES2131504T3 (es) * 1990-02-20 1999-08-01 Baxter Int Trombina humana purificada viricamente segura.

Also Published As

Publication number Publication date
JP3404038B2 (ja) 2003-05-06
FI117831B (fi) 2007-03-15
NO317018B1 (no) 2004-07-26
NO942456D0 (no) 1994-06-29
DE69229126T2 (de) 1999-12-30
EP0624199B1 (de) 1999-05-06
AU683834B2 (en) 1997-11-27
ES2134836T3 (es) 1999-10-16
GR3030820T3 (en) 1999-11-30
NO942456L (no) 1994-06-29
DK0624199T3 (da) 1999-11-01
DE69229126D1 (de) 1999-06-10
US5476777A (en) 1995-12-19
CA2125783C (en) 2003-03-25
US5502034A (en) 1996-03-26
WO1993013208A1 (en) 1993-07-08
AU3428793A (en) 1993-07-28
CA2125783A1 (en) 1993-07-08
FI943122A0 (fi) 1994-06-29
FI943122A (fi) 1994-06-29
EP0624199A1 (de) 1994-11-17
JPH07502659A (ja) 1995-03-23

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UEP Publication of translation of european patent specification