DK0662513T3 - Fremgangsmåde til at forhindre nedbrydning af protein C - Google Patents

Fremgangsmåde til at forhindre nedbrydning af protein C

Info

Publication number
DK0662513T3
DK0662513T3 DK95300042T DK95300042T DK0662513T3 DK 0662513 T3 DK0662513 T3 DK 0662513T3 DK 95300042 T DK95300042 T DK 95300042T DK 95300042 T DK95300042 T DK 95300042T DK 0662513 T3 DK0662513 T3 DK 0662513T3
Authority
DK
Denmark
Prior art keywords
apc
degradation
autodegradation
denaturant
incubating
Prior art date
Application number
DK95300042T
Other languages
Danish (da)
English (en)
Inventor
Walter Francis Prouty Jr
Josephine Secnik
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22650141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0662513(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0662513T3 publication Critical patent/DK0662513T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK95300042T 1994-01-05 1995-01-04 Fremgangsmåde til at forhindre nedbrydning af protein C DK0662513T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17783294A 1994-01-05 1994-01-05

Publications (1)

Publication Number Publication Date
DK0662513T3 true DK0662513T3 (da) 2001-05-28

Family

ID=22650141

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95300042T DK0662513T3 (da) 1994-01-05 1995-01-04 Fremgangsmåde til at forhindre nedbrydning af protein C

Country Status (29)

Country Link
EP (2) EP1087011A3 (es)
JP (1) JP3778588B2 (es)
KR (1) KR950032287A (es)
CN (1) CN1109891A (es)
AT (1) ATE201045T1 (es)
AU (1) AU1003195A (es)
BR (1) BR9500017A (es)
CA (1) CA2139468C (es)
CO (1) CO4600680A1 (es)
CZ (1) CZ1395A3 (es)
DE (2) DE69520844T2 (es)
DK (1) DK0662513T3 (es)
ES (1) ES2156190T3 (es)
FI (1) FI115635B (es)
GR (1) GR3036277T3 (es)
HU (1) HUT70465A (es)
IL (1) IL112236A (es)
LU (2) LU90993I2 (es)
NL (1) NL300108I2 (es)
NO (2) NO320157B1 (es)
NZ (1) NZ270271A (es)
PE (1) PE43995A1 (es)
PL (1) PL180703B1 (es)
PT (1) PT662513E (es)
RU (1) RU2167936C2 (es)
SI (1) SI0662513T1 (es)
UA (1) UA39178C2 (es)
YU (1) YU295A (es)
ZA (1) ZA9514B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002149B1 (ru) 1997-04-28 2001-12-24 Эли Лилли Энд Компани Улучшенные способы приготовления активированного белка с
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
EP1557463A1 (en) * 1997-04-28 2005-07-27 Eli Lilly & Company Improved methods for processing activated protein C
US7204981B2 (en) 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
EP1289543A2 (en) 2000-05-24 2003-03-12 Eli Lilly And Company Formulations and methods for treating hypercoagulable states

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c

Also Published As

Publication number Publication date
KR950032287A (ko) 1995-12-20
NZ270271A (en) 1996-07-26
NO2006006I1 (no) 2006-05-15
RU2167936C2 (ru) 2001-05-27
EP1087011A3 (en) 2002-02-06
ES2156190T3 (es) 2001-06-16
YU295A (sh) 1997-09-30
ZA9514B (en) 1996-07-03
HU9500021D0 (en) 1995-03-28
LU90992I2 (fr) 2003-02-18
LU90993I2 (fr) 2003-02-18
CN1109891A (zh) 1995-10-11
FI950044A0 (fi) 1995-01-04
IL112236A (en) 1999-12-31
SI0662513T1 (en) 2001-10-31
GR3036277T3 (en) 2001-10-31
AU1003195A (en) 1995-07-13
CA2139468C (en) 2007-08-21
CZ1395A3 (en) 1995-07-12
EP0662513A1 (en) 1995-07-12
PT662513E (pt) 2001-08-30
PE43995A1 (es) 1995-12-15
IL112236A0 (en) 1995-03-30
EP1087011A2 (en) 2001-03-28
ATE201045T1 (de) 2001-05-15
DE69520844T2 (de) 2001-11-08
FI950044A (fi) 1995-07-06
JPH07206704A (ja) 1995-08-08
PL180703B1 (pl) 2001-03-30
UA39178C2 (uk) 2001-06-15
DE10299053I2 (de) 2004-04-01
NL300108I1 (nl) 2003-02-03
NO320157B1 (no) 2005-11-07
JP3778588B2 (ja) 2006-05-24
CA2139468A1 (en) 1995-07-06
HUT70465A (en) 1995-10-30
NL300108I2 (nl) 2003-06-02
BR9500017A (pt) 1995-10-03
DE69520844D1 (de) 2001-06-13
PL306671A1 (en) 1995-07-10
NO950018L (no) 1995-07-06
NO950018D0 (no) 1995-01-03
FI115635B (fi) 2005-06-15
CO4600680A1 (es) 1998-05-08
DE10299053I1 (de) 2003-05-22
RU95100178A (ru) 1997-03-27
EP0662513B1 (en) 2001-05-09

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