UA26375A1 - Спосіб очищеhhя іhсуліhу - Google Patents

Спосіб очищеhhя іhсуліhу

Info

Publication number
UA26375A1
UA26375A1 UA5001389A UA5001389A UA26375A1 UA 26375 A1 UA26375 A1 UA 26375A1 UA 5001389 A UA5001389 A UA 5001389A UA 5001389 A UA5001389 A UA 5001389A UA 26375 A1 UA26375 A1 UA 26375A1
Authority
UA
Ukraine
Prior art keywords
purification
ishulih
insulin
chromatography
derivative
Prior art date
Application number
UA5001389A
Other languages
English (en)
Russian (ru)
Inventor
Райнер Дікхардт
Райнер Дикхардт
Бернхард УHГЕР
Леонард ХЕФHЕР
Original Assignee
Хьохст Актієhгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хьохст Актієhгезельшафт filed Critical Хьохст Актієhгезельшафт
Publication of UA26375A1 publication Critical patent/UA26375A1/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Спосіб очищення інсуліну і/або його похідних оснований на хроматографії у водному буферному середовищі, що містить органічний розчинник, який змішується з водою. Використовується середовище з розчиненими в ній амфотерними іонами і переважно із значенням pH, яке знаходиться близько ізоелектричної точки інсуліну, що очищається, або його похідного.
UA5001389A 1990-09-05 1991-09-03 Спосіб очищеhhя іhсуліhу UA26375A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028120A DE4028120C2 (de) 1990-09-05 1990-09-05 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Publications (1)

Publication Number Publication Date
UA26375A1 true UA26375A1 (uk) 1999-08-30

Family

ID=6413631

Family Applications (1)

Application Number Title Priority Date Filing Date
UA5001389A UA26375A1 (uk) 1990-09-05 1991-09-03 Спосіб очищеhhя іhсуліhу

Country Status (28)

Country Link
US (1) US5245008A (uk)
EP (1) EP0474213B1 (uk)
JP (1) JP3161770B2 (uk)
KR (1) KR100191699B1 (uk)
AT (1) ATE128145T1 (uk)
AU (1) AU637255B2 (uk)
CA (1) CA2050644C (uk)
CZ (1) CZ283356B6 (uk)
DE (2) DE4028120C2 (uk)
DK (1) DK0474213T3 (uk)
ES (1) ES2078405T3 (uk)
FI (1) FI98216C (uk)
GR (1) GR3017750T3 (uk)
HR (1) HRP940716B1 (uk)
HU (1) HU207100B (uk)
IE (1) IE68956B1 (uk)
IL (1) IL99384A (uk)
LT (1) LT3329B (uk)
LV (1) LV10105B (uk)
NO (1) NO180681C (uk)
NZ (1) NZ239650A (uk)
PL (1) PL168114B1 (uk)
PT (1) PT98864B (uk)
RU (1) RU2037500C1 (uk)
SK (1) SK278099B6 (uk)
UA (1) UA26375A1 (uk)
YU (1) YU147591A (uk)
ZA (1) ZA917006B (uk)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG44748A1 (en) * 1991-12-18 1997-12-19 Hoechst Ag Process for obtaining insulin-containing solutions
JP3279362B2 (ja) * 1992-10-05 2002-04-30 井上 聰一 糖尿病判定方法及び糖尿病判定装置
JP3319812B2 (ja) * 1993-04-05 2002-09-03 井上 聰一 リウマチ判定方法及びリウマチ判定装置
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US6248683B1 (en) * 1999-04-07 2001-06-19 Silicycle Inc. Process for the regeneration of used silica gel
US7309581B2 (en) * 2000-11-01 2007-12-18 Sysmex Corporation Method of staining, detection and counting bacteria, and a diluent for bacterial stain
KR101198346B1 (ko) * 2003-04-08 2012-11-06 노보 노르디스크 에이/에스 크로마토그래피 고정상의 재생
MX287895B (es) * 2003-04-08 2011-06-30 Novo Nordisk As Regeneracion de fases estacionarias cromatograficas.
RU2251426C1 (ru) * 2003-09-18 2005-05-10 Цыганков Владимир Владимирович Способ получения инсулина из природного источника и инсулин
KR101002296B1 (ko) * 2005-07-06 2010-12-20 주식회사 코오롱 전방향족 폴리아미드 필라멘트의 제조방법
GB0524782D0 (en) * 2005-12-05 2006-01-11 Chiron Srl Analysis of samples
JP5781308B2 (ja) * 2008-02-19 2015-09-16 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 異種タンパク質を得る方法およびインスリン類似体
WO2011021210A1 (en) * 2009-07-09 2011-02-24 Biocon Limited A preparative non-linear gradient based chromatographic method and purified products thereof
MX346473B (es) * 2009-08-11 2017-03-22 Biocon Ltd Procesos cromatograficos y compuestos purificados de los mismos.
WO2011107447A1 (en) * 2010-03-01 2011-09-09 Novo Nordisk A/S Preparative rp-hplc method for purifying peptides
EP2570183A1 (en) 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
WO2016014325A1 (en) 2014-07-21 2016-01-28 Merck Sharp & Dohme Corp. Chromatography process for purification of inlsulin and insulin analogs
CN115505035B (zh) * 2022-08-22 2023-09-05 南京汉欣医药科技有限公司 一种司美格鲁肽中间体多肽的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DE3147842A1 (de) * 1981-12-03 1983-06-23 Hoechst Ag, 6230 Frankfurt "verfahren zur trennung von gemischen aus insulin, insulinderivaten und gegebenenfalls verunreinigungen"
GB2119248A (en) * 1982-04-28 1983-11-16 John Kenneth Mcmullen Insulin formulations and method of producing them
WO1989001485A1 (en) * 1987-08-14 1989-02-23 Gebro Broschek Kg Purification of raw peptides by preparative medium-pressure liquid chromatography

Also Published As

Publication number Publication date
AU637255B2 (en) 1993-05-20
DE4028120C2 (de) 1996-09-19
CZ283356B6 (cs) 1998-03-18
KR920006372A (ko) 1992-04-27
US5245008A (en) 1993-09-14
EP0474213A1 (de) 1992-03-11
CA2050644C (en) 2001-11-27
PL168114B1 (pl) 1996-01-31
HRP940716A2 (en) 1997-06-30
EP0474213B1 (de) 1995-09-20
FI914150A0 (fi) 1991-09-03
IL99384A0 (en) 1992-08-18
NO913476L (no) 1992-03-06
NO180681C (no) 1997-05-28
KR100191699B1 (ko) 1999-06-15
RU2037500C1 (ru) 1995-06-19
LT3329B (en) 1995-07-25
DE59106519D1 (de) 1995-10-26
ES2078405T3 (es) 1995-12-16
JPH04230699A (ja) 1992-08-19
LV10105A (lv) 1994-05-10
PT98864B (pt) 1999-02-26
FI914150A (fi) 1992-03-06
IE68956B1 (en) 1996-07-24
NO180681B (no) 1997-02-17
DK0474213T3 (da) 1996-01-15
CA2050644A1 (en) 1992-03-06
HUT59418A (en) 1992-05-28
JP3161770B2 (ja) 2001-04-25
IL99384A (en) 1995-05-26
FI98216C (fi) 1997-05-12
NO913476D0 (no) 1991-09-04
PL291616A1 (en) 1992-03-09
GR3017750T3 (en) 1996-01-31
CS271791A3 (en) 1992-03-18
ATE128145T1 (de) 1995-10-15
AU8356891A (en) 1992-03-12
NZ239650A (en) 1992-09-25
ZA917006B (en) 1992-04-29
LV10105B (en) 1995-04-20
PT98864A (pt) 1992-07-31
FI98216B (fi) 1997-01-31
SK278099B6 (en) 1996-01-10
DE4028120A1 (de) 1992-03-12
IE913115A1 (en) 1992-03-11
HU207100B (en) 1993-03-01
HRP940716B1 (en) 1999-12-31
YU147591A (sh) 1995-10-24
LTIP713A (en) 1995-01-31

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