GR3030820T3 - Methods for producing thrombin. - Google Patents
Methods for producing thrombin.Info
- Publication number
- GR3030820T3 GR3030820T3 GR990401908T GR990401908T GR3030820T3 GR 3030820 T3 GR3030820 T3 GR 3030820T3 GR 990401908 T GR990401908 T GR 990401908T GR 990401908 T GR990401908 T GR 990401908T GR 3030820 T3 GR3030820 T3 GR 3030820T3
- Authority
- GR
- Greece
- Prior art keywords
- thrombin
- methods
- host cells
- produced
- transfected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81628191A | 1991-12-31 | 1991-12-31 | |
US86070192A | 1992-03-31 | 1992-03-31 | |
PCT/US1992/011357 WO1993013208A1 (en) | 1991-12-31 | 1992-12-30 | Methods for producing thrombin |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3030820T3 true GR3030820T3 (en) | 1999-11-30 |
Family
ID=27124054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR990401908T GR3030820T3 (en) | 1991-12-31 | 1999-07-20 | Methods for producing thrombin. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5476777A (el) |
EP (1) | EP0624199B1 (el) |
JP (1) | JP3404038B2 (el) |
AT (1) | ATE179754T1 (el) |
AU (1) | AU683834B2 (el) |
CA (1) | CA2125783C (el) |
DE (1) | DE69229126T2 (el) |
DK (1) | DK0624199T3 (el) |
ES (1) | ES2134836T3 (el) |
FI (1) | FI117831B (el) |
GR (1) | GR3030820T3 (el) |
NO (1) | NO317018B1 (el) |
WO (1) | WO1993013208A1 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
DE19710190A1 (de) * | 1997-03-12 | 1998-09-17 | Immuno Ag | Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung |
JP2002514960A (ja) * | 1997-06-18 | 2002-05-21 | コヘージョン テクノロジーズ,インコーポレイテッド | トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法 |
US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
CA2322741A1 (en) * | 1998-03-10 | 1999-09-16 | David H. Sierra | Thrombin preparation and products and fibrin sealant methods employing same |
WO1999058699A2 (en) * | 1998-05-14 | 1999-11-18 | Battelle Memorial Institute | Transgenic plant-derived human blood coagulation factors |
US20030096771A1 (en) * | 2001-07-26 | 2003-05-22 | Butler Madeline M. | Antisense modulation of hormone-sensitive lipase expression |
KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
IL129427A0 (en) | 1999-04-13 | 2000-02-17 | Yeda Res & Dev | Preparation of biologically active molecules |
WO2001011952A1 (en) * | 1999-08-19 | 2001-02-22 | Us Transgenics, Inc. | Transgenic prothrombin and related thrombin precursors and transgenics, methods, compositions, uses and the like relating thereto |
WO2002092841A2 (en) * | 2001-05-14 | 2002-11-21 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
EP1585386A4 (en) * | 2002-02-20 | 2009-09-02 | American Integrated Biolog Inc | GENE PRODUCTION IN SALIVA |
US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
AU2003224710A1 (en) * | 2002-03-18 | 2003-10-08 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
US20100254900A1 (en) * | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
US8293530B2 (en) * | 2006-10-17 | 2012-10-23 | Carnegie Mellon University | Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
ES2226587B1 (es) * | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
US20070011752A1 (en) * | 2005-05-06 | 2007-01-11 | American Integrated Biologics, Inc. | Production of human proteins in transgenic animal saliva |
US20060270015A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
US20060270014A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
WO2006132925A2 (en) * | 2005-06-01 | 2006-12-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
EP2093256A3 (en) | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biocompatible polymers and methods of use |
EP1939283A4 (en) | 2005-09-30 | 2009-02-25 | Chemo Sero Therapeut Res Inst | PROCESS FOR PRODUCING RECOMBINANT HUMAN THROMBIN BY A CULTIVATED CELL |
EP2407561A3 (en) | 2006-03-06 | 2012-05-30 | Humagene, Inc. | A method for the preparation of recombinant human fibrinogen |
US8529961B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US20100062981A1 (en) * | 2007-01-31 | 2010-03-11 | Anders Jeppsson | Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion |
AU2008296206A1 (en) * | 2007-09-05 | 2009-03-12 | Zymogenetics, Inc. | Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition |
WO2009132331A1 (en) * | 2008-04-25 | 2009-10-29 | Zymogenetics, Inc. | Medical devices for delivering fluids during surgery and methods for their use |
RU2015135227A (ru) | 2013-01-22 | 2018-12-25 | Кенкор Биотех Лтд. | Способ получения рекомбинантного человеческого протромбина и фибриногена |
WO2020229521A1 (en) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for inhibiting or reducing bacterial biofilms on a surface |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR910005081B1 (ko) * | 1988-09-23 | 1991-07-22 | 삼성전관 주식회사 | 칼라브라운관의 형광면 제작방법 |
DK0512011T3 (da) * | 1990-01-26 | 1994-05-09 | Immuno Ag | Blodfaktorer fremstillet ved rekombinant DNA-teknologi, fremgangsmåde til ekspression af blodfaktorerne samt vacciniavirusrekombinanter anvendt ved fremgangsmåden |
DE69130990T2 (de) * | 1990-02-20 | 1999-12-02 | Baxter Int | Gereinigtes, virusfreies menschliches Thrombin |
-
1992
- 1992-12-30 DK DK93902869T patent/DK0624199T3/da active
- 1992-12-30 WO PCT/US1992/011357 patent/WO1993013208A1/en active IP Right Grant
- 1992-12-30 DE DE69229126T patent/DE69229126T2/de not_active Expired - Lifetime
- 1992-12-30 AU AU34287/93A patent/AU683834B2/en not_active Expired
- 1992-12-30 US US07/998,972 patent/US5476777A/en not_active Expired - Lifetime
- 1992-12-30 JP JP51196893A patent/JP3404038B2/ja not_active Expired - Lifetime
- 1992-12-30 CA CA002125783A patent/CA2125783C/en not_active Expired - Lifetime
- 1992-12-30 EP EP93902869A patent/EP0624199B1/en not_active Expired - Lifetime
- 1992-12-30 ES ES93902869T patent/ES2134836T3/es not_active Expired - Lifetime
- 1992-12-30 AT AT93902869T patent/ATE179754T1/de active
-
1994
- 1994-06-29 FI FI943122A patent/FI117831B/fi not_active IP Right Cessation
- 1994-06-29 NO NO19942456A patent/NO317018B1/no not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/463,953 patent/US5502034A/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401908T patent/GR3030820T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI117831B (fi) | 2007-03-15 |
JPH07502659A (ja) | 1995-03-23 |
AU3428793A (en) | 1993-07-28 |
AU683834B2 (en) | 1997-11-27 |
WO1993013208A1 (en) | 1993-07-08 |
FI943122A0 (fi) | 1994-06-29 |
NO317018B1 (no) | 2004-07-26 |
ES2134836T3 (es) | 1999-10-16 |
NO942456D0 (no) | 1994-06-29 |
US5502034A (en) | 1996-03-26 |
DK0624199T3 (da) | 1999-11-01 |
FI943122A (fi) | 1994-06-29 |
US5476777A (en) | 1995-12-19 |
EP0624199A1 (en) | 1994-11-17 |
CA2125783C (en) | 2003-03-25 |
DE69229126T2 (de) | 1999-12-30 |
CA2125783A1 (en) | 1993-07-08 |
JP3404038B2 (ja) | 2003-05-06 |
EP0624199B1 (en) | 1999-05-06 |
NO942456L (no) | 1994-06-29 |
DE69229126D1 (de) | 1999-06-10 |
ATE179754T1 (de) | 1999-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GR3030820T3 (en) | Methods for producing thrombin. | |
AU6801487A (en) | Method of producing a recombinant protein complex having human factor VIII:C activity | |
EP0266190A3 (en) | Expression of protein c | |
AU5817496A (en) | Process for producing erythropoietin containing no animal pr oteins | |
DE69434408D1 (de) | Recombinante Herstellung aromatischer Polyketiden | |
AU603983B2 (en) | Expression of factor vii and ix activities in mammalian cells | |
ES2000178A6 (es) | Procedimiento para producir una secuencia de polipeptidos y metodo para purificar una sustancia. | |
DE3688900T2 (de) | Expression von Protein C. | |
GB9100825D0 (en) | Pasteurella haemolytica glycoprotease gene and the purified enzyme | |
DK0749489T3 (da) | Ekspressionskassette, der omfatter en promotor stammende fra pho4-genet fra Schizosaccharomyces pombe | |
ES8800725A1 (es) | Un procedimiento para producir un anticuerpo monoclonal | |
ZA978503B (en) | Vertebrate smoothened proteins | |
EP0169006A3 (en) | Genetically modified micro-organisms | |
HU890157D0 (en) | Process for producing plasminogene activator variants of human tissue type | |
AU6560886A (en) | DNA sequence containing the DNA sequence coding for human tissue plasminogen activator originating from human normal cells, recombinant DNA incorporating the DNA sequence, host cells transformed with the recombinant DNA, and process for producing human tissue plasminogen activator by use of the host cells | |
NL960017I1 (nl) | Expressie van Factor VIII-activiteit in zoogdiercellen. | |
CY1929A (en) | Expression of foreign genes in drosophila cells |