DK0730473T3 - Hirudinkonjugat af hirudin og lipofile forbindelser - Google Patents

Hirudinkonjugat af hirudin og lipofile forbindelser

Info

Publication number
DK0730473T3
DK0730473T3 DK95901432T DK95901432T DK0730473T3 DK 0730473 T3 DK0730473 T3 DK 0730473T3 DK 95901432 T DK95901432 T DK 95901432T DK 95901432 T DK95901432 T DK 95901432T DK 0730473 T3 DK0730473 T3 DK 0730473T3
Authority
DK
Denmark
Prior art keywords
hirudin
pct
lipophilic compounds
conjugate
date
Prior art date
Application number
DK95901432T
Other languages
Danish (da)
English (en)
Inventor
Juergen Schweden
Thomas Subkowski
Peter Eckes
Wilfried Hornberger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0730473T3 publication Critical patent/DK0730473T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Ink Jet (AREA)
  • Silicon Polymers (AREA)
DK95901432T 1993-12-02 1994-11-25 Hirudinkonjugat af hirudin og lipofile forbindelser DK0730473T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4341115 1993-12-02
PCT/EP1994/003901 WO1995015183A1 (de) 1993-12-02 1994-11-25 Hirudin-konjugate aus hirudin und lipophilen verbindungen

Publications (1)

Publication Number Publication Date
DK0730473T3 true DK0730473T3 (da) 2001-10-08

Family

ID=6504029

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95901432T DK0730473T3 (da) 1993-12-02 1994-11-25 Hirudinkonjugat af hirudin og lipofile forbindelser

Country Status (25)

Country Link
US (1) US5919762A (sk)
EP (1) EP0730473B1 (sk)
JP (1) JPH09505810A (sk)
CN (1) CN1142776A (sk)
AT (1) ATE204763T1 (sk)
AU (1) AU679811B2 (sk)
BR (1) BR9408195A (sk)
CA (1) CA2176967A1 (sk)
CZ (1) CZ157096A3 (sk)
DE (2) DE4437502A1 (sk)
DK (1) DK0730473T3 (sk)
ES (1) ES2163487T3 (sk)
FI (1) FI962299A0 (sk)
GR (1) GR3036938T3 (sk)
HR (1) HRP940968A2 (sk)
HU (1) HUT74390A (sk)
IL (1) IL111811A0 (sk)
NO (1) NO962261L (sk)
NZ (1) NZ276410A (sk)
PL (1) PL314797A1 (sk)
PT (1) PT730473E (sk)
SG (1) SG49156A1 (sk)
SK (1) SK67596A3 (sk)
WO (1) WO1995015183A1 (sk)
ZA (1) ZA949562B (sk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
EP1448263B1 (en) * 2001-10-24 2009-01-07 Power Paper Ltd. Device for controlled delivery of active substance into the skin
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
KR102366360B1 (ko) * 2021-06-29 2022-02-23 (주)네오팜 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077529B1 (de) * 1981-10-16 1985-07-17 Sanol Schwarz GmbH Arzneimittelformulierung
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
WO1990010448A2 (en) * 1989-03-07 1990-09-20 Genentech, Inc. Covalent conjugates of lipid and oligonucleotide
DE4014260A1 (de) * 1989-12-01 1991-06-06 Basf Ag Hirudinpolyalkylenglykolkonjugate
EP0502962B1 (de) * 1989-12-01 1996-03-13 BASF Aktiengesellschaft Hirudin-Muteine und deren Polyalkylenglykolkonjugate
DE69024230T2 (de) * 1989-12-22 1996-05-02 Commw Scient Ind Res Org An fette gebundene aminosäuren, peptide oder deren derivate
EP0537299A1 (en) * 1990-03-29 1993-04-21 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5256641A (en) * 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
WO1992019233A2 (en) * 1991-04-29 1992-11-12 Control Delivery Systems, Inc. Sustained release composition and methods of use thereof
DE69218888D1 (de) * 1991-05-02 1997-05-15 Pierre Baudet N-phenyl-cinnamamide, die einen schutz verleihen gegen schädigende effekte ultravioletten lichtes
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

Also Published As

Publication number Publication date
HUT74390A (en) 1996-12-30
US5919762A (en) 1999-07-06
GR3036938T3 (en) 2002-01-31
AU679811B2 (en) 1997-07-10
SK67596A3 (en) 1996-12-04
WO1995015183A1 (de) 1995-06-08
SG49156A1 (en) 1998-05-18
NO962261D0 (no) 1996-05-31
CN1142776A (zh) 1997-02-12
JPH09505810A (ja) 1997-06-10
AU1067095A (en) 1995-06-19
FI962299A (fi) 1996-05-31
EP0730473B1 (de) 2001-08-29
CA2176967A1 (en) 1995-06-08
NZ276410A (en) 1997-03-24
FI962299A0 (fi) 1996-05-31
DE59409847D1 (de) 2001-10-04
HU9601471D0 (en) 1996-07-29
EP0730473A1 (de) 1996-09-11
ES2163487T3 (es) 2002-02-01
HRP940968A2 (en) 1997-08-31
PL314797A1 (en) 1996-09-30
PT730473E (pt) 2002-02-28
BR9408195A (pt) 1997-08-26
NO962261L (no) 1996-05-31
CZ157096A3 (en) 1996-09-11
ZA949562B (en) 1996-06-03
ATE204763T1 (de) 2001-09-15
IL111811A0 (en) 1995-01-24
DE4437502A1 (de) 1995-06-08

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