HUP0002234A2 - Amin-oxidáz-aktivitású 1-es vaszkuláris adhéziós fehérje (VAP-1) - Google Patents

Amin-oxidáz-aktivitású 1-es vaszkuláris adhéziós fehérje (VAP-1)

Info

Publication number
HUP0002234A2
HUP0002234A2 HU0002234A HUP0002234A HUP0002234A2 HU P0002234 A2 HUP0002234 A2 HU P0002234A2 HU 0002234 A HU0002234 A HU 0002234A HU P0002234 A HUP0002234 A HU P0002234A HU P0002234 A2 HUP0002234 A2 HU P0002234A2
Authority
HU
Hungary
Prior art keywords
vap
oxidase activity
endothelial
subject
adhesion protein
Prior art date
Application number
HU0002234A
Other languages
English (en)
Inventor
Petri Bono
Sirpa Jalkanen
Marko Salmi
David John Smith
Original Assignee
Biotie Therapies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25338478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0002234(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotie Therapies Ltd. filed Critical Biotie Therapies Ltd.
Publication of HUP0002234A2 publication Critical patent/HUP0002234A2/hu
Publication of HUP0002234A3 publication Critical patent/HUP0002234A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát új, VAP-1-nek elnevezett endothelialissejtadhéziós fehérjét kódoló, tisztított nukleinsavak képezik. A VAP-1egy endothelialis szialoglikoprotein, amelynek adhéziós funkciója ésamin- oxidáz-aktivitása egyaránt van, és in vivo főként dimer, 170-180kDa-os formájában található meg. A VAP-1 a réztartalmú amin-oxidázokkal mutat hasonlóságot, a jelenleg ismert adhéziósmolekulákkal azonban nem. A találmány tárgyát képezik továbbá a VAP-1-nukleinsavat tartalmazó rekombináns gazdasejtek, továbbá eljárásokVAP-1-polipeptid előállítására, expressziójának megváltoztatására,amin-oxidáz-aktivitás gátlására, aminok oxidálására és endothelialissejtek limfocitákhoz történő kötődésének befolyásolására. Ó
HU0002234A 1997-05-23 1998-05-22 Vascular adhesion protein-1 having oxidase activity HUP0002234A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86243397A 1997-05-23 1997-05-23
PCT/FI1998/000429 WO1998053049A1 (en) 1997-05-23 1998-05-22 Vascular adhesion protein-1 having amine oxidase activity

Publications (2)

Publication Number Publication Date
HUP0002234A2 true HUP0002234A2 (hu) 2000-10-28
HUP0002234A3 HUP0002234A3 (en) 2005-11-28

Family

ID=25338478

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002234A HUP0002234A3 (en) 1997-05-23 1998-05-22 Vascular adhesion protein-1 having oxidase activity

Country Status (12)

Country Link
EP (1) EP0979271A1 (hu)
JP (1) JP2001507238A (hu)
KR (1) KR100533911B1 (hu)
CN (1) CN1269829A (hu)
AU (1) AU742098B2 (hu)
CA (1) CA2289903A1 (hu)
HU (1) HUP0002234A3 (hu)
NO (1) NO995725D0 (hu)
NZ (1) NZ501118A (hu)
PL (1) PL192459B1 (hu)
RU (1) RU2204838C2 (hu)
WO (1) WO1998053049A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285416B2 (en) 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
EP1362120A1 (en) * 2001-02-23 2003-11-19 Biovitrum Ab Method for purification of soluble ssao
FI20020807A0 (fi) * 2002-04-29 2002-04-29 Biotie Therapies Oyj Uusia humanisoituja anti-VAP-1 monoklonaalisia vasta-aineita
CA2526675A1 (en) 2003-05-26 2004-12-02 Biotie Therapies Corporation Crystalline vap-1 and uses thereof
FI20050640A0 (fi) * 2005-06-16 2005-06-16 Faron Pharmaceuticals Oy Yhdisteitä amiinioksidaasista riippuvien sairauksien tai häiriöiden hoitoon tai estoon
RU2009130380A (ru) 2007-01-10 2011-02-20 Санофи-Авентис (Fr) Способ определения стабильности органических метиленаминов в присутствии семикарбазид-чувствительной аминоксидазы
FI20075278A0 (fi) * 2007-04-20 2007-04-20 Biotie Therapies Corp Uudet täysin ihmisperäiset anti-VAP-1 monoklonaaliset vasta-aineet
UA112154C2 (uk) * 2009-09-08 2016-08-10 Біоті Терапіс Корп. Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US39447A (en) * 1863-08-04 Improvement in truss-bridges
NZ253151A (en) * 1992-06-09 1997-03-24 Sirpa Jalkanen Human endothelial vascular adhesion protein-1 (vap-1), antibodies, methods of diagnosis and pharmaceutical compositions

Also Published As

Publication number Publication date
JP2001507238A (ja) 2001-06-05
AU742098B2 (en) 2001-12-20
KR20010012920A (ko) 2001-02-26
PL337004A1 (en) 2000-07-31
WO1998053049A1 (en) 1998-11-26
NO995725L (no) 1999-11-22
NZ501118A (en) 2002-08-28
HUP0002234A3 (en) 2005-11-28
KR100533911B1 (ko) 2005-12-06
AU7531498A (en) 1998-12-11
CA2289903A1 (en) 1998-11-26
CN1269829A (zh) 2000-10-11
PL192459B1 (pl) 2006-10-31
NO995725D0 (no) 1999-11-22
EP0979271A1 (en) 2000-02-16
RU2204838C2 (ru) 2003-05-20

Similar Documents

Publication Publication Date Title
Denkewalter et al. Total synthesis of an enzyme. I. Objective and strategy
CA2165197A1 (en) Recombinant stratum corneum chymotryptic enzyme (scce)
DE60033138D1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
ATE319818T1 (de) Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren
BR9913360B1 (pt) proteÍna de uricase recombinante quimÉrica, molÉcula de Ácido nuclÉico isolada e purificada, vetor e cÉlula hospedeira transformada.
DK1295944T3 (da) GDP-dissociationsstimulerende protein, hjernespecifikt nukleosomsamlingsprotein, skeletmuskelspecifikt ubiquitinkonjugerende enzym, celleproliferationsprotein, phosphatidylinositolkinase, nelbeslægtede proteiner
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
ATE310090T1 (de) Gereinigte coprinus laccasen und nukleinsäuren welche dafür kodieren
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
ATE418563T1 (de) Nik proteine, nukleinsäure sowie verfahren
ATE450603T1 (de) Polypeptide mit verzweigungsenzym-aktivität und für diese kodierende nukleinsäuren
DE69840230D1 (de) Polypeptide mit prolyldipeptidylaminopeptidase-aktivität und dafür kodierende nukleinsäuren
ATE358724T1 (de) Expression regulierende sequenzen vom schimmelpilz chrysosporium
Roberts et al. Bovine brain acetylcholinesterase primary sequence involved in intersubunit disulfide linkages.
ATE384787T1 (de) Tripeptidyl-aminopeptidase
DE69837475D1 (de) Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
DK1117798T3 (da) Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider
HUP0002234A2 (hu) Amin-oxidáz-aktivitású 1-es vaszkuláris adhéziós fehérje (VAP-1)
ATE310091T1 (de) Carboxypeptidasen aus aspergillus oryzae und diese kodierende nukleinsäuren
KR940009329A (ko) 딕티오스텔륨 디펩티딜아미노펩티다아제
ATE345382T1 (de) 2,6-beta-d-fruktanhydrolase enzym und verfahren zu dessen verwendung
KR860006484A (ko) 단백질 또는 당단백질의 제조방법
WO2000044898A3 (en) Novel agouti and agouti-related peptide analogs
ATE121456T1 (de) Klonierung und überexpression von glucose-6- phosphat-dehydrogenase aus leuconostoc dextranicus.
WO1995021916A3 (en) Pp32: a newly identified cd45-associated protein