RU95100178A - Способы предотвращения разложения протеина с, фармацевтическая композиция, содержащая активированный протеин с - Google Patents

Способы предотвращения разложения протеина с, фармацевтическая композиция, содержащая активированный протеин с

Info

Publication number
RU95100178A
RU95100178A RU95100178/13A RU95100178A RU95100178A RU 95100178 A RU95100178 A RU 95100178A RU 95100178/13 A RU95100178/13 A RU 95100178/13A RU 95100178 A RU95100178 A RU 95100178A RU 95100178 A RU95100178 A RU 95100178A
Authority
RU
Russia
Prior art keywords
protein
activated protein
methods
apc
pharmaceutical composition
Prior art date
Application number
RU95100178/13A
Other languages
English (en)
Other versions
RU2167936C2 (ru
Inventor
Фрэнсис Праути Вальтер (младший)
Us]
Секник Джозефин
Original Assignee
Эли Лилли энд Компани (US)
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22650141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU95100178(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли энд Компани (US), Эли Лилли Энд Компани filed Critical Эли Лилли энд Компани (US)
Publication of RU95100178A publication Critical patent/RU95100178A/ru
Application granted granted Critical
Publication of RU2167936C2 publication Critical patent/RU2167936C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к способам предотвращения или минимизации аутодеградации активированного протеина С. Способ осуществляется процессингом, очисткой и/или хранением активированного протеина С при рН. Аутодеградацию аРС можно также минимизировать за счет инкубирования аРС в ЗМ мочевине (полное выделение аРС активности достигается после удаления денатурирующего агента) или за счет инкубирования аРС в присутствии экстремальных концентраций соли. Настоящее изобретения также включает аРС композиции, которые поддерживают аРС при низких значениях 6,3 - 6,5, в денатурирующем агенте или при экстремальных концентрациях соли.

Claims (1)

  1. Изобретение относится к способам предотвращения или минимизации аутодеградации активированного протеина С. Способ осуществляется процессингом, очисткой и/или хранением активированного протеина С при рН. Аутодеградацию аРС можно также минимизировать за счет инкубирования аРС в ЗМ мочевине (полное выделение аРС активности достигается после удаления денатурирующего агента) или за счет инкубирования аРС в присутствии экстремальных концентраций соли. Настоящее изобретения также включает аРС композиции, которые поддерживают аРС при низких значениях 6,3 - 6,5, в денатурирующем агенте или при экстремальных концентрациях соли.
RU95100178/13A 1994-01-05 1995-01-04 Способ минимизации деградации активированного протеина с (варианты), стабилизированная композиция активированного протеина с RU2167936C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17783294A 1994-01-05 1994-01-05
US08/177,832 1994-01-05

Publications (2)

Publication Number Publication Date
RU95100178A true RU95100178A (ru) 1997-03-27
RU2167936C2 RU2167936C2 (ru) 2001-05-27

Family

ID=22650141

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95100178/13A RU2167936C2 (ru) 1994-01-05 1995-01-04 Способ минимизации деградации активированного протеина с (варианты), стабилизированная композиция активированного протеина с

Country Status (29)

Country Link
EP (2) EP1087011A3 (ru)
JP (1) JP3778588B2 (ru)
KR (1) KR950032287A (ru)
CN (1) CN1109891A (ru)
AT (1) ATE201045T1 (ru)
AU (1) AU1003195A (ru)
BR (1) BR9500017A (ru)
CA (1) CA2139468C (ru)
CO (1) CO4600680A1 (ru)
CZ (1) CZ1395A3 (ru)
DE (2) DE10299053I2 (ru)
DK (1) DK0662513T3 (ru)
ES (1) ES2156190T3 (ru)
FI (1) FI115635B (ru)
GR (1) GR3036277T3 (ru)
HU (1) HUT70465A (ru)
IL (1) IL112236A (ru)
LU (2) LU90992I2 (ru)
NL (1) NL300108I2 (ru)
NO (2) NO320157B1 (ru)
NZ (1) NZ270271A (ru)
PE (1) PE43995A1 (ru)
PL (1) PL180703B1 (ru)
PT (1) PT662513E (ru)
RU (1) RU2167936C2 (ru)
SI (1) SI0662513T1 (ru)
UA (1) UA39178C2 (ru)
YU (1) YU295A (ru)
ZA (1) ZA9514B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL132325A (en) 1997-04-28 2005-07-25 Lilly Co Eli Activated protein c formulations
EP1557463A1 (en) * 1997-04-28 2005-07-27 Eli Lilly & Company Improved methods for processing activated protein C
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
US7204981B2 (en) 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
EP1289543A2 (en) 2000-05-24 2003-03-12 Eli Lilly And Company Formulations and methods for treating hypercoagulable states

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c

Also Published As

Publication number Publication date
DE69520844T2 (de) 2001-11-08
NO2006006I1 (no) 2006-05-15
NO950018D0 (no) 1995-01-03
EP1087011A2 (en) 2001-03-28
YU295A (sh) 1997-09-30
LU90992I2 (fr) 2003-02-18
NO320157B1 (no) 2005-11-07
CA2139468C (en) 2007-08-21
KR950032287A (ko) 1995-12-20
SI0662513T1 (en) 2001-10-31
PL306671A1 (en) 1995-07-10
CO4600680A1 (es) 1998-05-08
CN1109891A (zh) 1995-10-11
FI950044A0 (fi) 1995-01-04
HU9500021D0 (en) 1995-03-28
EP0662513A1 (en) 1995-07-12
JP3778588B2 (ja) 2006-05-24
DE10299053I1 (de) 2003-05-22
ATE201045T1 (de) 2001-05-15
UA39178C2 (ru) 2001-06-15
HUT70465A (en) 1995-10-30
DE69520844D1 (de) 2001-06-13
LU90993I2 (fr) 2003-02-18
IL112236A0 (en) 1995-03-30
CZ1395A3 (en) 1995-07-12
GR3036277T3 (en) 2001-10-31
NO950018L (no) 1995-07-06
BR9500017A (pt) 1995-10-03
ES2156190T3 (es) 2001-06-16
ZA9514B (en) 1996-07-03
RU2167936C2 (ru) 2001-05-27
PE43995A1 (es) 1995-12-15
DK0662513T3 (da) 2001-05-28
EP1087011A3 (en) 2002-02-06
FI115635B (fi) 2005-06-15
DE10299053I2 (de) 2004-04-01
IL112236A (en) 1999-12-31
CA2139468A1 (en) 1995-07-06
AU1003195A (en) 1995-07-13
PL180703B1 (pl) 2001-03-30
NL300108I2 (nl) 2003-06-02
JPH07206704A (ja) 1995-08-08
FI950044A (fi) 1995-07-06
NZ270271A (en) 1996-07-26
NL300108I1 (nl) 2003-02-03
PT662513E (pt) 2001-08-30
EP0662513B1 (en) 2001-05-09

Similar Documents

Publication Publication Date Title
RU95100178A (ru) Способы предотвращения разложения протеина с, фармацевтическая композиция, содержащая активированный протеин с
Uhteg et al. The modification of tryptophan in bovine thrombin
GR1001480B (el) Ενζυμικά σκευάσματα περιέχοντα παπαϊνη ή χυμο?ρυψίνη και μέ?οδοι μόνιμης ενζυμικής αποτρίχωσης.
Oommen et al. The inhibition of brain aryl acylamidase by 5-hydroxytryptamine and acetylcholine
Barker et al. Photooxidation of glucoamylase I from Aspergillus niger
KUBOTA et al. Carboxypeptidases from the exocarp of mandarin orange (Citrus unshiu MARC.). II. Chemical and enzymatic properties of carboxypeptidases Cua and Cub
MORIYA et al. Biochemical Studies on Kallikreins and Their Related Substances III. Preliminary Experiment of Studies on Human Plasma Kallikrein
Donadio et al. Alkylation of amide linkages and cleavage of the C chain in the enzyme-activated-substrate inhibition of. alpha.-chymotrypsin with N-nitrosamides
Monder et al. Studies on the non-enzymic conversion of dopa to melanin. III. The inhibition and mechanism of inhibition of dopa autoxidation by human blood plasma
TH19245A (th) วิธีป้องกันการสลายของโปรตีนซี
JPH0195779A (ja) 安定な酵素組成物および酵素組成物の安定化方法
CA2348739A1 (en) Methods of conversion of interferon isoforms and products thereof
MORIYA et al. Biochemical Studies on Kallikreins and Their Related Substances
Ashworth Structural Studies on Bovine Carbonic Anhydrase Isozymes
JPS59169498A (ja) 分離蛋白質の染色反応の停止法
Shargool Evidence for the importance of histidine at the active site of argininosuccinate synthetase from soybean
TH27627B (th) การยับยั้งการทำงานของเชื้อโรคโดยการใช้ไฮดรอกซิเมทิลเอมีน
SK124699A3 (en) Activated vitamin k-dependent blood factor and method for the production thereof