ATE423134T1 - Verbesserte sezernierung von neublastin - Google Patents
Verbesserte sezernierung von neublastinInfo
- Publication number
- ATE423134T1 ATE423134T1 AT04736510T AT04736510T ATE423134T1 AT E423134 T1 ATE423134 T1 AT E423134T1 AT 04736510 T AT04736510 T AT 04736510T AT 04736510 T AT04736510 T AT 04736510T AT E423134 T1 ATE423134 T1 AT E423134T1
- Authority
- AT
- Austria
- Prior art keywords
- neublastin
- construct
- region
- nervous system
- nucleotide sequence
- Prior art date
Links
- RVCKCEDKBVEEHL-UHFFFAOYSA-N 2,3,4,5,6-pentachlorobenzyl alcohol Chemical compound OCC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl RVCKCEDKBVEEHL-UHFFFAOYSA-N 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 102100026376 Artemin Human genes 0.000 abstract 6
- 101000785776 Homo sapiens Artemin Proteins 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300861 | 2003-06-10 | ||
US50748303P | 2003-10-02 | 2003-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE423134T1 true ATE423134T1 (de) | 2009-03-15 |
Family
ID=34485959
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09153016T ATE478092T1 (de) | 2003-06-10 | 2004-06-10 | Verbesserte sekretion von neublastin |
AT04736510T ATE423134T1 (de) | 2003-06-10 | 2004-06-10 | Verbesserte sezernierung von neublastin |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09153016T ATE478092T1 (de) | 2003-06-10 | 2004-06-10 | Verbesserte sekretion von neublastin |
Country Status (17)
Country | Link |
---|---|
US (1) | US7601518B2 (de) |
EP (2) | EP1636260B1 (de) |
JP (1) | JP5623685B2 (de) |
KR (1) | KR20060031618A (de) |
CN (1) | CN100475846C (de) |
AT (2) | ATE478092T1 (de) |
AU (1) | AU2004245175C1 (de) |
BR (1) | BRPI0411243A (de) |
CA (1) | CA2527914C (de) |
DE (2) | DE602004028769D1 (de) |
DK (2) | DK1636260T3 (de) |
ES (2) | ES2353457T3 (de) |
HK (1) | HK1082752A1 (de) |
IL (1) | IL172270A (de) |
NZ (1) | NZ544263A (de) |
RU (1) | RU2005138368A (de) |
WO (1) | WO2004108760A2 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7276580B2 (en) * | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
JP4742030B2 (ja) | 2003-04-18 | 2011-08-10 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ポリマーが結合したグリコシル化ニューブラスチン |
ES2521682T3 (es) | 2003-05-21 | 2014-11-13 | Genzyme Corporation | Procedimientos para producir preparaciones de viriones de AAV recombinantes sustancialmente exentas de cápsidas vacías |
NZ544263A (en) | 2003-06-10 | 2009-04-30 | Nsgene As | Improved secretion of neublastin |
US7598059B2 (en) * | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
US20060239966A1 (en) * | 2003-10-20 | 2006-10-26 | Tornoee Jens | In vivo gene therapy of parkinson's disease |
BRPI0514534A (pt) * | 2004-08-19 | 2008-06-17 | Biogen Idec Inc | variantes de neublastina |
KR101241551B1 (ko) | 2004-08-19 | 2013-03-11 | 바이오겐 아이덱 엠에이 인코포레이티드 | 전환 성장 인자 베타 패밀리 단백질의 리폴딩 |
ES2864039T3 (es) | 2005-05-20 | 2021-10-13 | Lonza Biologics Plc | Expresión de alto nivel de un anticuerpo recombinante en una célula huésped de mamífero |
US20080260702A1 (en) * | 2005-10-11 | 2008-10-23 | Jesper Roland Jorgensen | Treatment of Retinopathies Using Gfra3 Agonists |
ES2406716T3 (es) * | 2005-12-30 | 2013-06-07 | Neurotech Usa, Inc. | Dispositivo micronizado para el suministro de moléculas activas biológicamente y método de uso del mismo |
TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
WO2007103182A2 (en) * | 2006-03-01 | 2007-09-13 | Biogen Idec Ma Inc. | Compostions and methods for administering gdnf ligand family proteins |
EP2142205B1 (de) | 2007-05-01 | 2014-04-02 | Biogen Idec MA Inc. | Neublastin Peptide für erhöhte Vaskularisierung im Gewebe mit reduzierter Durchblutung |
EP2048237A1 (de) | 2007-10-05 | 2009-04-15 | Avir Green Hills Biotechnology Research Development Trade Ag | Replikationsdefizienter Influenza-Virus zur Expression heterologer Sequenzen |
RU2491344C2 (ru) * | 2007-06-29 | 2013-08-27 | Ф.Хоффманн-Ля Рош Аг | Промотор |
EP2205634A2 (de) * | 2007-08-08 | 2010-07-14 | Biogen Idec MA, Inc. | Anti-neublastin-antikörper und anwendungen davon |
JP6125751B2 (ja) * | 2008-03-21 | 2017-05-10 | ティシュージーン,インク. | 椎間板変性症の治療 |
EP2281047B1 (de) * | 2008-04-15 | 2020-04-08 | Genzyme Corporation | Verfahren zur herstellung des rod-derived cone viability-faktors (rdcvf) |
WO2010083841A2 (en) * | 2009-01-23 | 2010-07-29 | Nsgene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
EP2389191A2 (de) * | 2009-01-23 | 2011-11-30 | NsGene A/S | Expression von neuropeptiden in säugetierzellen |
EP2550362B1 (de) | 2010-03-25 | 2017-01-04 | Oregon Health&Science University | Cmv-glycoproteine und rekombinante vektoren |
RS57397B8 (sr) | 2011-06-10 | 2020-01-31 | Univ Oregon Health & Science | Cmv glikoproteini i rekombinantni vektori |
CN107530451A (zh) * | 2015-05-07 | 2018-01-02 | 南佛罗里达大学 | 用于天使人综合征的基因治疗方法的修饰的ube3a基因 |
GB201519086D0 (en) * | 2015-10-28 | 2015-12-09 | Syncona Partners Llp | Gene Therapy |
CA3015660A1 (en) * | 2016-03-04 | 2017-09-08 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for modulating body weight |
CN108610398B (zh) * | 2018-01-15 | 2020-08-11 | 武汉海特生物制药股份有限公司 | 一段功能序列及在分泌蛋白表达中的应用 |
EP3749754A4 (de) * | 2018-02-08 | 2021-10-20 | Applied Stemcell, Inc. | Verfahren für das screening von varianten eines zielgens |
CN114008191A (zh) * | 2018-12-21 | 2022-02-01 | 格洛丽亚娜治疗公司 | 哺乳动物细胞培养物产生的神经胚素抗体 |
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JP2005502582A (ja) * | 2000-12-22 | 2005-01-27 | ジェネンテック, インコーポレイテッド | Gdnfリガンドファミリーのメンバーである、アルテミンの新たな使用 |
BR0206852A (pt) | 2001-02-01 | 2005-05-03 | Biogen Inc | Conjugados de polìmero de neublastina e métodos para uso dos mesmos |
EP1395279B1 (de) * | 2001-03-28 | 2011-10-05 | Biogen Idec MA Inc. | Verwendung von neublastin-polypeptide zur behandlung von neuropathischen schmerzen |
JP4742030B2 (ja) | 2003-04-18 | 2011-08-10 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ポリマーが結合したグリコシル化ニューブラスチン |
NZ544263A (en) | 2003-06-10 | 2009-04-30 | Nsgene As | Improved secretion of neublastin |
US7598059B2 (en) | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
MXPA06004329A (es) | 2003-10-20 | 2006-06-05 | Nsgene As | Terapia genica in vivo de enfermedad de parkinson. |
-
2004
- 2004-06-10 NZ NZ544263A patent/NZ544263A/en not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
DE602004019524D1 (de) | 2009-04-02 |
IL172270A (en) | 2015-04-30 |
WO2004108760A3 (en) | 2005-04-07 |
EP1636260A2 (de) | 2006-03-22 |
CA2527914A1 (en) | 2004-12-16 |
HK1082752A1 (en) | 2006-06-16 |
RU2005138368A (ru) | 2006-07-27 |
KR20060031618A (ko) | 2006-04-12 |
WO2004108760A2 (en) | 2004-12-16 |
DK2058329T3 (da) | 2010-12-06 |
NZ544263A (en) | 2009-04-30 |
EP2058329B1 (de) | 2010-08-18 |
AU2004245175B2 (en) | 2009-10-15 |
AU2004245175A1 (en) | 2004-12-16 |
CN100475846C (zh) | 2009-04-08 |
DK1636260T3 (da) | 2009-06-22 |
ATE478092T1 (de) | 2010-09-15 |
JP5623685B2 (ja) | 2014-11-12 |
EP2058329A1 (de) | 2009-05-13 |
EP1636260B1 (de) | 2009-02-18 |
ES2323066T3 (es) | 2009-07-06 |
ES2353457T3 (es) | 2011-03-02 |
US7601518B2 (en) | 2009-10-13 |
IL172270A0 (en) | 2006-04-10 |
DE602004028769D1 (de) | 2010-09-30 |
JP2007535898A (ja) | 2007-12-13 |
CN1835971A (zh) | 2006-09-20 |
CA2527914C (en) | 2014-10-28 |
US20050089960A1 (en) | 2005-04-28 |
AU2004245175C1 (en) | 2010-03-18 |
BRPI0411243A (pt) | 2006-07-11 |
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