ES2058219T3 - Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano. - Google Patents

Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano.

Info

Publication number
ES2058219T3
ES2058219T3 ES88119774T ES88119774T ES2058219T3 ES 2058219 T3 ES2058219 T3 ES 2058219T3 ES 88119774 T ES88119774 T ES 88119774T ES 88119774 T ES88119774 T ES 88119774T ES 2058219 T3 ES2058219 T3 ES 2058219T3
Authority
ES
Spain
Prior art keywords
cell lines
human
receptor protein
express
human rhinovirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88119774T
Other languages
English (en)
Inventor
Alan Mcclelland
Ann Marie Meyer
Jeffrey M Greve
Gary Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ES2058219T3 publication Critical patent/ES2058219T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32711—Rhinovirus
    • C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

LAS LINEAS DE CALCULOS DE MACUSFEROS NO FUMANOS QUE REPRESENTAN LA MAYOR PROTEINA RECEPTORA DE SINOVIRUS HUMANO. LAS LINEAS DE CALCULOS ESTAN PREPARADAS POR LA TRANSFECCION DE GUIAS DE DNA HUMANO, TAL COMO DNA DE ALULE HELA, EN CELULAS DE MAMIFEROS NO HUMANOS, TAL COMO CELULAS DE RATON. LOS TRANSFECTANTES PRIMARIOS PUEDEN SER TRANSFECTADO EN CELULAS ADICIONALES DE MAMIFEROS NO HUMANOS PARA PRODUCIR TRANSFECTANTES SECUNDARIOS. LA CLORIZACION DE LOS TRANSFECTANTES SECUNDARIOS PLRODUCEN LINEAS DE CELULAS QUE PRESENTAN UNA REPRESENTACION AUMENTADA DE LA PROTEINA RECEPTORA DE SINOVIRUS HUMANO E INMUNOGENES PARA PRODUCIR ANTICUERPOS, SU PARTICULAR ANTICUERPOS NONOCLONALES, CONTRA LA PROTEINA RECEPTORA. UN METODO GENERAL PARA CRIBAR CANDIDATOS DE DROGAS POR SU FACULTAD PARA BLOQUEAR EL ENLAZADOR DESLIGANTE A LA PROTEINA RECEPTORA SUPERFICIAL DE CELULAS HUMANAS ES TAMBIEN PROPORCIONADO.
ES88119774T 1987-12-08 1988-11-28 Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano. Expired - Lifetime ES2058219T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13037887A 1987-12-08 1987-12-08
US26257088A 1988-10-25 1988-10-25

Publications (1)

Publication Number Publication Date
ES2058219T3 true ES2058219T3 (es) 1994-11-01

Family

ID=26828436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88119774T Expired - Lifetime ES2058219T3 (es) 1987-12-08 1988-11-28 Lineas celulares transfectadas que expresan el receptor principal del rinovirus humano.

Country Status (7)

Country Link
EP (1) EP0319815B1 (es)
JP (1) JPH0242977A (es)
AT (1) ATE110771T1 (es)
AU (1) AU623105B2 (es)
CA (1) CA1341055C (es)
DE (1) DE3851309T2 (es)
ES (1) ES2058219T3 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5831036A (en) * 1987-05-04 1998-11-03 Dana Farber Cancer Institute Soluble fragments of human intercellular adhesion molecule-1
US5284931A (en) * 1987-05-04 1994-02-08 Dana Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands
US7354588B1 (en) 1987-05-04 2008-04-08 Dana Farber Cancer Institute Functional derivatives of ICAM-1 with altered ability to bind LFA-1 or HRV
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
ES2141076T3 (es) 1988-09-01 2000-03-16 Bayer Ag Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ATE246245T1 (de) * 1988-09-28 2003-08-15 Dana Farber Cancer Inst Inc Interzellulare adhäsions-moleküle und deren bindungsliganden
US5235049A (en) * 1989-01-24 1993-08-10 Molecular Therapeutics, Inc. Nucleic acid sequences encoding a soluble molecule (SICAM-1) related to but distinct from ICAM-1
NO900155L (no) * 1989-01-24 1990-07-25 Molecular Therapeutics Inc Et opploeselig molekyl som er relatert til, men forskjellig fra icam-1.
CA2008368C (en) * 1989-01-24 2003-04-08 Jeffrey Greve Soluble molecule related to but distinct from icam-1
EP0387701B1 (en) * 1989-03-09 1992-08-12 Boehringer Ingelheim Pharmaceuticals Inc. Use of intercellular adhesion molecules, and their binding ligands in the treatment of asthma
US6777191B1 (en) 1989-03-16 2004-08-17 Center For Blood Research, Inc. Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in diagnosis of viral infection
ATE219838T1 (de) * 1989-03-16 2002-07-15 Blood Res Center Verwendung von funktionellen derivaten des interzellulär-adhäsions-moleküls icam-1 in einer antivirus-therapie
US6797270B1 (en) 1989-03-16 2004-09-28 Center For Blood Research, Inc. Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
EP0468257B1 (en) * 1990-07-20 1999-09-01 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
EP0510483A1 (en) * 1991-04-22 1992-10-28 Boehringer Ingelheim Pharmaceuticals Inc. Method for the detection of viruses
US7241569B2 (en) 1993-01-18 2007-07-10 Olympus Corporation Method and a device for the evaluation of biopolymer fitness
DE59405644D1 (de) 1993-01-18 1998-05-14 Evotec Biosystems Gmbh Verfahren und vorrichtung zur bewertung der fitness von biopolymeren
CN113402601A (zh) * 2021-06-09 2021-09-17 河南中泽生物工程有限公司 一种抗非洲猪瘟病毒p54蛋白单克隆抗体的制备方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432170A1 (fr) * 1978-06-12 1980-02-22 Corning Glass Works Procede de mesure de recepteurs d'antigene sur des membranes de cellules
EP0169146A3 (en) * 1984-07-20 1988-07-20 Merck & Co. Inc. Monoclonal antibodies directed against the cellular receptor of human rhinovirus
EP0169729A3 (en) * 1984-07-23 1988-08-03 Becton Dickinson and Company Recovery of cell receptors
DE3712678A1 (de) * 1987-04-14 1988-10-27 Boehringer Ingelheim Int Rezeptor der kleinen rhinovirus rezeptor gruppe
US4893075A (en) * 1988-08-29 1990-01-09 Eaton Corporation Dual speed sensor pickup assembly with anti-cross talk coils

Also Published As

Publication number Publication date
EP0319815B1 (en) 1994-08-31
CA1341055C (en) 2000-07-18
EP0319815A3 (en) 1989-09-27
JPH0242977A (ja) 1990-02-13
AU2659488A (en) 1989-06-08
AU623105B2 (en) 1992-05-07
DE3851309T2 (de) 1994-12-22
ATE110771T1 (de) 1994-09-15
DE3851309D1 (de) 1994-10-06
EP0319815A2 (en) 1989-06-14

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