PT1223966E - Utilizacao do gdnf para tratamento de defeitos na cornea - Google Patents
Utilizacao do gdnf para tratamento de defeitos na corneaInfo
- Publication number
- PT1223966E PT1223966E PT00983097T PT00983097T PT1223966E PT 1223966 E PT1223966 E PT 1223966E PT 00983097 T PT00983097 T PT 00983097T PT 00983097 T PT00983097 T PT 00983097T PT 1223966 E PT1223966 E PT 1223966E
- Authority
- PT
- Portugal
- Prior art keywords
- gdnf
- cornea
- defects
- take
- agonist
- Prior art date
Links
- 102000024452 GDNF Human genes 0.000 title abstract 4
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 abstract 2
- 230000005714 functional activity Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 210000004498 neuroglial cell Anatomy 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99121597 | 1999-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1223966E true PT1223966E (pt) | 2003-09-30 |
Family
ID=8239299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00983097T PT1223966E (pt) | 1999-10-29 | 2000-10-30 | Utilizacao do gdnf para tratamento de defeitos na cornea |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20030166537A1 (pt) |
| EP (1) | EP1223966B1 (pt) |
| JP (1) | JP2003512433A (pt) |
| AT (1) | ATE238806T1 (pt) |
| AU (1) | AU1997501A (pt) |
| CA (1) | CA2385929A1 (pt) |
| DE (1) | DE60002496T2 (pt) |
| DK (1) | DK1223966T3 (pt) |
| ES (1) | ES2198367T3 (pt) |
| PT (1) | PT1223966E (pt) |
| WO (1) | WO2001030375A2 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| US7276580B2 (en) * | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
| FR2825273B1 (fr) * | 2001-05-29 | 2006-11-24 | Oreal | Composition pour le traitement des signes cutanes du vieillissement |
| US20050222070A1 (en) * | 2002-05-29 | 2005-10-06 | Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung | Pancreas-specific proteins |
| JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Ｊｘ日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| EP1897552B1 (en) | 2003-04-18 | 2009-06-17 | Biogen Idec MA Inc. | Polymer-conjugated glycosylated neublastin |
| EP2058329B1 (en) | 2003-06-10 | 2010-08-18 | NsGene A/S | Improved secretion of neublastin |
| WO2005051415A1 (en) | 2003-11-27 | 2005-06-09 | Develogen Aktiengesellschaft | Method for preventing and treating diabetes using neurturin |
| US20050209148A1 (en) * | 2004-02-20 | 2005-09-22 | Arnon Rosenthal | Methods of treating obesity or diabetes using NT-4/5 |
| CA2561577A1 (en) | 2004-03-30 | 2005-10-13 | Nsgene A/S | Therapeutic use of a growth factor, nsg33 |
| WO2006023782A2 (en) | 2004-08-19 | 2006-03-02 | Biogen Ideca Ma Inc. | Refolding transforming growth factor beta family proteins |
| CN102924585A (zh) * | 2004-08-19 | 2013-02-13 | 比奥根艾迪克Ma公司 | 神经胚素变体 |
| NL2000464C2 (nl) * | 2006-02-02 | 2007-09-11 | Rinat Neuroscience Corp | Werkwijzen voor het behandelen van ongewenst gewichtsverlies of eetstoornissen door het toedienen van een TRKB-agonist. |
| JP2009525319A (ja) * | 2006-02-02 | 2009-07-09 | ライナット ニューロサイエンス コーポレイション | ｔｒｋＢアンタゴニストを投与することにより肥満を治療する方法 |
| TWI501774B (zh) * | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| EP1993590B1 (en) * | 2006-03-01 | 2013-12-25 | Biogen Idec MA Inc. | Compostions and methods for administering gdnf ligand family proteins |
| WO2008070513A1 (en) * | 2006-12-01 | 2008-06-12 | Alcon Research, Ltd. | Modulation of polysialylated neural adhesion molecules (psa-ncam) as a regulator of ocular disease |
| BRPI0720473A2 (pt) * | 2006-12-20 | 2014-01-14 | Rinat Neuroscience Corp | Agonistas de trkb para tratamento de distúbios autoimunes |
| ES2476253T3 (es) | 2007-05-01 | 2014-07-14 | Biogen Idec Ma Inc. | P�ptidos de neublastina para su uso en el aumento de la vascularizaci�n en tejido con flujo sanguíneo deteriorado |
| WO2009011892A2 (en) * | 2007-07-18 | 2009-01-22 | Boston Biomedical Research Institute | Use of suif proteins and heparan sulfate in gdnf-dependent neural innervation and protection |
| EP2205634A2 (en) * | 2007-08-08 | 2010-07-14 | Biogen Idec MA, Inc. | Anti-neublastin antibodies and uses thereof |
| WO2010086828A2 (en) * | 2009-02-02 | 2010-08-05 | Rinat Neuroscience Corporation | Agonist anti-trkb monoclonal antibodies |
| JP5429865B2 (ja) * | 2009-09-15 | 2014-02-26 | 学校法人日本大学 | 生体外創傷治癒試験用用具または創傷作製方法 |
| WO2014152511A1 (en) | 2013-03-15 | 2014-09-25 | The Jackson Laboratory | Methods for promoting wound healing and hair growth |
| JP6403217B2 (ja) | 2013-07-30 | 2018-10-10 | 京都府公立大学法人 | 角膜内皮ｅｃｍ治療薬 |
| CN107137698A (zh) * | 2017-03-03 | 2017-09-08 | 北京大学第三医院 | 一种包含gdnf的用于治疗角膜上皮损伤的药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733875A (en) * | 1994-11-15 | 1998-03-31 | Amgen Inc. | Methods of using GDNF as a neuroprotective agent |
| US5837681A (en) * | 1996-02-23 | 1998-11-17 | Amgen Inc. | Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US5929041A (en) * | 1996-02-23 | 1999-07-27 | Amgen Inc. | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
| WO1997049798A1 (en) * | 1996-06-27 | 1997-12-31 | University Of Helsinki | Glial cell line-derived neurotrophic factor regulation of ureteric budding and growth, and of enteric innervation |
| KR20000070357A (ko) * | 1997-01-23 | 2000-11-25 | 다께우찌 마사야쓰 | 당뇨병 치료제 |
-
2000
- 2000-10-30 PT PT00983097T patent/PT1223966E/pt unknown
- 2000-10-30 AU AU19975/01A patent/AU1997501A/en not_active Abandoned
- 2000-10-30 DE DE60002496T patent/DE60002496T2/de not_active Expired - Fee Related
- 2000-10-30 CA CA002385929A patent/CA2385929A1/en not_active Abandoned
- 2000-10-30 WO PCT/EP2000/010674 patent/WO2001030375A2/en active IP Right Grant
- 2000-10-30 ES ES00983097T patent/ES2198367T3/es not_active Expired - Lifetime
- 2000-10-30 JP JP2001532792A patent/JP2003512433A/ja active Pending
- 2000-10-30 DK DK00983097T patent/DK1223966T3/da active
- 2000-10-30 AT AT00983097T patent/ATE238806T1/de not_active IP Right Cessation
- 2000-10-30 EP EP00983097A patent/EP1223966B1/en not_active Expired - Lifetime
-
2002
- 2002-04-24 US US10/132,069 patent/US20030166537A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60002496T2 (de) | 2004-03-25 |
| ES2198367T3 (es) | 2004-02-01 |
| WO2001030375A3 (en) | 2002-03-21 |
| AU1997501A (en) | 2001-05-08 |
| EP1223966A2 (en) | 2002-07-24 |
| US20030166537A1 (en) | 2003-09-04 |
| EP1223966B1 (en) | 2003-05-02 |
| DE60002496D1 (de) | 2003-06-05 |
| ATE238806T1 (de) | 2003-05-15 |
| JP2003512433A (ja) | 2003-04-02 |
| WO2001030375A2 (en) | 2001-05-03 |
| CA2385929A1 (en) | 2001-05-03 |
| DK1223966T3 (da) | 2003-08-18 |
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