DE820303T1 - p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETES - Google Patents
p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETESInfo
- Publication number
- DE820303T1 DE820303T1 DE0820303T DE95944502T DE820303T1 DE 820303 T1 DE820303 T1 DE 820303T1 DE 0820303 T DE0820303 T DE 0820303T DE 95944502 T DE95944502 T DE 95944502T DE 820303 T1 DE820303 T1 DE 820303T1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- peptide
- hsp60
- iddm
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003745 diagnosis Methods 0.000 title claims 2
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 21
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000006303 Chaperonin 60 Human genes 0.000 claims 7
- 108010058432 Chaperonin 60 Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 238000002360 preparation method Methods 0.000 claims 7
- 108090000695 Cytokines Proteins 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 4
- 210000005087 mononuclear cell Anatomy 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 230000006052 T cell proliferation Effects 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 238000010382 chemical cross-linking Methods 0.000 claims 1
- 230000003436 cytoskeletal effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002706 hydrostatic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003127 radioimmunoassay Methods 0.000 claims 1
- 238000012827 research and development Methods 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Rehabilitation Therapy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11209494A IL112094A0 (en) | 1994-12-21 | 1994-12-21 | Novel peptides and pharmaceutical compositions comprising them |
| IL11446095A IL114460A0 (en) | 1995-07-05 | 1995-07-05 | Peptide p277 analogs and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes |
| PCT/US1995/016596 WO1996019236A1 (en) | 1994-12-21 | 1995-12-20 | PEPTIDE p277 ANALOGS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR TREATMENT OR DIAGNOSIS OF DIABETES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE820303T1 true DE820303T1 (de) | 1999-05-20 |
Family
ID=26322965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0820303T Pending DE820303T1 (de) | 1994-12-21 | 1995-12-20 | p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETES |
| DE69531004T Expired - Lifetime DE69531004T2 (de) | 1994-12-21 | 1995-12-20 | p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETES |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69531004T Expired - Lifetime DE69531004T2 (de) | 1994-12-21 | 1995-12-20 | p277 PEPTIDANALOGE, PHARMAZEUTISCHE ZUSAMMENSTELLUNG DAVON ZUR BEHANDLUNG UND DIAGNOSE VON DIABETES |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0820303B1 (enExample) |
| JP (2) | JP3420245B2 (enExample) |
| KR (1) | KR100400480B1 (enExample) |
| CN (1) | CN1233417C (enExample) |
| AR (1) | AR002949A1 (enExample) |
| AT (1) | ATE242005T1 (enExample) |
| AU (1) | AU707835B2 (enExample) |
| BR (1) | BR9510102A (enExample) |
| CA (1) | CA2208274C (enExample) |
| CZ (1) | CZ293784B6 (enExample) |
| DE (2) | DE820303T1 (enExample) |
| DK (1) | DK0820303T3 (enExample) |
| ES (1) | ES2201137T3 (enExample) |
| FI (1) | FI118373B (enExample) |
| HR (1) | HRP950612B1 (enExample) |
| HU (1) | HU224160B1 (enExample) |
| IL (1) | IL116499A0 (enExample) |
| IS (1) | IS1966B (enExample) |
| MX (1) | MX9704738A (enExample) |
| NO (1) | NO317350B1 (enExample) |
| NZ (1) | NZ301440A (enExample) |
| PL (1) | PL184145B1 (enExample) |
| PT (1) | PT820303E (enExample) |
| RO (1) | RO116777B1 (enExample) |
| RS (1) | RS49517B (enExample) |
| SI (1) | SI0820303T1 (enExample) |
| TR (1) | TR199501630A2 (enExample) |
| TW (1) | TW496872B (enExample) |
| UA (1) | UA42040C2 (enExample) |
| UY (1) | UY24130A1 (enExample) |
| WO (1) | WO1996019236A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6488933B2 (en) | 1995-07-05 | 2002-12-03 | Yeda Research And Development Co. Ltd. | Preparations for the treatment of T cell mediated diseases |
| JP3745380B2 (ja) * | 1996-05-14 | 2006-02-15 | ヴィンアッカー，エルンスト―ルートヴィッヒ | プリオンタンパク質に結合し、イソ型ＰｒＰ▲上ｃ▼とＰｒＰ▲上ｓｃ▼を識別することが可能なシャペロン |
| CA2420499A1 (en) * | 2000-08-25 | 2002-02-28 | Yeda Research And Development Co. Ltd. | Methods of treatment or prevention of autoimmune diseases with cpg-containing polynucleotide |
| IL140233A0 (en) * | 2000-12-11 | 2002-02-10 | Peptor Ltd | Backbone cyclized analogs of heat shock proteins |
| WO2003063759A2 (en) | 2002-01-31 | 2003-08-07 | Peptor Ltd. | Hsp peptides and analogs for modulation of immune responses via antigen presenting cells |
| WO2005072056A2 (en) * | 2004-01-28 | 2005-08-11 | Develogen Israel Ltd. | Hsp therapy in conjunction with a low antigenicity diet |
| DE102004043750A1 (de) * | 2004-09-10 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Formulierungen des Peptids p277 oder dessen Varianten mit optimierter Stabilität |
| RU2282453C2 (ru) * | 2004-12-14 | 2006-08-27 | Александр Борисович Смолянинов | Способ терапии больных сахарным диабетом ii типа |
| CN100352502C (zh) * | 2004-12-29 | 2007-12-05 | 中国药科大学 | 能通过免疫防治ⅰ型糖尿病的重组蛋白和重组基因 |
| EP1835933A4 (en) * | 2005-01-04 | 2015-01-07 | Yeda Res & Dev | HSP60, HSP60-PEPTIDES AND T-CELL VACCINES FOR IMMUNOMODULATION |
| WO2006096565A2 (en) * | 2005-03-04 | 2006-09-14 | Curedm Inc. | Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions |
| EP2295066B1 (en) | 2005-05-25 | 2016-04-27 | CureDM Group Holdings, LLC | Peptides, derivatives and analogs thereof, and methods of using same |
| JP4283812B2 (ja) * | 2006-01-06 | 2009-06-24 | 財団法人工業技術研究院 | 重症筋無力症の診断方法およびそのキット |
| WO2008064306A2 (en) | 2006-11-22 | 2008-05-29 | Curedm, Inc. | Methods and compositions relating to islet cell neogenesis |
| PT2193142E (pt) | 2007-08-30 | 2015-04-22 | Curedm Group Holdings Llc | Composições e procedimentos de utilização de peptídeos pro-ilhota e seus análogos |
| CU23701A1 (es) * | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
| CN104244967A (zh) | 2012-03-01 | 2014-12-24 | 耶达研究与发展有限公司 | 用于抑制和治疗非自身免疫性糖尿病的Hsp60衍生肽和肽类似物 |
| WO2013128453A1 (en) | 2012-03-01 | 2013-09-06 | Yeda Research And Development Co. Ltd. | Regeneration of islet beta cells by hsp60 derived peptides |
| CN104418948B (zh) * | 2013-09-10 | 2019-08-16 | 深圳翰宇药业股份有限公司 | 一种制备多肽药物的方法 |
| CN104650209B (zh) * | 2013-11-19 | 2018-04-06 | 深圳翰宇药业股份有限公司 | 多肽药物DiaPep277 的合成方法 |
| CN104650244B (zh) * | 2015-01-21 | 2017-12-08 | 中国药科大学 | 一种具有降血糖兼调脂作用的表位组合肽及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
-
1995
- 1995-12-20 WO PCT/US1995/016596 patent/WO1996019236A1/en not_active Ceased
- 1995-12-20 CA CA002208274A patent/CA2208274C/en not_active Expired - Lifetime
- 1995-12-20 PT PT95944502T patent/PT820303E/pt unknown
- 1995-12-20 EP EP95944502A patent/EP0820303B1/en not_active Expired - Lifetime
- 1995-12-20 CN CNB95197680XA patent/CN1233417C/zh not_active Expired - Lifetime
- 1995-12-20 NZ NZ301440A patent/NZ301440A/xx not_active IP Right Cessation
- 1995-12-20 DE DE0820303T patent/DE820303T1/de active Pending
- 1995-12-20 AT AT95944502T patent/ATE242005T1/de active
- 1995-12-20 UA UA97063404A patent/UA42040C2/uk unknown
- 1995-12-20 MX MX9704738A patent/MX9704738A/es unknown
- 1995-12-20 AU AU46866/96A patent/AU707835B2/en not_active Expired
- 1995-12-20 RO RO97-01173A patent/RO116777B1/ro unknown
- 1995-12-20 KR KR1019970704281A patent/KR100400480B1/ko not_active Expired - Lifetime
- 1995-12-20 CZ CZ19971908A patent/CZ293784B6/cs not_active IP Right Cessation
- 1995-12-20 ES ES95944502T patent/ES2201137T3/es not_active Expired - Lifetime
- 1995-12-20 SI SI9530664T patent/SI0820303T1/xx unknown
- 1995-12-20 HU HU9901771A patent/HU224160B1/hu active IP Right Grant
- 1995-12-20 PL PL95321091A patent/PL184145B1/pl unknown
- 1995-12-20 DE DE69531004T patent/DE69531004T2/de not_active Expired - Lifetime
- 1995-12-20 DK DK95944502T patent/DK0820303T3/da active
- 1995-12-20 JP JP51996596A patent/JP3420245B2/ja not_active Expired - Fee Related
- 1995-12-20 BR BR9510102A patent/BR9510102A/pt active IP Right Grant
- 1995-12-21 AR AR10071295A patent/AR002949A1/es unknown
- 1995-12-21 HR HR950612A patent/HRP950612B1/xx not_active IP Right Cessation
- 1995-12-21 IL IL11649995A patent/IL116499A0/xx not_active IP Right Cessation
- 1995-12-21 UY UY24130A patent/UY24130A1/es unknown
- 1995-12-21 TR TR95/01630A patent/TR199501630A2/xx unknown
- 1995-12-21 RS YU78795A patent/RS49517B/sr unknown
-
1996
- 1996-01-05 TW TW085100088A patent/TW496872B/zh not_active IP Right Cessation
-
1997
- 1997-06-19 NO NO19972849A patent/NO317350B1/no not_active IP Right Cessation
- 1997-06-19 IS IS4510A patent/IS1966B/is unknown
- 1997-06-19 FI FI972669A patent/FI118373B/fi not_active IP Right Cessation
-
2003
- 2003-01-30 JP JP2003022033A patent/JP3554319B2/ja not_active Expired - Fee Related
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