ATE423562T1 - Alpha-ketoamidhaltige multikatalytische protease inhibitoren - Google Patents

Alpha-ketoamidhaltige multikatalytische protease inhibitoren

Info

Publication number
ATE423562T1
ATE423562T1 AT98953274T AT98953274T ATE423562T1 AT E423562 T1 ATE423562 T1 AT E423562T1 AT 98953274 T AT98953274 T AT 98953274T AT 98953274 T AT98953274 T AT 98953274T AT E423562 T1 ATE423562 T1 AT E423562T1
Authority
AT
Austria
Prior art keywords
alpha
ketoamid
inhibitors
protease inhibitors
multicatalytic protease
Prior art date
Application number
AT98953274T
Other languages
English (en)
Inventor
Sankar Chatterjee
John MALLAMO
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE423562T1 publication Critical patent/ATE423562T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT98953274T 1997-10-07 1998-10-07 Alpha-ketoamidhaltige multikatalytische protease inhibitoren ATE423562T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6138297P 1997-10-07 1997-10-07
US09/167,163 US6096778A (en) 1997-10-07 1998-10-06 α-ketoamide multicatalytic protease inhibitors

Publications (1)

Publication Number Publication Date
ATE423562T1 true ATE423562T1 (de) 2009-03-15

Family

ID=26741004

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953274T ATE423562T1 (de) 1997-10-07 1998-10-07 Alpha-ketoamidhaltige multikatalytische protease inhibitoren

Country Status (12)

Country Link
US (2) US6096778A (de)
EP (1) EP1027056B1 (de)
JP (1) JP4317920B2 (de)
KR (1) KR100648578B1 (de)
CN (1) CN1172672C (de)
AT (1) ATE423562T1 (de)
AU (1) AU751963B2 (de)
CA (1) CA2303428C (de)
DE (1) DE69840603D1 (de)
ES (1) ES2321249T3 (de)
NZ (1) NZ503308A (de)
WO (1) WO1999017778A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150378A (en) * 1997-10-07 2000-11-21 Cephalon, Inc. Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors
US6902721B1 (en) * 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6455587B1 (en) * 2000-03-15 2002-09-24 Pharmacor Inc. Amino acid derivatives as HIV aspartyl protease inhibitors
JP4666440B2 (ja) * 2000-06-30 2011-04-06 生化学工業株式会社 アミノアルコール誘導体
EP1295876A4 (de) 2000-06-30 2005-10-19 Epoxycarbonsäure-amide, azide und amino alkohole sowie deren verwendung in verfahren zur herstellung von alpha-ketoamiden
FR2813315B1 (fr) 2000-08-23 2002-10-18 Genfit S A Procede d'identification de substances utiles pour le traitement de l'inflammation mettant en oeuvre l'element de reponse du recepteur ror du gene ikbalpha
EP1465862A1 (de) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Cycloalkyl-ketoamiden derivate und ihre verwendung als cathepsin-k-inhibitoren
US7576206B2 (en) * 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) * 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) * 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US20070027067A1 (en) * 2005-05-13 2007-02-01 Felicia Etzkorn Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof
EP2095828A1 (de) * 2008-02-29 2009-09-02 Gnosis S.p.A. Verwendung von S-Adenosylmethionin (SAM) und Superoxid-Dismutase (SOD) zur Herstellung von Medikamenten zur Behandlung der Alzheimerkrankheit
EP2297347B1 (de) 2008-05-14 2017-03-08 Millennium Pharmaceuticals, Inc. Verfahren und kits zur überwachung der wirkung von immunmodulatoren auf die adaptive immunität
DK2278978T3 (en) 2008-05-28 2015-09-21 Reveragen Biopharma Inc NON-HORMONAL STEROID MODULATORS OF NF-KB FOR TREATMENT OF DISEASE
WO2010096574A1 (en) 2009-02-20 2010-08-26 Lisanti Michael P A method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm
JP2013506687A (ja) 2009-09-30 2013-02-28 プレジデント アンド フェロウズ オブ ハーバード カレッジ オートファジー促進遺伝子産物の変調によりオートファジーを変調する方法
CA2785300A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
HUE029295T2 (en) 2011-08-11 2017-02-28 Janssen Pharmaceutica Nv Predictors for cancer treatment
CN106978487A (zh) 2011-10-28 2017-07-25 米伦纽姆医药公司 对nedd8活化酶(nae)抑制剂的反应的生物标记
CA2855368A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
JP6215235B2 (ja) 2012-01-24 2017-10-18 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 癌の治療方法
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
US10662477B2 (en) 2012-10-01 2020-05-26 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
WO2014172627A1 (en) 2013-04-19 2014-10-23 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034376A (en) * 1986-10-31 1991-07-23 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides
EP0423358A4 (en) * 1989-04-15 1992-05-06 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Postostatin and related compound thereof, or their salts
US5340825A (en) * 1990-08-31 1994-08-23 Warner-Lambert Company Pro drugs for CCK antagonists
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
US5650508A (en) * 1991-12-27 1997-07-22 Georgia Tech Research Corporation Peptide ketoamides
US5514694A (en) * 1992-09-21 1996-05-07 Georgia Tech Research Corp Peptidyl ketoamides
US5434265A (en) * 1992-12-22 1995-07-18 Eli Lilly And Company Inhibitors of HIV protease
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
US5658885A (en) * 1993-04-27 1997-08-19 The Dupont Merck Pharmaceutical Company Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
US5541290A (en) * 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
DE4331134A1 (de) * 1993-09-14 1995-03-16 Bayer Ag Neue antiviral wirksame Pseudopeptide
US5550262A (en) * 1994-11-14 1996-08-27 Cephalon, Inc. Multicatalytic protease inhibitors
US5614649A (en) * 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
CA2223625C (en) * 1995-06-06 2003-06-03 Pfizer Inc. Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA

Also Published As

Publication number Publication date
AU1068599A (en) 1999-04-27
KR20010030944A (ko) 2001-04-16
CN1274285A (zh) 2000-11-22
US6310057B1 (en) 2001-10-30
JP2002516817A (ja) 2002-06-11
HK1028568A1 (en) 2001-02-23
CN1172672C (zh) 2004-10-27
US6096778A (en) 2000-08-01
ES2321249T3 (es) 2009-06-03
DE69840603D1 (de) 2009-04-09
EP1027056A1 (de) 2000-08-16
AU751963B2 (en) 2002-09-05
KR100648578B1 (ko) 2006-11-24
CA2303428A1 (en) 1999-04-15
WO1999017778A1 (en) 1999-04-15
EP1027056A4 (de) 2001-03-21
EP1027056B1 (de) 2009-02-25
CA2303428C (en) 2011-05-24
NZ503308A (en) 2001-02-23
JP4317920B2 (ja) 2009-08-19

Similar Documents

Publication Publication Date Title
ATE423562T1 (de) Alpha-ketoamidhaltige multikatalytische protease inhibitoren
ATE231839T1 (de) Polyaromatische antivirale zusammensetzungen
DK0528858T3 (da) Inhibitorer af dipeptidyl-aminopeptidase type IV
DE69528528D1 (de) Thrombin-inhibitoren
DK0760848T3 (da) Lactobacillusstammer af menneskelig oprindelse, deres sammensætninger og anvendelse deraf
ZA981936B (en) Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
ATE214928T1 (de) Thrombininhibitoren
TR199901191T2 (xx) Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
DK1097173T3 (da) Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
DE69837324D1 (de) Behandlung der multiplen sklerose durch einnahme von copolymer-1
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
KR950700323A (ko) 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 아미노아세틸머캅토아세틸아미드 유도체(Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE)
SE9801494D0 (sv) Novel use
DK1089625T3 (da) Ektoparasiticide midler
ES2088128T3 (es) Aminosulfonilureas inhibidoras de acat.
MX9801190A (es) Inhibidores de prolil endopeptidasa.
BG100248A (bg) Инхибитори на скваленсинтетаза
DE69831737D1 (de) Neurotrypsin
MY127474A (en) Naphthyl compounds, intermediates, compositions, and methods of use
SE9904128D0 (sv) Novel compounds
NO20002191L (no) Dofetilid polymorfer
AU7028798A (en) Use of 2-methylthiazolidine-2,4-dicarboxylic acid as mucolytic agent
ATE213236T1 (de) Substituierte benzyloxyimino-verbindungen
DE59809344D1 (de) Disubstituierte biphenyloxazoline
DK0539465T3 (da) Anvendelse af 20(R)-22-oxa-D-vitamin-analoger til fremstilling af et farmaceutisk præparat til behandling og/eller forebyggelse af hudaldring

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties