ATE251448T1 - Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinen - Google Patents
Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinenInfo
- Publication number
- ATE251448T1 ATE251448T1 AT99968164T AT99968164T ATE251448T1 AT E251448 T1 ATE251448 T1 AT E251448T1 AT 99968164 T AT99968164 T AT 99968164T AT 99968164 T AT99968164 T AT 99968164T AT E251448 T1 ATE251448 T1 AT E251448T1
- Authority
- AT
- Austria
- Prior art keywords
- oil suspensions
- polyol
- proteins
- delayed release
- active agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/221,181 US6245740B1 (en) | 1998-12-23 | 1998-12-23 | Polyol:oil suspensions for the sustained release of proteins |
| US44820599A | 1999-11-23 | 1999-11-23 | |
| PCT/US1999/030527 WO2000038652A1 (en) | 1998-12-23 | 1999-12-20 | Polyol/oil suspensions for the sustained release of proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE251448T1 true ATE251448T1 (de) | 2003-10-15 |
Family
ID=26915566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99968164T ATE251448T1 (de) | 1998-12-23 | 1999-12-20 | Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinen |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1140018B1 (de) |
| JP (1) | JP2002533378A (de) |
| KR (1) | KR100491815B1 (de) |
| CN (1) | CN1158068C (de) |
| AT (1) | ATE251448T1 (de) |
| AU (1) | AU769610B2 (de) |
| CA (1) | CA2355618C (de) |
| DE (1) | DE69911993T2 (de) |
| DK (1) | DK1140018T3 (de) |
| ES (1) | ES2204187T3 (de) |
| HU (1) | HUP0104756A3 (de) |
| IL (2) | IL143706A0 (de) |
| PT (1) | PT1140018E (de) |
| SI (1) | SI1140018T1 (de) |
| TW (1) | TWI221777B (de) |
| WO (1) | WO2000038652A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| DK1274459T3 (da) | 2000-04-19 | 2006-02-06 | Genentech Inc | Præparater med vedholdende frigivelse indeholdende væksthormon |
| WO2002036072A2 (en) * | 2000-11-03 | 2002-05-10 | Biomedicines, Inc. | Method for short-term and long-term drug dosimetry |
| WO2003000282A1 (en) * | 2001-06-21 | 2003-01-03 | Genentech, Inc. | Sustained release formulation |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| FR2868704B1 (fr) * | 2004-04-07 | 2007-09-14 | Ethypharm Sa | Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires |
| US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| KR101106510B1 (ko) | 2006-05-30 | 2012-01-20 | 인타르시아 세라퓨틱스 인코포레이티드 | 투피스, 내부채널 삼투압 전달 시스템 유동 조절기 |
| DK2049081T3 (da) | 2006-08-09 | 2013-02-25 | Intarcia Therapeutics Inc | Osmotiske leveringssystemer og stempelarrangementer |
| CA2667678A1 (en) | 2006-10-25 | 2008-07-24 | Amgen Inc. | Toxin peptide therapeutic agents |
| KR101434706B1 (ko) * | 2007-02-16 | 2014-08-26 | 아스카 세이야쿠 가부시키가이샤 | 미립자 유성 현탁액을 포함하는 의약 조성물 |
| US20080227805A1 (en) | 2007-02-28 | 2008-09-18 | Abbott Laboratories | Sustained release parenteral formulations of buprenorphine |
| ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
| EP2162540A2 (de) | 2007-05-22 | 2010-03-17 | Amgen Inc. | Zusammensetzungen und verfahren zur herstellung biologisch aktiver fusionsproteine |
| EP2240155B1 (de) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe |
| CN107638562B (zh) | 2009-09-28 | 2022-12-02 | 精达制药公司 | 基本稳态药物递送的快速建立和/或终止 |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9340590B2 (en) | 2011-03-16 | 2016-05-17 | Amgen Inc. | Potent and selective inhibitors of NaV1.3 and NaV1.7 |
| WO2014099984A1 (en) | 2012-12-20 | 2014-06-26 | Amgen Inc. | Apj receptor agonists and uses thereof |
| WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
| CA2951391C (en) | 2014-06-10 | 2021-11-02 | Amgen Inc. | Apelin polypeptides |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| BR112018073511A2 (pt) | 2016-05-16 | 2019-03-26 | Intarcia Therapeutics, Inc. | polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| MX2019008006A (es) | 2017-01-03 | 2019-08-29 | Intarcia Therapeutics Inc | Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco. |
| US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61500439A (ja) * | 1983-11-21 | 1986-03-13 | リ−ジエンツ オヴ ザ ユニヴア−シテイ− オヴ ミネソタ | 慢性的非経口ホルモン投与用緩衝化ポリオ−ル−ホルモン混合物 |
| US5411951A (en) * | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| EP0374120A3 (de) * | 1988-12-13 | 1991-07-31 | Monsanto Company | Zusammensetzung mit kontrollierter Wirkstoffabgabe von Polypeptiden |
| US5114929A (en) * | 1989-03-21 | 1992-05-19 | Beecham Group P.L.C. | Pharmaceutical formulation |
| US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
-
1999
- 1999-12-20 HU HU0104756A patent/HUP0104756A3/hu unknown
- 1999-12-20 KR KR10-2001-7007843A patent/KR100491815B1/ko not_active IP Right Cessation
- 1999-12-20 JP JP2000590606A patent/JP2002533378A/ja not_active Withdrawn
- 1999-12-20 CA CA002355618A patent/CA2355618C/en not_active Expired - Fee Related
- 1999-12-20 EP EP99968164A patent/EP1140018B1/de not_active Expired - Lifetime
- 1999-12-20 DK DK99968164T patent/DK1140018T3/da active
- 1999-12-20 AU AU24838/00A patent/AU769610B2/en not_active Ceased
- 1999-12-20 AT AT99968164T patent/ATE251448T1/de not_active IP Right Cessation
- 1999-12-20 WO PCT/US1999/030527 patent/WO2000038652A1/en active IP Right Grant
- 1999-12-20 ES ES99968164T patent/ES2204187T3/es not_active Expired - Lifetime
- 1999-12-20 IL IL14370699A patent/IL143706A0/xx active IP Right Grant
- 1999-12-20 PT PT99968164T patent/PT1140018E/pt unknown
- 1999-12-20 CN CNB99816271XA patent/CN1158068C/zh not_active Expired - Fee Related
- 1999-12-20 DE DE69911993T patent/DE69911993T2/de not_active Expired - Fee Related
- 1999-12-20 SI SI9930434T patent/SI1140018T1/xx unknown
- 1999-12-21 TW TW088122540A patent/TWI221777B/zh active
-
2001
- 2001-06-12 IL IL143706A patent/IL143706A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2204187T3 (es) | 2004-04-16 |
| JP2002533378A (ja) | 2002-10-08 |
| CN1158068C (zh) | 2004-07-21 |
| KR100491815B1 (ko) | 2005-05-27 |
| HUP0104756A3 (en) | 2006-04-28 |
| HUP0104756A2 (hu) | 2002-04-29 |
| IL143706A (en) | 2008-04-13 |
| EP1140018A1 (de) | 2001-10-10 |
| CN1335765A (zh) | 2002-02-13 |
| DE69911993D1 (de) | 2003-11-13 |
| KR20010099864A (ko) | 2001-11-09 |
| PT1140018E (pt) | 2004-02-27 |
| AU2483800A (en) | 2000-07-31 |
| CA2355618C (en) | 2007-03-13 |
| EP1140018B1 (de) | 2003-10-08 |
| IL143706A0 (en) | 2002-04-21 |
| TWI221777B (en) | 2004-10-11 |
| DE69911993T2 (de) | 2004-05-19 |
| AU769610B2 (en) | 2004-01-29 |
| SI1140018T1 (en) | 2003-12-31 |
| WO2000038652A1 (en) | 2000-07-06 |
| CA2355618A1 (en) | 2000-07-06 |
| DK1140018T3 (da) | 2004-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1140018 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |