NO950018L - Fremgangsmåte for å forebygge nedbrytning av protein C - Google Patents

Fremgangsmåte for å forebygge nedbrytning av protein C

Info

Publication number
NO950018L
NO950018L NO950018A NO950018A NO950018L NO 950018 L NO950018 L NO 950018L NO 950018 A NO950018 A NO 950018A NO 950018 A NO950018 A NO 950018A NO 950018 L NO950018 L NO 950018L
Authority
NO
Norway
Prior art keywords
apc
degradation
autodegradation
denaturant
incubating
Prior art date
Application number
NO950018A
Other languages
English (en)
Other versions
NO950018D0 (no
NO320157B1 (no
Inventor
Jr Walter Francis Prouty
Josephine Secnik
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22650141&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO950018(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO950018D0 publication Critical patent/NO950018D0/no
Publication of NO950018L publication Critical patent/NO950018L/no
Publication of NO320157B1 publication Critical patent/NO320157B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
NO19950018A 1994-01-05 1995-01-03 Fremgangsmate for a minimalisere nedbrytning av aktivert protein C, samt stabilt farmasoytisk preparat omfattende aktivert protein C og vandig opplosning av dette. NO320157B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17783294A 1994-01-05 1994-01-05

Publications (3)

Publication Number Publication Date
NO950018D0 NO950018D0 (no) 1995-01-03
NO950018L true NO950018L (no) 1995-07-06
NO320157B1 NO320157B1 (no) 2005-11-07

Family

ID=22650141

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19950018A NO320157B1 (no) 1994-01-05 1995-01-03 Fremgangsmate for a minimalisere nedbrytning av aktivert protein C, samt stabilt farmasoytisk preparat omfattende aktivert protein C og vandig opplosning av dette.
NO2006006C NO2006006I1 (no) 1994-01-05 2006-05-02 Aktivert protein C

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2006006C NO2006006I1 (no) 1994-01-05 2006-05-02 Aktivert protein C

Country Status (29)

Country Link
EP (2) EP0662513B1 (no)
JP (1) JP3778588B2 (no)
KR (1) KR950032287A (no)
CN (1) CN1109891A (no)
AT (1) ATE201045T1 (no)
AU (1) AU1003195A (no)
BR (1) BR9500017A (no)
CA (1) CA2139468C (no)
CO (1) CO4600680A1 (no)
CZ (1) CZ1395A3 (no)
DE (2) DE10299053I2 (no)
DK (1) DK0662513T3 (no)
ES (1) ES2156190T3 (no)
FI (1) FI115635B (no)
GR (1) GR3036277T3 (no)
HU (1) HUT70465A (no)
IL (1) IL112236A (no)
LU (2) LU90993I2 (no)
NL (1) NL300108I2 (no)
NO (2) NO320157B1 (no)
NZ (1) NZ270271A (no)
PE (1) PE43995A1 (no)
PL (1) PL180703B1 (no)
PT (1) PT662513E (no)
RU (1) RU2167936C2 (no)
SI (1) SI0662513T1 (no)
UA (1) UA39178C2 (no)
YU (1) YU295A (no)
ZA (1) ZA9514B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1557463A1 (en) * 1997-04-28 2005-07-27 Eli Lilly & Company Improved methods for processing activated protein C
BR9809304B1 (pt) * 1997-04-28 2011-02-08 formulação liofilizada estável, processo para preparação da mesma, bem como forma de dosagem unitária.
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
US7204981B2 (en) 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
WO2001089558A2 (en) 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c

Also Published As

Publication number Publication date
IL112236A (en) 1999-12-31
EP0662513B1 (en) 2001-05-09
NL300108I1 (nl) 2003-02-03
CA2139468C (en) 2007-08-21
LU90993I2 (fr) 2003-02-18
NL300108I2 (nl) 2003-06-02
SI0662513T1 (en) 2001-10-31
DE69520844T2 (de) 2001-11-08
FI950044A0 (fi) 1995-01-04
BR9500017A (pt) 1995-10-03
DE69520844D1 (de) 2001-06-13
AU1003195A (en) 1995-07-13
CZ1395A3 (en) 1995-07-12
PE43995A1 (es) 1995-12-15
NO2006006I1 (no) 2006-05-15
IL112236A0 (en) 1995-03-30
RU95100178A (ru) 1997-03-27
DE10299053I1 (de) 2003-05-22
JPH07206704A (ja) 1995-08-08
YU295A (sh) 1997-09-30
PL180703B1 (pl) 2001-03-30
FI950044A (fi) 1995-07-06
NO950018D0 (no) 1995-01-03
HUT70465A (en) 1995-10-30
CA2139468A1 (en) 1995-07-06
PT662513E (pt) 2001-08-30
DE10299053I2 (de) 2004-04-01
FI115635B (fi) 2005-06-15
DK0662513T3 (da) 2001-05-28
GR3036277T3 (en) 2001-10-31
CO4600680A1 (es) 1998-05-08
ATE201045T1 (de) 2001-05-15
UA39178C2 (uk) 2001-06-15
LU90992I2 (fr) 2003-02-18
NZ270271A (en) 1996-07-26
EP0662513A1 (en) 1995-07-12
CN1109891A (zh) 1995-10-11
KR950032287A (ko) 1995-12-20
HU9500021D0 (en) 1995-03-28
RU2167936C2 (ru) 2001-05-27
EP1087011A3 (en) 2002-02-06
EP1087011A2 (en) 2001-03-28
ES2156190T3 (es) 2001-06-16
NO320157B1 (no) 2005-11-07
ZA9514B (en) 1996-07-03
PL306671A1 (en) 1995-07-10
JP3778588B2 (ja) 2006-05-24

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Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: XIGRIS (DROTRECOGIN ALFA); NAT. REG. NO/DATE: EU102225001 20020913; FIRST ERG. NO/DATE: EU , 5590801 20020627

Spc suppl protection certif: 2006006

Filing date: 20060502

MM1K Lapsed by not paying the annual fees