DE69229126D1 - Verfahren zur Herstellung von Thrombin - Google Patents
Verfahren zur Herstellung von ThrombinInfo
- Publication number
- DE69229126D1 DE69229126D1 DE69229126T DE69229126T DE69229126D1 DE 69229126 D1 DE69229126 D1 DE 69229126D1 DE 69229126 T DE69229126 T DE 69229126T DE 69229126 T DE69229126 T DE 69229126T DE 69229126 D1 DE69229126 D1 DE 69229126D1
- Authority
- DE
- Germany
- Prior art keywords
- thrombin
- host cells
- produced
- transfected
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81628191A | 1991-12-31 | 1991-12-31 | |
US86070192A | 1992-03-31 | 1992-03-31 | |
PCT/US1992/011357 WO1993013208A1 (en) | 1991-12-31 | 1992-12-30 | Methods for producing thrombin |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229126D1 true DE69229126D1 (de) | 1999-06-10 |
DE69229126T2 DE69229126T2 (de) | 1999-12-30 |
Family
ID=27124054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229126T Expired - Lifetime DE69229126T2 (de) | 1991-12-31 | 1992-12-30 | Verfahren zur Herstellung von Thrombin |
Country Status (13)
Country | Link |
---|---|
US (2) | US5476777A (de) |
EP (1) | EP0624199B1 (de) |
JP (1) | JP3404038B2 (de) |
AT (1) | ATE179754T1 (de) |
AU (1) | AU683834B2 (de) |
CA (1) | CA2125783C (de) |
DE (1) | DE69229126T2 (de) |
DK (1) | DK0624199T3 (de) |
ES (1) | ES2134836T3 (de) |
FI (1) | FI117831B (de) |
GR (1) | GR3030820T3 (de) |
NO (1) | NO317018B1 (de) |
WO (1) | WO1993013208A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5457294A (en) * | 1992-10-29 | 1994-05-24 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
DE19710190A1 (de) * | 1997-03-12 | 1998-09-17 | Immuno Ag | Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung |
AU7977298A (en) * | 1997-06-18 | 1999-01-04 | Cohesion Technologies, Inc. | Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof |
US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
JP2002506038A (ja) * | 1998-03-10 | 2002-02-26 | バクスター・インターナショナル・インコーポレイテッド | トロンビン調製およびトロンビン産物ならびにそれを使用するフィブリンシーラント方法 |
WO1999058699A2 (en) * | 1998-05-14 | 1999-11-18 | Battelle Memorial Institute | Transgenic plant-derived human blood coagulation factors |
US20030096771A1 (en) * | 2001-07-26 | 2003-05-22 | Butler Madeline M. | Antisense modulation of hormone-sensitive lipase expression |
KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
IL129427A0 (en) * | 1999-04-13 | 2000-02-17 | Yeda Res & Dev | Preparation of biologically active molecules |
AU6913600A (en) * | 1999-08-19 | 2001-03-13 | Us Transgenics, Inc. | Transgenic prothrombin and related thrombin precursors and transgenics, methods,compositions, uses and the like relating thereto |
KR20040080940A (ko) * | 2001-05-14 | 2004-09-20 | 덴드레온 코포레이션 | 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법 |
EP1585386A4 (de) * | 2002-02-20 | 2009-09-02 | American Integrated Biolog Inc | Rekombinante produktion im speichel |
US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
US8293530B2 (en) * | 2006-10-17 | 2012-10-23 | Carnegie Mellon University | Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
WO2003079985A2 (en) * | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
US20100254900A1 (en) * | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
ES2226587B1 (es) | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
US20070011752A1 (en) * | 2005-05-06 | 2007-01-11 | American Integrated Biologics, Inc. | Production of human proteins in transgenic animal saliva |
US20060270015A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
US20060270014A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
US7825231B2 (en) * | 2005-06-01 | 2010-11-02 | Darren P. Wolfe | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
EP2093256A3 (de) | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biokompatible Polymere und Verwendungsverfahren |
CA2624072A1 (en) | 2005-09-30 | 2007-04-12 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Process for producing recombinant human thrombin by cultured cell |
RU2008139428A (ru) * | 2006-03-06 | 2010-05-20 | Хьюмэджин, Инк. (Us) | Способ получения рекомбинантного тромбина и фибриногена человека |
US8529961B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
EP2114440A1 (de) * | 2007-01-31 | 2009-11-11 | Anders Jeppsson | Verwendung von fibrinogen als prophylaktische behandlung zur verhinderung von blutungen während und nach einer operation und als biomarker zur identifizierung von patienten mit erhöhten risiko für übermässige blutungen und bluttransfusion |
US20090101809A1 (en) * | 2007-09-05 | 2009-04-23 | Zymogenetics, Inc. | Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition |
AU2009240441B2 (en) * | 2008-04-25 | 2014-08-21 | Baxter International Inc. | Medical devices for delivering fluids during surgery and methods for their use |
WO2014115087A2 (en) | 2013-01-22 | 2014-07-31 | Cencor Biotech Ltd. | A method for the preparation of recombinant human prothrombin and fibrinogen |
WO2020229521A1 (en) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for inhibiting or reducing bacterial biofilms on a surface |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR910005081B1 (ko) * | 1988-09-23 | 1991-07-22 | 삼성전관 주식회사 | 칼라브라운관의 형광면 제작방법 |
ATE103982T1 (de) * | 1990-01-26 | 1994-04-15 | Immuno Ag | Rekombinant hergestellte blutfaktoren, verfahren zur exprimierung besagter blutfaktoren sowie in besagtem prozess verwendeter rekombinanter vaccina-virus. |
DE69130990T2 (de) * | 1990-02-20 | 1999-12-02 | Baxter Int | Gereinigtes, virusfreies menschliches Thrombin |
-
1992
- 1992-12-30 US US07/998,972 patent/US5476777A/en not_active Expired - Lifetime
- 1992-12-30 WO PCT/US1992/011357 patent/WO1993013208A1/en active IP Right Grant
- 1992-12-30 DK DK93902869T patent/DK0624199T3/da active
- 1992-12-30 DE DE69229126T patent/DE69229126T2/de not_active Expired - Lifetime
- 1992-12-30 JP JP51196893A patent/JP3404038B2/ja not_active Expired - Lifetime
- 1992-12-30 ES ES93902869T patent/ES2134836T3/es not_active Expired - Lifetime
- 1992-12-30 AT AT93902869T patent/ATE179754T1/de active
- 1992-12-30 EP EP93902869A patent/EP0624199B1/de not_active Expired - Lifetime
- 1992-12-30 CA CA002125783A patent/CA2125783C/en not_active Expired - Lifetime
- 1992-12-30 AU AU34287/93A patent/AU683834B2/en not_active Expired
-
1994
- 1994-06-29 NO NO19942456A patent/NO317018B1/no not_active IP Right Cessation
- 1994-06-29 FI FI943122A patent/FI117831B/fi not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/463,953 patent/US5502034A/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401908T patent/GR3030820T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5502034A (en) | 1996-03-26 |
FI943122A0 (fi) | 1994-06-29 |
CA2125783A1 (en) | 1993-07-08 |
JPH07502659A (ja) | 1995-03-23 |
WO1993013208A1 (en) | 1993-07-08 |
ATE179754T1 (de) | 1999-05-15 |
US5476777A (en) | 1995-12-19 |
AU683834B2 (en) | 1997-11-27 |
NO942456L (no) | 1994-06-29 |
DK0624199T3 (da) | 1999-11-01 |
NO942456D0 (no) | 1994-06-29 |
ES2134836T3 (es) | 1999-10-16 |
FI117831B (fi) | 2007-03-15 |
CA2125783C (en) | 2003-03-25 |
DE69229126T2 (de) | 1999-12-30 |
EP0624199A1 (de) | 1994-11-17 |
GR3030820T3 (en) | 1999-11-30 |
JP3404038B2 (ja) | 2003-05-06 |
FI943122A (fi) | 1994-06-29 |
NO317018B1 (no) | 2004-07-26 |
AU3428793A (en) | 1993-07-28 |
EP0624199B1 (de) | 1999-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
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