NZ501118A - Vascular adhesion protein-1 having amine oxidase activity - Google Patents

Vascular adhesion protein-1 having amine oxidase activity

Info

Publication number
NZ501118A
NZ501118A NZ501118A NZ50111898A NZ501118A NZ 501118 A NZ501118 A NZ 501118A NZ 501118 A NZ501118 A NZ 501118A NZ 50111898 A NZ50111898 A NZ 50111898A NZ 501118 A NZ501118 A NZ 501118A
Authority
NZ
New Zealand
Prior art keywords
oxidase activity
amine oxidase
amine
adhesion protein
vap
Prior art date
Application number
NZ501118A
Inventor
David John Smith
Petri Bono
Marko Salmi
Sirpa Jalkanen
Original Assignee
Biotie Therapies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25338478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ501118(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotie Therapies Corp filed Critical Biotie Therapies Corp
Publication of NZ501118A publication Critical patent/NZ501118A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method of oxidizing an amine such as benzylamine or methylamine comprises reacting the amine with a transmembrane form of a vascular adhesion protein-1 (VAP-1) polypeptide having amine oxidase activity. The VAP-1 polypeptide can have the amino acid sequence SEQ ID No 2 or the amino acid sequence encoded by the VAP-1 nucleotide sequence SEQ ID NO 2. A method of inhibiting amine oxidase activity comprises adding an inhibitor such as semicarbazide, hydroxylamine, propargylamine, isoniazid, nialamide, hydrallazine or procarbazine to a sample possessing the amine oxidase activity.
NZ501118A 1997-05-23 1998-05-22 Vascular adhesion protein-1 having amine oxidase activity NZ501118A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86243397A 1997-05-23 1997-05-23
PCT/FI1998/000429 WO1998053049A1 (en) 1997-05-23 1998-05-22 Vascular adhesion protein-1 having amine oxidase activity

Publications (1)

Publication Number Publication Date
NZ501118A true NZ501118A (en) 2002-08-28

Family

ID=25338478

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ501118A NZ501118A (en) 1997-05-23 1998-05-22 Vascular adhesion protein-1 having amine oxidase activity

Country Status (12)

Country Link
EP (1) EP0979271A1 (en)
JP (1) JP2001507238A (en)
KR (1) KR100533911B1 (en)
CN (1) CN1269829A (en)
AU (1) AU742098B2 (en)
CA (1) CA2289903A1 (en)
HU (1) HUP0002234A3 (en)
NO (1) NO995725D0 (en)
NZ (1) NZ501118A (en)
PL (1) PL192459B1 (en)
RU (1) RU2204838C2 (en)
WO (1) WO1998053049A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285416B2 (en) 2000-01-24 2007-10-23 Gendaq Limited Regulated gene expression in plants
CA2433408A1 (en) * 2001-02-23 2002-08-29 Biovitrum Ab Method for purification of soluble ssao
FI20020807A0 (en) * 2002-04-29 2002-04-29 Biotie Therapies Oyj Novel humanized anti-VAP-1 monoclonal antibodies
EP1633861B1 (en) * 2003-05-26 2009-11-04 Biotie Therapies Corp. Crystalline vap-1 and uses thereof
FI20050640A0 (en) * 2005-06-16 2005-06-16 Faron Pharmaceuticals Oy Compounds for treating or preventing diseases or disorders related to amine oxidases
RU2009130380A (en) 2007-01-10 2011-02-20 Санофи-Авентис (Fr) METHOD FOR DETERMINING ORGANIC METHYLENENINE STABILITY IN THE PRESENCE OF SEMICARBASIDE-SENSITIVE AMINOXIDASE
FI20075278A0 (en) 2007-04-20 2007-04-20 Biotie Therapies Corp Novel completely human anti-VAP-1 monoclonal antibodies
UA112154C2 (en) * 2009-09-08 2016-08-10 Біоті Терапіс Корп. Use of vap-1 inhibitors for treating fibrotic conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US39447A (en) * 1863-08-04 Improvement in truss-bridges
EP0656906B1 (en) * 1992-06-09 1999-09-08 Oy Biotie Therapies A novel endothelial cell molecule mediating lymphocyte binding in man

Also Published As

Publication number Publication date
HUP0002234A3 (en) 2005-11-28
JP2001507238A (en) 2001-06-05
CN1269829A (en) 2000-10-11
HUP0002234A2 (en) 2000-10-28
KR20010012920A (en) 2001-02-26
RU2204838C2 (en) 2003-05-20
AU7531498A (en) 1998-12-11
CA2289903A1 (en) 1998-11-26
PL192459B1 (en) 2006-10-31
PL337004A1 (en) 2000-07-31
KR100533911B1 (en) 2005-12-06
NO995725L (en) 1999-11-22
EP0979271A1 (en) 2000-02-16
WO1998053049A1 (en) 1998-11-26
AU742098B2 (en) 2001-12-20
NO995725D0 (en) 1999-11-22

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