NO305660B1 - DNA-sekvens som koder for et human-aktivert protein C, rekombinant ekspresjonsvektor som omfatter DNA-sekvensen, pattedyrceller transfektert med ekspresjonsvektoren og fremgangsmÕte for fremstilling av human-aktivert protein C - Google Patents
DNA-sekvens som koder for et human-aktivert protein C, rekombinant ekspresjonsvektor som omfatter DNA-sekvensen, pattedyrceller transfektert med ekspresjonsvektoren og fremgangsmÕte for fremstilling av human-aktivert protein C Download PDFInfo
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- NO305660B1 NO305660B1 NO862601A NO862601A NO305660B1 NO 305660 B1 NO305660 B1 NO 305660B1 NO 862601 A NO862601 A NO 862601A NO 862601 A NO862601 A NO 862601A NO 305660 B1 NO305660 B1 NO 305660B1
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- activated protein
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- 150000003384 small molecules Chemical class 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 108010026668 snake venom protein C activator Proteins 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- KNFMYSSYYFKXDE-UHFFFAOYSA-K trisodium;benzenecarboximidamide;phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O.NC(=N)C1=CC=CC=C1 KNFMYSSYYFKXDE-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74960085A | 1985-06-27 | 1985-06-27 | |
| US06/766,109 US4968626A (en) | 1985-08-15 | 1985-08-15 | DNA sequence coding for protein C |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO862601D0 NO862601D0 (no) | 1986-06-27 |
| NO862601L NO862601L (no) | 1986-12-29 |
| NO305660B1 true NO305660B1 (no) | 1999-07-05 |
Family
ID=27115147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO862601A NO305660B1 (no) | 1985-06-27 | 1986-06-27 | DNA-sekvens som koder for et human-aktivert protein C, rekombinant ekspresjonsvektor som omfatter DNA-sekvensen, pattedyrceller transfektert med ekspresjonsvektoren og fremgangsmÕte for fremstilling av human-aktivert protein C |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0215548B2 (de) |
| JP (2) | JP2614848B2 (de) |
| AT (1) | ATE93272T1 (de) |
| CA (1) | CA1341228C (de) |
| DE (1) | DE3688900T3 (de) |
| DK (1) | DK175574B1 (de) |
| NO (1) | NO305660B1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| US5550036A (en) * | 1986-04-09 | 1996-08-27 | Eli Lilly And Company | Method for co-amplification of human protein C genes in human cells |
| USH1148H (en) | 1987-04-17 | 1993-03-02 | Method of separating activated human protein C | |
| EP0296413A2 (de) * | 1987-06-12 | 1988-12-28 | Hoechst Japan Limited | Hybrides Protein C und Verfahren zur Herstellung |
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US4992373A (en) * | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
| US5196322A (en) * | 1987-12-28 | 1993-03-23 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
| JP2728240B2 (ja) * | 1988-07-26 | 1998-03-18 | ヘキスト薬品工業株式会社 | ヒトプロテインｃ変異体及びその製造方法 |
| CA1332049C (en) * | 1988-10-07 | 1994-09-20 | Eli Lilly And Company | Eukaryotic expression |
| AU6295390A (en) * | 1989-08-11 | 1991-03-11 | Zymogenetics Inc. | Cell culture methods for producing activated protein c |
| JP2774156B2 (ja) * | 1989-09-05 | 1998-07-09 | 帝人株式会社 | ヒトプロテインｃおよび／または活性化ヒトプロテインｃ様活性を有する蛋白 |
| JP2774163B2 (ja) * | 1989-11-14 | 1998-07-09 | 帝人株式会社 | ヒトプロテインｃ様活性を有する蛋白 |
| AU7168591A (en) * | 1989-12-29 | 1991-07-24 | Zymogenetics Inc. | Hybrid protein c |
| US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
| US5270178A (en) * | 1990-02-23 | 1993-12-14 | Eli Lilly And Company | Vectors and compounds for expression of zymogen forms of human protein C |
| IL97311A0 (en) * | 1990-02-23 | 1992-05-25 | Lilly Co Eli | Vectors and compounds for expression of glycosylation mutants of human protein c |
| AT402263B (de) | 1991-06-20 | 1997-03-25 | Immuno Ag | Pharmazeutische präparation enthaltend eine thrombolytisch wirkende substanz |
| EP0592692B1 (de) * | 1992-05-01 | 1997-07-02 | Teijin Limited | Fed-batch-Verfahren für Proteine sekretierende Zellen |
| DE4320294A1 (de) * | 1993-06-18 | 1994-12-22 | Immuno Ag | Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen |
| US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
| EP1237917A2 (de) * | 1999-11-19 | 2002-09-11 | Eli Lilly And Company | Derivate aus protein c |
| JP2009502118A (ja) * | 2005-05-24 | 2009-01-29 | アベスタゲン リミテッド | 敗血症治療のための組み換え活性化ヒトタンパク質ｃを生成する方法 |
| JP6460996B2 (ja) | 2012-10-23 | 2019-01-30 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | ストレス測定システム |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8327860D0 (en) * | 1983-10-18 | 1983-11-16 | Fujisawa Pharmaceutical Co | Monoclonal antiprotein c antibody |
| US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
-
1986
- 1986-06-26 AT AT86304970T patent/ATE93272T1/de not_active IP Right Cessation
- 1986-06-26 EP EP86304970A patent/EP0215548B2/de not_active Expired - Lifetime
- 1986-06-26 DE DE3688900T patent/DE3688900T3/de not_active Expired - Lifetime
- 1986-06-26 CA CA000512483A patent/CA1341228C/en not_active Expired - Fee Related
- 1986-06-27 JP JP61151303A patent/JP2614848B2/ja not_active Expired - Lifetime
- 1986-06-27 DK DK198603085A patent/DK175574B1/da not_active IP Right Cessation
- 1986-06-27 NO NO862601A patent/NO305660B1/no not_active IP Right Cessation
-
1996
- 1996-07-09 JP JP8179612A patent/JP2688407B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09107976A (ja) | 1997-04-28 |
| DE3688900T2 (de) | 1993-12-09 |
| DE3688900D1 (de) | 1993-09-23 |
| EP0215548B2 (de) | 1998-01-07 |
| JP2688407B2 (ja) | 1997-12-10 |
| EP0215548B1 (de) | 1993-08-18 |
| DK175574B1 (da) | 2004-12-13 |
| DK308586D0 (da) | 1986-06-27 |
| JPS62111690A (ja) | 1987-05-22 |
| NO862601L (no) | 1986-12-29 |
| EP0215548A1 (de) | 1987-03-25 |
| DE3688900T3 (de) | 1998-06-10 |
| ATE93272T1 (de) | 1993-09-15 |
| NO862601D0 (no) | 1986-06-27 |
| JP2614848B2 (ja) | 1997-05-28 |
| CA1341228C (en) | 2001-05-15 |
| DK308586A (da) | 1986-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |