DE69124518T2 - Herstellung monoklonaler Antikörper gegen menschliches Vbeta T-Zellrezeptorelement unter Verwendung rekombinanter DNA-Vektoren - Google Patents
Herstellung monoklonaler Antikörper gegen menschliches Vbeta T-Zellrezeptorelement unter Verwendung rekombinanter DNA-VektorenInfo
- Publication number
- DE69124518T2 DE69124518T2 DE69124518T DE69124518T DE69124518T2 DE 69124518 T2 DE69124518 T2 DE 69124518T2 DE 69124518 T DE69124518 T DE 69124518T DE 69124518 T DE69124518 T DE 69124518T DE 69124518 T2 DE69124518 T2 DE 69124518T2
- Authority
- DE
- Germany
- Prior art keywords
- monoclonal antibodies
- recombinant dna
- antibodies against
- vbeta
- dna vectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000013598 vector Substances 0.000 title abstract 3
- 108020004511 Recombinant DNA Proteins 0.000 title abstract 2
- 101500027988 Mus musculus ADGRV1 subunit beta Proteins 0.000 title 1
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56543990A | 1990-08-09 | 1990-08-09 | |
PCT/US1991/005653 WO1992002629A1 (en) | 1990-08-09 | 1991-08-08 | Producing monoclonal antibodies against human t-cell receptor elements using recombinant dna vectors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69124518D1 DE69124518D1 (de) | 1997-03-13 |
DE69124518T2 true DE69124518T2 (de) | 1997-05-15 |
Family
ID=24258606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69124518T Expired - Fee Related DE69124518T2 (de) | 1990-08-09 | 1991-08-08 | Herstellung monoklonaler Antikörper gegen menschliches Vbeta T-Zellrezeptorelement unter Verwendung rekombinanter DNA-Vektoren |
Country Status (12)
Country | Link |
---|---|
US (1) | US5616472A (de) |
EP (1) | EP0542897B1 (de) |
JP (1) | JPH06502529A (de) |
KR (1) | KR930701620A (de) |
AT (1) | ATE148499T1 (de) |
AU (1) | AU652959B2 (de) |
CA (1) | CA2088905A1 (de) |
DE (1) | DE69124518T2 (de) |
DK (1) | DK0542897T3 (de) |
ES (1) | ES2098368T3 (de) |
GR (1) | GR3023102T3 (de) |
WO (1) | WO1992002629A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766947A (en) * | 1988-12-14 | 1998-06-16 | Astra Ab | Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor |
US5552300A (en) * | 1994-01-13 | 1996-09-03 | T Cell Sciences, Inc. | T cell antigen receptor V region proteins and methods of preparation thereof |
KR100712256B1 (ko) * | 1997-10-02 | 2007-04-27 | 알토 바이오사이언스 코포레이션 | 가용성 단일쇄 t-세포 수용체 단백질 |
DK1124568T3 (da) * | 1998-10-21 | 2008-01-02 | Altor Bioscience Corp | Polyspecifikke bindingsmolekyler og anvendelser deraf |
WO2004070002A2 (en) * | 2002-11-18 | 2004-08-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Cell lines and host nucleic acid sequences related to infectious disease |
US11885806B2 (en) | 2014-03-05 | 2024-01-30 | Autolus Limited | Method for depleting malignant T-cells |
SG10201906460PA (en) * | 2014-03-05 | 2019-09-27 | Ucl Business Plc | Chimeric Antigen Receptor (Car) With Antigen Binding Domains to the T Cell Receptor Beta Constant Region |
EA201792661A1 (ru) * | 2015-06-01 | 2018-05-31 | Медиджин Иммьюнотерапиз Гмбх | Способ получения антител против т-клеточного рецептора |
CN107922950B (zh) | 2015-06-01 | 2021-12-31 | 基因医疗免疫疗法有限责任公司 | T细胞受体文库 |
JP6697562B2 (ja) | 2015-12-23 | 2020-05-20 | メディジーン イミュノテラピーズ ゲーエムベーハー | 樹状細胞組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189147A (en) * | 1984-06-13 | 1993-02-23 | Massachusetts Institute Of Technology | Meterodimeric T lymphocyte receptor antibody |
US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
-
1991
- 1991-08-08 AU AU85006/91A patent/AU652959B2/en not_active Ceased
- 1991-08-08 ES ES91915852T patent/ES2098368T3/es not_active Expired - Lifetime
- 1991-08-08 DK DK91915852.7T patent/DK0542897T3/da active
- 1991-08-08 WO PCT/US1991/005653 patent/WO1992002629A1/en active IP Right Grant
- 1991-08-08 EP EP91915852A patent/EP0542897B1/de not_active Expired - Lifetime
- 1991-08-08 DE DE69124518T patent/DE69124518T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91915852T patent/ATE148499T1/de not_active IP Right Cessation
- 1991-08-08 KR KR1019930700335A patent/KR930701620A/ko not_active Application Discontinuation
- 1991-08-08 JP JP3514673A patent/JPH06502529A/ja active Pending
- 1991-08-08 CA CA002088905A patent/CA2088905A1/en not_active Abandoned
-
1994
- 1994-07-21 US US08/278,629 patent/US5616472A/en not_active Expired - Fee Related
-
1997
- 1997-04-10 GR GR970400764T patent/GR3023102T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU8500691A (en) | 1992-03-02 |
EP0542897B1 (de) | 1997-01-29 |
ES2098368T3 (es) | 1997-05-01 |
DE69124518D1 (de) | 1997-03-13 |
WO1992002629A1 (en) | 1992-02-20 |
CA2088905A1 (en) | 1992-02-10 |
KR930701620A (ko) | 1993-06-12 |
AU652959B2 (en) | 1994-09-15 |
ATE148499T1 (de) | 1997-02-15 |
JPH06502529A (ja) | 1994-03-24 |
US5616472A (en) | 1997-04-01 |
GR3023102T3 (en) | 1997-07-30 |
EP0542897A4 (en) | 1993-08-18 |
EP0542897A1 (de) | 1993-05-26 |
DK0542897T3 (da) | 1997-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |