DK0782616T3 - Thrombinproduktion og -produkter af terapeutisk kvalitet - Google Patents
Thrombinproduktion og -produkter af terapeutisk kvalitetInfo
- Publication number
- DK0782616T3 DK0782616T3 DK95931863T DK95931863T DK0782616T3 DK 0782616 T3 DK0782616 T3 DK 0782616T3 DK 95931863 T DK95931863 T DK 95931863T DK 95931863 T DK95931863 T DK 95931863T DK 0782616 T3 DK0782616 T3 DK 0782616T3
- Authority
- DK
- Denmark
- Prior art keywords
- thrombin
- viral
- phosphate buffer
- products
- ion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/309,583 US5506127A (en) | 1994-09-21 | 1994-09-21 | Therapeutic grade thrombin produced by chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0782616T3 true DK0782616T3 (da) | 2006-05-22 |
Family
ID=23198815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95931863T DK0782616T3 (da) | 1994-09-21 | 1995-09-21 | Thrombinproduktion og -produkter af terapeutisk kvalitet |
Country Status (12)
Country | Link |
---|---|
US (1) | US5506127A (fr) |
EP (1) | EP0782616B1 (fr) |
JP (1) | JP3628703B2 (fr) |
AT (1) | ATE315641T1 (fr) |
AU (1) | AU711298B2 (fr) |
DE (1) | DE69534749T2 (fr) |
DK (1) | DK0782616T3 (fr) |
ES (1) | ES2258264T3 (fr) |
NO (1) | NO323460B1 (fr) |
PT (1) | PT782616E (fr) |
RU (1) | RU2144081C1 (fr) |
WO (1) | WO1996009376A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4137996A1 (de) * | 1991-11-19 | 1993-05-27 | Behringwerke Ag | Verfahren zur herstellung eines virussicheren thrombinkonzentrates |
DK83092D0 (da) * | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
JPH07308190A (ja) * | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | トロンビンの製造方法 |
FI952196A0 (fi) * | 1995-05-08 | 1995-05-08 | Suomen Punainen Risti Veripalv | Framstaellning av immunoglobulin |
US5702715A (en) * | 1995-10-27 | 1997-12-30 | Drying Technology | Reinforced biological sealants |
WO2000062828A1 (fr) * | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Fibrine autologue d'obturation et ses methodes de fabrication |
US5981254A (en) * | 1997-10-30 | 1999-11-09 | Haemacure Corporation | Process for producing thrombin from plasma |
US6274090B1 (en) | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
CA2342606A1 (fr) * | 1998-10-07 | 2000-04-13 | Sigma-Aldrich Co. | Reactifs de thromboplastine, procedes de preparation et d'utilisation correspondants |
US6472162B1 (en) | 1999-06-04 | 2002-10-29 | Thermogenesis Corp. | Method for preparing thrombin for use in a biological glue |
JP4399615B2 (ja) * | 1999-09-27 | 2010-01-20 | シスメックス株式会社 | トロンビンの安定化手段および組成物 |
DE10012732A1 (de) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung |
ES2214967B1 (es) * | 2003-03-06 | 2005-06-16 | Probitas Pharma, S.A | Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento. |
ES2226587B1 (es) * | 2004-10-22 | 2005-12-16 | Probitas Pharma, S.A. | Composicion de trombina estable. |
US20060270014A1 (en) * | 2005-05-26 | 2006-11-30 | Dan Pawlak | Thrombin purification |
AU2007264735B2 (en) * | 2006-06-26 | 2012-11-08 | Omrix Biopharmaceuticals Inc. | Virus removal by nanofiltration |
RU2457248C2 (ru) * | 2010-06-09 | 2012-07-27 | Общество с ограниченной ответственностью фирма "Технология-Стандарт" | Способ промышленного получения тромбина |
RU2610667C2 (ru) * | 2010-10-11 | 2017-02-14 | Эббви Бахамаз Лтд., | Способ очистки белков |
US20140377248A1 (en) * | 2011-12-23 | 2014-12-25 | Merz Pharma Gmbh & Co. Kgaa | Method for the manufacturing of di-chain proteins for use in humans |
US10066224B2 (en) * | 2015-02-25 | 2018-09-04 | Omrix Biopharmaceuticals Ltd. | Method for purifying and quantifying thrombin and its degradation polypeptides |
BR112020016727A2 (pt) * | 2018-02-19 | 2020-12-15 | Bayer Healthcare Llc | Membrana filtrante modificada e método |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4083957A (en) * | 1974-07-26 | 1978-04-11 | Lang John L | Process for the alteration of the sex-ratio of mammals |
NL7602423A (nl) * | 1976-03-08 | 1977-09-12 | Leuven Res & Dev Vzw | Bepaling van heparine in bloedplasma. |
US4380511A (en) * | 1981-08-12 | 1983-04-19 | Miles Laboratories, Inc. | Purification of bovine thrombin |
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
US4696812A (en) * | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
JPS63243032A (ja) * | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
JPS6440433A (en) * | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
SU1527261A1 (ru) * | 1988-03-21 | 1989-12-07 | Институт Химической И Биологической Физики Ан Эсср | Способ получени тромбина |
JP2832835B2 (ja) * | 1988-12-21 | 1998-12-09 | 旭化成工業株式会社 | ウイルス除去方法 |
DE3843126C3 (de) * | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
DE69011136T3 (de) * | 1989-01-13 | 2003-10-23 | Mitsubishi Pharma Corp | Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung. |
US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
IE73210B1 (en) * | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
EP0443724B1 (fr) * | 1990-02-20 | 1999-03-17 | Baxter International Inc. | Thrombine humaine purifiée et exempte de virus |
JPH0813750B2 (ja) * | 1990-03-01 | 1996-02-14 | 持田製薬株式会社 | 経口用トロンビン製剤 |
JP3127232B2 (ja) * | 1990-03-08 | 2001-01-22 | ウェルファイド株式会社 | 蛋白質製剤の製造法 |
JP3093821B2 (ja) * | 1991-06-19 | 2000-10-03 | 旭化成工業株式会社 | 銅アンモニア法再生セルロース多孔性中空糸膜の製造方法 |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
AT398079B (de) * | 1991-11-04 | 1994-09-26 | Immuno Ag | Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung |
US5331092A (en) * | 1992-11-06 | 1994-07-19 | Coletica | Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby |
US5229172A (en) * | 1993-01-19 | 1993-07-20 | Medtronic, Inc. | Modification of polymeric surface by graft polymerization |
JP2003318980A (ja) * | 2002-04-24 | 2003-11-07 | Mitsubishi Electric Corp | ショートパケット用伝送フォーマット並びにゲートウェイシステム |
-
1994
- 1994-09-21 US US08/309,583 patent/US5506127A/en not_active Expired - Lifetime
-
1995
- 1995-09-21 RU RU97106349A patent/RU2144081C1/ru not_active IP Right Cessation
- 1995-09-21 JP JP51048396A patent/JP3628703B2/ja not_active Expired - Fee Related
- 1995-09-21 PT PT95931863T patent/PT782616E/pt unknown
- 1995-09-21 DK DK95931863T patent/DK0782616T3/da active
- 1995-09-21 DE DE69534749T patent/DE69534749T2/de not_active Expired - Lifetime
- 1995-09-21 AU AU35151/95A patent/AU711298B2/en not_active Ceased
- 1995-09-21 WO PCT/CA1995/000541 patent/WO1996009376A1/fr active IP Right Grant
- 1995-09-21 EP EP95931863A patent/EP0782616B1/fr not_active Expired - Lifetime
- 1995-09-21 AT AT95931863T patent/ATE315641T1/de not_active IP Right Cessation
- 1995-09-21 ES ES95931863T patent/ES2258264T3/es not_active Expired - Lifetime
-
1997
- 1997-03-11 NO NO19971104A patent/NO323460B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO323460B1 (no) | 2007-05-14 |
US5506127A (en) | 1996-04-09 |
NO971104D0 (no) | 1997-03-11 |
AU711298B2 (en) | 1999-10-07 |
WO1996009376A1 (fr) | 1996-03-28 |
JP3628703B2 (ja) | 2005-03-16 |
DE69534749D1 (de) | 2006-04-06 |
DE69534749T2 (de) | 2006-11-02 |
EP0782616A1 (fr) | 1997-07-09 |
NO971104L (no) | 1997-04-24 |
RU2144081C1 (ru) | 2000-01-10 |
PT782616E (pt) | 2006-05-31 |
ATE315641T1 (de) | 2006-02-15 |
JPH10505753A (ja) | 1998-06-09 |
EP0782616B1 (fr) | 2006-01-11 |
AU3515195A (en) | 1996-04-09 |
ES2258264T3 (es) | 2006-08-16 |
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