NO862601D0 - Ekspresjon av protein c. - Google Patents
Ekspresjon av protein c.Info
- Publication number
- NO862601D0 NO862601D0 NO862601A NO862601A NO862601D0 NO 862601 D0 NO862601 D0 NO 862601D0 NO 862601 A NO862601 A NO 862601A NO 862601 A NO862601 A NO 862601A NO 862601 D0 NO862601 D0 NO 862601D0
- Authority
- NO
- Norway
- Prior art keywords
- protein
- nucleotide sequence
- disclosed
- mammalian host
- biological activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74960085A | 1985-06-27 | 1985-06-27 | |
US06/766,109 US4968626A (en) | 1985-08-15 | 1985-08-15 | DNA sequence coding for protein C |
Publications (3)
Publication Number | Publication Date |
---|---|
NO862601D0 true NO862601D0 (no) | 1986-06-27 |
NO862601L NO862601L (no) | 1986-12-29 |
NO305660B1 NO305660B1 (no) | 1999-07-05 |
Family
ID=27115147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO862601A NO305660B1 (no) | 1985-06-27 | 1986-06-27 | DNA-sekvens som koder for et human-aktivert protein C, rekombinant ekspresjonsvektor som omfatter DNA-sekvensen, pattedyrceller transfektert med ekspresjonsvektoren og fremgangsmÕte for fremstilling av human-aktivert protein C |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0215548B2 (no) |
JP (2) | JP2614848B2 (no) |
AT (1) | ATE93272T1 (no) |
CA (1) | CA1341228C (no) |
DE (1) | DE3688900T3 (no) |
DK (1) | DK175574B1 (no) |
NO (1) | NO305660B1 (no) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
US5550036A (en) | 1986-04-09 | 1996-08-27 | Eli Lilly And Company | Method for co-amplification of human protein C genes in human cells |
USH1148H (en) | 1987-04-17 | 1993-03-02 | Method of separating activated human protein C | |
JP2799316B2 (ja) * | 1987-06-12 | 1998-09-17 | ヘキスト・マリオン・ルセル株式会社 | 雑種ヒトプロテインcおよびその遺伝子工学的製法 |
US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
US5196322A (en) * | 1987-12-28 | 1993-03-23 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
JP2728240B2 (ja) * | 1988-07-26 | 1998-03-18 | ヘキスト薬品工業株式会社 | ヒトプロテインc変異体及びその製造方法 |
CA1332049C (en) * | 1988-10-07 | 1994-09-20 | Eli Lilly And Company | Eukaryotic expression |
JP3045307B2 (ja) * | 1989-08-11 | 2000-05-29 | ザイモジェネティクス,インコーポレイティド | 活性化プロテインcを生成するための細胞培養法 |
JP2774156B2 (ja) * | 1989-09-05 | 1998-07-09 | 帝人株式会社 | ヒトプロテインcおよび/または活性化ヒトプロテインc様活性を有する蛋白 |
JP2774163B2 (ja) * | 1989-11-14 | 1998-07-09 | 帝人株式会社 | ヒトプロテインc様活性を有する蛋白 |
US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
DE69032029T2 (de) * | 1989-12-29 | 1998-08-20 | Zymogenetics Inc | Hybrides protein c |
US5270178A (en) * | 1990-02-23 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
IL97311A0 (en) * | 1990-02-23 | 1992-05-25 | Lilly Co Eli | Vectors and compounds for expression of glycosylation mutants of human protein c |
AT402263B (de) * | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
US5443968A (en) * | 1992-05-01 | 1995-08-22 | Teijin Limited | Fed batch culture method for protein secreting cells |
DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
CA2391651A1 (en) * | 1999-11-19 | 2001-05-25 | Eli Lilly And Company | Protein c derivatives |
BRPI0611376A2 (pt) * | 2005-05-24 | 2010-08-31 | Avestha Gengraine Tech Pvt Ltd | processo para a producão de proteìna c ativada humana para o tratamento de sepsia |
US10758179B2 (en) | 2012-10-23 | 2020-09-01 | Koninklijke Philips N.V. | Stress-measuring system |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
-
1986
- 1986-06-26 DE DE3688900T patent/DE3688900T3/de not_active Expired - Lifetime
- 1986-06-26 AT AT86304970T patent/ATE93272T1/de not_active IP Right Cessation
- 1986-06-26 EP EP86304970A patent/EP0215548B2/en not_active Expired - Lifetime
- 1986-06-26 CA CA000512483A patent/CA1341228C/en not_active Expired - Fee Related
- 1986-06-27 NO NO862601A patent/NO305660B1/no not_active IP Right Cessation
- 1986-06-27 JP JP61151303A patent/JP2614848B2/ja not_active Expired - Lifetime
- 1986-06-27 DK DK198603085A patent/DK175574B1/da not_active IP Right Cessation
-
1996
- 1996-07-09 JP JP8179612A patent/JP2688407B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK308586D0 (da) | 1986-06-27 |
DK175574B1 (da) | 2004-12-13 |
JPS62111690A (ja) | 1987-05-22 |
CA1341228C (en) | 2001-05-15 |
DE3688900T3 (de) | 1998-06-10 |
JPH09107976A (ja) | 1997-04-28 |
JP2614848B2 (ja) | 1997-05-28 |
EP0215548B1 (en) | 1993-08-18 |
EP0215548B2 (en) | 1998-01-07 |
ATE93272T1 (de) | 1993-09-15 |
JP2688407B2 (ja) | 1997-12-10 |
DK308586A (da) | 1986-12-28 |
NO305660B1 (no) | 1999-07-05 |
NO862601L (no) | 1986-12-29 |
DE3688900D1 (de) | 1993-09-23 |
DE3688900T2 (de) | 1993-12-09 |
EP0215548A1 (en) | 1987-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO874495L (no) | Ekspresjon av protein c. | |
NO862601L (no) | Ekspresjon av protein c. | |
ATE391175T1 (de) | Multidrug resistenz gen | |
FI963246A (fi) | Geeniterapiassa käytettävä isäntävektorijärjestelmä | |
ATE88501T1 (de) | Rekombinante dns-expressionsvektoren. | |
NO870323L (no) | Fremgangsmaate for fremstilling av et rekombinant proteinkompleks med humanfaktor v111:c-aktivitet. | |
DE69828193D1 (de) | Hyaluronan synthase gen und seine verwendung | |
EP0111814A3 (en) | The cloning and expression of nucleotide sequences encoding bovine growth hormone | |
EP0835661A3 (en) | Human interferon-Beta2A for use as a medicament | |
ES2078243T3 (es) | Mejoras en o relativas a la expresion eucariotica. | |
EP0336383A3 (en) | Novel recombinant human lymphotoxin | |
AU6560886A (en) | DNA sequence containing the DNA sequence coding for human tissue plasminogen activator originating from human normal cells, recombinant DNA incorporating the DNA sequence, host cells transformed with the recombinant DNA, and process for producing human tissue plasminogen activator by use of the host cells | |
EP0282512A4 (en) | STABILIZATION OF MESSENGER RNA IN ANIMAL CELLS. | |
ATE111527T1 (de) | Herstellung und verwendung einer dna zur erhöhung der ausbeute bei der expression von rekombinanten genen. | |
WO1991009951A3 (en) | Recombinant protein c with truncated light chain |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |