FI98216B - Menetelmä insuliinien puhdistamiseksi kromatografisesti - Google Patents

Menetelmä insuliinien puhdistamiseksi kromatografisesti

Info

Publication number
FI98216B
FI98216B FI914150A FI914150A FI98216B FI 98216 B FI98216 B FI 98216B FI 914150 A FI914150 A FI 914150A FI 914150 A FI914150 A FI 914150A FI 98216 B FI98216 B FI 98216B
Authority
FI
Finland
Prior art keywords
insulin
chromatography
purification
zwitterions
aqueous buffered
Prior art date
Application number
FI914150A
Other languages
English (en)
Swedish (sv)
Other versions
FI98216C (fi
FI914150A0 (fi
FI914150A (fi
Inventor
Rainer Dickhardt
Bernhard Unger
Leonard Haefner
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI914150A0 publication Critical patent/FI914150A0/fi
Publication of FI914150A publication Critical patent/FI914150A/fi
Application granted granted Critical
Publication of FI98216B publication Critical patent/FI98216B/fi
Publication of FI98216C publication Critical patent/FI98216C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
FI914150A 1990-09-05 1991-09-03 Menetelmä insuliinien puhdistamiseksi kromatografisesti FI98216C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4028120A DE4028120C2 (de) 1990-09-05 1990-09-05 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE4028120 1990-09-05

Publications (4)

Publication Number Publication Date
FI914150A0 FI914150A0 (fi) 1991-09-03
FI914150A FI914150A (fi) 1992-03-06
FI98216B true FI98216B (fi) 1997-01-31
FI98216C FI98216C (fi) 1997-05-12

Family

ID=6413631

Family Applications (1)

Application Number Title Priority Date Filing Date
FI914150A FI98216C (fi) 1990-09-05 1991-09-03 Menetelmä insuliinien puhdistamiseksi kromatografisesti

Country Status (28)

Country Link
US (1) US5245008A (fi)
EP (1) EP0474213B1 (fi)
JP (1) JP3161770B2 (fi)
KR (1) KR100191699B1 (fi)
AT (1) ATE128145T1 (fi)
AU (1) AU637255B2 (fi)
CA (1) CA2050644C (fi)
CZ (1) CZ283356B6 (fi)
DE (2) DE4028120C2 (fi)
DK (1) DK0474213T3 (fi)
ES (1) ES2078405T3 (fi)
FI (1) FI98216C (fi)
GR (1) GR3017750T3 (fi)
HR (1) HRP940716B1 (fi)
HU (1) HU207100B (fi)
IE (1) IE68956B1 (fi)
IL (1) IL99384A (fi)
LT (1) LT3329B (fi)
LV (1) LV10105B (fi)
NO (1) NO180681C (fi)
NZ (1) NZ239650A (fi)
PL (1) PL168114B1 (fi)
PT (1) PT98864B (fi)
RU (1) RU2037500C1 (fi)
SK (1) SK278099B6 (fi)
UA (1) UA26375A1 (fi)
YU (1) YU147591A (fi)
ZA (1) ZA917006B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59208181D1 (de) * 1991-12-18 1997-04-17 Hoechst Ag Verfahren zur Gewinnung von insulinhaltigen Lösungen
JP3279362B2 (ja) * 1992-10-05 2002-04-30 井上 聰一 糖尿病判定方法及び糖尿病判定装置
JP3319812B2 (ja) * 1993-04-05 2002-09-03 井上 聰一 リウマチ判定方法及びリウマチ判定装置
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US6248683B1 (en) * 1999-04-07 2001-06-19 Silicycle Inc. Process for the regeneration of used silica gel
US7309581B2 (en) * 2000-11-01 2007-12-18 Sysmex Corporation Method of staining, detection and counting bacteria, and a diluent for bacterial stain
BRPI0408978B8 (pt) * 2003-04-08 2021-07-27 Novo Nordisk As processos para regenerar uma fase estacionária cromatográfica
MX287895B (es) * 2003-04-08 2011-06-30 Novo Nordisk As Regeneracion de fases estacionarias cromatograficas.
RU2251426C1 (ru) * 2003-09-18 2005-05-10 Цыганков Владимир Владимирович Способ получения инсулина из природного источника и инсулин
KR101002296B1 (ko) * 2005-07-06 2010-12-20 주식회사 코오롱 전방향족 폴리아미드 필라멘트의 제조방법
GB0524782D0 (en) * 2005-12-05 2006-01-11 Chiron Srl Analysis of samples
CN102015762B (zh) * 2008-02-19 2015-03-18 百康有限公司 获得纯化的生物活性异源蛋白的方法
CA2766571A1 (en) * 2009-07-09 2011-02-24 Biocon Limited A preparative non-linear gradient based chromatographic method and purified products thereof
CN102471368A (zh) * 2009-08-11 2012-05-23 拜康有限公司 色谱方法及其纯化的化合物
US9422330B2 (en) 2010-03-01 2016-08-23 Novo Nordisk A/S Preparative RP-HPLC method for purifying peptides
EP2570183A1 (en) 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN115505035B (zh) * 2022-08-22 2023-09-05 南京汉欣医药科技有限公司 一种司美格鲁肽中间体多肽的纯化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
DE3147842A1 (de) * 1981-12-03 1983-06-23 Hoechst Ag, 6230 Frankfurt "verfahren zur trennung von gemischen aus insulin, insulinderivaten und gegebenenfalls verunreinigungen"
GB2119248A (en) * 1982-04-28 1983-11-16 John Kenneth Mcmullen Insulin formulations and method of producing them
WO1989001485A1 (en) * 1987-08-14 1989-02-23 Gebro Broschek Kg Purification of raw peptides by preparative medium-pressure liquid chromatography

Also Published As

Publication number Publication date
EP0474213A1 (de) 1992-03-11
FI98216C (fi) 1997-05-12
HRP940716B1 (en) 1999-12-31
KR100191699B1 (ko) 1999-06-15
FI914150A0 (fi) 1991-09-03
SK278099B6 (en) 1996-01-10
NZ239650A (en) 1992-09-25
KR920006372A (ko) 1992-04-27
PL168114B1 (pl) 1996-01-31
CZ283356B6 (cs) 1998-03-18
JP3161770B2 (ja) 2001-04-25
NO913476L (no) 1992-03-06
ATE128145T1 (de) 1995-10-15
PT98864B (pt) 1999-02-26
AU637255B2 (en) 1993-05-20
ZA917006B (en) 1992-04-29
NO180681B (no) 1997-02-17
GR3017750T3 (en) 1996-01-31
IL99384A0 (en) 1992-08-18
IE913115A1 (en) 1992-03-11
HU207100B (en) 1993-03-01
DE4028120C2 (de) 1996-09-19
CA2050644A1 (en) 1992-03-06
LV10105B (en) 1995-04-20
HUT59418A (en) 1992-05-28
CS271791A3 (en) 1992-03-18
UA26375A1 (uk) 1999-08-30
JPH04230699A (ja) 1992-08-19
IE68956B1 (en) 1996-07-24
IL99384A (en) 1995-05-26
LT3329B (en) 1995-07-25
FI914150A (fi) 1992-03-06
HRP940716A2 (en) 1997-06-30
YU147591A (sh) 1995-10-24
EP0474213B1 (de) 1995-09-20
PT98864A (pt) 1992-07-31
NO180681C (no) 1997-05-28
PL291616A1 (en) 1992-03-09
DK0474213T3 (da) 1996-01-15
CA2050644C (en) 2001-11-27
ES2078405T3 (es) 1995-12-16
AU8356891A (en) 1992-03-12
DE4028120A1 (de) 1992-03-12
DE59106519D1 (de) 1995-10-26
LV10105A (lv) 1994-05-10
NO913476D0 (no) 1991-09-04
RU2037500C1 (ru) 1995-06-19
LTIP713A (en) 1995-01-31
US5245008A (en) 1993-09-14

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Legal Events

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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH

Free format text: SANOFI-AVENTIS DEUTSCHLAND GMBH

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