FI943122A0 - Menetelmiä trombiinin tuottamiseksi - Google Patents

Menetelmiä trombiinin tuottamiseksi

Info

Publication number
FI943122A0
FI943122A0 FI943122A FI943122A FI943122A0 FI 943122 A0 FI943122 A0 FI 943122A0 FI 943122 A FI943122 A FI 943122A FI 943122 A FI943122 A FI 943122A FI 943122 A0 FI943122 A0 FI 943122A0
Authority
FI
Finland
Prior art keywords
thrombin
methods
host cells
produced
transfected
Prior art date
Application number
FI943122A
Other languages
English (en)
Swedish (sv)
Other versions
FI117831B (fi
FI943122A (fi
Inventor
Richard D Holly
Donald C Foster
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of FI943122A0 publication Critical patent/FI943122A0/fi
Publication of FI943122A publication Critical patent/FI943122A/fi
Application granted granted Critical
Publication of FI117831B publication Critical patent/FI117831B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
FI943122A 1991-12-31 1994-06-29 Menetelmiä trombiinin tuottamiseksi FI117831B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81628191A 1991-12-31 1991-12-31
US81628191 1991-12-31
US86070192A 1992-03-31 1992-03-31
US86070192 1992-03-31
US9211357 1992-12-30
PCT/US1992/011357 WO1993013208A1 (en) 1991-12-31 1992-12-30 Methods for producing thrombin

Publications (3)

Publication Number Publication Date
FI943122A0 true FI943122A0 (fi) 1994-06-29
FI943122A FI943122A (fi) 1994-06-29
FI117831B FI117831B (fi) 2007-03-15

Family

ID=27124054

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943122A FI117831B (fi) 1991-12-31 1994-06-29 Menetelmiä trombiinin tuottamiseksi

Country Status (13)

Country Link
US (2) US5476777A (fi)
EP (1) EP0624199B1 (fi)
JP (1) JP3404038B2 (fi)
AT (1) ATE179754T1 (fi)
AU (1) AU683834B2 (fi)
CA (1) CA2125783C (fi)
DE (1) DE69229126T2 (fi)
DK (1) DK0624199T3 (fi)
ES (1) ES2134836T3 (fi)
FI (1) FI117831B (fi)
GR (1) GR3030820T3 (fi)
NO (1) NO317018B1 (fi)
WO (1) WO1993013208A1 (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010322A1 (en) * 1992-10-29 1994-05-11 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
EP0993311B1 (en) 1997-06-18 2012-11-14 Angiotech Pharmaceuticals (US), Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
WO1999045938A1 (en) * 1998-03-10 1999-09-16 Baxter International Inc. Thrombin preparation and products and fibrin sealant methods employing same
EP1076698A2 (en) * 1998-05-14 2001-02-21 Battelle Memorial Institute Transgenic plant-derived human blood coagulation factors
US20030096771A1 (en) * 2001-07-26 2003-05-22 Butler Madeline M. Antisense modulation of hormone-sensitive lipase expression
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
WO2001011952A1 (en) * 1999-08-19 2001-02-22 Us Transgenics, Inc. Transgenic prothrombin and related thrombin precursors and transgenics, methods, compositions, uses and the like relating thereto
EP1539942A4 (en) * 2001-05-14 2005-10-19 Dendreon Corp A TRANSMEMBRANE SERINE PROTEASE 10 CODING NUCLEIC ACID MOLECULES, THE POLYPEPTIDE CODED AND METHOD THEREOF
CA2476894A1 (en) * 2002-02-20 2003-08-28 American Integrated Biologics, Inc. Transgenic production in saliva
WO2003079985A2 (en) * 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
WO2006132925A2 (en) * 2005-06-01 2006-12-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
CA2616865C (en) 2005-07-28 2014-07-08 Carnegie Mellon University Biocompatible polymers and methods of use
US20090137001A1 (en) 2005-09-30 2009-05-28 Tatsufumi Onchi Process for preparing recombinant human thrombin with culture cell
CN101501216B (zh) * 2006-03-06 2013-10-02 胡玛基因公司 制备重组人凝血酶的方法
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100062981A1 (en) * 2007-01-31 2010-03-11 Anders Jeppsson Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion
CA2697078A1 (en) * 2007-09-05 2010-02-16 Zymogenetics, Inc. Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition
US9597062B2 (en) * 2008-04-25 2017-03-21 Mallinckrodt Pharma Ip Trading D.A.C. Medical devices for delivering fluids during surgery and methods for their use
WO2014115087A2 (en) 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910005081B1 (ko) * 1988-09-23 1991-07-22 삼성전관 주식회사 칼라브라운관의 형광면 제작방법
DE69101634D1 (de) * 1990-01-26 1994-05-11 Immuno Ag Wien Rekombinant hergestellte blutfaktoren, verfahren zur exprimierung besagter blutfaktoren sowie in besagtem prozess verwendeter rekombinanter vaccina-virus.
DE69130990T2 (de) * 1990-02-20 1999-12-02 Baxter Int Gereinigtes, virusfreies menschliches Thrombin

Also Published As

Publication number Publication date
US5476777A (en) 1995-12-19
US5502034A (en) 1996-03-26
GR3030820T3 (en) 1999-11-30
ATE179754T1 (de) 1999-05-15
AU683834B2 (en) 1997-11-27
EP0624199A1 (en) 1994-11-17
JP3404038B2 (ja) 2003-05-06
NO942456D0 (no) 1994-06-29
CA2125783C (en) 2003-03-25
DE69229126T2 (de) 1999-12-30
AU3428793A (en) 1993-07-28
DK0624199T3 (da) 1999-11-01
FI117831B (fi) 2007-03-15
EP0624199B1 (en) 1999-05-06
JPH07502659A (ja) 1995-03-23
NO317018B1 (no) 2004-07-26
FI943122A (fi) 1994-06-29
DE69229126D1 (de) 1999-06-10
CA2125783A1 (en) 1993-07-08
WO1993013208A1 (en) 1993-07-08
ES2134836T3 (es) 1999-10-16
NO942456L (no) 1994-06-29

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