US5981165A
(en)
*
|
1991-07-08 |
1999-11-09 |
Neurospheres Holdings Ltd. |
In vitro induction of dopaminergic cells
|
CA2170751A1
(en)
*
|
1993-09-01 |
1995-03-09 |
Timothy J. Cunningham |
Neuron regulatory factor for promoting neuron survival
|
WO1995017203A1
(en)
*
|
1993-12-22 |
1995-06-29 |
The University Of Medicine And Dentistry Of New Jersey |
Novel nucleic acid sequences isolated from glial cells
|
US5534615A
(en)
*
|
1994-04-25 |
1996-07-09 |
Genentech, Inc. |
Cardiac hypertrophy factor and uses therefor
|
US6472585B1
(en)
|
1994-04-25 |
2002-10-29 |
Genentech, Inc. |
Cardiotrophin-1 defective mouse
|
US7258983B2
(en)
|
1994-04-25 |
2007-08-21 |
Genentech, Inc. |
Cardiotrophin-1 compositions and methods for the treatment of tumor
|
ES2276393T3
(es)
*
|
1994-04-25 |
2007-06-16 |
Genentech, Inc. |
Cardiotrofina y sus usos.
|
US5853385A
(en)
*
|
1994-08-26 |
1998-12-29 |
Cytotherapeutics, Inc. |
Encapsulated PC12 cell transplants for treatment of Parkinson's disease
|
US5733875A
(en)
*
|
1994-11-15 |
1998-03-31 |
Amgen Inc. |
Methods of using GDNF as a neuroprotective agent
|
JP3093974B2
(ja)
*
|
1995-06-27 |
2000-10-03 |
住友ベークライト株式会社 |
神経細胞用培養液、その製造方法及びこれを用いる神経細胞の培養方法
|
US6743628B1
(en)
|
1995-08-28 |
2004-06-01 |
Washington University |
Method of cell culture using neurturin
|
US5739307A
(en)
*
|
1995-08-28 |
1998-04-14 |
Washington University |
Polynucleotide encoding neurturin neurotrophic factor
|
US5731284A
(en)
*
|
1995-09-28 |
1998-03-24 |
Amgen Inc. |
Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
|
US6184200B1
(en)
|
1995-09-28 |
2001-02-06 |
Amgen Inc. |
Truncated glial cell line-derived neurotrophic factor
|
US5641750A
(en)
*
|
1995-11-29 |
1997-06-24 |
Amgen Inc. |
Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
|
US5641749A
(en)
*
|
1995-11-29 |
1997-06-24 |
Amgen Inc. |
Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
|
WO1997019693A1
(en)
*
|
1995-11-29 |
1997-06-05 |
Amgen Inc. |
Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
|
US5905027A
(en)
*
|
1995-12-27 |
1999-05-18 |
Uab Research Foundation |
Method of diagnosing and treating gliomas
|
US5929041A
(en)
*
|
1996-02-23 |
1999-07-27 |
Amgen Inc. |
Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
|
US5837681A
(en)
*
|
1996-02-23 |
1998-11-17 |
Amgen Inc. |
Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
|
AU716846B2
(en)
*
|
1996-03-14 |
2000-03-09 |
Washington University |
Persephin and related growth factors
|
US6716600B1
(en)
|
1996-03-14 |
2004-04-06 |
Washington University |
Persephin and related growth factors
|
ATE247667T1
(de)
*
|
1996-03-14 |
2003-09-15 |
Genentech Inc |
Gdnf-rezeptor und dessen verwendung
|
US6222022B1
(en)
|
1996-03-14 |
2001-04-24 |
Washington University |
Persephin and related growth factors
|
US5741778A
(en)
*
|
1996-03-19 |
1998-04-21 |
Amgen Inc. |
Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product
|
US6299895B1
(en)
|
1997-03-24 |
2001-10-09 |
Neurotech S.A. |
Device and method for treating ophthalmic diseases
|
US6455277B1
(en)
|
1996-04-22 |
2002-09-24 |
Amgen Inc. |
Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
|
US7138251B1
(en)
|
1996-04-22 |
2006-11-21 |
Amgen Inc. |
Polynucleotides encoding a neurotrophic factor receptor
|
WO1997039629A1
(en)
*
|
1996-04-25 |
1997-10-30 |
Genetic Therapy, Inc. |
Viral vectors including polynucleotides encoding neurotrophic factors and uses therefor
|
ES2213221T3
(es)
*
|
1996-07-29 |
2004-08-16 |
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh |
Factor de tipo egf de granulos de cromafina y factor neurotrofico derivado de celulas de glia con actividad promotora de la supervivencia sobre neuronas daergicas.
|
AU6020998A
(en)
|
1997-01-08 |
1998-08-03 |
Life Technologies, Inc. |
Methods for production of proteins
|
US6777196B2
(en)
|
1997-02-18 |
2004-08-17 |
Genentech, Inc. |
Neurturin receptor
|
US6372453B1
(en)
|
1997-02-18 |
2002-04-16 |
Genetech, Inc. |
Neurturin receptor
|
US6025157A
(en)
*
|
1997-02-18 |
2000-02-15 |
Genentech, Inc. |
Neurturin receptor
|
US6042579A
(en)
*
|
1997-04-30 |
2000-03-28 |
Medtronic, Inc. |
Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
|
EP1304119A3
(en)
*
|
1997-07-30 |
2004-01-21 |
Amgen Inc. |
Method for preventing and treating hearing loss using a neurturin protein product
|
US6043221A
(en)
*
|
1997-07-30 |
2000-03-28 |
Amgen Inc. |
Method for preventing and treating hearing loss using a neuturin protein product
|
CA2299586C
(en)
*
|
1997-08-05 |
2007-09-18 |
F. Hoffmann-La Roche Ag |
Human glial cell line-derived neurotrophic factor promoters, vectors containing same, and methods of screening compounds therewith
|
WO1999049039A2
(en)
|
1998-03-23 |
1999-09-30 |
Genentech, Inc. |
GFRα3 AND ITS USES
|
US7026138B1
(en)
|
1998-03-23 |
2006-04-11 |
Genentech, Inc. |
Polynucleotides encoding GFRα3
|
DE19816186A1
(de)
*
|
1998-04-14 |
1999-10-21 |
Univ Muenchen L Maximilians |
GDNF-kodierende DNA, Teile davon und GDNF-Varianten
|
US6593133B1
(en)
|
1998-07-06 |
2003-07-15 |
Nsgene A/S |
Neurotrophic factors
|
US6284540B1
(en)
*
|
1998-09-29 |
2001-09-04 |
Washington University |
Artemin, a novel neurotrophic factor
|
US7060676B2
(en)
*
|
1999-12-20 |
2006-06-13 |
Trustees Of Tufts College |
T. cruzi-derived neurotrophic agents and methods of use therefor
|
US20040014082A1
(en)
*
|
2000-08-11 |
2004-01-22 |
Invitrogen Corporation |
Highly homogeneous molecular markers for electrophoresis
|
US6426065B1
(en)
*
|
2000-11-07 |
2002-07-30 |
Clairol Incorporated |
Use of tris(hydroxymethyl)aminomethane in cold permanent waving processes
|
US7442370B2
(en)
|
2001-02-01 |
2008-10-28 |
Biogen Idec Ma Inc. |
Polymer conjugates of mutated neublastin
|
US7276580B2
(en)
|
2001-03-12 |
2007-10-02 |
Biogen Idec Ma Inc. |
Neurotrophic factors
|
EP1395279B1
(en)
|
2001-03-28 |
2011-10-05 |
Biogen Idec MA Inc. |
Use of neublastin polypeptides for treating neuropathic pain
|
US20030050273A1
(en)
*
|
2001-08-29 |
2003-03-13 |
Keiya Ozawa |
Compositions and methods for treating neurodegenerative diseases
|
US7613491B2
(en)
*
|
2002-05-22 |
2009-11-03 |
Dexcom, Inc. |
Silicone based membranes for use in implantable glucose sensors
|
US8364229B2
(en)
*
|
2003-07-25 |
2013-01-29 |
Dexcom, Inc. |
Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
|
US7497827B2
(en)
|
2004-07-13 |
2009-03-03 |
Dexcom, Inc. |
Transcutaneous analyte sensor
|
US7828728B2
(en)
*
|
2003-07-25 |
2010-11-09 |
Dexcom, Inc. |
Analyte sensor
|
WO2003090689A2
(en)
*
|
2002-04-25 |
2003-11-06 |
Wisconsin Alumni Research Foundation |
Neurodegenerative disorder treatment using gdnf secreting neural cells
|
US20060088899A1
(en)
*
|
2002-05-31 |
2006-04-27 |
Alvarez Vernon L |
Combination chemotherapy with chlorotoxin
|
US7528112B2
(en)
|
2002-11-15 |
2009-05-05 |
Drexel University |
Small survival-promoting/immunomodulatory peptide for treatment of brain damage, neurodegenerative disorders, and inflammatory disorders
|
US7388079B2
(en)
*
|
2002-11-27 |
2008-06-17 |
The Regents Of The University Of California |
Delivery of pharmaceutical agents via the human insulin receptor
|
US20050048041A1
(en)
*
|
2003-01-13 |
2005-03-03 |
Rao Mahendra S. |
Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products
|
JP2006517101A
(ja)
*
|
2003-01-13 |
2006-07-20 |
エス. ラオ、マヘンドラ |
治療用産物を送達するための、増殖性の幹細胞および前駆細胞における候補分子の持続的発現
|
US20040209810A1
(en)
*
|
2003-02-24 |
2004-10-21 |
Gill Steven S. |
Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor
|
US8946151B2
(en)
|
2003-02-24 |
2015-02-03 |
Northern Bristol N.H.S. Trust Frenchay Hospital |
Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
|
ES2479942T3
(es)
|
2003-04-18 |
2014-07-25 |
Biogen Idec Ma Inc. |
Neublastina glucosilada conjugada con polímero
|
US7875293B2
(en)
*
|
2003-05-21 |
2011-01-25 |
Dexcom, Inc. |
Biointerface membranes incorporating bioactive agents
|
ATE423134T1
(de)
|
2003-06-10 |
2009-03-15 |
Nsgene As |
Verbesserte sezernierung von neublastin
|
US9763609B2
(en)
|
2003-07-25 |
2017-09-19 |
Dexcom, Inc. |
Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
|
EP1648298A4
(en)
*
|
2003-07-25 |
2010-01-13 |
Dexcom Inc |
OXYGEN-IMPROVED MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
|
US7591801B2
(en)
|
2004-02-26 |
2009-09-22 |
Dexcom, Inc. |
Integrated delivery device for continuous glucose sensor
|
US9135402B2
(en)
|
2007-12-17 |
2015-09-15 |
Dexcom, Inc. |
Systems and methods for processing sensor data
|
US7920906B2
(en)
|
2005-03-10 |
2011-04-05 |
Dexcom, Inc. |
System and methods for processing analyte sensor data for sensor calibration
|
EP1662879A4
(en)
*
|
2003-08-29 |
2009-03-11 |
Univ New York |
INDIRECT ADMINISTRATION OF GROWTH FACTORS IN THE CENTRAL NERVOUS SYSTEM
|
WO2005023861A2
(en)
*
|
2003-09-05 |
2005-03-17 |
Licentia, Ltd. |
Gdnf-related neuropeptides
|
US7598059B2
(en)
|
2003-10-02 |
2009-10-06 |
Biogen Idec Ma Inc. |
Neublastin expression constructs
|
US20060239966A1
(en)
*
|
2003-10-20 |
2006-10-26 |
Tornoee Jens |
In vivo gene therapy of parkinson's disease
|
US9247900B2
(en)
|
2004-07-13 |
2016-02-02 |
Dexcom, Inc. |
Analyte sensor
|
US20050123526A1
(en)
*
|
2003-12-01 |
2005-06-09 |
Medtronic Inc. |
Administration of growth factors for neurogenesis and gliagenesis
|
US8093205B2
(en)
*
|
2003-12-01 |
2012-01-10 |
Medtronic, Inc. |
Method for treating a stroke by implanting a first therapy delivery element in the CNS and a second therapy delivery element in a damaged tissue of the CNS to promote neurogenesis
|
US7364592B2
(en)
*
|
2004-02-12 |
2008-04-29 |
Dexcom, Inc. |
Biointerface membrane with macro-and micro-architecture
|
US20050208090A1
(en)
*
|
2004-03-18 |
2005-09-22 |
Medtronic, Inc. |
Methods and systems for treatment of neurological diseases of the central nervous system
|
GB2414934A
(en)
*
|
2004-06-11 |
2005-12-14 |
Gill Steven Streatfield |
Treatment of Parkinson's disease with GDNF
|
CA2568150A1
(en)
*
|
2004-06-21 |
2006-01-05 |
Medtronic, Inc. |
Medical systems and methods for delivering compositions to cells
|
AU2005277227B2
(en)
|
2004-08-19 |
2011-10-06 |
Biogen Ma Inc. |
Refolding transforming growth factor beta family proteins
|
RS51453B
(en)
|
2004-08-19 |
2011-04-30 |
Biogen Idec Ma Inc. |
NEUBLASTIN
|
US8133178B2
(en)
|
2006-02-22 |
2012-03-13 |
Dexcom, Inc. |
Analyte sensor
|
WO2007019860A2
(en)
*
|
2005-08-16 |
2007-02-22 |
Copenhagen University |
Gdnf derived peptides
|
US8053569B2
(en)
*
|
2005-10-07 |
2011-11-08 |
Armagen Technologies, Inc. |
Nucleic acids encoding and methods of producing fusion proteins
|
US8741260B2
(en)
*
|
2005-10-07 |
2014-06-03 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of GDNF to the CNS
|
US8124095B2
(en)
*
|
2005-10-07 |
2012-02-28 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of erythropoietin to the CNS
|
JP2009513584A
(ja)
*
|
2005-10-28 |
2009-04-02 |
エヌエスゲーネ・アクティーゼルスカブ |
Gdnfの送達のための移植可能な生体適合性免疫隔離ビヒクル
|
DE602005023550D1
(de)
|
2005-12-14 |
2010-10-21 |
Licentia Ltd |
Verwendungen eines neurotrophischen Faktors
|
TWI501774B
(zh)
|
2006-02-27 |
2015-10-01 |
Biogen Idec Inc |
神經性病症之治療
|
ES2618787T5
(es)
|
2006-04-25 |
2022-10-21 |
Univ California |
Administración de factores de crecimiento para el tratamiento de trastornos del SNC
|
US20070259031A1
(en)
*
|
2006-04-26 |
2007-11-08 |
The Regents Of The University Of California |
Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
|
EP1872790A1
(en)
|
2006-06-26 |
2008-01-02 |
DeveloGen Aktiengesellschaft |
New formulation for increasing bioavailability of neurturin
|
WO2008022349A2
(en)
*
|
2006-08-18 |
2008-02-21 |
Armagen Technologies, Inc. |
Agents for blood-brain barrier delivery
|
KR100770440B1
(ko)
*
|
2006-08-29 |
2007-10-26 |
삼성전기주식회사 |
질화물 반도체 발광소자
|
US8637459B2
(en)
*
|
2006-11-08 |
2014-01-28 |
Emory University |
Enhancing a population of insulin releasing cells using GFR-A1 agonists
|
JP5583005B2
(ja)
|
2007-05-01 |
2014-09-03 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
血管新生を増大させるための組成物および方法
|
US20090011040A1
(en)
*
|
2007-05-02 |
2009-01-08 |
Naash Muna I |
Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases
|
US20200037874A1
(en)
|
2007-05-18 |
2020-02-06 |
Dexcom, Inc. |
Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
|
EP2167071B1
(en)
*
|
2007-06-13 |
2020-03-18 |
Wayne State University Board Of Governors |
A baclofen solution for low-volume therapeutic delivery
|
WO2008157308A2
(en)
*
|
2007-06-13 |
2008-12-24 |
Wayne State University Board Of Governors |
A zwitterion solution for low-volume therapeutic delivery
|
CA3184105A1
(en)
*
|
2007-07-27 |
2009-02-05 |
Armagen Inc. |
Methods and compositions for increasing alpha-l-iduronidase activity in the cns
|
EP2227132B1
(en)
|
2007-10-09 |
2023-03-08 |
DexCom, Inc. |
Integrated insulin delivery system with continuous glucose sensor
|
US8417312B2
(en)
|
2007-10-25 |
2013-04-09 |
Dexcom, Inc. |
Systems and methods for processing sensor data
|
FI20070808A0
(fi)
|
2007-10-25 |
2007-10-25 |
Mart Saarma |
GDNF:n silmukointivariantit ja niiden käytöt
|
US8290559B2
(en)
*
|
2007-12-17 |
2012-10-16 |
Dexcom, Inc. |
Systems and methods for processing sensor data
|
GB0803352D0
(en)
|
2008-02-22 |
2008-04-02 |
Ntnu Technology Transfer As |
Oligopeptidic compounds and uses thereof
|
US20090247856A1
(en)
|
2008-03-28 |
2009-10-01 |
Dexcom, Inc. |
Polymer membranes for continuous analyte sensors
|
FI20080326A0
(fi)
|
2008-04-30 |
2008-04-30 |
Licentia Oy |
Neurotroofinen tekijä MANF ja sen käytöt
|
BRPI0912683A2
(pt)
|
2008-05-15 |
2016-01-26 |
Transmolecular Inc |
tratamento de tumores metastáticos
|
EP2396408B1
(en)
|
2009-02-12 |
2017-09-20 |
CuRNA, Inc. |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
JP5873003B2
(ja)
|
2009-03-18 |
2016-03-01 |
アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. |
IgGデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法
|
WO2010144696A1
(en)
|
2009-06-11 |
2010-12-16 |
Burnham Institute For Medical Research |
Directed differentiation of stem cells
|
DK2485761T3
(da)
|
2009-10-09 |
2019-05-06 |
Armagen Inc |
Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS
|
WO2011064437A2
(es)
|
2009-11-26 |
2011-06-03 |
Proyecto De Biomedicina Cima, S.L. |
Vectores virales y procedimientos útiles en la preparación de gdnf
|
CN102844044B
(zh)
|
2010-02-04 |
2016-10-26 |
摩尔弗泰克有限公司 |
氯毒素多肽和结合物及其应用
|
EP2569330B1
(en)
|
2010-05-11 |
2016-09-28 |
Fred Hutchinson Cancer Research Center |
Chlorotoxin variants, conjugates, and methods for their use
|
WO2012075184A2
(en)
|
2010-12-02 |
2012-06-07 |
Neurotech Usa, Inc. |
Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof
|
UA112981C2
(uk)
|
2011-04-11 |
2016-11-25 |
Елі Ліллі Енд Компані |
Варіант людського gdnf
|
US20130053666A1
(en)
|
2011-08-26 |
2013-02-28 |
Dexcom, Inc. |
Polymer membranes for continuous analyte sensors
|
EP2785378B1
(en)
|
2011-12-02 |
2020-05-13 |
Armagen, Inc. |
Methods and compositions for increasing arylsulfatase a activity in the cns
|
US9788765B2
(en)
|
2012-09-28 |
2017-10-17 |
Dexcom, Inc. |
Zwitterion surface modifications for continuous sensors
|
AU2013359429A1
(en)
|
2012-12-10 |
2015-07-09 |
Fred Hutchinson Cancer Research Center |
Methods for screening
|
US10376562B2
(en)
|
2013-03-15 |
2019-08-13 |
The Jackson Laboratory |
Methods for promoting wound healing and hair growth comprising GDNF administration
|
US9737250B2
(en)
|
2013-03-15 |
2017-08-22 |
Dexcom, Inc. |
Membrane for continuous analyte sensors
|
US11559580B1
(en)
|
2013-09-17 |
2023-01-24 |
Blaze Bioscience, Inc. |
Tissue-homing peptide conjugates and methods of use thereof
|
US10369329B2
(en)
|
2014-01-30 |
2019-08-06 |
Renishaw Plc |
Neurosurgical apparatus and method
|
CN106460062A
(zh)
|
2014-05-05 |
2017-02-22 |
美敦力公司 |
用于scd、crt、crt‑d或sca治疗识别和/或选择的方法和组合物
|
US10538589B2
(en)
|
2015-01-14 |
2020-01-21 |
Armagen Inc. |
Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
|
GB201506052D0
(en)
|
2015-04-09 |
2015-05-27 |
Renishaw Plc |
Movement disorder
|
US10456356B2
(en)
|
2015-05-27 |
2019-10-29 |
Neurotech Usa, Inc. |
Use of encapsulated cell therapy for treatment of ophthalmic disorders
|
JP6983765B2
(ja)
|
2015-12-30 |
2021-12-17 |
デックスコム・インコーポレーテッド |
分析物センサのための酵素固定化接着層
|
CA3021011A1
(en)
|
2016-04-15 |
2017-10-19 |
Blaze Bioscience, Inc. |
Methods of treating breast cancer
|
AU2017357931A1
(en)
|
2016-11-10 |
2019-06-20 |
Keros Therapeutics, Inc. |
GDNF fusion polypeptides and methods of use thereof
|
AU2022238919A1
(en)
|
2021-03-19 |
2023-10-19 |
Dexcom, Inc. |
Drug releasing membrane for analyte sensor
|
WO2023043908A1
(en)
|
2021-09-15 |
2023-03-23 |
Dexcom, Inc. |
Bioactive releasing membrane for analyte sensor
|
TW202325850A
(zh)
|
2021-11-29 |
2023-07-01 |
大陸商上海瑞宏迪醫藥有限公司 |
Aadc、gdnf多核苷酸及其用於治療帕金森病
|
CA3228457A1
(en)
|
2022-02-02 |
2023-08-10 |
Dexcom, Inc. |
Sensing systems and methods for diagnosing, staging, treating, and assessing risks of liver disease using monitored analyte data
|
AU2023224275A1
(en)
|
2022-02-23 |
2024-09-12 |
Dexcom, Inc. |
Sensing systems and methods for providing decision support around kidney health and/or diabetes
|
WO2023235443A1
(en)
|
2022-06-01 |
2023-12-07 |
Dexcom, Inc. |
Sensing systems and methods for diagnosing kidney disease
|
US20240090802A1
(en)
|
2022-09-02 |
2024-03-21 |
Dexcom, Inc. |
Continuous analyte sensor devices and methods
|
US20240225490A1
(en)
|
2022-12-30 |
2024-07-11 |
Dexcom, Inc. |
Sensing systems and methods for hybrid glucose and ketone monitoring
|