PT725824E - Epitopos de celulas t humanas imunodominantes do virus da hepatite c - Google Patents
Epitopos de celulas t humanas imunodominantes do virus da hepatite cInfo
- Publication number
- PT725824E PT725824E PT94931000T PT94931000T PT725824E PT 725824 E PT725824 E PT 725824E PT 94931000 T PT94931000 T PT 94931000T PT 94931000 T PT94931000 T PT 94931000T PT 725824 E PT725824 E PT 725824E
- Authority
- PT
- Portugal
- Prior art keywords
- cell
- epitops
- hepatitis
- virus
- immunodominant
- Prior art date
Links
- 241000711549 Hepacivirus C Species 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010076039 Polyproteins Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93402718 | 1993-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT725824E true PT725824E (pt) | 2003-08-29 |
Family
ID=8214764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT94931000T PT725824E (pt) | 1993-11-04 | 1994-10-28 | Epitopos de celulas t humanas imunodominantes do virus da hepatite c |
PT99116671T PT992580E (pt) | 1993-11-04 | 1994-10-28 | Epitopos para celulas t humanas imunodominantes do virus da hepatite c |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99116671T PT992580E (pt) | 1993-11-04 | 1994-10-28 | Epitopos para celulas t humanas imunodominantes do virus da hepatite c |
Country Status (11)
Country | Link |
---|---|
US (4) | US6555114B1 (pt) |
EP (4) | EP0725824B1 (pt) |
JP (2) | JPH09504534A (pt) |
AT (3) | ATE274578T1 (pt) |
AU (1) | AU698878B2 (pt) |
CA (1) | CA2175692A1 (pt) |
DE (3) | DE69432475T2 (pt) |
DK (2) | DK0725824T3 (pt) |
ES (2) | ES2197170T3 (pt) |
PT (2) | PT725824E (pt) |
WO (1) | WO1995012677A2 (pt) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
US7070790B1 (en) * | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
EP0725824B1 (en) * | 1993-11-04 | 2003-04-09 | Innogenetics N.V. | Immunodominant human t-cell epitopes of hepatitis c virus |
US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
DE69517521T2 (de) * | 1994-04-08 | 2001-03-08 | Us Gov Health & Human Serv | Peptid aus dem inneren des hepatitis-c-virus brauchbar für die stimulation cytotoxischer t-lymphocyten und die diagnose des hcv-kontaktes |
ATE482974T1 (de) | 1997-11-06 | 2010-10-15 | Innogenetics Nv | Multimere peptide, die auf dem hepatitis c virus hüllprotein basieren, für diagnostische verwendung und für impfzwecke |
TR200003024T2 (tr) | 1998-04-17 | 2000-12-21 | Innogenetics N.V. | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
WO1999058561A1 (fr) * | 1998-05-14 | 1999-11-18 | Pasteur Merieux Serums & Vaccins | Mimotopes du virus de l'hepatite c |
NZ508812A (en) * | 1998-06-12 | 2002-11-26 | Aventis Pasteur | Peptides for the prevention or treatment of HIV |
US7108855B2 (en) | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
WO1999067285A1 (en) * | 1998-06-24 | 1999-12-29 | Innogenetics N.V. | Particles of hcv envelope proteins: use for vaccination |
US6685944B1 (en) | 1998-08-21 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Modified HCV peptide vaccines |
DE19908423A1 (de) * | 1999-02-26 | 2000-08-31 | Deutsches Krebsforsch | An der Entwicklung des ZNS beteiligtes Protein (TP) |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
EP1535628B1 (en) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-like particle |
US6858590B2 (en) * | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
ATE502952T1 (de) * | 2000-09-01 | 2011-04-15 | Epimmune Inc | Hla-bindungspeptide und ihre anwendungszwecke |
GB0026094D0 (en) * | 2000-10-25 | 2000-12-13 | Imp College Innovations Ltd | Methods |
US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US8129349B2 (en) * | 2000-10-27 | 2012-03-06 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
US7101561B2 (en) | 2000-12-01 | 2006-09-05 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US7314925B2 (en) | 2001-04-24 | 2008-01-01 | Innogenetics N.V. | Constructs and methods for expression of recombinant HCV envelope proteins |
FR2825093B1 (fr) * | 2001-05-28 | 2003-07-18 | Bio Merieux | Polypeptide reagissant avecles anticorps de patients infectes par vhc et utilisations |
FR2825363A1 (fr) * | 2001-05-31 | 2002-12-06 | Bio Merieux | Polypeptides reagissant avec les anticorps de patients infectes par vhc et utilisations |
US7736677B2 (en) * | 2001-06-20 | 2010-06-15 | Metaproteomics, Llc | Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment |
JP2003064096A (ja) * | 2001-08-29 | 2003-03-05 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | C型肝炎ウイルス特異的細胞障害性t細胞認識エピトープ |
GB0126782D0 (en) * | 2001-11-07 | 2002-01-02 | Medical Res Council | Assay |
US20040126395A1 (en) * | 2001-12-18 | 2004-07-01 | Geert Maertens | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
AU2002361160B2 (en) * | 2001-12-18 | 2008-07-03 | Genimmune N.V. | Purified Hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US7201904B2 (en) | 2002-05-16 | 2007-04-10 | The General Hospital Corporation | Epitopes of hepatitis C virus |
US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
US8025873B2 (en) | 2002-06-20 | 2011-09-27 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
JP2005532064A (ja) * | 2002-07-02 | 2005-10-27 | カイロン コーポレイション | 改変したns3ドメインを有するhcv融合タンパク質 |
CA2504711A1 (en) * | 2002-11-08 | 2004-05-21 | Innogenetics N.V. | Hcv vaccine compositions comprising e1 and ns3 peptides |
EP1583773A1 (fr) * | 2003-01-07 | 2005-10-12 | Biomerieux | Polypeptides f' du virus de l'hepatite c, epitopes et leurs applications diagnostiques et therapeutiques |
US8007805B2 (en) * | 2003-08-08 | 2011-08-30 | Paladin Labs, Inc. | Chimeric antigens for breaking host tolerance to foreign antigens |
EP1778719A1 (en) * | 2004-07-03 | 2007-05-02 | Mogam Biotechnology Research Institute | Supertype epitopes, oligonucleotides coding the same which induce effective ctl response against hcv and the use thereof |
US7785875B2 (en) | 2004-07-03 | 2010-08-31 | Mogam Biotechnology Research Institute | Polynucleotide encoding HCV epitopes which can bind to various HLA supertypes, immunogenic composition comprising same and method of inducing an HCV-specific immune response using same |
CU23470A1 (es) * | 2004-08-11 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Vectores vivos recombinantes y su uso en composiciones farmacéuticas contra el virus de la hepatitis c |
US7381705B2 (en) * | 2004-09-29 | 2008-06-03 | The Administrators Of The Tulane Educational Fund | Inhibitors of hepatitis C virus |
JP2008516610A (ja) | 2004-10-18 | 2008-05-22 | グローブイミューン,インコーポレイテッド | 酵母を用いた慢性c型肝炎感染の治療 |
US7968697B2 (en) * | 2005-05-25 | 2011-06-28 | Chrontech Pharma Ab | Hepatitis C virus non-structural NS3/4A fusion gene |
BRPI0617330A2 (pt) * | 2005-10-13 | 2011-07-19 | Virexx Medical Corp | antìgeno quimérico contendo polipeptìdeo do vìrus da hepatite c e fragmento fc para despertar uma resposta imunológica |
TW200817027A (en) * | 2006-06-20 | 2008-04-16 | Metaproteomics Llc | Isoalpha acid based protein kinase modulation cancer treatment |
WO2008000261A2 (en) * | 2006-06-28 | 2008-01-03 | Statens Serum Institut | Expanding the t cell repertoire to include subdominant epitopes by vaccination with antigens delivered as protein fragments or peptide cocktails |
EP2185195A2 (en) * | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
ES2303496B1 (es) * | 2008-02-21 | 2009-07-07 | Fundacion Para El Estudio De Las Hepatitis Virales | Metodo analitico perfeccionado para la deteccion de hepatitis c oculta, aplicaciones del mismo y su correspondiente kit de diagnostico. |
WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
JP2012503011A (ja) | 2008-09-19 | 2012-02-02 | グローブイミューン,インコーポレイテッド | 慢性c型肝炎ウイルス感染の免疫療法 |
EP2411049B1 (en) | 2009-03-27 | 2020-01-15 | Academia Sinica | Methods and compositions for immunization against virus |
WO2010112733A1 (fr) * | 2009-03-30 | 2010-10-07 | bioMérieux | Support solide de détection du vhc |
WO2012033142A1 (ja) * | 2010-09-08 | 2012-03-15 | 学校法人 埼玉医科大学 | C型肝炎ウイルスリポソームワクチン |
TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
NZ611176A (en) | 2010-12-02 | 2015-07-31 | Bionor Immuno As | Peptide scaffold design |
KR101993431B1 (ko) | 2011-01-06 | 2019-06-26 | 바이오노르 이뮤노 에이에스 | 단량체형 및 다량체형 면역원성 펩타이드 |
EA201492262A1 (ru) | 2012-06-06 | 2015-08-31 | Бионор Иммуно Ас | Конструкция пептидного каркаса |
WO2014129412A1 (ja) * | 2013-02-19 | 2014-08-28 | 国立大学法人神戸大学 | 免疫原性ポリペプチド表層発現ビフィズス菌 |
EP2971046A4 (en) * | 2013-03-14 | 2016-11-02 | Abbott Lab | MONOCLONAL ANTIBODIES WITH LIPID BINDING TO THE HEART OF HCV |
US9194873B2 (en) | 2013-03-14 | 2015-11-24 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
CN105209616A (zh) | 2013-03-14 | 2015-12-30 | 雅培制药有限公司 | 用于改进的抗体检测的hcv ns3重组抗原及其突变体 |
EP3019192A4 (en) | 2013-07-08 | 2017-07-05 | Nanjingjinsirui Science&Technology Biology Corporation | Compositions and methods for increasing protein half-life in a serum |
WO2018055535A2 (en) | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
CA3093314A1 (en) * | 2018-03-16 | 2019-09-19 | The Governors Of The University Of Alberta | Hepatitis c virus peptide compositions and methods of use thereof |
CN109160942B (zh) * | 2018-09-26 | 2021-06-29 | 广州市第八人民医院 | Hcv包膜蛋白高度保守区域的肽段502-518及其用途 |
US20220090040A1 (en) * | 2019-01-25 | 2022-03-24 | Senti Biosciences, Inc. | Fusion Constructs for Controlling Protein Function |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
US6027729A (en) | 1989-04-20 | 2000-02-22 | Chiron Corporation | NANBV Diagnostics and vaccines |
US5639594A (en) | 1990-02-16 | 1997-06-17 | United Biomedical, Inc. | Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis |
US5747239A (en) * | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
IE911130A1 (en) * | 1990-04-04 | 1991-10-09 | Protos | Hepatitis c protease inhibitors |
US5747339A (en) | 1990-06-25 | 1998-05-05 | Research Foundation For Microbial Diseases Of Osaka | Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptide |
EP0468657A3 (en) | 1990-07-09 | 1992-02-05 | Tonen Corporation | Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis |
CA2047792C (en) * | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
CA2049679C (en) * | 1990-08-24 | 2005-06-21 | Sushil G. Devare | Hepatitis c assay utilizing recombinant antigens |
EP0485209A1 (en) | 1990-11-08 | 1992-05-13 | Immuno Japan Inc. | Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides |
CA2087974A1 (en) * | 1991-06-13 | 1992-12-14 | David C. Leahy | Immunoassay for non-a non-b hepatitis |
UA40572C2 (uk) * | 1991-06-24 | 2001-08-15 | Чірон Корпорейшн | Поліпептид, що містить укорочену послідовність вірусу гепатиту с, ізольований епітоп, реагент для імуноаналізу на вірус гепатиту с (варіанти), спосіб виявлення наявності антитіл (варіанти) |
DE4209215A1 (de) * | 1991-07-04 | 1993-01-07 | Boehringer Mannheim Gmbh | Hcv peptidantigene und verfahren zur bestimmung von hcv |
US5428145A (en) | 1991-08-09 | 1995-06-27 | Immuno Japan, Inc. | Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems |
WO1993004088A1 (en) * | 1991-08-21 | 1993-03-04 | Abbott Laboratories | Hepatitis c assay utilizing recombinant antigens to ns1 |
AU679429B2 (en) * | 1991-09-13 | 1997-07-03 | Novartis Vaccines And Diagnostics, Inc. | Immunoreactive hepatitis C virus polypeptide compositions |
WO1993006247A1 (en) * | 1991-09-16 | 1993-04-01 | Abbott Laboratories | Hepatitis c assay |
DE69332045T2 (de) * | 1992-02-04 | 2002-10-17 | Chiron Corp | Hepatistherapeutikum |
PT891982E (pt) * | 1992-03-06 | 2007-07-27 | Innogenetics Nv | Péptidos de hiv |
AU685521B2 (en) * | 1993-10-19 | 1998-01-22 | Ajinomoto Co., Inc. | Peptide capable of inducing immune response against HIV and aids preventive or remedy containing the peptide |
EP0725824B1 (en) * | 1993-11-04 | 2003-04-09 | Innogenetics N.V. | Immunodominant human t-cell epitopes of hepatitis c virus |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
US5543657A (en) * | 1994-10-07 | 1996-08-06 | International Business Machines Corporation | Single layer leadframe design with groundplane capability |
-
1994
- 1994-10-28 EP EP94931000A patent/EP0725824B1/en not_active Revoked
- 1994-10-28 DK DK94931000T patent/DK0725824T3/da active
- 1994-10-28 US US08/635,886 patent/US6555114B1/en not_active Expired - Fee Related
- 1994-10-28 DE DE69432475T patent/DE69432475T2/de not_active Revoked
- 1994-10-28 PT PT94931000T patent/PT725824E/pt unknown
- 1994-10-28 AT AT99116672T patent/ATE274578T1/de not_active IP Right Cessation
- 1994-10-28 DE DE69434295T patent/DE69434295T2/de not_active Revoked
- 1994-10-28 AU AU79932/94A patent/AU698878B2/en not_active Ceased
- 1994-10-28 AT AT99116671T patent/ATE290592T1/de not_active IP Right Cessation
- 1994-10-28 ES ES94931000T patent/ES2197170T3/es not_active Expired - Lifetime
- 1994-10-28 WO PCT/EP1994/003555 patent/WO1995012677A2/en not_active Application Discontinuation
- 1994-10-28 DE DE69433971T patent/DE69433971T2/de not_active Expired - Fee Related
- 1994-10-28 ES ES99116671T patent/ES2239819T3/es not_active Expired - Lifetime
- 1994-10-28 PT PT99116671T patent/PT992580E/pt unknown
- 1994-10-28 EP EP99116672A patent/EP0992581B2/en not_active Expired - Lifetime
- 1994-10-28 DK DK99116671T patent/DK0992580T3/da active
- 1994-10-28 EP EP99116673A patent/EP0979867A3/en not_active Withdrawn
- 1994-10-28 EP EP99116671A patent/EP0992580B1/en not_active Revoked
- 1994-10-28 JP JP7513004A patent/JPH09504534A/ja active Pending
- 1994-10-28 CA CA002175692A patent/CA2175692A1/en not_active Abandoned
- 1994-10-28 AT AT94931000T patent/ATE236981T1/de not_active IP Right Cessation
-
1997
- 1997-11-19 US US08/974,690 patent/US6613333B1/en not_active Expired - Fee Related
- 1997-11-19 US US08/974,685 patent/US6689368B1/en not_active Expired - Fee Related
-
2003
- 2003-08-29 US US10/651,165 patent/US20040047877A1/en not_active Abandoned
-
2004
- 2004-02-12 JP JP2004034983A patent/JP2004194668A/ja active Pending
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