DE3688900T2 - Expression von Protein C. - Google Patents
Expression von Protein C.Info
- Publication number
- DE3688900T2 DE3688900T2 DE86304970T DE3688900T DE3688900T2 DE 3688900 T2 DE3688900 T2 DE 3688900T2 DE 86304970 T DE86304970 T DE 86304970T DE 3688900 T DE3688900 T DE 3688900T DE 3688900 T2 DE3688900 T2 DE 3688900T2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- nucleotide sequence
- disclosed
- mammalian host
- biological activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74960085A | 1985-06-27 | 1985-06-27 | |
US06/766,109 US4968626A (en) | 1985-08-15 | 1985-08-15 | DNA sequence coding for protein C |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3688900D1 DE3688900D1 (de) | 1993-09-23 |
DE3688900T2 true DE3688900T2 (de) | 1993-12-09 |
DE3688900T3 DE3688900T3 (de) | 1998-06-10 |
Family
ID=27115147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3688900T Expired - Lifetime DE3688900T3 (de) | 1985-06-27 | 1986-06-26 | Expression von Protein C. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0215548B2 (de) |
JP (2) | JP2614848B2 (de) |
AT (1) | ATE93272T1 (de) |
CA (1) | CA1341228C (de) |
DE (1) | DE3688900T3 (de) |
DK (1) | DK175574B1 (de) |
NO (1) | NO305660B1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
US5550036A (en) * | 1986-04-09 | 1996-08-27 | Eli Lilly And Company | Method for co-amplification of human protein C genes in human cells |
USH1148H (en) | 1987-04-17 | 1993-03-02 | Method of separating activated human protein C | |
JP2799316B2 (ja) * | 1987-06-12 | 1998-09-17 | ヘキスト・マリオン・ルセル株式会社 | 雑種ヒトプロテインcおよびその遺伝子工学的製法 |
US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
US5196322A (en) * | 1987-12-28 | 1993-03-23 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
JP2728240B2 (ja) * | 1988-07-26 | 1998-03-18 | ヘキスト薬品工業株式会社 | ヒトプロテインc変異体及びその製造方法 |
CA1332049C (en) * | 1988-10-07 | 1994-09-20 | Eli Lilly And Company | Eukaryotic expression |
WO1991002065A1 (en) * | 1989-08-11 | 1991-02-21 | Zymogenetics, Inc. | Cell culture methods for producing activated protein c |
JP2774156B2 (ja) * | 1989-09-05 | 1998-07-09 | 帝人株式会社 | ヒトプロテインcおよび/または活性化ヒトプロテインc様活性を有する蛋白 |
JP2774163B2 (ja) * | 1989-11-14 | 1998-07-09 | 帝人株式会社 | ヒトプロテインc様活性を有する蛋白 |
US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
DE69032029T2 (de) * | 1989-12-29 | 1998-08-20 | Zymogenetics Inc | Hybrides protein c |
US5270178A (en) * | 1990-02-23 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
IL97311A0 (en) * | 1990-02-23 | 1992-05-25 | Lilly Co Eli | Vectors and compounds for expression of glycosylation mutants of human protein c |
AT402263B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
US5443968A (en) * | 1992-05-01 | 1995-08-22 | Teijin Limited | Fed batch culture method for protein secreting cells |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
AU1751801A (en) * | 1999-11-19 | 2001-05-30 | Eli Lilly And Company | Protein c derivatives |
CA2609435A1 (en) * | 2005-05-24 | 2006-11-30 | Avestha Gengraine Technologies Pvt Ltd. | A process comprising codon optimization for the production of recombinant activated human protein c for the treatment of sepsis |
CN104755020B (zh) | 2012-10-23 | 2018-01-12 | 皇家飞利浦有限公司 | 精神压力测量系统 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
-
1986
- 1986-06-26 CA CA000512483A patent/CA1341228C/en not_active Expired - Fee Related
- 1986-06-26 DE DE3688900T patent/DE3688900T3/de not_active Expired - Lifetime
- 1986-06-26 AT AT86304970T patent/ATE93272T1/de not_active IP Right Cessation
- 1986-06-26 EP EP86304970A patent/EP0215548B2/de not_active Expired - Lifetime
- 1986-06-27 DK DK198603085A patent/DK175574B1/da not_active IP Right Cessation
- 1986-06-27 JP JP61151303A patent/JP2614848B2/ja not_active Expired - Lifetime
- 1986-06-27 NO NO862601A patent/NO305660B1/no not_active IP Right Cessation
-
1996
- 1996-07-09 JP JP8179612A patent/JP2688407B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0215548A1 (de) | 1987-03-25 |
ATE93272T1 (de) | 1993-09-15 |
DK308586D0 (da) | 1986-06-27 |
DK175574B1 (da) | 2004-12-13 |
NO305660B1 (no) | 1999-07-05 |
JPS62111690A (ja) | 1987-05-22 |
EP0215548B1 (de) | 1993-08-18 |
NO862601D0 (no) | 1986-06-27 |
DE3688900D1 (de) | 1993-09-23 |
JP2614848B2 (ja) | 1997-05-28 |
JPH09107976A (ja) | 1997-04-28 |
JP2688407B2 (ja) | 1997-12-10 |
DK308586A (da) | 1986-12-28 |
DE3688900T3 (de) | 1998-06-10 |
CA1341228C (en) | 2001-05-15 |
NO862601L (no) | 1986-12-29 |
EP0215548B2 (de) | 1998-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings |