ATE315641T1 - Herstellung von thrombin therapeutischer qualitätsstufe - Google Patents

Herstellung von thrombin therapeutischer qualitätsstufe

Info

Publication number
ATE315641T1
ATE315641T1 AT95931863T AT95931863T ATE315641T1 AT E315641 T1 ATE315641 T1 AT E315641T1 AT 95931863 T AT95931863 T AT 95931863T AT 95931863 T AT95931863 T AT 95931863T AT E315641 T1 ATE315641 T1 AT E315641T1
Authority
AT
Austria
Prior art keywords
thrombin
viral
phosphate buffer
ion
production
Prior art date
Application number
AT95931863T
Other languages
English (en)
Inventor
Zbigniew Proba
Teresa Brodniewicz
Nicolas Dupuis
Trung Bui-Khac
Original Assignee
Haemacure Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haemacure Biotech Inc filed Critical Haemacure Biotech Inc
Application granted granted Critical
Publication of ATE315641T1 publication Critical patent/ATE315641T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95931863T 1994-09-21 1995-09-21 Herstellung von thrombin therapeutischer qualitätsstufe ATE315641T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/309,583 US5506127A (en) 1994-09-21 1994-09-21 Therapeutic grade thrombin produced by chromatography

Publications (1)

Publication Number Publication Date
ATE315641T1 true ATE315641T1 (de) 2006-02-15

Family

ID=23198815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95931863T ATE315641T1 (de) 1994-09-21 1995-09-21 Herstellung von thrombin therapeutischer qualitätsstufe

Country Status (12)

Country Link
US (1) US5506127A (de)
EP (1) EP0782616B1 (de)
JP (1) JP3628703B2 (de)
AT (1) ATE315641T1 (de)
AU (1) AU711298B2 (de)
DE (1) DE69534749T2 (de)
DK (1) DK0782616T3 (de)
ES (1) ES2258264T3 (de)
NO (1) NO323460B1 (de)
PT (1) PT782616E (de)
RU (1) RU2144081C1 (de)
WO (1) WO1996009376A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
FI952196A0 (fi) * 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
US5702715A (en) * 1995-10-27 1997-12-30 Drying Technology Reinforced biological sealants
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US5981254A (en) * 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
ES2252986T3 (es) * 1998-10-07 2006-05-16 Trinity Biotech Manufacturing Ltd. Reactivos de tromboplastina y metodos para preparar y usar tales reactivos.
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
ATE346145T1 (de) * 1999-09-27 2006-12-15 Sysmex Corp Verfahren zur stabilisierung von thrombin
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
ES2214967B1 (es) * 2003-03-06 2005-06-16 Probitas Pharma, S.A Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento.
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US20060270014A1 (en) * 2005-05-26 2006-11-30 Dan Pawlak Thrombin purification
CA2655897C (en) * 2006-06-26 2015-09-29 Omrix Biopharmaceuticals Inc. Virus removal by nanofiltration
RU2457248C2 (ru) * 2010-06-09 2012-07-27 Общество с ограниченной ответственностью фирма "Технология-Стандарт" Способ промышленного получения тромбина
SG189872A1 (en) * 2010-10-11 2013-06-28 Abbvie Inc Processes for purification of proteins
EP2793934B1 (de) * 2011-12-23 2017-08-23 Merz Pharma GmbH & Co. KGaA Neuartiges verfahren zur herstellung von di-ketten-proteinen zur verwendung bei menschen
WO2016135719A1 (en) 2015-02-25 2016-09-01 Omrix Biopharmaceuticals Ltd. Method for purifying and quantifying thrombin and its degradation polypeptides
WO2019161199A1 (en) * 2018-02-19 2019-08-22 Bayer Healthcare Llc Modified filter membrane and method

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083957A (en) * 1974-07-26 1978-04-11 Lang John L Process for the alteration of the sex-ratio of mammals
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
US4380511A (en) * 1981-08-12 1983-04-19 Miles Laboratories, Inc. Purification of bovine thrombin
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPS63243032A (ja) * 1987-03-27 1988-10-07 Green Cross Corp:The トロンビンの加熱処理方法
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
SU1527261A1 (ru) * 1988-03-21 1989-12-07 Институт Химической И Биологической Физики Ан Эсср Способ получени тромбина
JP2832835B2 (ja) * 1988-12-21 1998-12-09 旭化成工業株式会社 ウイルス除去方法
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
DE69011136T3 (de) * 1989-01-13 2003-10-23 Mitsubishi Pharma Corp Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung.
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
EP0443724B1 (de) * 1990-02-20 1999-03-17 Baxter International Inc. Gereinigtes, virusfreies menschliches Thrombin
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
JP3127232B2 (ja) * 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
JP3093821B2 (ja) * 1991-06-19 2000-10-03 旭化成工業株式会社 銅アンモニア法再生セルロース多孔性中空糸膜の製造方法
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5331092A (en) * 1992-11-06 1994-07-19 Coletica Process of preparation of collagen containing in major proportion insoluble collagen and collagen having high mechanical resistance and thermal stability obtained thereby
US5229172A (en) * 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
JP2003318980A (ja) * 2002-04-24 2003-11-07 Mitsubishi Electric Corp ショートパケット用伝送フォーマット並びにゲートウェイシステム

Also Published As

Publication number Publication date
EP0782616B1 (de) 2006-01-11
AU711298B2 (en) 1999-10-07
RU2144081C1 (ru) 2000-01-10
ES2258264T3 (es) 2006-08-16
JPH10505753A (ja) 1998-06-09
DK0782616T3 (da) 2006-05-22
NO971104D0 (no) 1997-03-11
AU3515195A (en) 1996-04-09
EP0782616A1 (de) 1997-07-09
NO323460B1 (no) 2007-05-14
NO971104L (no) 1997-04-24
JP3628703B2 (ja) 2005-03-16
DE69534749T2 (de) 2006-11-02
DE69534749D1 (de) 2006-04-06
US5506127A (en) 1996-04-09
PT782616E (pt) 2006-05-31
WO1996009376A1 (en) 1996-03-28

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