NO317018B1 - DNA konstruksjon, vertcelle, fremgangsmater for fremstilling av Trombin, farmasoytisk sammensettning samt anvendelser derav - Google Patents
DNA konstruksjon, vertcelle, fremgangsmater for fremstilling av Trombin, farmasoytisk sammensettning samt anvendelser derav Download PDFInfo
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- NO317018B1 NO317018B1 NO19942456A NO942456A NO317018B1 NO 317018 B1 NO317018 B1 NO 317018B1 NO 19942456 A NO19942456 A NO 19942456A NO 942456 A NO942456 A NO 942456A NO 317018 B1 NO317018 B1 NO 317018B1
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- thrombin
- prothrombin
- dna
- sequence
- host cell
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81628191A | 1991-12-31 | 1991-12-31 | |
| US86070192A | 1992-03-31 | 1992-03-31 | |
| PCT/US1992/011357 WO1993013208A1 (en) | 1991-12-31 | 1992-12-30 | Methods for producing thrombin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942456L NO942456L (no) | 1994-06-29 |
| NO942456D0 NO942456D0 (no) | 1994-06-29 |
| NO317018B1 true NO317018B1 (no) | 2004-07-26 |
Family
ID=27124054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19942456A NO317018B1 (no) | 1991-12-31 | 1994-06-29 | DNA konstruksjon, vertcelle, fremgangsmater for fremstilling av Trombin, farmasoytisk sammensettning samt anvendelser derav |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5476777A (fi) |
| EP (1) | EP0624199B1 (fi) |
| JP (1) | JP3404038B2 (fi) |
| AT (1) | ATE179754T1 (fi) |
| AU (1) | AU683834B2 (fi) |
| CA (1) | CA2125783C (fi) |
| DE (1) | DE69229126T2 (fi) |
| DK (1) | DK0624199T3 (fi) |
| ES (1) | ES2134836T3 (fi) |
| FI (1) | FI117831B (fi) |
| GR (1) | GR3030820T3 (fi) |
| NO (1) | NO317018B1 (fi) |
| WO (1) | WO1993013208A1 (fi) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5457294A (en) * | 1992-10-29 | 1994-05-24 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
| DE19710190A1 (de) * | 1997-03-12 | 1998-09-17 | Immuno Ag | Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung |
| AU7977298A (en) * | 1997-06-18 | 1999-01-04 | Cohesion Technologies, Inc. | Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof |
| US20030207402A1 (en) * | 1997-08-22 | 2003-11-06 | Erhard Kopetzki | Autocatalytically activatable zymogenic precursors of proteases and their use |
| JP2002506038A (ja) * | 1998-03-10 | 2002-02-26 | バクスター・インターナショナル・インコーポレイテッド | トロンビン調製およびトロンビン産物ならびにそれを使用するフィブリンシーラント方法 |
| WO1999058699A2 (en) * | 1998-05-14 | 1999-11-18 | Battelle Memorial Institute | Transgenic plant-derived human blood coagulation factors |
| US20030096771A1 (en) * | 2001-07-26 | 2003-05-22 | Butler Madeline M. | Antisense modulation of hormone-sensitive lipase expression |
| KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
| IL129427A0 (en) * | 1999-04-13 | 2000-02-17 | Yeda Res & Dev | Preparation of biologically active molecules |
| AU6913600A (en) * | 1999-08-19 | 2001-03-13 | Us Transgenics, Inc. | Transgenic prothrombin and related thrombin precursors and transgenics, methods,compositions, uses and the like relating thereto |
| KR20040080940A (ko) * | 2001-05-14 | 2004-09-20 | 덴드레온 코포레이션 | 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법 |
| EP1585386A4 (en) * | 2002-02-20 | 2009-09-02 | American Integrated Biolog Inc | GENE PRODUCTION IN SALIVA |
| US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| US8293530B2 (en) * | 2006-10-17 | 2012-10-23 | Carnegie Mellon University | Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| WO2003079985A2 (en) * | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| US20100254900A1 (en) * | 2002-03-18 | 2010-10-07 | Campbell Phil G | Biocompatible polymers and Methods of use |
| ES2226587B1 (es) | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
| US20070011752A1 (en) * | 2005-05-06 | 2007-01-11 | American Integrated Biologics, Inc. | Production of human proteins in transgenic animal saliva |
| US20060270015A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
| US20060270014A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
| US7825231B2 (en) * | 2005-06-01 | 2010-11-02 | Darren P. Wolfe | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
| EP2093256A3 (en) | 2005-07-28 | 2009-10-14 | Carnegie Mellon University | Biocompatible polymers and methods of use |
| CA2624072A1 (en) | 2005-09-30 | 2007-04-12 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Process for producing recombinant human thrombin by cultured cell |
| RU2008139428A (ru) * | 2006-03-06 | 2010-05-20 | Хьюмэджин, Инк. (Us) | Способ получения рекомбинантного тромбина и фибриногена человека |
| US8529961B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| EP2114440A1 (en) * | 2007-01-31 | 2009-11-11 | Anders Jeppsson | Use of fibrinogen as a prophylactic treatment to prevent bleeding during and after surgery and as a biomarker to identify patient with an increased risk for excessive bleeding and blood transfusion |
| US20090101809A1 (en) * | 2007-09-05 | 2009-04-23 | Zymogenetics, Inc. | Mass spectrometry-based quantitative assay for determining abundance of molecular species in a composition |
| AU2009240441B2 (en) * | 2008-04-25 | 2014-08-21 | Baxter International Inc. | Medical devices for delivering fluids during surgery and methods for their use |
| WO2014115087A2 (en) | 2013-01-22 | 2014-07-31 | Cencor Biotech Ltd. | A method for the preparation of recombinant human prothrombin and fibrinogen |
| WO2020229521A1 (en) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for inhibiting or reducing bacterial biofilms on a surface |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910005081B1 (ko) * | 1988-09-23 | 1991-07-22 | 삼성전관 주식회사 | 칼라브라운관의 형광면 제작방법 |
| ATE103982T1 (de) * | 1990-01-26 | 1994-04-15 | Immuno Ag | Rekombinant hergestellte blutfaktoren, verfahren zur exprimierung besagter blutfaktoren sowie in besagtem prozess verwendeter rekombinanter vaccina-virus. |
| DE69130990T2 (de) * | 1990-02-20 | 1999-12-02 | Baxter Int | Gereinigtes, virusfreies menschliches Thrombin |
-
1992
- 1992-12-30 US US07/998,972 patent/US5476777A/en not_active Expired - Lifetime
- 1992-12-30 WO PCT/US1992/011357 patent/WO1993013208A1/en active IP Right Grant
- 1992-12-30 DK DK93902869T patent/DK0624199T3/da active
- 1992-12-30 DE DE69229126T patent/DE69229126T2/de not_active Expired - Lifetime
- 1992-12-30 JP JP51196893A patent/JP3404038B2/ja not_active Expired - Lifetime
- 1992-12-30 ES ES93902869T patent/ES2134836T3/es not_active Expired - Lifetime
- 1992-12-30 AT AT93902869T patent/ATE179754T1/de active
- 1992-12-30 EP EP93902869A patent/EP0624199B1/en not_active Expired - Lifetime
- 1992-12-30 CA CA002125783A patent/CA2125783C/en not_active Expired - Lifetime
- 1992-12-30 AU AU34287/93A patent/AU683834B2/en not_active Expired
-
1994
- 1994-06-29 NO NO19942456A patent/NO317018B1/no not_active IP Right Cessation
- 1994-06-29 FI FI943122A patent/FI117831B/fi not_active IP Right Cessation
-
1995
- 1995-06-05 US US08/463,953 patent/US5502034A/en not_active Expired - Lifetime
-
1999
- 1999-07-20 GR GR990401908T patent/GR3030820T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5502034A (en) | 1996-03-26 |
| FI943122A0 (fi) | 1994-06-29 |
| CA2125783A1 (en) | 1993-07-08 |
| JPH07502659A (ja) | 1995-03-23 |
| WO1993013208A1 (en) | 1993-07-08 |
| ATE179754T1 (de) | 1999-05-15 |
| US5476777A (en) | 1995-12-19 |
| AU683834B2 (en) | 1997-11-27 |
| NO942456L (no) | 1994-06-29 |
| DK0624199T3 (da) | 1999-11-01 |
| NO942456D0 (no) | 1994-06-29 |
| ES2134836T3 (es) | 1999-10-16 |
| FI117831B (fi) | 2007-03-15 |
| CA2125783C (en) | 2003-03-25 |
| DE69229126T2 (de) | 1999-12-30 |
| EP0624199A1 (en) | 1994-11-17 |
| GR3030820T3 (en) | 1999-11-30 |
| JP3404038B2 (ja) | 2003-05-06 |
| FI943122A (fi) | 1994-06-29 |
| AU3428793A (en) | 1993-07-28 |
| EP0624199B1 (en) | 1999-05-06 |
| DE69229126D1 (de) | 1999-06-10 |
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Legal Events
| Date | Code | Title | Description |
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| MK1K | Patent expired |