DK0388054T3 - Pyrrolidin-derivater - Google Patents

Pyrrolidin-derivater

Info

Publication number
DK0388054T3
DK0388054T3 DK90302269.7T DK90302269T DK0388054T3 DK 0388054 T3 DK0388054 T3 DK 0388054T3 DK 90302269 T DK90302269 T DK 90302269T DK 0388054 T3 DK0388054 T3 DK 0388054T3
Authority
DK
Denmark
Prior art keywords
chem
formula
pyrrolidine derivatives
pyrrolidine
ch2s
Prior art date
Application number
DK90302269.7T
Other languages
Danish (da)
English (en)
Inventor
Peter Edward Dr Cross
Alexander Roderick D Mackenzie
Original Assignee
Pfizer
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10653525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0388054(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Pfizer Ltd filed Critical Pfizer
Application granted granted Critical
Publication of DK0388054T3 publication Critical patent/DK0388054T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
DK90302269.7T 1989-03-17 1990-03-02 Pyrrolidin-derivater DK0388054T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898906166A GB8906166D0 (en) 1989-03-17 1989-03-17 Therapeutic agents

Publications (1)

Publication Number Publication Date
DK0388054T3 true DK0388054T3 (da) 1993-12-06

Family

ID=10653525

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90302269.7T DK0388054T3 (da) 1989-03-17 1990-03-02 Pyrrolidin-derivater

Country Status (37)

Country Link
US (1) US5096890B1 (cs)
EP (1) EP0388054B1 (cs)
JP (2) JPH0764809B2 (cs)
KR (2) KR920008166B1 (cs)
CN (1) CN1023007C (cs)
AT (1) ATE96783T1 (cs)
AU (1) AU614224B2 (cs)
BA (1) BA98300A (cs)
CA (1) CA2012295C (cs)
CL (1) CL2003002756A1 (cs)
CY (2) CY1812A (cs)
CZ (1) CZ280053B6 (cs)
DD (1) DD292911A5 (cs)
DE (2) DE69004302T2 (cs)
DK (1) DK0388054T3 (cs)
EG (1) EG18951A (cs)
ES (1) ES2060020T3 (cs)
FI (1) FI95573C (cs)
GB (1) GB8906166D0 (cs)
HK (1) HK130294A (cs)
HU (2) HU217433B (cs)
IE (1) IE62515B1 (cs)
IL (1) IL93694A (cs)
LU (1) LU91161I2 (cs)
MX (1) MX9319890A (cs)
MY (1) MY105527A (cs)
NL (1) NL300191I2 (cs)
NO (2) NO176316C (cs)
NZ (1) NZ232958A (cs)
PL (1) PL164136B1 (cs)
PT (1) PT93443B (cs)
RU (2) RU1833374C (cs)
SG (1) SG143394G (cs)
SK (1) SK278434B6 (cs)
UA (1) UA18263A (cs)
YU (1) YU47587B (cs)
ZA (1) ZA901982B (cs)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932594A (en) * 1988-11-01 1999-08-03 Pfizer, Inc. Muscarinic receptor antagonists
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
US5486527A (en) * 1990-01-06 1996-01-23 Pfizer Inc. Anticholinergic agents
US5607950A (en) * 1990-01-06 1997-03-04 Pfizer Inc. Muscarinic receptor antagonists
WO1993022309A1 (en) * 1992-04-23 1993-11-11 Merrell Dow Pharmaceuticals Inc. 4-imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy
GB9400600D0 (en) * 1994-01-14 1994-03-09 Pfizer Ltd Treatment of motion seckness
US5639763A (en) * 1994-03-01 1997-06-17 Fmc Corporation Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US6017931A (en) * 1994-03-01 2000-01-25 Fmc Corporation Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
CN1191243C (zh) * 1994-07-27 2005-03-02 范德比尔特大学 用作抗炎剂的二氢苯并呋喃和相关化合物
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US6071950A (en) * 1996-12-02 2000-06-06 Kyorin Pharmaceutical Co., Ltd. N-substituted pyrrolidine derivatives and process for preparing the same
US6131129A (en) * 1997-07-30 2000-10-10 Sony Corporation Of Japan Computer system within an AV/C based media changer subunit providing a standarized command set
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
IL141235A (en) * 2000-02-09 2012-04-30 Novartis Int Pharm Ltd Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6653339B2 (en) 2001-08-15 2003-11-25 Pfizer Inc. Method of treating irritable bowel syndrome
JP3981357B2 (ja) * 2001-10-26 2007-09-26 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 第４級アンモニウム化合物および抗ムスカリン剤としてのそれらの使用
SE0103668D0 (sv) * 2001-11-02 2001-11-02 Astrazeneca Ab Method for the treatment of overactive blader
TW200300079A (en) * 2001-11-05 2003-05-16 Upjohn Co Antimuscarinic aerosol
GB0129962D0 (en) * 2001-12-14 2002-02-06 Pfizer Ltd Method of treatment
GB0207104D0 (en) * 2002-03-26 2002-05-08 Pfizer Ltd Stable hydrate of a muscarinic receptor antagonist
CA2492121A1 (en) 2002-07-08 2004-01-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
AU2002368152A1 (en) 2002-07-31 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists
US7410993B2 (en) 2002-08-09 2008-08-12 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
DE60231341D1 (de) 2002-08-23 2009-04-09 Ranbaxy Lab Ltd Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten
TW200412945A (en) * 2002-10-25 2004-08-01 Upjohn Co Quaternary ammonium compounds
TW200800953A (en) 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
ATE400553T1 (de) 2002-12-10 2008-07-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
US7465751B2 (en) 2002-12-23 2008-12-16 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7317102B2 (en) 2003-04-01 2008-01-08 Theravance, Inc. Diarylmethyl and related compounds
EP1618091A1 (en) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
DE60313898T2 (de) 2003-04-10 2008-01-17 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
US7560479B2 (en) 2003-04-10 2009-07-14 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1626957A1 (en) 2003-04-11 2006-02-22 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
WO2004091597A2 (en) * 2003-04-15 2004-10-28 Pharmacia & Upjohn Company Llc Method of treating irritable bowel syndrome (ibs)
US20040242569A1 (en) * 2003-04-15 2004-12-02 Pfizer Inc. Quatemary ammonium compounds
MXPA05011225A (es) * 2003-04-18 2005-12-14 Pharmacia & Upjohn Co Llc Politerapias.
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
JP2007524641A (ja) 2003-07-11 2007-08-30 セラヴァンス， インコーポレーテッド 置換４−アミノ−１−ベンジルピペリジン化合物
EP1725525A1 (en) * 2004-03-11 2006-11-29 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2005092341A1 (en) * 2004-03-22 2005-10-06 Ranbaxy Laboratories Limited Combination therapy for lower urinary tract symptoms
US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
CA2625858A1 (en) 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
AR062676A1 (es) 2006-09-07 2008-11-26 Medichem Sa Procedimiento mejorado para preparar compuestos de pirrolidina 1,3-disustituidas
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
EP2109601A2 (en) * 2007-01-05 2009-10-21 Dr. Reddy's Laboratories Ltd. Preparation of darifenacin and its salts
AU2008218962B2 (en) 2007-02-23 2013-03-14 Theravance Biopharma R&D Ip, Llc Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2008126106A2 (en) * 2007-04-16 2008-10-23 Manne Satyanarayana Reddy Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts
US20100204296A1 (en) * 2007-06-08 2010-08-12 Actavis Group Ptc Ehf Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt
EP2160372A1 (en) * 2007-06-15 2010-03-10 Medichem, S.A. Method for determining enantiomeric purity of darifenacin and intermediates
US20090005431A1 (en) * 2007-06-30 2009-01-01 Auspex Pharmaceuticals, Inc. Substituted pyrrolidines
WO2009010846A2 (en) * 2007-07-13 2009-01-22 Medichem, S.A. Amorphous form of darifenacin hydrobromide and processes for the preparation thereof
CZ300895B6 (cs) 2008-01-28 2009-09-02 Zentiva, A. S. Zpusob prípravy Darifenacinu
WO2009125430A2 (en) * 2008-03-17 2009-10-15 Matrix Laboratoires Limited Improved process for producing darifenacin
CN101983187A (zh) * 2008-04-02 2011-03-02 株式会社钟化 (s)-3-(1-氰基-1，1-二苯基甲基)吡咯烷的制备方法
WO2010032225A2 (en) * 2008-09-22 2010-03-25 Watson Pharma Private Limited Process for preparation of darifenacin and intermediates used in the process
EP2236509A1 (en) 2009-04-01 2010-10-06 Ragactives, S.L. Method for obtaining 1,3-difunctionalized pyrrolidine derivatives
SG176056A1 (en) 2009-05-15 2011-12-29 Redx Pharma Ltd Redox drug derivatives
WO2011070419A1 (en) 2009-12-10 2011-06-16 Aurobindo Pharma Limited An improved process for the preparation of darifenacin hydrobromide
US8748433B2 (en) 2010-04-30 2014-06-10 Merck Sharp & Dohme Corp. β3 adrenergic receptor agonists
CN101857581A (zh) * 2010-06-22 2010-10-13 浙江美诺华药物化学有限公司 一种制备达非那新中间体5-(2-溴乙基)-2,3-二氢-1-苯并呋喃的方法
WO2011161504A1 (en) 2010-06-23 2011-12-29 Micro Labs Limited Extended release formulations containing darifenacin or pharmaceutically acceptable salts thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1057145A (en) * 1963-08-16 1967-02-01 Bellon Labor Sa Roger Phenylcyclohexylacetonitrile derivatives
US4002766A (en) * 1974-12-26 1977-01-11 A. H. Robins Company, Incorporated Antiarrhythmia methods
US4242261A (en) * 1979-07-19 1980-12-30 A. H. Robins Company, Inc. Production of methylene-cycloamines
US4594343A (en) * 1984-10-19 1986-06-10 Shanklin Jr James R 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
IL76583A (en) * 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
EP0228893A3 (en) * 1985-12-20 1990-01-03 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl group in allergy treatment
IN163948B (cs) * 1986-01-17 1988-12-10 Robins Co Inc A H

Also Published As

Publication number Publication date
KR900014367A (ko) 1990-10-23
IL93694A (en) 1994-08-26
IE900955L (en) 1990-09-17
JPH0764809B2 (ja) 1995-07-12
JPH07149640A (ja) 1995-06-13
SK129590A3 (en) 1997-05-07
PT93443B (pt) 1996-02-29
NZ232958A (en) 1992-05-26
CY1812A (en) 1995-10-20
EP0388054A1 (en) 1990-09-19
ES2060020T3 (es) 1994-11-16
NO2005008I1 (en) 2005-04-11
FI95573C (fi) 1996-02-26
KR960015142B1 (ko) 1996-11-01
DE69004302T2 (de) 1994-02-24
DE122005000022I2 (de) 2006-02-02
AU614224B2 (en) 1991-08-22
BA98300A (bs) 2001-09-14
NO176316C (no) 1995-03-15
NO176316B (no) 1994-12-05
DE69004302D1 (de) 1993-12-09
SG143394G (en) 1995-01-13
CY2005005I2 (el) 2010-07-28
EP0388054B1 (en) 1993-11-03
JPH02282360A (ja) 1990-11-19
NO2005008I2 (no) 2006-11-27
CL2003002756A1 (es) 2005-02-11
RU2015965C1 (ru) 1994-07-15
PL164136B1 (pl) 1994-06-30
MX9319890A (es) 1993-08-01
DD292911A5 (de) 1991-08-14
HU217433B (hu) 2000-01-28
YU47587B (sh) 1995-10-24
HU901580D0 (en) 1990-06-28
DE122005000022I1 (de) 2005-08-04
RU1833374C (ru) 1993-08-07
CA2012295C (en) 1996-11-12
CY2005005I1 (el) 2010-07-28
GB8906166D0 (en) 1989-05-04
CZ129590A3 (en) 1995-05-17
PT93443A (pt) 1990-11-07
SK278434B6 (en) 1997-05-07
EG18951A (en) 1994-03-30
KR920008166B1 (ko) 1992-09-24
HU211640A9 (en) 1995-12-28
HK130294A (en) 1994-12-02
ZA901982B (en) 1991-10-30
US5096890B1 (en) 1995-03-28
FI95573B (fi) 1995-11-15
FI901333A0 (fi) 1990-03-16
IE62515B1 (en) 1995-02-08
CN1045580A (zh) 1990-09-26
NL300191I2 (nl) 2005-08-01
YU52790A (sh) 1992-07-20
NO901241D0 (no) 1990-03-16
CA2012295A1 (en) 1990-09-17
CZ280053B6 (cs) 1995-10-18
MY105527A (en) 1994-10-31
US5096890A (en) 1992-03-17
LU91161I2 (fr) 2005-06-13
HUT58313A (en) 1992-02-28
AU5140290A (en) 1990-09-20
NO901241L (no) 1990-09-18
IL93694A0 (en) 1990-12-23
UA18263A (uk) 1997-12-25
NL300191I1 (nl) 2005-07-01
CN1023007C (zh) 1993-12-08
ATE96783T1 (de) 1993-11-15

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