DK0490281T3 - - Google Patents

Info

Publication number
DK0490281T3
DK0490281T3 DK91120935.1T DK91120935T DK0490281T3 DK 0490281 T3 DK0490281 T3 DK 0490281T3 DK 91120935 T DK91120935 T DK 91120935T DK 0490281 T3 DK0490281 T3 DK 0490281T3
Authority
DK
Denmark
Prior art keywords
synthesis
polymerases
oligonucleotides
oligonucleotide
amino
Prior art date
Application number
DK91120935.1T
Other languages
Danish (da)
English (en)
Inventor
Joachim Engels
Mathias Herrlein
Renate Konrad
Matthias Mag
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0490281T3 publication Critical patent/DK0490281T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91120935.1T 1990-12-11 1991-12-06 DK0490281T3 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4039488 1990-12-11

Publications (1)

Publication Number Publication Date
DK0490281T3 true DK0490281T3 (pt) 1997-02-10

Family

ID=6420050

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91120935.1T DK0490281T3 (pt) 1990-12-11 1991-12-06

Country Status (27)

Country Link
US (3) US5679785A (pt)
EP (1) EP0490281B1 (pt)
JP (1) JP3140127B2 (pt)
KR (1) KR920012107A (pt)
AT (1) ATE142222T1 (pt)
AU (1) AU643856B2 (pt)
BG (1) BG61484B1 (pt)
BR (1) BR9105335A (pt)
CA (1) CA2057475A1 (pt)
CS (1) CS374391A3 (pt)
DE (1) DE59108143D1 (pt)
DK (1) DK0490281T3 (pt)
ES (1) ES2093671T3 (pt)
FI (1) FI915779A (pt)
GR (1) GR3021041T3 (pt)
HU (1) HUT60505A (pt)
IE (1) IE75726B1 (pt)
IL (1) IL100298A (pt)
MX (1) MX9102468A (pt)
NO (1) NO914859L (pt)
NZ (1) NZ240900A (pt)
PL (1) PL168874B1 (pt)
PT (1) PT99747A (pt)
RO (1) RO111575B1 (pt)
RU (1) RU2073682C1 (pt)
TR (1) TR27715A (pt)
YU (1) YU187991A (pt)

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US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
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US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US6017702A (en) * 1996-12-05 2000-01-25 The Perkin-Elmer Corporation Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
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US6761877B2 (en) * 2000-02-18 2004-07-13 Biocrystal, Ltd. Functionalized encapsulated fluorescent nanocrystals
ATE352586T2 (de) * 2000-09-29 2007-02-15 Molecular Probes Inc Modifizierte carbocyaninfarbstoffe und deren konjugate
US7563618B2 (en) 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
KR100762261B1 (ko) 2001-04-27 2007-10-04 (주)바이오니아 전장 상보 디옥시리보핵산 제조 방법과 이에 사용되는앵커와 프라이머
US7214428B2 (en) * 2001-09-17 2007-05-08 Invitrogen Corporation Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications
US7205048B2 (en) 2001-09-17 2007-04-17 Invitrogen Corporation Functionalized fluorescent nanocrystal compositions and methods of making
WO2003054507A2 (en) * 2001-09-17 2003-07-03 Biocrystal, Ltd. Nanocrystals
WO2004055160A2 (en) * 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
JP4177123B2 (ja) * 2003-01-10 2008-11-05 富士通株式会社 配線図形検証方法、プログラム及び装置
KR100890885B1 (ko) 2003-03-31 2009-03-31 에프. 호프만-라 로슈 아게 일본 뇌염 바이러스 혈청군의 구성원을 포함하는, 특정플라비바이러스 검출용 조성물 및 방법
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
WO2006033732A1 (en) * 2004-08-17 2006-03-30 Invitrogen Corporation Synthesis of highly luminescent colloidal particles
US7368086B2 (en) * 2004-10-29 2008-05-06 Invitrogen Corporation Functionalized fluorescent nanocrystals, and methods for their preparation and use
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
EP2233581A1 (en) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nucleic acid sequencing by performing successive cycles of duplex extension
US7544471B2 (en) * 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
US7700289B2 (en) * 2006-04-03 2010-04-20 Agilent Technologies, Inc. Method for labeling RNA
CA2649725A1 (en) * 2006-04-19 2007-10-25 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
US7572585B2 (en) * 2006-07-31 2009-08-11 Agilent Technologies, Inc. Enzymatic labeling of RNA
BRPI0719923B1 (pt) * 2006-12-05 2021-08-17 Agilent Technologies Inc Métodos para sequenciamento de um ácido nucléico alvo, para conversão de um componente de ocorrência não natural em uma molécula de ácido nucléico em um componente de ocorrência natural, para terminar uma síntese de ácido nucléico, e para realizar o sequenciamento de sanger ou tipo sanger, e compostos
AU2008283902B2 (en) 2007-08-06 2014-03-13 Orion Genomics Llc Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the IGF2 gene
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験
US20090191553A1 (en) * 2007-10-01 2009-07-30 Applied Biosystems Inc. Chase Ligation Sequencing
US20100086914A1 (en) * 2008-10-03 2010-04-08 Roche Molecular Systems, Inc. High resolution, high throughput hla genotyping by clonal sequencing
EP2955234A1 (en) 2009-02-11 2015-12-16 Orion Genomics, LLC Combinations of polymorphisms for determining allele-specific expression of igf2
US8431416B2 (en) 2009-04-01 2013-04-30 Becton, Dickinson And Company Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
EP2473563B1 (en) * 2009-08-31 2019-06-19 Promega Corporation Reactive cyanine compounds
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
PL2576837T3 (pl) 2010-06-04 2018-04-30 Chronix Biomedical Krążeniowe biomarkery typu kwasu nukleinowego związane z rakiem prostaty
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
EP2768985B1 (en) 2011-10-21 2019-03-20 Chronix Biomedical Colorectal cancer associated circulating nucleic acid biomarkers
ES2413566B1 (es) 2011-12-14 2014-05-20 Fundación Pública Andaluza Progreso Y Salud Método de obtención de datos útiles para el diagnóstico y pronóstico de la hipoacusia neurosensorial.
US9957549B2 (en) 2012-06-18 2018-05-01 Nugen Technologies, Inc. Compositions and methods for negative selection of non-desired nucleic acid sequences
ES2703764T3 (es) 2012-12-14 2019-03-12 Chronix Biomedical Biomarcadores personalizados para el cáncer
SI3004388T2 (sl) 2013-05-29 2023-11-30 Chronix Biomedical Odkrivanje in kvantifikacija donorjeve brezcelične DNK v cirkulaciji prejemnikov presajenih organov
DK3201361T3 (da) 2014-10-01 2020-05-18 Chronix Biomedical Fremgangsmåder til kvantificering af cellefrit DNA
JP2019512573A (ja) 2016-03-28 2019-05-16 エーエーティー バイオクエスト インコーポレイテッド ポリフルオレノ［４，５−ｃｄｅ］オキセピンコンジュゲート及び分析物検出方法におけるそれらの使用
US11220628B2 (en) 2019-02-20 2022-01-11 Aat Bioquest, Inc. Condensed polycyclic conjugated polymers and their use for biological detection
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WO2023147355A2 (en) * 2022-01-25 2023-08-03 Oregon Health & Science University Methods and systems for increasing capture potential of a spatial array

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US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
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US5541307A (en) * 1990-07-27 1996-07-30 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs and solid phase synthesis thereof

Also Published As

Publication number Publication date
NO914859D0 (no) 1991-12-10
YU187991A (sh) 1994-09-09
CA2057475A1 (en) 1992-06-12
BR9105335A (pt) 1992-08-25
NO914859L (no) 1992-06-12
KR920012107A (ko) 1992-07-25
AU643856B2 (en) 1993-11-25
IL100298A (en) 1997-03-18
EP0490281A1 (de) 1992-06-17
HU913885D0 (en) 1992-02-28
BG61484B1 (bg) 1997-09-30
ES2093671T3 (es) 1997-01-01
IE75726B1 (en) 1997-09-24
GR3021041T3 (en) 1996-12-31
PL168874B1 (pl) 1996-04-30
JPH04290896A (ja) 1992-10-15
MX9102468A (es) 1992-06-01
US5679785A (en) 1997-10-21
IE914301A1 (en) 1992-06-17
RO111575B1 (ro) 1996-11-29
DE59108143D1 (de) 1996-10-10
RU2073682C1 (ru) 1997-02-20
PT99747A (pt) 1992-11-30
IL100298A0 (en) 1992-09-06
JP3140127B2 (ja) 2001-03-05
NZ240900A (en) 1994-07-26
AU8892791A (en) 1992-06-18
ATE142222T1 (de) 1996-09-15
US5659025A (en) 1997-08-19
HUT60505A (en) 1992-09-28
TR27715A (tr) 1995-06-22
US5668269A (en) 1997-09-16
FI915779A0 (fi) 1991-12-09
EP0490281B1 (de) 1996-09-04
CS374391A3 (en) 1992-06-17
PL292701A1 (en) 1992-09-21
FI915779A (fi) 1992-06-12

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