DK0649651T3 - Fremstilling af bløde gelatinekapsler - Google Patents

Fremstilling af bløde gelatinekapsler

Info

Publication number
DK0649651T3
DK0649651T3 DK94115081T DK94115081T DK0649651T3 DK 0649651 T3 DK0649651 T3 DK 0649651T3 DK 94115081 T DK94115081 T DK 94115081T DK 94115081 T DK94115081 T DK 94115081T DK 0649651 T3 DK0649651 T3 DK 0649651T3
Authority
DK
Denmark
Prior art keywords
soft gelatin
gelatin capsules
preparation
solvent
capsules
Prior art date
Application number
DK94115081T
Other languages
Danish (da)
English (en)
Inventor
Werner Brox
Horst Zande
Armin Dr Meinzer
Original Assignee
Scherer Gmbh R P
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6498793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0649651(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scherer Gmbh R P, Novartis Ag filed Critical Scherer Gmbh R P
Application granted granted Critical
Publication of DK0649651T3 publication Critical patent/DK0649651T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Cosmetics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
DK94115081T 1993-09-28 1994-09-24 Fremstilling af bløde gelatinekapsler DK0649651T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4332931 1993-09-28

Publications (1)

Publication Number Publication Date
DK0649651T3 true DK0649651T3 (da) 2001-02-26

Family

ID=6498793

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00103110.3T DK1033128T4 (da) 1993-09-28 1994-09-24 Blød gelatinekapselfremstilling
DK94115081T DK0649651T3 (da) 1993-09-28 1994-09-24 Fremstilling af bløde gelatinekapsler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK00103110.3T DK1033128T4 (da) 1993-09-28 1994-09-24 Blød gelatinekapselfremstilling

Country Status (31)

Country Link
US (4) US5985321A (de)
EP (3) EP0649651B1 (de)
JP (1) JP3071642B2 (de)
KR (1) KR100200174B1 (de)
CN (2) CN1182842C (de)
AT (2) ATE398448T1 (de)
AU (1) AU690571B2 (de)
CA (3) CA2332631C (de)
CZ (1) CZ290314B6 (de)
DE (2) DE69426408T2 (de)
DK (2) DK1033128T4 (de)
ES (2) ES2308955T5 (de)
FI (1) FI120718B (de)
FR (1) FR2710532B1 (de)
GB (1) GB2282586B (de)
GR (1) GR3035179T3 (de)
HK (1) HK1078478A1 (de)
HU (2) HU228201B1 (de)
IL (1) IL111067A (de)
IT (1) IT1274931B (de)
NO (1) NO312334B1 (de)
NZ (1) NZ264536A (de)
PE (1) PE31295A1 (de)
PL (1) PL178884B1 (de)
PT (2) PT649651E (de)
RU (1) RU2140783C1 (de)
SG (1) SG46531A1 (de)
SI (2) SI0649651T1 (de)
SK (2) SK285204B6 (de)
TW (1) TW438609B (de)
ZA (1) ZA947567B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2083846T3 (es) * 1992-01-17 1996-04-16 Alfatec Pharma Gmbh Procedimiento para fabricar capsulas de gelatina blanda por un procedimiento de goteo.
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
DE69426408T2 (de) * 1993-09-28 2001-07-12 Novartis Ag, Basel Herstellung von Weichgelatinekapseln
PE52896A1 (es) * 1994-10-26 1996-12-12 Novartis Ag Composicion farmaceutica
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
US7205279B2 (en) * 1995-10-25 2007-04-17 Novartis Ag Pharmaceutical compositions
US5603951A (en) * 1994-11-09 1997-02-18 Hanmi Pharm. Ind. Co., Ltd. Cyclosporin-containing soft capsule compositions
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
JPH1071186A (ja) * 1996-08-29 1998-03-17 Shionogi & Co Ltd カプセルのバンドシール形成方法
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag, Basel Pharmazeutische Zusammensetzungen
ATE262916T1 (de) * 1998-08-18 2004-04-15 Panacea Biotec Ltd Zusammensetzung enthalten cyclsoporin in einem hydrophilen träger
KR100446118B1 (ko) * 1998-11-17 2004-08-30 에프. 호프만-라 로슈 아게 액체 충전된 캡슐의 제조 방법
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US20030104048A1 (en) * 1999-02-26 2003-06-05 Lipocine, Inc. Pharmaceutical dosage forms for highly hydrophilic materials
PT1200090E (pt) 1999-08-03 2013-11-25 Icos Corp Formulação farmacêutica à base de um beta-carbolina e seu uso para tratar a disfunção sexual.
JP4601100B2 (ja) * 1999-11-08 2010-12-22 三生医薬株式会社 マスティックの油液を内包した軟カプセル
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2001225459B2 (en) * 2000-09-18 2005-12-22 Rpg Life Sciences Limited Selfemulsifiable formulation having enhanced bioabsorption and immunosuppression activities
SI1292281T1 (en) * 2000-10-12 2004-12-31 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
EE200300201A (et) * 2000-10-31 2003-08-15 Boehringer Ingelheim Pharmaceuticals, Inc. Püranoonsete proteaasi inhibiitorite iseemulgeeruva kompositsiooni oraalne doos
JP4214350B2 (ja) * 2001-01-15 2009-01-28 日本電気株式会社 携帯電話のｓｉｍカード取り付け構造
US20030138483A1 (en) * 2001-05-25 2003-07-24 Sergio Petriconi Soft elastic capsules and compositions thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US20040013732A1 (en) * 2001-09-25 2004-01-22 Michael Farber Starch-based delivery system for creatine
EP1435910B9 (de) * 2001-10-19 2010-02-03 Isotechnika Inc. Neue cyclosporin-analoge mikroemulsionsvorkonzentrate
US6752953B2 (en) * 2001-12-03 2004-06-22 Yung Shin Pharmaceutical Co., Ltd. Method for manufacturing hard non-gelatin pharmaceutical capsules
KR20030062894A (ko) * 2002-01-21 2003-07-28 주식회사 보창 소프트젤라틴캡슐제조기의 성형드럼 냉각장치
US7067150B2 (en) 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
ATE373472T1 (de) * 2002-07-29 2007-10-15 Alza Corp Verfahren und dosierformen für die kontrollierte abgabe von paliperidon
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
US7134978B2 (en) * 2003-07-28 2006-11-14 Sagittarius Life Science Corporation Seamless BB paintball
US7247010B2 (en) * 2003-10-01 2007-07-24 Technophar Equipment & Service Limited Servo control for capsule making machine
FR2861992B1 (fr) * 2003-11-10 2007-07-20 Sanofi Synthelabo Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide.
WO2005104674A2 (en) * 2003-11-12 2005-11-10 National Paintball Supply, Inc. Projectile, projectile core, and method of making
US20050175686A1 (en) * 2004-02-11 2005-08-11 Ramachandran Radhakrishnan Drug delivery system using a solubilized gelatin shell composition and unit dose drug delivery using a special shape soft gelatin capsule
JP2005255677A (ja) * 2004-02-12 2005-09-22 Nof Corp シクロスポリン製剤
US20080160086A1 (en) * 2004-02-19 2008-07-03 Scepter Holdings, Inc. Delivery Systems For Calcium
US20060153824A1 (en) * 2005-01-13 2006-07-13 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
ES2573539T3 (es) 2005-03-21 2016-06-08 Teva Czech Industries S.R.O. Inhibidor de la cristalización y su uso en cápsulas de gelatina
US20060275361A1 (en) * 2005-06-03 2006-12-07 Cadbury Adams Usa Llc. Rapidly dissolving gelatin compositions and products made therefrom
EP1962839A4 (de) 2005-11-14 2010-08-25 Ariad Pharma Inc Verabreichung von mntor-inhibitoren zur behandlung von krebspatienten
CN1919194A (zh) * 2006-08-17 2007-02-28 刘瑜玲 西罗莫司的液体组合物
WO2008106787A1 (en) * 2007-03-06 2008-09-12 Bioriginal Food & Science Corporation Soft gelatin capsule shells containing oil soluble flavoring and methods of making the same
US20090110724A1 (en) * 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of pain
ES2474992T3 (es) 2008-09-16 2014-07-10 Boehringer Ingelheim International Gmbh Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de HCV
CA2743491C (en) 2008-11-11 2016-10-11 Zelton Dave Sharp Inhibition of mammalian target of rapamycin
KR101685941B1 (ko) 2009-07-07 2016-12-13 베링거 인겔하임 인터내셔날 게엠베하 Ｃ형 간염 바이러스 프로테아제 억제제를 위한 약제학적 조성물
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
GB201006012D0 (en) * 2010-04-09 2010-05-26 Ayanda As Composition
CA2817959A1 (en) * 2010-07-19 2012-01-26 Procaps Sa Improved apparatus and process for making soft gel capsules
WO2012044520A1 (en) 2010-09-30 2012-04-05 Boehringer Ingelheim International Gmbh Solid state forms of a potent hcv inhibitor
US20120107395A1 (en) * 2010-11-01 2012-05-03 Viva Pharmaceutical Inc. Probiotic Soft Gel Compositions
US8621764B2 (en) 2011-03-16 2014-01-07 John PUCKETT Gelatin capsule formulation and drying system
WO2012138669A1 (en) 2011-04-04 2012-10-11 Gilead Sciences, Inc. Solid state forms of hiv inhibitor
JP2013063970A (ja) * 2011-09-02 2013-04-11 Fujifilm Corp ソフトカプセル製剤、ソフトカプセル製剤用組成物、及びソフトカプセル製剤の製造方法
US20130261134A1 (en) 2012-03-30 2013-10-03 Boehringer Ingelheim International Gmbh Mesylate salt forms of a potent hcv inhibitor
WO2014055618A1 (en) 2012-10-03 2014-04-10 Gilead Sciences, Inc. Solid state forms of hiv inhibitor: hemi-succinate of (2s)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid)
US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
CN103315975B (zh) * 2013-06-05 2015-09-02 天津科技大学 一种明胶-CaCO3矿物质胶囊壳及其制备方法
WO2015013397A2 (en) * 2013-07-25 2015-01-29 Neuren Pharmaceuticals Limited Neuroprotective bicyclic compounds and methods for their use in treating autism spectrum disorders and neurodevelopmental disorders
CA3206208A1 (en) 2013-12-31 2015-07-09 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
EP3337463A4 (de) * 2015-08-19 2019-04-03 Vivus, Inc. Pharmazeutische formulierungen
CN112240659A (zh) * 2020-10-17 2021-01-19 温州桑盾信息科技有限公司 一种胶囊机安全防护用自动降温机构

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198391A (en) * 1973-07-20 1980-04-15 R. P. Scherer Ltd. Pharmaceutical compositions
US3870547A (en) 1974-01-24 1975-03-11 Owens Corning Fiberglass Corp Starch coated fibers for embedding in resin matrix forming materials and composites so formed
AT366576B (de) * 1974-02-22 1982-04-26 Wellcome Found Verfahren zur herstellung von pharmazeutischen praeparaten
GB1508770A (en) 1974-04-01 1978-04-26 Scherer Ltd R Pharmaceutical compositions
US4067960A (en) * 1975-06-20 1978-01-10 R. P. Scherer Limited Pharmaceutical compositions containing cardiac glycoside
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
JPS5933018B2 (ja) * 1980-03-17 1984-08-13 森下仁丹株式会社 高融点物質のマイクロカプセル製造方法とその製造装置
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
DE3307353C2 (de) 1983-03-02 1985-01-31 R.P. Scherer GmbH, 6930 Eberbach Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung
GB8305693D0 (en) * 1983-03-02 1983-04-07 Scherer Ltd R P Pharmaceutical compositions
DE3406497A1 (de) 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US4609403A (en) * 1984-03-12 1986-09-02 Warner-Lambert Company Foam soft gelatin capsules and their method of manufacture
US4713246A (en) 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
DE3579384D1 (de) * 1984-07-24 1990-10-04 Scherer Gmbh R P Oxytetracyclin-hc1-weichgelatinekapseln und verfahren zu ihrer herstellung.
DE3445237C1 (de) * 1984-12-12 1986-06-05 R.P. Scherer GmbH, 6930 Eberbach Weichgelatinekapseln und Verfahren zu ihrer Herstellung
DE3529694A1 (de) 1985-08-20 1987-02-26 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
JPS62207460A (ja) 1986-03-07 1987-09-11 株式会社三協 ゼラチンカプセルの製造装置におけるゼラチンシ−ト成型装置
EP0240581B1 (de) 1986-04-05 1991-01-02 R.P. Scherer GmbH Gelatinekapseln mit gesteuerter Wirkstofffreisetzung und Verfahren zur Herstellung derselben
DE3629386A1 (de) * 1986-08-29 1988-03-03 Scherer Gmbh R P Gelatinekapseln und verfahren zu ihrer herstellung
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
JPS63309264A (ja) 1987-06-10 1988-12-16 Kamata Seisakusho:Kk ソフトカプセル製造機
US4817367A (en) * 1987-08-10 1989-04-04 Sankyo Co., Ltd. Apparatus for manufacturing gelatin capsule and method therefor
GB8721455D0 (en) 1987-09-11 1987-10-21 Lilly Industries Ltd Capsules
HU205010B (en) * 1987-09-15 1992-03-30 Sandoz Ag Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity
DE68900991D1 (de) * 1988-01-29 1992-04-23 Sankyo Co Cyclosporin-zusammensetzungen.
US5376381A (en) * 1988-02-25 1994-12-27 The Liposome Company, Inc. Integrity protected gelatin
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US4935293A (en) 1988-10-25 1990-06-19 Unifi, Inc. Continuous multi-filament polyester substrate readily adherable to a vinyl sheet
US4935243A (en) * 1988-12-19 1990-06-19 Pharmacaps, Inc. Chewable, edible soft gelatin capsule
WO1991002520A1 (en) * 1989-08-17 1991-03-07 Cortecs Limited Pharmaceutical formulations
US5532002A (en) * 1989-08-17 1996-07-02 Cortecs Limited Gelatin pharmaceutical formulations
US5178877A (en) * 1991-01-04 1993-01-12 Abbott Laboratories Encapsulated renin inhibitor composition
US6262022B1 (en) * 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
US5224294A (en) * 1991-07-25 1993-07-06 E. I. Du Pont De Nemours And Company Hydroponic growth system
US5200191A (en) * 1991-09-11 1993-04-06 Banner Gelatin Products Corp. Softgel manufacturing process
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
DE4201178C2 (de) * 1992-01-17 1995-12-07 Alfatec Pharma Gmbh Verfahren zur Herstellung von Weichgelatinekapseln nach einem Tropfverfahren
EP0573978B1 (de) * 1992-06-12 1999-04-21 Kao Corporation Badezusatzzusammensetzung enthaltend oberflächenaktive Mittel enthaltende nahtlose Kapsel und Verfahren zur Herrstellung der Kapsel
US5626872A (en) * 1992-06-16 1997-05-06 Roemmers S.A.I.C.F. Pharmaceutical soft capsules containing lysine clonixinate and a process for their preparation
SK278290B6 (en) 1992-09-07 1996-08-07 Milan Stuchlik Medicaments with n-methylated cyclic undecapeptides
US5376293A (en) * 1992-09-14 1994-12-27 State Of South Dakota As Represented By The Department Of Transportation Deicer
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
JPH06157916A (ja) 1992-11-30 1994-06-07 Warner Lambert Kk カプセル硬皮膜組成物
US5376688A (en) * 1992-12-18 1994-12-27 R. P. Scherer Corporation Enhanced solubility pharmaceutical solutions
US5431916A (en) * 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
CN1077800C (zh) 1993-07-01 2002-01-16 韩美药品工业株式会社 环孢菌素软胶囊组合物
US5505961A (en) * 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution
US6204243B1 (en) * 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
IL110752A (en) * 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
DE69426408T2 (de) * 1993-09-28 2001-07-12 Novartis Ag, Basel Herstellung von Weichgelatinekapseln
KR0146671B1 (ko) * 1994-02-25 1998-08-17 김충환 사이클로스포린-함유 분말 조성물
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US5614217A (en) * 1995-06-07 1997-03-25 R.P. Scherer Corporation Capsule shell formulation to produce brittle capsules
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5958876A (en) 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
EP1208847B8 (de) * 1996-07-30 2007-02-14 Novartis AG Pharmazeutische zusammensetzungen zur behandlung der transplantatabstossung sowie der autoimmun- oder entzündlichen zustände
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
FR2755368B1 (fr) * 1996-11-04 1999-03-19 Oreal Composition rincable pour le soin de la peau

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ZA947567B (en) 1996-06-28
CN100473377C (zh) 2009-04-01
US6555132B1 (en) 2003-04-29
DE69435104D1 (de) 2008-07-31
JPH07149625A (ja) 1995-06-13
HU228201B1 (en) 2013-01-28
KR100200174B1 (ko) 1999-06-15
ITRM940613A1 (it) 1996-03-26
FI944452A0 (fi) 1994-09-26
CZ290314B6 (cs) 2002-07-17
DE69426408T2 (de) 2001-07-12
EP1033128A3 (de) 2001-02-28
DK1033128T3 (da) 2008-10-20
CN1636554A (zh) 2005-07-13
US20030206930A1 (en) 2003-11-06
US5985321A (en) 1999-11-16
CN1182842C (zh) 2005-01-05
PL305188A1 (en) 1995-04-03
HK1078478A1 (en) 2006-03-17
SK284268B6 (sk) 2004-12-01
GB2282586B (en) 1998-04-22
HUT70417A (en) 1995-10-30
ES2152281T3 (es) 2001-02-01
ES2308955T5 (es) 2012-04-03
EP1033128A2 (de) 2000-09-06
SG46531A1 (en) 1998-02-20
KR950007820A (ko) 1995-04-15
ATE398448T1 (de) 2008-07-15
CA2332631A1 (en) 1995-03-29
NO943563L (no) 1995-03-29
CN1108930A (zh) 1995-09-27
EP1033128B1 (de) 2008-06-18
AU7423794A (en) 1995-04-13
DE69426408D1 (de) 2001-01-18
IL111067A (en) 1999-12-31
PT1033128E (pt) 2008-08-08
FR2710532A1 (fr) 1995-04-07
IT1274931B (it) 1997-07-29
EP0649651A1 (de) 1995-04-26
EP1033128B2 (de) 2011-11-23
CA2332631C (en) 2002-11-19
GB9419353D0 (en) 1994-11-09
JP3071642B2 (ja) 2000-07-31
RU2140783C1 (ru) 1999-11-10
CA2132933C (en) 2000-07-18
ES2308955T3 (es) 2008-12-16
SI1033128T2 (sl) 2012-02-29
US7078054B2 (en) 2006-07-18
CA2302963C (en) 2001-10-23
RU94034106A (ru) 1996-11-10
HU9402772D0 (en) 1994-12-28
FR2710532B1 (fr) 1997-06-20
FI120718B (fi) 2010-02-15
PE31295A1 (es) 1995-10-16
FI944452A (fi) 1995-03-29
EP1029538A3 (de) 2003-10-15
US6589536B1 (en) 2003-07-08
SK285204B6 (sk) 2006-08-03
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ITRM940613A0 (it) 1994-09-26
GR3035179T3 (en) 2001-04-30
NO312334B1 (no) 2002-04-29
PT649651E (pt) 2001-03-30
NZ264536A (en) 1996-09-25
EP0649651B1 (de) 2000-12-13
AU690571B2 (en) 1998-04-30
HU0105382D0 (en) 2002-02-28
IL111067A0 (en) 1994-12-29
HU221681B1 (hu) 2002-12-28
NO943563D0 (no) 1994-09-26
SK115794A3 (en) 1995-05-10
SI1033128T1 (sl) 2009-02-28
PL178884B1 (pl) 2000-06-30
CA2302963A1 (en) 1995-03-29
ATE198041T1 (de) 2000-12-15
CA2132933A1 (en) 1995-03-29
TW438609B (en) 2001-06-07
CZ236094A3 (en) 1995-04-12

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