DK0725824T3 - Immunodominante humane T-celleepitoper af hepatitis C virus - Google Patents

Immunodominante humane T-celleepitoper af hepatitis C virus

Info

Publication number
DK0725824T3
DK0725824T3 DK94931000T DK94931000T DK0725824T3 DK 0725824 T3 DK0725824 T3 DK 0725824T3 DK 94931000 T DK94931000 T DK 94931000T DK 94931000 T DK94931000 T DK 94931000T DK 0725824 T3 DK0725824 T3 DK 0725824T3
Authority
DK
Denmark
Prior art keywords
hepatitis
virus
cell epitopes
amino acids
immunodominant
Prior art date
Application number
DK94931000T
Other languages
Danish (da)
English (en)
Inventor
Geert Leroux-Roels
Robert Deleys
Geert Maertens
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8214764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0725824(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK0725824T3 publication Critical patent/DK0725824T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK94931000T 1993-11-04 1994-10-28 Immunodominante humane T-celleepitoper af hepatitis C virus DK0725824T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93402718 1993-11-04
PCT/EP1994/003555 WO1995012677A2 (en) 1993-11-04 1994-10-28 Immunodominant human t-cell epitopes of hepatitis c virus

Publications (1)

Publication Number Publication Date
DK0725824T3 true DK0725824T3 (da) 2003-08-11

Family

ID=8214764

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94931000T DK0725824T3 (da) 1993-11-04 1994-10-28 Immunodominante humane T-celleepitoper af hepatitis C virus
DK99116671T DK0992580T3 (da) 1993-11-04 1994-10-28 Epitoper på human T-celler, som er immundominante for hepatitis C-virus

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK99116671T DK0992580T3 (da) 1993-11-04 1994-10-28 Epitoper på human T-celler, som er immundominante for hepatitis C-virus

Country Status (11)

Country Link
US (4) US6555114B1 (ja)
EP (4) EP0992581B2 (ja)
JP (2) JPH09504534A (ja)
AT (3) ATE236981T1 (ja)
AU (1) AU698878B2 (ja)
CA (1) CA2175692A1 (ja)
DE (3) DE69434295T2 (ja)
DK (2) DK0725824T3 (ja)
ES (2) ES2239819T3 (ja)
PT (2) PT992580E (ja)
WO (1) WO1995012677A2 (ja)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1421951A3 (en) 1993-05-12 2005-10-05 Chiron Corporation Conserved motif of hepatitis C virus E2/NS1 region
US7070790B1 (en) * 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
EP0992581B2 (en) * 1993-11-04 2011-05-25 Innogenetics N.V. Immunodominant human T-cell epitopes of hepatitis C virus
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
JPH10503473A (ja) * 1994-04-08 1998-03-31 アメリカ合衆国 細胞傷害性ｔリンパ球刺激およびｈｃｖ曝露診断用ｃ型肝炎ウイルスコアペプチド
JP2001522599A (ja) 1997-11-06 2001-11-20 イノジェネティックス・ナムローゼ・フェンノートシャップ 診断用及びワクチン用、ｃ型肝炎ウイルスエンベロープタンパク質由来マルチマーペプチド
TR200202213T2 (tr) 1998-04-17 2002-11-21 Innogenetics N.V. İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller
AU3714499A (en) * 1998-05-14 1999-11-29 Pasteur Merieux Serums Et Vaccins Hepatitis c virus mimotopes
WO1999066046A1 (fr) * 1998-06-12 1999-12-23 Aventis Pasteur Mimotopes du virus hiv
DE69922958T3 (de) * 1998-06-24 2008-06-26 Innogenetics N.V. Hcv hüllproteine partikel : verwendung für therapeutische impfung
US7108855B2 (en) 1998-06-24 2006-09-19 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
WO2000011186A1 (en) 1998-08-21 2000-03-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modified hcv peptide vaccines
DE19908423A1 (de) * 1999-02-26 2000-08-31 Deutsches Krebsforsch An der Entwicklung des ZNS beteiligtes Protein (TP)
AT408721B (de) * 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
RU2286172C2 (ru) * 2000-08-17 2006-10-27 Трипеп Аб Вакцины, содержащие рибавирин, и способы их использования
WO2002020035A1 (en) * 2000-09-01 2002-03-14 Epimmune Inc. Hla binding peptides and their uses
GB0026094D0 (en) * 2000-10-25 2000-12-13 Imp College Innovations Ltd Methods
US8129349B2 (en) * 2000-10-27 2012-03-06 The Regents Of The University Of California Treatment of disease by inducing cell apoptosis
US7402567B2 (en) * 2000-10-27 2008-07-22 The Regents Of The University Of California Treatment of disease by inducing cell apoptosis
US7101561B2 (en) 2000-12-01 2006-09-05 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
WO2002085932A2 (en) 2001-04-24 2002-10-31 Innogenetics N.V. Constructs and methods for expression of recombinant hcv envelope proteins
FR2825093B1 (fr) * 2001-05-28 2003-07-18 Bio Merieux Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations
FR2825363A1 (fr) * 2001-05-31 2002-12-06 Bio Merieux Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations
US7736677B2 (en) * 2001-06-20 2010-06-15 Metaproteomics, Llc Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment
JP2003064096A (ja) * 2001-08-29 2003-03-05 Mitsubishi Kagaku Bio-Clinical Laboratories Inc Ｃ型肝炎ウイルス特異的細胞障害性ｔ細胞認識エピトープ
GB0126782D0 (en) * 2001-11-07 2002-01-02 Medical Res Council Assay
US20040126395A1 (en) * 2001-12-18 2004-07-01 Geert Maertens Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
EP1461080A2 (en) * 2001-12-18 2004-09-29 Innogenetics N.V. Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use
WO2004041842A2 (en) * 2002-05-16 2004-05-21 The General Hospital Corporation Epitopes of hepatitis c virus
US8029803B2 (en) * 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
EP1539809A4 (en) * 2002-07-02 2006-03-08 Chiron Corp HCV fusion proteins with modified NS3 domains
JP2006516955A (ja) * 2002-11-08 2006-07-13 イノジェネティックス・ナムローゼ・フェンノートシャップ Ｅ１ペプチド及びｎｓ３ペプチドを含むｈｃｖワクチン組成物
WO2004069864A1 (fr) * 2003-01-07 2004-08-19 Biomerieux Polypeptides f’ du virus de l’hepatite c, epitopes et leurs applications diagnostiques et therapeutiques
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
US7785875B2 (en) 2004-07-03 2010-08-31 Mogam Biotechnology Research Institute Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same
CN1976946A (zh) * 2004-07-03 2007-06-06 财团法人牧岩生命工学研究所 诱导抗hcv有效ctl应答的超型表位、其编码寡核苷酸及其应用
CU23470A1 (es) * 2004-08-11 2009-12-17 Ct Ingenieria Genetica Biotech Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c
WO2006039326A2 (en) * 2004-09-29 2006-04-13 The Administrators Of The Tulane Educational Fund Inhibitors of hepatitits c virus
BRPI0516356A (pt) 2004-10-18 2008-09-02 Globeimmune Inc terapia à base de levedura para infecções crÈnicas da hepatite c
WO2007031867A2 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-stru tural ns3/4a fusion gene
ZA200804078B (en) * 2005-10-13 2009-09-30 Virexx Medical Corp Chimeric hepatitis C virus antigens for eliciting an immune response
EP2046353A4 (en) * 2006-06-20 2010-01-27 Metaproteomics Llc TREATMENT OF CANCER BY MODULATION OF PROTEIN KINASE, BASED ON ISO-ALPHA TETRAHYDRO ACIDS
KR20090024292A (ko) * 2006-06-28 2009-03-06 스태튼스 세룸 인스티튜트 단백질 단편 또는 펩타이드 혼합물로서 전달되는 항원을 가진 백신접종에 의해 준우성 항원결정기를 포함하는 ｔ세포 레퍼토리 확장
EP2185195A2 (en) * 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
ES2303496B1 (es) * 2008-02-21 2009-07-07 Fundacion Para El Estudio De Las Hepatitis Virales Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico.
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
WO2010033841A1 (en) 2008-09-19 2010-03-25 Globeimmune, Inc. Immunotherapy for chronic hepatitis c virus infection
ES2784189T3 (es) 2009-03-27 2020-09-23 Academia Sinica Métodos y composiciones para la inmunización contra virus
US20120046188A1 (en) * 2009-03-30 2012-02-23 bioMerieux, SA Solid Support for HCV Detection
EP2615104B1 (en) 2010-09-08 2017-03-22 Saitama Medical University Hepatitis c virus liposome vaccine
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
EA025152B1 (ru) 2010-12-02 2016-11-30 Бионор Иммуно Ас Конструкция пептидного каркаса
JP6294076B2 (ja) 2011-01-06 2018-03-14 ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ 多量体ペプチド
NZ702146A (en) 2012-06-06 2016-11-25 Bionor Immuno As Peptides derived from viral proteins for use as immunogens and dosage reactants
US9925259B2 (en) 2013-02-19 2018-03-27 National University Corporation Kobe University Immunogenic polypeptide surface layer-expressing bifidobacterium
JP6505076B2 (ja) 2013-03-14 2019-04-24 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ Ｈｃｖ抗原−抗体組み合わせアッセイおよびこれに使用するための方法および組成物
MX2015012825A (es) * 2013-03-14 2016-06-10 Abbott Lab Anticuerpos monoclonales del dominio de union de lipido del núcleo del virus de la hepatitis c vhc.
JP2016512241A (ja) 2013-03-14 2016-04-25 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 改良された抗体検出のためのｈｃｖｎｓ３組換え抗原およびこの突然変異体
CN105555310B (zh) 2013-07-08 2019-07-23 南京传奇生物科技有限公司 一种提高蛋白血清半衰期的组合物和方法
EP3515483A4 (en) 2016-09-21 2020-12-16 The Governors of the University of Alberta HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND THEIR USE PROCEDURES
AU2019233861A1 (en) 2018-03-16 2020-10-01 The Governors Of The University Of Alberta Hepatitis C virus peptide compositions and methods of use thereof
CN109160942B (zh) * 2018-09-26 2021-06-29 广州市第八人民医院 Hcv包膜蛋白高度保守区域的肽段502-518及其用途
JP2022518488A (ja) * 2019-01-25 2022-03-15 センティ バイオサイエンシズ インコーポレイテッド タンパク質機能を制御するための融合構築物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6027729A (en) 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5639594A (en) * 1990-02-16 1997-06-17 United Biomedical, Inc. Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
US5747239A (en) * 1990-02-16 1998-05-05 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines
WO1991015596A1 (en) * 1990-04-04 1991-10-17 Protos, Inc. Hepatitis c virus protease inhibitors
US5747339A (en) 1990-06-25 1998-05-05 Research Foundation For Microbial Diseases Of Osaka Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide
KR0181517B1 (ko) * 1990-07-09 1999-04-01 나까하라 노부유끼 비-에이 비-비형 간염-특이 항원 및 간염 진단에서 그의 용도
CA2047792C (en) * 1990-07-26 2002-07-02 Chang Y. Wang Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines
CA2049679C (en) * 1990-08-24 2005-06-21 Sushil G. Devare Hepatitis c assay utilizing recombinant antigens
EP0485209A1 (en) 1990-11-08 1992-05-13 Immuno Japan Inc. Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides
CA2087974A1 (en) 1991-06-13 1992-12-14 David C. Leahy Immunoassay for non-a non-b hepatitis
JP3516681B2 (ja) * 1991-06-24 2004-04-05 カイロン コーポレイション Ｃ型肝炎ウイルス（ｈｃｖ）ポリペプチド
DE4209215A1 (de) * 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
US5428145A (en) 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
WO1993004088A1 (en) * 1991-08-21 1993-03-04 Abbott Laboratories Hepatitis c assay utilizing recombinant antigens to ns1
DK0608261T3 (da) 1991-09-13 2003-03-17 Chiron Corp Sammensætninger med immunreaktivt hepatitis C virus polypeptid
JP3219409B2 (ja) * 1991-09-16 2001-10-15 アボツト・ラボラトリーズ Ｃ型肝炎アッセイ
WO1993015207A2 (en) 1992-02-04 1993-08-05 Viagene, Inc. Hepatitis therapeutics
KR20030096423A (ko) 1992-03-06 2003-12-31 엔. 브이. 이노제네틱스 소시에떼아노님 면역학적으로 중요한 에피토프에 상응하는 펩티드의 측정방법 및 면역학적으로 중요한 에피토프에 상응하는 항체또는 비오티닐화된 펩티드의 측정 방법에 상기 펩티드를사용하는 방법, 상기 펩티드의 제조방법 및 상기 펩티드를함유하는 조성물
KR100235849B1 (ko) * 1993-10-19 1999-12-15 에가시라 구니오 HIV에 대한 면역응답을 유도할 수 있는 펩티드 및 그 펩티드를 함유하는 항 AIDS 예방, 치료제(Peptides Capable of Inducing Immune Response to HIV and Anti-AIDS Agent for Preventing and Curing AIDS)
EP0992581B2 (en) * 1993-11-04 2011-05-25 Innogenetics N.V. Immunodominant human T-cell epitopes of hepatitis C virus
US5709995A (en) 1994-03-17 1998-01-20 The Scripps Research Institute Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses
US5543657A (en) * 1994-10-07 1996-08-06 International Business Machines Corporation Single layer leadframe design with groundplane capability

Also Published As

Publication number Publication date
EP0992581B1 (en) 2004-08-25
AU698878B2 (en) 1998-11-12
JP2004194668A (ja) 2004-07-15
ES2239819T3 (es) 2005-10-01
EP0725824A1 (en) 1996-08-14
EP0979867A2 (en) 2000-02-16
US6613333B1 (en) 2003-09-02
JPH09504534A (ja) 1997-05-06
WO1995012677A3 (en) 1995-07-27
US6555114B1 (en) 2003-04-29
DE69434295T2 (de) 2006-02-16
PT725824E (pt) 2003-08-29
ATE274578T1 (de) 2004-09-15
EP0992580A2 (en) 2000-04-12
US6689368B1 (en) 2004-02-10
EP0979867A3 (en) 2007-06-13
DE69432475T2 (de) 2004-03-04
DK0992580T3 (da) 2005-07-11
DE69434295D1 (de) 2005-04-14
EP0725824B1 (en) 2003-04-09
EP0992580A3 (en) 2000-08-09
PT992580E (pt) 2005-07-29
CA2175692A1 (en) 1995-05-11
WO1995012677A2 (en) 1995-05-11
EP0992581A3 (en) 2001-03-07
US20040047877A1 (en) 2004-03-11
EP0992581B2 (en) 2011-05-25
AU7993294A (en) 1995-05-23
ES2197170T3 (es) 2004-01-01
ATE290592T1 (de) 2005-03-15
DE69432475D1 (de) 2003-05-15
EP0992580B1 (en) 2005-03-09
DE69433971D1 (de) 2004-09-30
EP0992581A2 (en) 2000-04-12
ATE236981T1 (de) 2003-04-15
DE69433971T2 (de) 2005-09-08

Similar Documents

Publication Publication Date Title
DK0725824T3 (da) Immunodominante humane T-celleepitoper af hepatitis C virus
FI935808A (fi) Hepatit-C-virus (HCV) polypeptider
DK643387A (da) T-celle-epitoper af hepatitis b-virus-nucleocapsid-protein
DK0608261T3 (da) Sammensætninger med immunreaktivt hepatitis C virus polypeptid
ES2138784T3 (es) Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c.
DK0523395T3 (da) Seroreaktive områder på proteinerne E1 og E2 i HPV 16
ATE170220T1 (de) Zusammensetzung verwendbar als therapeutisches mittel gegen chronische virale leberkrankheiten
ATE359089T1 (de) Peptide zum induzieren einer antwort der zytotoxischen t-lymphozyten gerichtet gegen das hepatitis-b-virus
AU2370592A (en) Epitopes of the env protein of the hepatitis c virus
DK0492500T3 (da) Protektive Plasmodium falciparum-hybridproteiner, der indeholder delsekvenser af malaria-antigenerne HRPII og SERP
ATE205220T1 (de) Hepatitis-a-impfstoff
DK204588D0 (da) Humane rhinoviruspeptider, fremgangsmaade til deres fremstilling samt vacciner med inhold af saadanne peptider
FI943929A (fi) Hepatiitti C-viruspeptidejä
EP0637631A3 (de) Hoch effiziente Expression eines Polypeptids, das eine modifizierte preS1-Region des grossen Hepatitis B-Virus-Antigens enthält.
IT1270941B (it) Peptidi di hcv e loro usi.