ATE157966T1 - 22-oxacholecalziferol-derivate und ihre herstellung - Google Patents
22-oxacholecalziferol-derivate und ihre herstellungInfo
- Publication number
- ATE157966T1 ATE157966T1 AT93900419T AT93900419T ATE157966T1 AT E157966 T1 ATE157966 T1 AT E157966T1 AT 93900419 T AT93900419 T AT 93900419T AT 93900419 T AT93900419 T AT 93900419T AT E157966 T1 ATE157966 T1 AT E157966T1
- Authority
- AT
- Austria
- Prior art keywords
- oxacholecalziferol
- derivatives
- preparation
- same
- hyperparathyroidism
- Prior art date
Links
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 201000002980 Hyperparathyroidism Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36105191 | 1991-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157966T1 true ATE157966T1 (de) | 1997-09-15 |
Family
ID=18471985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93900419T ATE157966T1 (de) | 1991-12-18 | 1992-12-18 | 22-oxacholecalziferol-derivate und ihre herstellung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5436401A (enExample) |
| EP (1) | EP0619304B1 (enExample) |
| JP (1) | JP3493037B2 (enExample) |
| KR (1) | KR100247214B1 (enExample) |
| AT (1) | ATE157966T1 (enExample) |
| DE (1) | DE69222183T2 (enExample) |
| DK (1) | DK0619304T3 (enExample) |
| ES (1) | ES2107650T3 (enExample) |
| GR (1) | GR3025468T3 (enExample) |
| HK (1) | HK1002729A1 (enExample) |
| SG (1) | SG78265A1 (enExample) |
| TW (1) | TW222621B (enExample) |
| WO (1) | WO1993012083A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3563310D1 (en) * | 1985-07-30 | 1988-07-21 | Salzgitter Ind | Method and device for the preparation of suspensions with constant indications from basic materials with variable properties |
| US6103709A (en) * | 1993-12-23 | 2000-08-15 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases |
| US6121469A (en) | 1993-12-23 | 2000-09-19 | The Regents Of The University Of California | Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs |
| EP0764443B1 (en) * | 1994-04-19 | 2002-08-14 | Chugai Seiyaku Kabushiki Kaisha | Products for the treatment of cachexia associated with tumors |
| GB9607034D0 (en) * | 1996-04-03 | 1996-06-05 | Leo Pharm Prod Ltd | Chemical compounds |
| AU4244997A (en) * | 1996-09-03 | 1998-03-26 | Chugai Seiyaku Kabushiki Kaisha | Intermediates for the synthesis of vitamin d and steroid derivatives and processes for preparation thereof |
| GB9804861D0 (en) * | 1998-03-06 | 1998-04-29 | Res Inst Medicine Chem | Chemical compounds |
| CN1150973C (zh) | 1998-07-03 | 2004-05-26 | 中外制药株式会社 | 光化学反应用紫外线照射装置以及使用它的维生素d衍生物的制备方法 |
| DK1219599T3 (da) * | 1999-08-27 | 2010-05-25 | Hiroaki Takayama | Vitamin-D-derivater som har substituenter i 2-alfa-position |
| EP1275643A4 (en) | 2000-04-19 | 2009-06-03 | Chugai Pharmaceutical Co Ltd | DERIVATIVES OF VITAMIN D |
| DK1295871T3 (da) | 2000-06-15 | 2011-07-11 | Chugai Pharmaceutical Co Ltd | Vitamin D-derivater med et 22-oxa- eller 22-thiaatom, en C17-sidekæde substitueret med en syre-, ester- eller amid-gruppe og en 16(17)-dobbeltbinding |
| WO2002017932A1 (fr) * | 2000-08-30 | 2002-03-07 | Chugai Seiyaku Kabushiki Kaisha | Preparations d'oct |
| WO2012122451A2 (en) | 2011-03-09 | 2012-09-13 | Teva Pharmaceutical Industries Ltd. | Polymorphs of maxacalcitol and process for the preparation of maxacalcitol |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| CN103508999B (zh) | 2013-10-12 | 2015-05-13 | 浙江海正药业股份有限公司 | 马沙骨化醇的合成中间体及其制备方法和用途 |
| CN107286067A (zh) * | 2016-04-05 | 2017-10-24 | 湖南华腾制药有限公司 | 一种马沙骨化醇的制备方法 |
| CN114728874B (zh) | 2019-11-27 | 2024-04-26 | 研成精密化学株式会社 | 用于制备马沙骨化醇的方法及用于其的中间体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61140560A (ja) * | 1984-12-12 | 1986-06-27 | Chugai Pharmaceut Co Ltd | ２０−オキサ−２１−ノルビタミンｄ３誘導体 |
| JPS61267550A (ja) * | 1984-12-28 | 1986-11-27 | Chugai Pharmaceut Co Ltd | ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体 |
| JP3050564B2 (ja) * | 1989-12-15 | 2000-06-12 | 中外製薬株式会社 | 新規な２２―オキサビタミンｄ誘導体 |
-
1992
- 1992-11-27 JP JP35436292A patent/JP3493037B2/ja not_active Expired - Fee Related
- 1992-12-18 DK DK93900419.8T patent/DK0619304T3/da active
- 1992-12-18 TW TW081110206A patent/TW222621B/zh active
- 1992-12-18 DE DE69222183T patent/DE69222183T2/de not_active Expired - Fee Related
- 1992-12-18 US US08/244,818 patent/US5436401A/en not_active Expired - Fee Related
- 1992-12-18 HK HK98101901A patent/HK1002729A1/en not_active IP Right Cessation
- 1992-12-18 SG SG1996009648A patent/SG78265A1/en unknown
- 1992-12-18 ES ES93900419T patent/ES2107650T3/es not_active Expired - Lifetime
- 1992-12-18 KR KR1019940702111A patent/KR100247214B1/ko not_active Expired - Fee Related
- 1992-12-18 AT AT93900419T patent/ATE157966T1/de not_active IP Right Cessation
- 1992-12-18 WO PCT/JP1992/001662 patent/WO1993012083A1/ja not_active Ceased
- 1992-12-18 EP EP93900419A patent/EP0619304B1/en not_active Expired - Lifetime
-
1997
- 1997-11-25 GR GR970403118T patent/GR3025468T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG78265A1 (en) | 2001-02-20 |
| DE69222183T2 (de) | 1998-01-22 |
| DK0619304T3 (da) | 1998-02-16 |
| EP0619304B1 (en) | 1997-09-10 |
| EP0619304A4 (en) | 1995-03-29 |
| WO1993012083A1 (fr) | 1993-06-24 |
| TW222621B (enExample) | 1994-04-21 |
| EP0619304A1 (en) | 1994-10-12 |
| HK1002729A1 (en) | 1998-09-11 |
| US5436401A (en) | 1995-07-25 |
| KR940703807A (ko) | 1994-12-12 |
| ES2107650T3 (es) | 1997-12-01 |
| GR3025468T3 (en) | 1998-02-27 |
| DE69222183D1 (de) | 1997-10-16 |
| JPH0672994A (ja) | 1994-03-15 |
| KR100247214B1 (ko) | 2000-03-15 |
| JP3493037B2 (ja) | 2004-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |