DE69925279D1 - Monoklonaler antikörper als hemmstoff für gm-csf, il-3, il-5 und andere zytokine und deren verwendung - Google Patents

Monoklonaler antikörper als hemmstoff für gm-csf, il-3, il-5 und andere zytokine und deren verwendung

Info

Publication number
DE69925279D1
DE69925279D1 DE69925279T DE69925279T DE69925279D1 DE 69925279 D1 DE69925279 D1 DE 69925279D1 DE 69925279 T DE69925279 T DE 69925279T DE 69925279 T DE69925279 T DE 69925279T DE 69925279 D1 DE69925279 D1 DE 69925279D1
Authority
DE
Germany
Prior art keywords
sub
antibody
receptor
monoclonal antibody
csf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69925279T
Other languages
English (en)
Other versions
DE69925279T2 (de
Inventor
Angel Lopez
Andrea Richard D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medvet Science Pty Ltd
Original Assignee
Medvet Science Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medvet Science Pty Ltd filed Critical Medvet Science Pty Ltd
Publication of DE69925279D1 publication Critical patent/DE69925279D1/de
Application granted granted Critical
Publication of DE69925279T2 publication Critical patent/DE69925279T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69925279T 1998-08-13 1999-08-13 Monoklonaler antikörper als hemmstoff für gm-csf, il-3, il-5 und andere zytokine und deren verwendung Expired - Lifetime DE69925279T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP5251A AUPP525198A0 (en) 1998-08-13 1998-08-13 Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof
AUPP525198 1998-08-13
PCT/AU1999/000659 WO2000009561A1 (en) 1998-08-13 1999-08-13 Monoclonal antibody inhibitor of gm-csf, il-3, il-5 and other cytokines, and uses thereof

Publications (2)

Publication Number Publication Date
DE69925279D1 true DE69925279D1 (de) 2005-06-16
DE69925279T2 DE69925279T2 (de) 2006-01-26

Family

ID=3809483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69925279T Expired - Lifetime DE69925279T2 (de) 1998-08-13 1999-08-13 Monoklonaler antikörper als hemmstoff für gm-csf, il-3, il-5 und andere zytokine und deren verwendung

Country Status (6)

Country Link
US (2) US6720155B1 (de)
EP (1) EP1105426B1 (de)
AT (1) ATE295376T1 (de)
AU (1) AUPP525198A0 (de)
DE (1) DE69925279T2 (de)
WO (1) WO2000009561A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
JP2002541061A (ja) 1999-02-08 2002-12-03 メドベット・サイエンス・プロプライエタリー・リミテッド サイトカイン結合ドメイン
US7108852B2 (en) * 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
US7455836B2 (en) 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
US8062637B2 (en) 2000-05-08 2011-11-22 Morphosys Ag Methods of ameliorating inflammatory disease using an uPA antagonist
US8658773B2 (en) 2011-05-02 2014-02-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
ES2527428T3 (es) * 2005-05-18 2015-01-23 Morphosys Ag Anticuerpos anti-GM-CSF y usos de los mismos
US20080171038A1 (en) * 2006-11-08 2008-07-17 Kalobios Pharmaceuticals, Inc. Methods of treating idiopathic thrombocytopenia purpura using a gm-csf antagonist
US8398972B2 (en) 2006-11-21 2013-03-19 Kalobios Pharmaceuticals, Inc. Methods of treating dementia using a GM-CSF antagonist
WO2009006688A1 (en) * 2007-07-11 2009-01-15 Medvet Science Pty Ltd Regulating il-4 and il- 13 levels by blocking high affinity binding by il-3, il-5 and gm-csf to their common receptor
GB0723179D0 (en) * 2007-11-27 2008-01-02 Immunovia Ab Diagnostic methods and arrays for use in the same
EP2193790A1 (de) * 2008-12-04 2010-06-09 Klinikum der Universität Regensburg IL-3-Inhibitoren zur Verwendung bei der Behandlung von rheumatoider Arthritis im Frühstadium
CN102256621B (zh) 2008-12-22 2017-12-12 墨尔本大学 疼痛治疗
US9243061B2 (en) 2008-12-22 2016-01-26 University Of Melbourne Osteoarthritis treatment
US20100209341A1 (en) * 2009-02-18 2010-08-19 Csl Limited Treatment of chronic inflammatory conditions
GB201009798D0 (en) 2010-06-11 2010-07-21 Immunovia Ab Method,array and use thereof
EP2885002A4 (de) 2012-08-14 2016-04-20 Ibc Pharmaceuticals Inc Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten
WO2014092804A1 (en) 2012-12-13 2014-06-19 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
WO2015126548A1 (en) 2014-02-21 2015-08-27 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to trop-2 expressing cells
CN106029098A (zh) 2014-02-25 2016-10-12 免疫医疗公司 人源化rfb4抗cd22抗体
WO2015200260A1 (en) 2014-06-24 2015-12-30 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
EP3204018B1 (de) 2014-10-07 2021-08-25 Immunomedics, Inc. Neoadjuvante verwendung von antikörper-wirkstoff-konjugaten
CN107428837A (zh) 2015-04-22 2017-12-01 免疫医疗公司 循环trop‑2阳性癌细胞的分离、检测、诊断和/或鉴定
PT3313443T (pt) 2015-06-25 2023-08-30 Immunomedics Inc Combinação de anticorpos anti-hla-dr ou anti-trop-2 com inibidores de microtúbulos, inibidores de parp, inibidores de bruton quinase ou inibidores de fosfoinositídeo 3-quinase melhora significativamente o resultado terapêutico no cancro
SI3316885T1 (sl) 2015-07-01 2021-09-30 Immunomedics, Inc. Imunokonjugati protitelo-SN-38 z linkerjem CL2A
WO2017027898A1 (en) * 2015-08-18 2017-02-23 University Of South Australia Novel cancer treatment involving modulation of il-3 activity
CN108368167B (zh) * 2015-11-27 2023-09-05 杰特有限公司 Cd131结合蛋白及其应用
CN109942706A (zh) * 2017-12-21 2019-06-28 三生国健药业（上海）股份有限公司 结合人il-5的单克隆抗体、其制备方法和用途
WO2022239720A1 (ja) 2021-05-10 2022-11-17 公益財団法人川崎市産業振興財団 抗原への結合親和性を低減させた抗体
WO2023173173A1 (en) * 2022-03-16 2023-09-21 CSL Innovation Pty Ltd Method of treating an eosinophil-associated disease
WO2024081996A1 (en) * 2022-10-20 2024-04-25 CSL Innovation Pty Ltd Method of treating severe asthma

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU706462B2 (en) * 1996-01-30 1999-06-17 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
AUPN780096A0 (en) * 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists

Also Published As

Publication number Publication date
EP1105426A1 (de) 2001-06-13
EP1105426B1 (de) 2005-05-11
AUPP525198A0 (en) 1998-09-03
EP1105426A4 (de) 2002-03-27
ATE295376T1 (de) 2005-05-15
US7427401B2 (en) 2008-09-23
US6720155B1 (en) 2004-04-13
WO2000009561A1 (en) 2000-02-24
DE69925279T2 (de) 2006-01-26
US20040265957A1 (en) 2004-12-30

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