BRPI0514534A - variantes de neublastina - Google Patents

variantes de neublastina

Info

Publication number
BRPI0514534A
BRPI0514534A BRPI0514534-1A BRPI0514534A BRPI0514534A BR PI0514534 A BRPI0514534 A BR PI0514534A BR PI0514534 A BRPI0514534 A BR PI0514534A BR PI0514534 A BRPI0514534 A BR PI0514534A
Authority
BR
Brazil
Prior art keywords
neublastin polypeptides
variant neublastin
amino acid
disclosed
acid residues
Prior art date
Application number
BRPI0514534-1A
Other languages
English (en)
Inventor
Anthony Rossomando
Laura Silvian
R Blake Pepinsky
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of BRPI0514534A publication Critical patent/BRPI0514534A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

VARIANTES DE NEUBLASTINA. Trata-se de polipeptídeos de Neublastina variante que possuem substituições em resíduos de aminoácidos selecionados. A substituição em um ou mais resíduos de aminoácido selecionados diminui a ligação a heparina e aumenta a exposição de soro de polipeptídeos de Neublastina variante. Trata-se também de métodos para utilização de polipeptídeos de Neubiastina variante para tratamento de distúrbios e ativar o receptor RET receptor em um mamífero.
BRPI0514534-1A 2004-08-19 2005-08-18 variantes de neublastina BRPI0514534A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60282504P 2004-08-19 2004-08-19
US69406705P 2005-06-24 2005-06-24
PCT/US2005/029637 WO2006023781A2 (en) 2004-08-19 2005-08-18 Neublastin variants

Publications (1)

Publication Number Publication Date
BRPI0514534A true BRPI0514534A (pt) 2008-06-17

Family

ID=35968235

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514534-1A BRPI0514534A (pt) 2004-08-19 2005-08-18 variantes de neublastina

Country Status (27)

Country Link
US (2) US8263553B2 (pt)
EP (3) EP2335713A3 (pt)
JP (2) JP4852545B2 (pt)
KR (2) KR101215697B1 (pt)
CN (1) CN102924585A (pt)
AT (1) ATE474586T1 (pt)
AU (1) AU2005277226B2 (pt)
BR (1) BRPI0514534A (pt)
CA (1) CA2577755C (pt)
CY (1) CY1111136T1 (pt)
DE (1) DE602005022457D1 (pt)
DK (1) DK1786454T3 (pt)
EA (1) EA013565B1 (pt)
GE (1) GEP20115196B (pt)
HK (1) HK1103991A1 (pt)
HR (1) HRP20100474T1 (pt)
IL (2) IL181311A (pt)
MX (1) MX2007002029A (pt)
NO (1) NO20071449L (pt)
NZ (1) NZ553431A (pt)
PL (1) PL1786454T3 (pt)
PT (1) PT1786454E (pt)
RS (1) RS51453B (pt)
SI (1) SI1786454T1 (pt)
UA (1) UA92590C2 (pt)
WO (1) WO2006023781A2 (pt)
ZA (1) ZA200701395B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
JP4571776B2 (ja) * 2002-11-05 2010-10-27 Ｊｘ日鉱日石エネルギー株式会社 潤滑油組成物
EP1897552B1 (en) 2003-04-18 2009-06-17 Biogen Idec MA Inc. Polymer-conjugated glycosylated neublastin
AU2005277227B2 (en) 2004-08-19 2011-10-06 Biogen Ma Inc. Refolding transforming growth factor beta family proteins
MX2007002029A (es) 2004-08-19 2007-03-28 Biogen Idec Inc Variantes de neublastina.
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
US20100056440A1 (en) * 2006-03-01 2010-03-04 Biogen Idec Ma Inc. Compositions and methods for administering gdnf ligand family proteins
CA2685686A1 (en) 2007-05-01 2008-11-13 Biogen Idec Ma Inc. Neublastin polypeptides for use increasing vascularization in a tissue
WO2009020964A2 (en) * 2007-08-08 2009-02-12 Biogen Idec Ma Inc. Anti-neublastin antibodies and uses thereof
WO2015042580A1 (en) 2013-09-23 2015-03-26 Biogen Idec Ma Inc. Compositions and methods for treatment of neuropathic pain
WO2016022800A1 (en) 2014-08-07 2016-02-11 Biogen Ma Inc. Characterization of cystine knot superfamily proteins
CA3124660A1 (en) * 2018-12-21 2020-06-25 Gloriana Therapeutics Sarl Mammalian cell culture-produced neublastin antibodies

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Also Published As

Publication number Publication date
UA92590C2 (uk) 2010-11-25
EP2238983A2 (en) 2010-10-13
PT1786454E (pt) 2010-08-18
EP2335713A3 (en) 2011-11-02
CA2577755A1 (en) 2006-03-02
EA013565B1 (ru) 2010-06-30
KR20110126732A (ko) 2011-11-23
NO20071449L (no) 2007-05-18
ZA200701395B (en) 2009-03-25
ATE474586T1 (de) 2010-08-15
GEP20115196B (en) 2011-04-11
EP2335713A2 (en) 2011-06-22
KR20070050964A (ko) 2007-05-16
EP1786454A4 (en) 2008-06-18
JP2011155987A (ja) 2011-08-18
KR101215697B1 (ko) 2012-12-28
JP4852545B2 (ja) 2012-01-11
EP2238983B1 (en) 2014-07-23
AU2005277226A1 (en) 2006-03-02
NZ553431A (en) 2010-04-30
CA2577755C (en) 2014-05-13
IL181311A0 (en) 2007-07-04
DK1786454T3 (da) 2010-09-06
WO2006023781A2 (en) 2006-03-02
MX2007002029A (es) 2007-03-28
WO2006023781A3 (en) 2007-08-16
DE602005022457D1 (de) 2010-09-02
CN102924585A (zh) 2013-02-13
EA200700460A1 (ru) 2007-10-26
SI1786454T1 (sl) 2010-10-29
HK1103991A1 (en) 2008-01-04
EP1786454A2 (en) 2007-05-23
IL181311A (en) 2013-06-27
JP2008510468A (ja) 2008-04-10
EP2238983A3 (en) 2011-03-09
EP1786454B1 (en) 2010-07-21
AU2005277226B2 (en) 2012-01-19
US20080039385A1 (en) 2008-02-14
US20130096065A1 (en) 2013-04-18
PL1786454T3 (pl) 2010-12-31
CY1111136T1 (el) 2015-06-11
HRP20100474T1 (hr) 2010-10-31
RS51453B (en) 2011-04-30
US8263553B2 (en) 2012-09-11
IL205201A0 (en) 2011-07-31

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