DK0734249T3 - Hidtil ukendt og forbedret aminoglycosidformulering til aerosolisering - Google Patents

Hidtil ukendt og forbedret aminoglycosidformulering til aerosolisering

Info

Publication number
DK0734249T3
DK0734249T3 DK95937397T DK95937397T DK0734249T3 DK 0734249 T3 DK0734249 T3 DK 0734249T3 DK 95937397 T DK95937397 T DK 95937397T DK 95937397 T DK95937397 T DK 95937397T DK 0734249 T3 DK0734249 T3 DK 0734249T3
Authority
DK
Denmark
Prior art keywords
aerosolization
aminoglycoside
formulation
hitherto unknown
aminoglycoside formulation
Prior art date
Application number
DK95937397T
Other languages
English (en)
Inventor
Arnold L Smith
Bonnie W Ramsey
Alan B Montgomery
Original Assignee
Pathogenesis Corp
Children S Hospital And Region
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23269063&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0734249(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pathogenesis Corp, Children S Hospital And Region filed Critical Pathogenesis Corp
Application granted granted Critical
Publication of DK0734249T3 publication Critical patent/DK0734249T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
DK95937397T 1994-10-19 1995-10-17 Hidtil ukendt og forbedret aminoglycosidformulering til aerosolisering DK0734249T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/325,705 US5508269A (en) 1994-10-19 1994-10-19 Aminoglycoside formulation for aerosolization
PCT/US1995/012972 WO1996012471A1 (en) 1994-10-19 1995-10-17 Novel and improved aminoglycoside formulation for aerosolization

Publications (1)

Publication Number Publication Date
DK0734249T3 true DK0734249T3 (da) 1999-12-06

Family

ID=23269063

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95937397T DK0734249T3 (da) 1994-10-19 1995-10-17 Hidtil ukendt og forbedret aminoglycosidformulering til aerosolisering

Country Status (11)

Country Link
US (1) US5508269A (da)
EP (1) EP0734249B3 (da)
JP (1) JP3474195B2 (da)
AT (1) ATE183080T1 (da)
AU (1) AU688166B2 (da)
CA (1) CA2179305C (da)
DE (1) DE69511374T3 (da)
DK (1) DK0734249T3 (da)
ES (1) ES2136883T7 (da)
GR (1) GR3031770T3 (da)
WO (1) WO1996012471A1 (da)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083922A (en) * 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
US6076520A (en) * 1997-05-12 2000-06-20 Cooper; Emily L. Device for nasal therapeutic inhalation
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
TW465235B (en) 1998-09-17 2001-11-21 United Video Properties Inc Electronic program guide with digital storage
DZ2947A1 (fr) * 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
CZ20012147A3 (cs) * 1998-12-17 2003-01-15 Chiron Corporation Farmaceutický prostředek ve formě suchého práąku nebo rozpráąeného aerosolového prostředku pro léčení chronické bronchitidy
US6613352B2 (en) 1999-04-13 2003-09-02 Universite De Montreal Low-rigidity liposomal formulation
US6576224B1 (en) * 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
US8820316B2 (en) * 2000-02-11 2014-09-02 Respironics Respiratory Drug Delivery (Uk) Ltd Drug delivery apparatus
ATE444771T1 (de) * 2000-02-11 2009-10-15 Respironics Respiratory Drug D Wirkstoffabgabevorrichtung
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
PT2301524E (pt) * 2000-12-27 2013-07-10 Gilead Sciences Inc Aztreonam inalável sem arginina para tratamento e prevenção de infecções bacterianas pulmonares
US7214364B2 (en) 2000-12-27 2007-05-08 Corus Pharma, Inc. Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
EP1598059A1 (en) 2001-05-18 2005-11-23 Chiron Corporation Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics
JP2004534763A (ja) * 2001-05-18 2004-11-18 カイロン コーポレイション アミノグリコシド抗生物質の吸入投与のための方法および単位用量処方物
DE60103527T2 (de) * 2001-07-02 2005-06-16 Chiesi Farmaceutici S.P.A. Optimierte Tobramycin-Formulierung zur Aerosolbildung
US20040022740A1 (en) * 2001-07-10 2004-02-05 Baker William R. Macrolide formulations for inhalation and methods of treatment of endobronchial infections
MXPA04005865A (es) * 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
MXPA04008372A (es) * 2002-03-01 2004-11-26 Chiesi Farma Spa Formulacion superfina de formoterol.
US8245708B2 (en) * 2002-05-07 2012-08-21 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
US7607436B2 (en) * 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
AU2003238846A1 (en) * 2002-05-31 2003-12-19 Childrens Hospital And Regional Medical Center Endobronchial delivery of antibiotic in individuals with impaired lung tissue or lung function
US6966649B2 (en) * 2002-08-12 2005-11-22 John H Shadduck Adaptive optic lens system and method of use
US20040045546A1 (en) * 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
US7718189B2 (en) * 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
AU2004281532B2 (en) * 2003-10-15 2010-03-18 Pari Pharma Gmbh Liquid preparation containing tobramycin
BRPI0509026A (pt) 2004-05-17 2007-09-18 Corus Pharma Inc formulação de aerossol, método para a prevenção e tratamento de infecção causada por bactéria do trato respiratório, e, solução
KR20070026604A (ko) * 2004-06-18 2007-03-08 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 기관지 감염의 치료 방법
US20060073173A1 (en) * 2004-10-04 2006-04-06 Maria Banach Large-scale manufacturing process for the production of pharmaceutical compositions
US8524735B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AU2013206401B2 (en) * 2005-09-29 2016-06-23 Novartis Ag Antibiotic formulations, unit doses, kits, and methods
BRPI0616642A2 (pt) * 2005-09-29 2011-06-28 Nektar Therapeutics formulações de antibióticos, doses unitárias, kits e métodos
ES2594368T3 (es) 2005-12-08 2016-12-19 Insmed Incorporated Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
WO2007070875A1 (en) * 2005-12-15 2007-06-21 Aerosol Science Laboratories, Inc. Treatment of active infections and related compositions
WO2007117550A2 (en) * 2006-04-06 2007-10-18 Transave, Inc. Methods for coacervation induced liposomal encapsulation and formulations thereof
EP2012801A4 (en) * 2006-04-24 2009-08-05 Gloucester Pharmaceuticals Inc GEMCITABINE COMBINATION THERAPY
PE20080712A1 (es) * 2006-06-07 2008-05-22 Wyeth Corp Tratamiento de fibrosis cistica con antibioticos por via de suministro de un torbellinador
WO2007145868A1 (en) * 2006-06-07 2007-12-21 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
US20070286817A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via a swirler delivery
US20070286818A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
WO2007146730A2 (en) 2006-06-08 2007-12-21 Gloucester Pharmaceuticals Deacetylase inhibitor therapy
US20080221132A1 (en) 2006-09-11 2008-09-11 Xiong Cai Multi-Functional Small Molecules as Anti-Proliferative Agents
MX2009003002A (es) * 2006-09-19 2009-06-01 Discovery Lab Inc Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco.
JP2008199905A (ja) * 2007-02-16 2008-09-04 Snow Brand Milk Prod Co Ltd 乳酸菌生残性向上剤
US20100196455A1 (en) * 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
JP2010540526A (ja) * 2007-09-25 2010-12-24 ノバルティス アーゲー エアロゾル化されたバンコマイシンのような薬剤での肺障害の処置
AU2009246217B2 (en) 2008-05-15 2013-01-10 Novartis Ag Pulmonary delivery of a fluoroquinolone
WO2010042549A1 (en) 2008-10-07 2010-04-15 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
KR101411889B1 (ko) 2009-02-27 2014-06-27 이난타 파마슈티칼스, 인코포레이티드 C형 간염 바이러스 억제제
EP2408425A1 (en) * 2009-03-20 2012-01-25 Livia Tiba Method of creating salt aerosol for breathing by nebulizing an aqueous saline solution
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
PT2473170T (pt) 2009-09-04 2019-08-23 Horizon Orphan Llc Utilização de levofloxacina em aerossol para tratamento de fibrose cística
UA107095C2 (uk) 2009-12-14 2014-11-25 Антибіотичні мікрочастинки для інгаляції
AU2010339689B2 (en) 2010-01-07 2015-02-19 Alkermes Pharma Ireland Limited Quaternary ammonium salt prodrugs
EP2388008A1 (en) 2010-05-14 2011-11-23 Combino Pharm, S.L. Stable, preservative-free, aqueous formulation for the administration by aerosolization comprising tobramycin
CA2802733C (en) 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP2593110B1 (en) 2010-07-12 2021-01-06 Xellia Pharmaceuticals ApS Treatment of lung infections by administration of tobramycin by aerolisation
WO2012088441A1 (en) 2010-12-23 2012-06-28 Alkermes, Inc. Multi- api loading prodrugs
TWI574687B (zh) 2011-01-03 2017-03-21 古利斯股份有限公司 具有鋅結合部份之刺蝟拮抗劑
CA2830822C (en) 2011-04-01 2018-10-02 Curis, Inc. A thienopyrimidine phosphoinositide 3-kinase inhibitor with a zinc binding moiety
US8826904B2 (en) 2011-07-12 2014-09-09 Cardeas Pharma Corporation Formulations of aminoglycoside and fosfomycin combinations and methods and systems for treatment of ventilator associated pneumonia (VAP) and ventilator associated tracheal (VAT) bronchitis
JP2014523909A (ja) 2011-07-12 2014-09-18 カーディアス ファーマ コーポレイション 人工呼吸器関連肺炎(vap)及び人工呼吸器関連気管(vat)気管支炎の治療のためのアミカシンとホスホマイシンの組み合わせの製剤並びに方法及びシステム
EP2567691B1 (en) 2011-09-12 2014-12-24 Meiji Seika Pharma Co., Ltd. Aqueous compositions comprising arbekacin
HUE044957T2 (hu) 2011-12-15 2019-11-28 Alkermes Pharma Ireland Ltd Samidorphan (ALKS 33) opioid agonistákkal alkotott kombinációja
EP2790734B1 (en) 2011-12-15 2019-02-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
GB201208080D0 (en) 2012-05-09 2012-06-20 Norton Healthcare Ltd Tobramycin formulation
HRP20220158T1 (hr) 2012-05-21 2022-04-15 Insmed Incorporated Sustavi za liječenje plućnih infekcija
CN102949379B (zh) * 2012-11-14 2014-11-05 中山大学 硫酸奈替米星吸入粉雾剂及其制备方法
CN104884047A (zh) 2012-11-29 2015-09-02 英斯梅德股份有限公司 稳定的万古霉素制剂
EP2968285A4 (en) 2013-03-13 2016-12-21 Flatley Discovery Lab COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
SG10201808565QA (en) 2014-03-31 2018-11-29 Debiopharm Int Sa Fgfr fusions
CA2949078C (en) 2014-05-15 2022-09-20 Insmed Incorporated Methods for treating pulmonary non-tuberculous mycobacterial infections
CN112870345A (zh) 2014-08-26 2021-06-01 哈斯福制药公司 新型免疫剂及其使用方法
ES2971157T3 (es) 2014-10-06 2024-06-03 Apm Therapeutics 1 Inc Compuestos de triazolopiridina y métodos para el tratamiento de la fibrosis quística
WO2016089981A1 (en) * 2014-12-04 2016-06-09 Carefusion 2200, Inc. Breath-actuated nebulizer for medicine inhalation
CN105616345B (zh) * 2016-03-01 2018-08-21 上海方予健康医药科技有限公司 一种妥布霉素吸入组合物及其制备方法和用途
ES2938341T3 (es) 2016-03-07 2023-04-10 Enanta Pharm Inc Agentes antivirales contra la hepatitis B
EP3512602B1 (en) 2016-09-16 2024-03-27 HSF Pharmaceuticals Inhibitors of heat shock factors (hsf) and uses thereof
EP3688184A1 (en) * 2017-09-29 2020-08-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of developing pulmonary colonization/infection bypseudomonas aeruginosa
EP3762024A1 (en) 2018-03-08 2021-01-13 HSF Pharmaceuticals Localized activation of virus replication boosts herpesvirus-vectored vaccines
EP3773505A4 (en) 2018-03-30 2021-12-22 Insmed Incorporated PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS
CA3096754A1 (en) 2018-05-10 2019-11-14 Cis Pharma Ag Biocompatible copolymer containing multiple active agent molecules
WO2020055840A1 (en) 2018-09-11 2020-03-19 Curis Inc. Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
CN112955142A (zh) 2018-09-21 2021-06-11 英安塔制药有限公司 官能化杂环化合物作为抗病毒剂
EP3653716A1 (en) 2018-11-19 2020-05-20 HSF Pharmaceuticals Replication-competent controlled alpha-herpesvirus virus vectors and uses therefore
GB2565941A (en) * 2018-11-27 2019-02-27 Norton Healthcare Ltd A process for preparing a formulation
US20220409737A1 (en) 2019-10-30 2022-12-29 Cis Pharma Ag Biocompatible polymeric drug carriers for delivering active agents
CN115003296A (zh) 2019-12-05 2022-09-02 弗拉特利发现实验室有限责任公司 用于治疗囊肿状纤维化的化合物及其治疗方法
US20240229065A1 (en) 2020-04-24 2024-07-11 Hsf Pharmaceuticals Sa Replication-competent controlled herpesviruses expressing a sars cov-2 antigen
WO2021262799A1 (en) 2020-06-23 2021-12-30 Flagship Pioneering, Inc. Anti-viral compounds and methods of using same
ES2922973T1 (es) 2020-07-20 2022-09-22 Enanta Pharm Inc Peptidos funcionalizados como agentes antivirales
KR20230124582A (ko) 2020-11-23 2023-08-25 이난타 파마슈티칼스, 인코포레이티드 신규한 스피로피롤리딘 유래 항바이러스제
WO2023006993A1 (en) 2021-07-30 2023-02-02 Atmosr Fused amino pyridine or pyrimidine derivatives for the treatment of congenital central hypoventilation syndrome
CN114177140A (zh) * 2021-12-10 2022-03-15 卓和药业集团股份有限公司 一种硫酸奈替米星气雾剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424216A (en) * 1979-07-31 1984-01-03 The Rockefeller University Method for the reduction of mucin viscosity
JPH01283225A (ja) * 1988-05-10 1989-11-14 Toyo Jozo Co Ltd 牛呼吸器感染症治療用エアゾール製剤およびそれを用いる治療方法
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances

Also Published As

Publication number Publication date
JP3474195B2 (ja) 2003-12-08
DE69511374T2 (de) 2000-02-24
DE69511374D1 (de) 1999-09-16
GR3031770T3 (en) 2000-02-29
EP0734249B3 (en) 2011-12-21
ES2136883T7 (es) 2012-06-14
CA2179305C (en) 2000-10-31
CA2179305A1 (en) 1996-05-02
ATE183080T1 (de) 1999-08-15
DE69511374T3 (de) 2012-04-12
AU688166B2 (en) 1998-03-05
ES2136883T3 (es) 1999-12-01
JPH09511254A (ja) 1997-11-11
US5508269A (en) 1996-04-16
EP0734249B1 (en) 1999-08-11
EP0734249A4 (en) 1997-09-10
EP0734249A1 (en) 1996-10-02
AU3952295A (en) 1996-05-15
WO1996012471A1 (en) 1996-05-02

Similar Documents

Publication Publication Date Title
DK0734249T3 (da) Hidtil ukendt og forbedret aminoglycosidformulering til aerosolisering
WO1992019104A3 (en) Fatty acid based compositions for the control of established plant infections
WO2005110022A3 (en) Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections
MD1838F2 (en) 5,6-dichlorbenzimidazole derivatives, process for obtaining thereof, pharmaceutical composition and method of treatment or prevention of herpetic viral infections
TW347339B (en) Oral delivery of discrete units
BR9714312A (pt) Método de tratamento de bronquite com trifosfato de uridina e composto relacionados
MXPA03000321A (es) Formulaciones de macrolido para inhalacion y metodos de tratamiento de infecciones endobronquiales.
AU6617596A (en) Cyclo-oxygenase inhibitor and amidine derivative salts, their preparation process, their use as medicaments, and pharmaceutical compositions containing them
ES8504178A1 (es) Procedimiento para preparar 1-(1,3-dioxolan-2-ilmetil)-azoles.
GB2383041A (en) Process for the preparation of gabapentin
CA2429639A1 (en) Stable azithromycin monohydrate
ES2162913T3 (es) Preparado farmaceutico que contiene activadores de plasminogeno.
YU16399A (sh) ) UPOTREBA INHIBITOR H +, K+ - ATP- aze I FARMACEUTSKA FORMULACIJA ZA SIMULTANU, SEPARATNU ILI SEKVENCIJALNU UPOTREBU, KOJA SADRZI INHIBITOR H +, K+-ATP- aze I GLUKOKORTIKOID INHIBITOR H +, K+- ATP- aze
AU5169790A (en) New concentrated aqueous emulsions, process for preparing them and their use in the field of pesticides
IL125474A0 (en) Solid instant-release forms of administration and process for producing the same
AU1777595A (en) Methods for treating neurofibromatosis
AU8678682A (en) Aminoglycoside derivatives
GB2405338A (en) Method of prophylaxis of infection
FR2754824B1 (fr) Nouvelle composition contenant du chitosan
DK0751940T3 (da) Sesquiterpenderivater
DE59510583D1 (de) Pharmazeutische zusammensetzung zur systemischen transdermalen verabreichung mit dem wirkstoff morphin-6-glucuronid
DE3870736D1 (de) Antivirales mittel.
Shibata Development of the metabolic system for 2-keto-L-gulonic acid production in Pseudomonas sp. and its basic aspects
AU5269696A (en) Anellated beta-carbolines
UA22100A (uk) Дезиhфекційhа композиція