DK0624199T3 - Fremgangsmåder til fremstilling af thrombin - Google Patents

Fremgangsmåder til fremstilling af thrombin

Info

Publication number
DK0624199T3
DK0624199T3 DK93902869T DK93902869T DK0624199T3 DK 0624199 T3 DK0624199 T3 DK 0624199T3 DK 93902869 T DK93902869 T DK 93902869T DK 93902869 T DK93902869 T DK 93902869T DK 0624199 T3 DK0624199 T3 DK 0624199T3
Authority
DK
Denmark
Prior art keywords
thrombin
methods
host cells
produced
transfected
Prior art date
Application number
DK93902869T
Other languages
English (en)
Inventor
Richard D Holly
Donald C Foster
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK0624199T3 publication Critical patent/DK0624199T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK93902869T 1991-12-31 1992-12-30 Fremgangsmåder til fremstilling af thrombin DK0624199T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81628191A 1991-12-31 1991-12-31
US86070192A 1992-03-31 1992-03-31
PCT/US1992/011357 WO1993013208A1 (en) 1991-12-31 1992-12-30 Methods for producing thrombin

Publications (1)

Publication Number Publication Date
DK0624199T3 true DK0624199T3 (da) 1999-11-01

Family

ID=27124054

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93902869T DK0624199T3 (da) 1991-12-31 1992-12-30 Fremgangsmåder til fremstilling af thrombin

Country Status (13)

Country Link
US (2) US5476777A (da)
EP (1) EP0624199B1 (da)
JP (1) JP3404038B2 (da)
AT (1) ATE179754T1 (da)
AU (1) AU683834B2 (da)
CA (1) CA2125783C (da)
DE (1) DE69229126T2 (da)
DK (1) DK0624199T3 (da)
ES (1) ES2134836T3 (da)
FI (1) FI117831B (da)
GR (1) GR3030820T3 (da)
NO (1) NO317018B1 (da)
WO (1) WO1993013208A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5457294A (en) * 1992-10-29 1994-05-24 Board Of Regents, The University Of Texas System Adenovirus-mediated ldl receptor gene transfer and targeting
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
JP2002514960A (ja) 1997-06-18 2002-05-21 コヘージョン テクノロジーズ，インコーポレイテッド トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法
US20030207402A1 (en) * 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
AU2900599A (en) * 1998-03-10 1999-09-27 Baxter International Inc. Thrombin preparation and products and fibrin sealant methods employing same
JP2002514433A (ja) * 1998-05-14 2002-05-21 バッテル メモリアル インスティテュート トランスジェニック植物由来ヒト凝血因子
US20030096771A1 (en) * 2001-07-26 2003-05-22 Butler Madeline M. Antisense modulation of hormone-sensitive lipase expression
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
AU6913600A (en) * 1999-08-19 2001-03-13 Us Transgenics, Inc. Transgenic prothrombin and related thrombin precursors and transgenics, methods,compositions, uses and the like relating thereto
KR20040080940A (ko) * 2001-05-14 2004-09-20 덴드레온 코포레이션 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법
WO2003069984A2 (en) * 2002-02-20 2003-08-28 American Integrated Biologics, Inc. Transgenic production in saliva
WO2003079985A2 (en) * 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US8529956B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) * 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100254900A1 (en) * 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US20060270015A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
US7825231B2 (en) * 2005-06-01 2010-11-02 Darren P. Wolfe Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
JP5475283B2 (ja) 2005-07-28 2014-04-16 カーネギー メロン ユニバーシティ 生体適合性ポリマーおよび使用方法
AU2006298160A1 (en) 2005-09-30 2007-04-12 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for preparing recombinant human thrombin with culture cell
RU2008139428A (ru) * 2006-03-06 2010-05-20 Хьюмэджин, Инк. (Us) Способ получения рекомбинантного тромбина и фибриногена человека
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US20100062981A1 (en) * 2007-01-31 2010-03-11 Anders Jeppsson Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion
WO2009032966A1 (en) * 2007-09-05 2009-03-12 Zymogenetics, Inc. Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition
CA2721462C (en) * 2008-04-25 2019-02-05 Zymogenetics, Inc. Medical devices for delivering fluids during surgery and methods for their use
WO2014115087A2 (en) 2013-01-22 2014-07-31 Cencor Biotech Ltd. A method for the preparation of recombinant human prothrombin and fibrinogen
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910005081B1 (ko) * 1988-09-23 1991-07-22 삼성전관 주식회사 칼라브라운관의 형광면 제작방법
CA2073859A1 (en) * 1990-01-26 1991-07-27 Falko-Guenter Falkner Recombinantly produced blood factors and process for the expression of said blood factors, as well as vaccinia virus recombinants used in said process
ATE177781T1 (de) * 1990-02-20 1999-04-15 Baxter Int Gereinigtes, virusfreies menschliches thrombin

Also Published As

Publication number Publication date
NO942456D0 (no) 1994-06-29
GR3030820T3 (en) 1999-11-30
CA2125783A1 (en) 1993-07-08
ATE179754T1 (de) 1999-05-15
JP3404038B2 (ja) 2003-05-06
US5502034A (en) 1996-03-26
FI943122A (fi) 1994-06-29
ES2134836T3 (es) 1999-10-16
DE69229126D1 (de) 1999-06-10
FI943122A0 (fi) 1994-06-29
EP0624199A1 (en) 1994-11-17
US5476777A (en) 1995-12-19
JPH07502659A (ja) 1995-03-23
FI117831B (fi) 2007-03-15
DE69229126T2 (de) 1999-12-30
AU3428793A (en) 1993-07-28
WO1993013208A1 (en) 1993-07-08
CA2125783C (en) 2003-03-25
NO942456L (no) 1994-06-29
EP0624199B1 (en) 1999-05-06
NO317018B1 (no) 2004-07-26
AU683834B2 (en) 1997-11-27

Similar Documents

Publication Publication Date Title
DK0624199T3 (da) Fremgangsmåder til fremstilling af thrombin
DE69434408D1 (de) Recombinante Herstellung aromatischer Polyketiden
ES8800343A1 (es) Un metodo para producir una proteina que contiene actividad biologica para coagulacion de sangre, mediada por factor viia
DE3786321D1 (de) Expression von protein-c.
NO179106C (no) Fremgangsmåte for fremstilling av og ekspresjonssystem som koder for og kan uttrykke et rekombinant proteinkompleks med humanfaktor V111:C-aktivitet
DK0830376T3 (da) Fremgangsmåde til fremstilling af erythropoietin, som er fri for animalske proteiner
EP0575546A4 (en) Prad1 cyclin and its cdna
DK308586D0 (da) Dna-sekvens, der koder for et specifikt protein, rekombinantvektor, der omfatter sekvensen, og celler, der er transficerede til ekspression af proteinet
FI951680A (fi) DNA-yhdisteitä, jotka sisältävät mannuronaani-C-5-epimeraasia koodaavia sekvenssejä
DK0567503T3 (da) Gen for Pasteurella haemolytica glycoprotease, samt det rensede enzym.
KR880001816A (ko) 변이 인간 프로유로키나제 및 이의 제조방법
IL129139A0 (en) Vertebrate smoothened proteins
HUP9701904A2 (hu) D-panolakton hidroláz és az azt kódoló gén
ES8800725A1 (es) Un procedimiento para producir un anticuerpo monoclonal
NL960017I2 (nl) Expressie van Factor VIII-activiteit in zoogdiercellen.
ATE112319T1 (de) Klonierungs- und/oder expressionsvektoren, verfahren zur ihrer herstellung und verwendung.
KR900018378A (ko) 사람 프로우로키나제 변이체, 이를 제조하는 방법, 이에 대한 dna 서열, 플라스미드 및 숙주