DK2058329T3 - Forbedret udskillelse af neublastin - Google Patents
Forbedret udskillelse af neublastinInfo
- Publication number
- DK2058329T3 DK2058329T3 DK09153016.2T DK09153016T DK2058329T3 DK 2058329 T3 DK2058329 T3 DK 2058329T3 DK 09153016 T DK09153016 T DK 09153016T DK 2058329 T3 DK2058329 T3 DK 2058329T3
- Authority
- DK
- Denmark
- Prior art keywords
- neublastin
- construct
- region
- nervous system
- nucleotide sequence
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300861 | 2003-06-10 | ||
US50748303P | 2003-10-02 | 2003-10-02 | |
EP04736510A EP1636260B1 (en) | 2003-06-10 | 2004-06-10 | Improved secretion of neublastin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2058329T3 true DK2058329T3 (da) | 2010-12-06 |
Family
ID=34485959
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04736510T DK1636260T3 (da) | 2003-06-10 | 2004-06-10 | Forbedret udskillelse af Neublastin |
DK09153016.2T DK2058329T3 (da) | 2003-06-10 | 2004-06-10 | Forbedret udskillelse af neublastin |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04736510T DK1636260T3 (da) | 2003-06-10 | 2004-06-10 | Forbedret udskillelse af Neublastin |
Country Status (17)
Country | Link |
---|---|
US (1) | US7601518B2 (da) |
EP (2) | EP2058329B1 (da) |
JP (1) | JP5623685B2 (da) |
KR (1) | KR20060031618A (da) |
CN (1) | CN100475846C (da) |
AT (2) | ATE423134T1 (da) |
AU (1) | AU2004245175C1 (da) |
BR (1) | BRPI0411243A (da) |
CA (1) | CA2527914C (da) |
DE (2) | DE602004019524D1 (da) |
DK (2) | DK1636260T3 (da) |
ES (2) | ES2323066T3 (da) |
HK (1) | HK1082752A1 (da) |
IL (1) | IL172270A (da) |
NZ (1) | NZ544263A (da) |
RU (1) | RU2005138368A (da) |
WO (1) | WO2004108760A2 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
US7276580B2 (en) * | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
ES2328640T3 (es) | 2003-04-18 | 2009-11-16 | Biogen Idec Ma Inc. | Neublastina conjugada con un polimero glicosilada. |
JP4559429B2 (ja) | 2003-05-21 | 2010-10-06 | ジェンザイム・コーポレーション | 空キャプシドを実質的に含まない組換えaavビリオン調製物を生成するための方法 |
WO2004108760A2 (en) | 2003-06-10 | 2004-12-16 | Nsgene A/S | Improved secretion of neublastin |
US7598059B2 (en) | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
CN1897977A (zh) * | 2003-10-20 | 2007-01-17 | Ns基因公司 | 帕金森氏病的体内基因治疗 |
PT1786454E (pt) * | 2004-08-19 | 2010-08-18 | Biogen Idec Inc | Variantes de neublastina |
CN101123978B (zh) | 2004-08-19 | 2012-12-12 | 比奥根艾迪克Ma公司 | 神经胚素变体 |
AU2006249087B2 (en) | 2005-05-20 | 2012-05-17 | Lonza Biologics Plc | High-level expression of recombinant antibody in a mammalian host cell |
EP1937295A2 (en) * | 2005-10-11 | 2008-07-02 | NS Gene A/S | Treatment of retinopathies using gfr 3 agonists |
AU2006332971B2 (en) * | 2005-12-30 | 2013-03-07 | Neurotech Usa, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
EP1993590B1 (en) * | 2006-03-01 | 2013-12-25 | Biogen Idec MA Inc. | Compostions and methods for administering gdnf ligand family proteins |
TWI445544B (zh) | 2007-05-01 | 2014-07-21 | Biogen Idec Inc | 增進血管形成之組合物及方法 |
EP2048237A1 (en) | 2007-10-05 | 2009-04-15 | Avir Green Hills Biotechnology Research Development Trade Ag | Replication deficient Influenza virus for the expression of heterologous sequences |
CN101688222B (zh) * | 2007-06-29 | 2013-03-06 | 弗·哈夫曼-拉罗切有限公司 | 启动子 |
US20110135648A1 (en) * | 2007-08-08 | 2011-06-09 | Biogen Idec Ma Inc. | Anti-neublastin antibodies and uses thereof |
EP2268312A4 (en) * | 2008-03-21 | 2012-09-05 | Tissuegene Inc | TREATMENT OF WIPE DISPENSING |
WO2009146183A1 (en) | 2008-04-15 | 2009-12-03 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (rdcvf) |
EP2389191A2 (en) * | 2009-01-23 | 2011-11-30 | NsGene A/S | Expression of neuropeptides in mammalian cells |
AU2010206374B2 (en) * | 2009-01-23 | 2013-01-17 | Gloriana Therapeutics Sarl | Improved cell lines and their use in encapsulated cell biodelivery |
CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
EP3291843B1 (en) | 2015-05-07 | 2023-03-22 | University of South Florida | Modified ube3a gene for a gene therapy approach for angelman syndrome |
GB201519086D0 (en) * | 2015-10-28 | 2015-12-09 | Syncona Partners Llp | Gene Therapy |
EP3423097A4 (en) * | 2016-03-04 | 2019-08-21 | NGM Biopharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR MODULATING BODY WEIGHT |
CN108610398B (zh) * | 2018-01-15 | 2020-08-11 | 武汉海特生物制药股份有限公司 | 一段功能序列及在分泌蛋白表达中的应用 |
US20200385710A1 (en) | 2018-02-08 | 2020-12-10 | Applied Stemcell, Inc. | Methods for screening variant of target gene |
WO2020132583A1 (en) * | 2018-12-21 | 2020-06-25 | Gloriana Therapeutics Sarl | Mammalian cell culture-produced neublastin antibodies |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
AU6131086A (en) | 1985-07-05 | 1987-01-30 | Whitehead Institute For Biomedical Research | Epithelial cells expressing foreign genetic material |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
EP0633318A1 (en) | 1987-09-11 | 1995-01-11 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
US5156844A (en) | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
US5487739A (en) | 1987-11-17 | 1996-01-30 | Brown University Research Foundation | Implantable therapy systems and methods |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
JP2791418B2 (ja) * | 1987-12-02 | 1998-08-27 | 株式会社ミドリ十字 | 異種蛋白質の製造方法、組換えdna、形質転換体 |
DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
IL95330A0 (en) * | 1989-08-11 | 1991-06-30 | Lilly Co Eli | Expression of a functional insect specific toxin gene in mammalian cells |
EP0585368B1 (en) | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
CA2119463C (en) | 1991-09-20 | 2003-09-16 | Leu-Fen H. Lin | Glial cell line-derived neutrophic factor |
US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
AU688776B2 (en) | 1993-06-23 | 1998-03-19 | Brown University Research Foundation | Method and apparatus for sealing implantable, membrane encapsulation devices |
CA2169292C (en) | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
WO1995024929A2 (en) | 1994-03-15 | 1995-09-21 | Brown University Research Foundation | Polymeric gene delivery system |
US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
US5656465A (en) | 1994-05-04 | 1997-08-12 | Therion Biologics Corporation | Methods of in vivo gene delivery |
US5677158A (en) | 1995-06-07 | 1997-10-14 | Research Foundation Of State University Of New York | In vitro packaging of adeno-associated virus DNA |
US5739307A (en) | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
US5904144A (en) | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
US6027721A (en) | 1996-05-20 | 2000-02-22 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
US6054142A (en) | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
US6136597A (en) | 1997-09-18 | 2000-10-24 | The Salk Institute For Biological Studies | RNA export element |
WO1999039724A1 (en) * | 1998-02-10 | 1999-08-12 | Oregon Health Sciences University | Treatment of bony defects with osteoblast precursor cells |
US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
US6683058B1 (en) | 1998-04-15 | 2004-01-27 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
PT1080202E (pt) | 1998-05-27 | 2006-05-31 | Avigen Inc | Distribuicao de vectores aav codificando aadc intensificada por conveccao |
US20020055467A1 (en) * | 1998-07-06 | 2002-05-09 | Johansen Teit E. | Novel neurotrophic factors |
US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
HU226073B1 (en) | 1998-07-14 | 2008-04-28 | Janssen Pharmaceutica Nv | Neurotrophic growth factor |
US20020002269A1 (en) | 1998-09-29 | 2002-01-03 | Jeffrey D. Milbrandt | Artemin, a neurotrophic factor |
IL126562A0 (en) * | 1998-10-14 | 1999-08-17 | Interpharm Lab Ltd | Expression and secretion of icil-1 receptor antagonist type ii |
US6361741B1 (en) | 1999-02-01 | 2002-03-26 | Alcoa Inc. | Brazeable 6XXX alloy with B-rated or better machinability |
US6420345B1 (en) * | 1999-03-01 | 2002-07-16 | Cell Genesys, Inc. | Methods and reagents for inhibiting angiogenesis |
US6361771B1 (en) * | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
AU1997501A (en) | 1999-10-29 | 2001-05-08 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Use of GDNF for treating corneal defects |
US6866851B1 (en) | 1999-12-28 | 2005-03-15 | Washington University | GFRα1-RET specific agonists and methods therefor |
CA2410015A1 (en) | 2000-05-26 | 2001-12-06 | Thomas W. Dubensky, Jr. | Methods of transducing neural cells using lentivirus vectors |
GB0018876D0 (en) * | 2000-08-01 | 2000-09-20 | Applied Research Systems | Method of producing polypeptides |
JP2005502582A (ja) * | 2000-12-22 | 2005-01-27 | ジェネンテック, インコーポレイテッド | Gdnfリガンドファミリーのメンバーである、アルテミンの新たな使用 |
DK1355936T3 (da) | 2001-02-01 | 2007-10-29 | Biogen Idec Inc | Polymerkonjugater af neublastin og fremgangsmåder til anvendelse af samme |
EP1395279B1 (en) * | 2001-03-28 | 2011-10-05 | Biogen Idec MA Inc. | Use of neublastin polypeptides for treating neuropathic pain |
ES2328640T3 (es) | 2003-04-18 | 2009-11-16 | Biogen Idec Ma Inc. | Neublastina conjugada con un polimero glicosilada. |
WO2004108760A2 (en) | 2003-06-10 | 2004-12-16 | Nsgene A/S | Improved secretion of neublastin |
US7598059B2 (en) * | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
BRPI0415563A (pt) | 2003-10-20 | 2007-01-02 | Nsgene As | método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional |
-
2004
- 2004-06-10 WO PCT/DK2004/000411 patent/WO2004108760A2/en active Application Filing
- 2004-06-10 US US10/864,891 patent/US7601518B2/en not_active Expired - Fee Related
- 2004-06-10 ES ES04736510T patent/ES2323066T3/es active Active
- 2004-06-10 DK DK04736510T patent/DK1636260T3/da active
- 2004-06-10 ES ES09153016T patent/ES2353457T3/es active Active
- 2004-06-10 CN CNB2004800229462A patent/CN100475846C/zh not_active Expired - Fee Related
- 2004-06-10 EP EP09153016A patent/EP2058329B1/en active Active
- 2004-06-10 KR KR1020057023631A patent/KR20060031618A/ko not_active Application Discontinuation
- 2004-06-10 AT AT04736510T patent/ATE423134T1/de not_active IP Right Cessation
- 2004-06-10 AU AU2004245175A patent/AU2004245175C1/en not_active Ceased
- 2004-06-10 DE DE602004019524T patent/DE602004019524D1/de active Active
- 2004-06-10 EP EP04736510A patent/EP1636260B1/en active Active
- 2004-06-10 BR BRPI0411243-1A patent/BRPI0411243A/pt not_active IP Right Cessation
- 2004-06-10 NZ NZ544263A patent/NZ544263A/en not_active IP Right Cessation
- 2004-06-10 RU RU2005138368/13A patent/RU2005138368A/ru not_active Application Discontinuation
- 2004-06-10 DK DK09153016.2T patent/DK2058329T3/da active
- 2004-06-10 AT AT09153016T patent/ATE478092T1/de not_active IP Right Cessation
- 2004-06-10 DE DE602004028769T patent/DE602004028769D1/de active Active
- 2004-06-10 JP JP2006515713A patent/JP5623685B2/ja not_active Expired - Fee Related
- 2004-06-10 CA CA2527914A patent/CA2527914C/en not_active Expired - Fee Related
-
2005
- 2005-11-30 IL IL172270A patent/IL172270A/en not_active IP Right Cessation
-
2006
- 2006-04-26 HK HK06105018.1A patent/HK1082752A1/ not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2004245175C1 (en) | 2010-03-18 |
IL172270A0 (en) | 2006-04-10 |
EP1636260A2 (en) | 2006-03-22 |
HK1082752A1 (en) | 2006-06-16 |
WO2004108760A2 (en) | 2004-12-16 |
CA2527914A1 (en) | 2004-12-16 |
AU2004245175A1 (en) | 2004-12-16 |
JP5623685B2 (ja) | 2014-11-12 |
US7601518B2 (en) | 2009-10-13 |
EP1636260B1 (en) | 2009-02-18 |
NZ544263A (en) | 2009-04-30 |
CN1835971A (zh) | 2006-09-20 |
ES2323066T3 (es) | 2009-07-06 |
DE602004019524D1 (de) | 2009-04-02 |
WO2004108760A3 (en) | 2005-04-07 |
ATE478092T1 (de) | 2010-09-15 |
ATE423134T1 (de) | 2009-03-15 |
AU2004245175B2 (en) | 2009-10-15 |
KR20060031618A (ko) | 2006-04-12 |
EP2058329A1 (en) | 2009-05-13 |
JP2007535898A (ja) | 2007-12-13 |
CN100475846C (zh) | 2009-04-08 |
BRPI0411243A (pt) | 2006-07-11 |
US20050089960A1 (en) | 2005-04-28 |
DE602004028769D1 (de) | 2010-09-30 |
RU2005138368A (ru) | 2006-07-27 |
DK1636260T3 (da) | 2009-06-22 |
IL172270A (en) | 2015-04-30 |
ES2353457T3 (es) | 2011-03-02 |
EP2058329B1 (en) | 2010-08-18 |
CA2527914C (en) | 2014-10-28 |
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