DE69936927T2 - Polyspezifische bindemoleküle und deren verwendung - Google Patents

Polyspezifische bindemoleküle und deren verwendung Download PDF

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Publication number
DE69936927T2
DE69936927T2 DE69936927T DE69936927T DE69936927T2 DE 69936927 T2 DE69936927 T2 DE 69936927T2 DE 69936927 T DE69936927 T DE 69936927T DE 69936927 T DE69936927 T DE 69936927T DE 69936927 T2 DE69936927 T2 DE 69936927T2
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Germany
Prior art keywords
chain
tcr
binding
cells
protein
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69936927T
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German (de)
English (en)
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DE69936927D1 (de
Inventor
Jon A. Miami Weidanz
Kimberlyn Card
Linda A. La Jolla SHERMAN
Norman R. La Jolla KLINMAN
Hing C. Fort Lauderdale WONG
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Altor Bioscience LLC
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Altor Bioscience LLC
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Publication of DE69936927D1 publication Critical patent/DE69936927D1/de
Publication of DE69936927T2 publication Critical patent/DE69936927T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69936927T 1998-10-21 1999-10-21 Polyspezifische bindemoleküle und deren verwendung Expired - Lifetime DE69936927T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10516498P 1998-10-21 1998-10-21
US105164P 1998-10-21
PCT/US1999/024645 WO2000023087A1 (en) 1998-10-21 1999-10-21 Polyspecific binding molecules and uses thereof

Publications (2)

Publication Number Publication Date
DE69936927D1 DE69936927D1 (de) 2007-10-04
DE69936927T2 true DE69936927T2 (de) 2008-05-15

Family

ID=22304401

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936927T Expired - Lifetime DE69936927T2 (de) 1998-10-21 1999-10-21 Polyspezifische bindemoleküle und deren verwendung

Country Status (9)

Country Link
US (3) US6534633B1 (https=)
EP (1) EP1124568B1 (https=)
JP (1) JP4467188B2 (https=)
AT (1) ATE370967T1 (https=)
AU (1) AU1218000A (https=)
DE (1) DE69936927T2 (https=)
DK (1) DK1124568T3 (https=)
ES (1) ES2293748T3 (https=)
WO (1) WO2000023087A1 (https=)

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Also Published As

Publication number Publication date
EP1124568B1 (en) 2007-08-22
US20030171552A1 (en) 2003-09-11
ES2293748T3 (es) 2008-03-16
ATE370967T1 (de) 2007-09-15
US6534633B1 (en) 2003-03-18
US8105830B2 (en) 2012-01-31
EP1124568A4 (en) 2003-08-27
US20120230995A1 (en) 2012-09-13
EP1124568A1 (en) 2001-08-22
AU1218000A (en) 2000-05-08
JP4467188B2 (ja) 2010-05-26
JP2004537952A (ja) 2004-12-24
WO2000023087A1 (en) 2000-04-27
DK1124568T3 (da) 2008-01-02
DE69936927D1 (de) 2007-10-04

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