DK0619304T3 - 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf - Google Patents
22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0619304T3 DK0619304T3 DK93900419.8T DK93900419T DK0619304T3 DK 0619304 T3 DK0619304 T3 DK 0619304T3 DK 93900419 T DK93900419 T DK 93900419T DK 0619304 T3 DK0619304 T3 DK 0619304T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxacholecalciferol
- derivatives
- preparation
- same
- hyperparathyroidism
- Prior art date
Links
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 201000002980 Hyperparathyroidism Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36105191 | 1991-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0619304T3 true DK0619304T3 (da) | 1998-02-16 |
Family
ID=18471985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93900419.8T DK0619304T3 (da) | 1991-12-18 | 1992-12-18 | 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5436401A (enExample) |
| EP (1) | EP0619304B1 (enExample) |
| JP (1) | JP3493037B2 (enExample) |
| KR (1) | KR100247214B1 (enExample) |
| AT (1) | ATE157966T1 (enExample) |
| DE (1) | DE69222183T2 (enExample) |
| DK (1) | DK0619304T3 (enExample) |
| ES (1) | ES2107650T3 (enExample) |
| GR (1) | GR3025468T3 (enExample) |
| HK (1) | HK1002729A1 (enExample) |
| SG (1) | SG78265A1 (enExample) |
| TW (1) | TW222621B (enExample) |
| WO (1) | WO1993012083A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0210294B1 (de) * | 1985-07-30 | 1988-06-15 | Salzgitter Anlagenbau Zweigniederlassung der Preussag Anlagenbau GmbH | Verfahren und Vorrichtung zur Herstellung von Suspensionen mit konstanten Merkmalen aus Grundstoffen mit veränderlichen Eigenschaften |
| US6103709A (en) * | 1993-12-23 | 2000-08-15 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases |
| US6121469A (en) | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
| EP0764443B1 (en) * | 1994-04-19 | 2002-08-14 | Chugai Seiyaku Kabushiki Kaisha | Products for the treatment of cachexia associated with tumors |
| GB9607034D0 (en) * | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
| KR100503919B1 (ko) * | 1996-09-03 | 2005-07-27 | 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 | 비타민 디 및 스테로이드 유도체들의 합성에 사용되는 중간체들의 제조방법 |
| GB9804861D0 (en) * | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| AU4291299A (en) | 1998-07-03 | 2000-01-24 | Chugai Seiyaku Kabushiki Kaisha | Ultraviolet irradiation apparatus for photochemical reaction and method for preparing vitamin d derivative using the same |
| WO2001016099A1 (fr) * | 1999-08-27 | 2001-03-08 | Chugai Seiyaku Kabushiki Kaisha | DÉRIVÉS DE VITAMINE D AYANT DES SUBSTITUANTS À LA POSITION 2$g(a) |
| AU2001248777A1 (en) | 2000-04-19 | 2001-10-30 | Chugai Seiyaku Kabushiki Kaisha | Vitamin d derivatives |
| EP1295871B1 (en) | 2000-06-15 | 2011-05-18 | Chugai Seiyaku Kabushiki Kaisha | Vitamin d derivatives possessing a 22-oxa or 22-thia atom, a c17-side chain substituted by an acid, ester or amide group and a 16(17)-double bond |
| CN1781487A (zh) * | 2000-08-30 | 2006-06-07 | 中外制药株式会社 | Oct制剂 |
| JP2014514274A (ja) | 2011-03-09 | 2014-06-19 | テバ ファーマシューティカル インダストリーズ リミティド | マキサカルシトールの多形およびマキサカルシトールの調製方法 |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| CN103508999B (zh) | 2013-10-12 | 2015-05-13 | 浙江海正药业股份有限公司 | 马沙骨化醇的合成中间体及其制备方法和用途 |
| CN107286067A (zh) * | 2016-04-05 | 2017-10-24 | 湖南华腾制药有限公司 | 一种马沙骨化醇的制备方法 |
| JP7302918B2 (ja) | 2019-11-27 | 2023-07-04 | ヨンスン ファイン ケミカル カンパニー，リミテッド | マキサカルシトールの製造方法及びそのための中間体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61140560A (ja) * | 1984-12-12 | 1986-06-27 | Chugai Pharmaceut Co Ltd | ２０−オキサ−２１−ノルビタミンｄ３誘導体 |
| JPS61267550A (ja) * | 1984-12-28 | 1986-11-27 | Chugai Pharmaceut Co Ltd | ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体 |
| JP3050564B2 (ja) * | 1989-12-15 | 2000-06-12 | 中外製薬株式会社 | 新規な２２―オキサビタミンｄ誘導体 |
-
1992
- 1992-11-27 JP JP35436292A patent/JP3493037B2/ja not_active Expired - Fee Related
- 1992-12-18 DK DK93900419.8T patent/DK0619304T3/da active
- 1992-12-18 AT AT93900419T patent/ATE157966T1/de not_active IP Right Cessation
- 1992-12-18 DE DE69222183T patent/DE69222183T2/de not_active Expired - Fee Related
- 1992-12-18 KR KR1019940702111A patent/KR100247214B1/ko not_active Expired - Fee Related
- 1992-12-18 EP EP93900419A patent/EP0619304B1/en not_active Expired - Lifetime
- 1992-12-18 TW TW081110206A patent/TW222621B/zh active
- 1992-12-18 HK HK98101901A patent/HK1002729A1/en not_active IP Right Cessation
- 1992-12-18 US US08/244,818 patent/US5436401A/en not_active Expired - Fee Related
- 1992-12-18 SG SG1996009648A patent/SG78265A1/en unknown
- 1992-12-18 WO PCT/JP1992/001662 patent/WO1993012083A1/ja not_active Ceased
- 1992-12-18 ES ES93900419T patent/ES2107650T3/es not_active Expired - Lifetime
-
1997
- 1997-11-25 GR GR970403118T patent/GR3025468T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0619304A1 (en) | 1994-10-12 |
| DE69222183D1 (de) | 1997-10-16 |
| ATE157966T1 (de) | 1997-09-15 |
| EP0619304B1 (en) | 1997-09-10 |
| EP0619304A4 (en) | 1995-03-29 |
| KR940703807A (ko) | 1994-12-12 |
| WO1993012083A1 (fr) | 1993-06-24 |
| DE69222183T2 (de) | 1998-01-22 |
| JPH0672994A (ja) | 1994-03-15 |
| TW222621B (enExample) | 1994-04-21 |
| KR100247214B1 (ko) | 2000-03-15 |
| ES2107650T3 (es) | 1997-12-01 |
| US5436401A (en) | 1995-07-25 |
| SG78265A1 (en) | 2001-02-20 |
| HK1002729A1 (en) | 1998-09-11 |
| JP3493037B2 (ja) | 2004-02-03 |
| GR3025468T3 (en) | 1998-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0619304T3 (da) | 22-Oxacholecalciferolderivater og fremgangsmåde til fremstilling deraf | |
| ES2186672T3 (es) | Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos. | |
| ZA200110520B (en) | Pyrazole derivatives and process for producing the same, and pesticides containing the same as the active ingredient. | |
| SE8804609D0 (sv) | Adenosine derivatives | |
| NZ240676A (en) | Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof | |
| MX9606331A (es) | Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor. | |
| AU747521C (en) | Cycloalkene derivatives, process for producing the same, and use | |
| YU7086A (en) | Process for obtaining derivatives of pyrazolsulphonamide | |
| HUT59378A (en) | Process for producing urea derivatives and pharmaceutical compositions comprising such compounds | |
| DK0474243T3 (da) | 1-methylcarbapenemderivater og fremgangsmåde til fremstilling deraf | |
| NO913087L (no) | Ny tricyklisk forbindelse eller salter derav, fremgangsmaate for fremstilling derav og antimikrobielt middel inneholdende slike. | |
| HUT49349A (en) | Process for producing substituted 6-phenyldihydro-3-/2h/-pyridazinone derivatives and pharmaceutical compositions comprising such compounds | |
| DE69333223D1 (de) | Bicyclische Aminderivate | |
| DK0394889T3 (da) | Heterocycliske dioner som pesticider og plantevækstregulatorer | |
| DK0424899T3 (da) | Hidtil ukendte anthracyclinglycosidderivater og fremgangsmåde til fremstilling deraf | |
| ES526922A0 (es) | Un procedimiento para producir derivados de antraciclina | |
| GB9121943D0 (en) | Organic compounds,processes for their production and their use | |
| DK0665221T3 (da) | Vitamin D derivat og fremgangsmåde til fremstilling af dette | |
| DK480389D0 (da) | Antitumorstof, fremgangsmaade til dets fremstilling og anticancermiddel indeholdende stoffet | |
| DK1142860T3 (da) | Mellemprodukter og fremgangsmåde til fremstilling af en fluorholdig aminosyreforbindelse ved anvendelse deraf | |
| HU906407D0 (en) | Process for producing new inozine- and guanozine derivatives and pharmaceutical compositions containing them as active components | |
| MX9304444A (es) | Nuevos derivados de acido piridinecarboxilico, proceso para preparar los mismos. | |
| SE9002445D0 (sv) | Nytt cyklobutanderivat och foerfarande foer framstaellning av detsamma |