DK0428376T3 - Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon - Google Patents

Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon

Info

Publication number
DK0428376T3
DK0428376T3 DK90312366.9T DK90312366T DK0428376T3 DK 0428376 T3 DK0428376 T3 DK 0428376T3 DK 90312366 T DK90312366 T DK 90312366T DK 0428376 T3 DK0428376 T3 DK 0428376T3
Authority
DK
Denmark
Prior art keywords
heteroaryl
alkynyl
aryl
alkenyl
alkyl
Prior art date
Application number
DK90312366.9T
Other languages
Danish (da)
English (en)
Inventor
Robert A Holton
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/436,235 external-priority patent/US5015744A/en
Application filed by Univ Florida State filed Critical Univ Florida State
Application granted granted Critical
Publication of DK0428376T3 publication Critical patent/DK0428376T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/84—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing rings with more than eight members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK90312366.9T 1989-11-14 1990-11-13 Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon DK0428376T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/436,235 US5015744A (en) 1989-11-14 1989-11-14 Method for preparation of taxol using an oxazinone
US07/603,041 US5136060A (en) 1989-11-14 1990-10-30 Method for preparation of taxol using an oxazinone

Publications (1)

Publication Number Publication Date
DK0428376T3 true DK0428376T3 (da) 1996-02-05

Family

ID=27030868

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90312366.9T DK0428376T3 (da) 1989-11-14 1990-11-13 Fremgangsmåde til fremstilling af taxol under anvendelse af en oxazinon

Country Status (28)

Country Link
US (3) US5136060A (zh)
EP (1) EP0428376B1 (zh)
JP (1) JP2507830B2 (zh)
KR (1) KR0161499B1 (zh)
CN (1) CN1043528C (zh)
AT (1) ATE132860T1 (zh)
AU (1) AU633375B2 (zh)
BG (1) BG60478B1 (zh)
CA (2) CA2347588C (zh)
CZ (2) CZ283539B6 (zh)
DE (1) DE69024757T2 (zh)
DK (1) DK0428376T3 (zh)
EG (1) EG19641A (zh)
ES (1) ES2083438T3 (zh)
FI (1) FI104487B (zh)
GR (1) GR3019192T3 (zh)
HU (1) HU209299B (zh)
IE (2) IE76279B1 (zh)
IL (3) IL109246A (zh)
MY (1) MY106071A (zh)
NO (1) NO177902C (zh)
NZ (1) NZ235993A (zh)
OA (1) OA09327A (zh)
PL (1) PL167898B1 (zh)
PT (1) PT95870B (zh)
RO (1) RO110491B1 (zh)
RU (1) RU2033994C1 (zh)
YU (1) YU48232B (zh)

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US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
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CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
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US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) * 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
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US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
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US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
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US7074945B2 (en) * 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
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Also Published As

Publication number Publication date
PT95870B (pt) 1997-04-30
US5136060A (en) 1992-08-04
CN1043528C (zh) 1999-06-02
IE76279B1 (en) 1997-10-08
FI104487B (fi) 2000-02-15
IL96304A0 (en) 1991-08-16
NO177902C (no) 1995-12-13
ES2083438T3 (es) 1996-04-16
BG93228A (bg) 1993-12-24
US5532363A (en) 1996-07-02
YU48232B (sh) 1997-08-22
PL167898B1 (pl) 1995-12-30
JP2507830B2 (ja) 1996-06-19
IL109246A (en) 1998-01-04
CA2347588A1 (en) 1991-05-15
DE69024757T2 (de) 1996-05-15
IE74154B1 (en) 1997-07-02
FI905609A0 (fi) 1990-11-13
EP0428376A1 (en) 1991-05-22
PT95870A (pt) 1991-09-30
CZ563490A3 (cs) 1998-01-14
EP0428376B1 (en) 1996-01-10
GR3019192T3 (en) 1996-06-30
RO110491B1 (ro) 1996-01-30
HU209299B (en) 1994-04-28
EG19641A (en) 1995-08-30
IL96304A (en) 1995-06-29
NO177902B (no) 1995-09-04
ATE132860T1 (de) 1996-01-15
CZ283581B6 (cs) 1998-05-13
JPH03232869A (ja) 1991-10-16
NZ235993A (en) 1992-10-28
US5384399A (en) 1995-01-24
NO904923D0 (no) 1990-11-13
CN1053427A (zh) 1991-07-31
NO904923L (no) 1991-05-15
DE69024757D1 (de) 1996-02-22
AU6590490A (en) 1991-05-23
CZ283539B6 (cs) 1998-04-15
PL287757A1 (en) 1991-12-16
KR0161499B1 (ko) 1998-12-01
CA2029787A1 (en) 1991-05-15
IL109246A0 (en) 1994-07-31
IE904061A1 (en) 1991-05-22
CA2029787C (en) 2001-10-09
BG60478B1 (bg) 1995-05-31
MY106071A (en) 1995-03-31
RU2033994C1 (ru) 1995-04-30
HUT57200A (en) 1991-11-28
HU907131D0 (en) 1991-05-28
CZ313695A3 (en) 1997-11-12
OA09327A (en) 1992-09-15
CA2347588C (en) 2005-08-16
YU216090A (sh) 1993-10-20
KR910009681A (ko) 1991-06-28
AU633375B2 (en) 1993-01-28

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