HUP9902298A2 - Tirozin-hidroxiláz génből származó expressziós rendszer - Google Patents

Tirozin-hidroxiláz génből származó expressziós rendszer

Info

Publication number
HUP9902298A2
HUP9902298A2 HU9902298A HUP9902298A HUP9902298A2 HU P9902298 A2 HUP9902298 A2 HU P9902298A2 HU 9902298 A HU9902298 A HU 9902298A HU P9902298 A HUP9902298 A HU P9902298A HU P9902298 A2 HUP9902298 A2 HU P9902298A2
Authority
HU
Hungary
Prior art keywords
tyrosine hydroxylase
hydroxylase gene
gene expression
subject
expression system
Prior art date
Application number
HU9902298A
Other languages
English (en)
Inventor
Jacques Mallet
Rolando Meloni
Philippe Ravassard
Fabienne Treilhou
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of HUP9902298A2 publication Critical patent/HUP9902298A2/hu
Publication of HUP9902298A3 publication Critical patent/HUP9902298A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgya egy DNS-fragmentűm, amely transzkripciós enhanceraktivitással rendelkezik, és amely alapvetően a tirőzin-hidrőxiláz génelső intrőnjának egy részéből áll. A találmány tárgyát képezi egyexpressziós kazetta is, amely egy kódőló szekvenciát, egy annakexpresszióját lehetővé tevő prőmótert, és egy fenti transzkripciósenhancert tartalmaz. A találmány tárgya ezenkívül a fenti fragmentűmőtvagy kazettát tartalmazó vektőr, és rekőmbináns gazdasejt is. Atalálmány szerinti fragmentűm példáűl a génterápiában, vagy egy kívántfehérje kifejezésénél alkalmazható transzkripciós enhan- cerként. ŕ
HU9902298A 1996-04-25 1997-04-10 Derived tyrosine hydroxylase gene expression system HUP9902298A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9605223A FR2748032B1 (fr) 1996-04-25 1996-04-25 Systeme d'expression derive du gene de la tyrosine hydroxylase

Publications (2)

Publication Number Publication Date
HUP9902298A2 true HUP9902298A2 (hu) 1999-11-29
HUP9902298A3 HUP9902298A3 (en) 2000-03-28

Family

ID=9491582

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902298A HUP9902298A3 (en) 1996-04-25 1997-04-10 Derived tyrosine hydroxylase gene expression system

Country Status (14)

Country Link
US (1) US6432701B1 (hu)
EP (1) EP0895542A1 (hu)
JP (1) JP2000508904A (hu)
KR (1) KR20000010608A (hu)
AU (1) AU722960B2 (hu)
BR (1) BR9708964A (hu)
CA (1) CA2252529A1 (hu)
FR (1) FR2748032B1 (hu)
HU (1) HUP9902298A3 (hu)
IL (1) IL126719A0 (hu)
NO (1) NO984879D0 (hu)
SK (1) SK146998A3 (hu)
WO (1) WO1997040172A1 (hu)
ZA (1) ZA973510B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928342A1 (de) * 1999-06-21 2000-12-28 Deutsches Krebsforsch Vektoren zur gentherapeutischen Tumorbehandlung
US7195910B2 (en) 2000-08-30 2007-03-27 Thomas Jefferson University Human tyrosine hydroxylase promoter and uses thereof
WO2002018548A2 (en) * 2000-08-30 2002-03-07 Thomas Jefferson University Tyrosine hydroxylase 5' control elements and uses thereof

Also Published As

Publication number Publication date
NO984879L (no) 1998-10-19
ZA973510B (en) 1997-11-18
US6432701B1 (en) 2002-08-13
KR20000010608A (ko) 2000-02-15
FR2748032A1 (fr) 1997-10-31
WO1997040172A1 (fr) 1997-10-30
CA2252529A1 (fr) 1997-10-30
EP0895542A1 (fr) 1999-02-10
SK146998A3 (en) 1999-04-13
BR9708964A (pt) 1999-08-03
FR2748032B1 (fr) 1998-05-22
AU2641097A (en) 1997-11-12
NO984879D0 (no) 1998-10-19
IL126719A0 (en) 1999-08-17
JP2000508904A (ja) 2000-07-18
HUP9902298A3 (en) 2000-03-28
AU722960B2 (en) 2000-08-17

Similar Documents

Publication Publication Date Title
CY1106216T1 (el) 5´ ESTs ΓΙΑ ΜΗ ΙΣΤΟ-ΕΙΔΙΚΕΣ ΕΚΚΡΙΤΙΚΕΣ ΠΡΩΤΕΪΝΕΣ
SG141233A1 (en) Control of gene expression
FI951404A0 (fi) Adenovirusvektoreita vieraiden geenien siirtämiseksi keskushermostojärjestelmän, erityisesti aivojen, soluihin
NO990025D0 (no) Hamster-EF-1<alfa> transkripsjonsregulatorisk DNA
HUP9900018A1 (hu) Cirkuláris DNS-molekula feltételes replikációs origóval, eljárás előállítására és génterápiában való felhasználására
NZ332634A (en) Isolated autophosphorylating polypeptide having phosphoinositide-3-kinase activity
MX9603002A (es) Procedimiento para la preparacion de virus asociados a los adenovirus (aav), recombinantes, y usos de los mismos.
DK0857211T3 (da) Stærk homolog promoter fra hamster
HUP9902710A2 (hu) Rekombináns sertés-poxvírus
DE69534733D1 (de) NEUARTIGE AUF p53 ANSPRECHENDE GENE
ATE384787T1 (de) Tripeptidyl-aminopeptidase
WO1990003435A3 (fr) Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) humaine, et ses applications, notamment pour le diagnostic in vitro de l'hypertension arterielle
HUT68379A (en) Method for modifying the cell, tissue or host tropism of a recombinant microorganism obtained this way and use thereof in medicine and veterinary medicine
NZ242124A (en) Dna encoding an enzyme having arabinan-degrading activity
CA2309600A1 (en) Low-temperature inducible expression vector
HUP9902298A2 (hu) Tirozin-hidroxiláz génből származó expressziós rendszer
PT599971E (pt) Promotor de levedura e sua utilizacao
DE69739346D1 (de) Gereinigtes sr-p70 protein
WO1999020760A3 (en) Herg family potassium ion channel genes and protein
DE69632963D1 (de) Mch3, eine apoptosis-protease, kodierende nukleinsäuren und methoden zur verwendung
ATE397065T1 (de) Regulatorische konstrukte, die das intron 3 des prostat-spezifischen membranatigen-gens enthalten
FR2693463B1 (fr) Promoteur de levure et son utilisation.
EP0154566A3 (en) Viral enhancer dna segments
HUP0002234A2 (hu) Amin-oxidáz-aktivitású 1-es vaszkuláris adhéziós fehérje (VAP-1)
HUP0103208A2 (hu) Proteáz kódoló szekvenciákat vagy inhibítoraikat tartalmazó DNS konstrukciók

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees